Gene 83275.m00150 (T.vaginalis)

83275.m00150

Species: T.vaginalis
Alias: TvagK0772, 83275.m00150
External Links:
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK1

Sequence

Name Sequence Type Origin Length Description Download
83275.m00150.AA Protein None 522 None Fasta, JSON
83275.m00150.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of 83275.m00150.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 83275.m00150.AA PLK 23-277 43 1.1e-107 351.77 In-house 1-258 (258) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-258/258
Sequence Identity: 43% (112 aa)

YKRREELGRGGFAAVYRVQESETGQDFAIKVINKSKYTKPKSIEKLKGEISIQSSLNHPNVLRSFGHYEDSRYHYILLEYCPGKSVRDMVRGS-RRLPEK
|.| . ||.|||| .|.. . .|.| .||||. ||  .||.  ||.| || |...|.|||...   . ||. . ||.||||...|  .. .   .|| | 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

KVVEITKDILSGVCYLHDNRIIHRDLKLENYLVGADGKIKVADFGLSAKLDYDDEKKFTVCGTPNYLCPEIL--RSKGHSYEVDVWAIGVSVYVMLFGKQ
 |  ..  | .|. |||..||||||||| | .   .  .|..||||...|.||.|.| |.||||||  ||.|    .|||||||.|..|. .|..|.|| 
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFDCIKTKLLYEHIKNGNYVIPIEPQVSKNAKEFIKSTLQINPNLRPSVQQLLCHPFI
||.    |  |. ||. .|..| ....|..||..|.. |. ||  ||.  |.|.||| 
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 83275.m00150.AA PLK-Unclassified 23-277 43 1.7e-98 333.49 In-house 1-264 (264) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-264/264
Sequence Identity: 43% (115 aa)

YKRREELGRGGFAAVYRVQESETGQDFAIKVINKSKYTKPKSIEKLKGEISIQSSLNHPNVLRSFGHYEDSRYHYILLEYCPGKSVRDMVRGS-------
|.| . || |||| .| | . || . .|.|.| ||  || .  .||. || |..||.|.|. .     ||. . ||||||||.... .. .         
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

RRLPEKKVVEITKDILSGVCYLHDNRIIHRDLKLENYLVGADGKIKVADFGLSAKLDYDDEKKFTVCGTPNYLCPEIL--RSKGHSYEVDVWAIGVSVYV
 || |  |  .|  |. .. |||.|||||||||| | ... . ..| .||||..|| .| ||| |.||||||  ||||  . .|||||||.|..|. .| 
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

MLFGKQPFDCIKTKLLYEHIKNGNYVIPIEPQVSKNAKEFIKSTLQINPNLRPSVQQLLCHPFI
.| || ||     |  |. ||. .|  | ....|.||| .|.. |..||  ||.  |.. ||| 
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase 83275.m00150.AA AGC 23-277 21 1e-93 241.99 In-house 1-395 (395) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-395/395
Sequence Identity: 21% (85 aa)

YKRREELGRGGFAAVYRVQES------ETGQDFAIKVINKSK---YTKPKSIEKLKGE------------ISIQSSLN----------HPNVLR-SFGHY
..    .|.|.|  || |..        ||. .|.||..|..    .| . .|. . |              | . .|          ||.. .  .  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDSRY--HYILLEYCP----------G-KSVRDMV-R-GSRRLPEKKVVEITKD-------ILSGVCYLHD-NRIIHRD-LKLENYLVGADGKIKVADFG
.| ..   |...||.|          |  .   .  | ...|..|. .  ..         |.... |||. . ||||| ||.|| |  .|| || .|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSAKLDYDD--------------------------------------------------EKKFTVCG--TPNYLCPEILRSKGHSYEVDVWA--IGVSVY
|. ..  |.                                                  ..  | ||  ||.|. ||||    .....| |.   |.  |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

VMLFGKQPFDCI----------KTKLLYEHIKNGNYVIPIE--------------PQVSKNAKEFIKSTLQINPNLRPS----------VQQLLCHPFI
 ||.|. ||               . ... |.||.|.|. .              ...|..|| .||  |. .|. |.           ....  ||. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 83275.m00150.AA CAMK 28-277 22 4.6e-93 300.17 In-house 1-425 (425) Show / Hide 
Range on Protein: 28-277
Range on HMM: 1-425/425
Sequence Identity: 22% (95 aa)

ELGRGGFAAVYRVQESETG------------QDFAIKVINKSKYTK-------------------------PKSIEKLKGEISIQSS-------LNHPNV
.||||.|. |..... .|.            | .|||.|.|.| ..                         ||. .... ||.| ..       |.|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRSFGHYEDSRY-------------------HYILL---EYCPGK----SVRDMV--RGS-------------RRLPEKKVVEITKDILSGVCYLHDNRI
.. . .|||..|                    |. .   |||.|      . |..  .|.             .|..|. .  . . |.|.| |.|.. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKLENYLVGAD-----------------GKIKVADFGLSAKLDY-----------------------DDEKKFTVCGTPNYLC-PEILRS------
.|||||.|| |.  .                 ..||..|||...|.|                        ...|  |.|||| | . ||.|..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KGHSYEVDVWAIGVSVYVMLFGKQPFDCI-------------KTKLLYEHIKNGNYVIPIEP----------------------QVSKNAKE
        .......|.|..||  |.|| |. ||.                 . |.| |..|.|  | ..                      .||. .| 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FIKSTLQINPNLRPSVQQLLCHPFI
.|.. || .|. |....| | ||..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 83275.m00150.AA S_TKc 23-277 30 1.4e-90 308.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-231/231
Sequence Identity: 30% (82 aa)

YKRREELGRGGFAAVYRVQESETGQDFAIKVINKSKYTKPKSIEKLKGEISIQSSLNHPNVLRSFGHYEDSRYHYILLEYCPG--KSVRDMVRGSRR---
|.  ...|.|.|. ||.... .||. .|||.|.          |... ||.| .. .|||. . .....|  . |. .|||.|   ...|. .  .|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPEKKVVEITKDILSGVCYLHDNRIIHRDLKLENYLVGADGKIKVADFGLSAKLDYDDEKKFTVCGTPNYLCPEILRSKGHSY-EVDVWAIGVSVYV
   .||  .  ... |.... |.|...||||||| || |.     ||..||||...|        |.||||.|. ||.|   |... ..|.|..|. .| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLFGKQPFDCIKTKLLYEHIKNGNYVIPIEPQVSKNAKEFIKSTLQINPNLRPSVQQLLC-------HPFI
|| |. ||.    ......|.            |. ||.||.  || .|. ||.. ..|        ||..
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 83275.m00150.AA PLK1 23-277 38 4.6e-85 279.52 In-house 1-253 (253) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-253/253
Sequence Identity: 38% (99 aa)

YKRREELGRGGFAAVYRVQESETGQDFAIKVINKSKYTKPKSIEKLKGEISIQSSLNHPNVLRSFGHYEDSRYHYILLEYCPGKSVRDMVRGSRRLPEKK
|.. . ||.||||  | ... .| . || ||. ||   |..  .|.  ||.|  .|.|... . . ..||... ||.|| |  .|. .. .  . . |  
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

VVEITKDILSGVCYLHDNRIIHRDLKLENYLVGADGKIKVADFGLSAKLDYDDEKKFTVCGTPNYLCPEILRSKGHSYEVDVWAIGVSVYVMLFGKQPFD
    .. |. |. |||.|.|||||||| |  .  . ..|. ||||  |..|| |.| | ||||||. ||.|  ||||.|||.|.||  .|..|||. ||.
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFE

CIKTKLLYEHIKNGNYVIPIEPQVSKNAKEFIKSTLQINPNLRPSVQQLLCHPFI
  . |  | .||. .|.||   ..|. |...|.. |. .|. || ..|.|   |.
TKCLKETYSRIKKNEYRIPS--HISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase 83275.m00150.AA Ciliate-E2 23-277 26 7.9e-83 281.49 In-house 1-365 (365) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-365/365
Sequence Identity: 26% (100 aa)

YKRREELGRGGFAAVYRVQESETGQDFAIK--------------VINKS---KYTKPKSIEKLKGEISIQ----------------SSLNHPNVLRSFGH
||  . .|.|.|. ||...  .....||||              | .|    |. |.. || .| ||.|                 ..|||||... . .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--DSRYHYILLEYCPGKSVRDMVR------------GSRRLPEKKVVEITKDILS---------------GVCYLHDNR-IIHRDLKLENYLVGADGK
..  |  . |. .||| |.. .|  .            .  .. ||.. .|.| ||.               .. ||| .  |||||.|.|| |.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKVADFGLSAKLDYDDEKK-------------------------------FTVCGTPNYLCPEILRSKG---------HSYEVDVWAIGVSVYVMLFGKQ
||..||||| |.| | ...                               .|.||||.|..||||..|.         ..|..|.|..||  | ||||| 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFDCIKTKLLYEHIKNGNYVIP----------------IEPQVSKNAKEFIKS----TLQINPNLRPS-VQQLLCHPFI
||        .. ||.... .|                .  ..|...| .||      || .|. |..  .|.| ||..
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 83275.m00150.AA CAMKL 23-277 31 2.4e-82 262.59 In-house 1-297 (297) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-297/297
Sequence Identity: 31% (95 aa)

YKRREELGRGGFAAVYRVQE-SETGQDFAIKVINKSKYTKPKSIEK------------LKGEISIQSSLN---HPNVLRSFGHYEDSRY------HYILL
|.  ..||.|.|. |   .  . ||.  |||.|.|.| ..   ..|            .. ||.|...||   |||. . . ..|....       |. .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCPGKS--VRDMV--RGSRR--LPEKKVVEITKDILSGVCYLHDNRIIHRDLKLENYLVGADG--KIKVADFGLSAKLD-Y---DDEKKFTVCGTPNYL
|||.| .    |..  .| ||  .||.    . . |.|.| |.|...|.|||.|.|| |.  .|  .||..|||.|.. . .   ...|  | ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

CPEILRS--KGHS-YEVDVWAIGVSVYVMLFGKQPFDCIKTK-------LLYEHIKNGNYVIPIEPQVSKNAKEFIKSTLQINPNLRPSVQQLLCHPFI
.|||. .  | .  ..||.|..||  |.|..|. |||.   .       .||. |. | | .|| ..||  .. .|.. || ||. ||...|.. ||. 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 83275.m00150.AA Pkinase 23-277 29 3.6e-79 274.12 Pfam 1-293 (293) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

YKRREELGRGGFAAVYRVQESETGQDFAIKVINKSKYTKPKSIEKLK-GEISIQSSLNHPNVLRSFGHYEDSRYHYILLEYCPGK----SVRDMVR--GS
|.. . .|.|.|. ||. ..  ||. .|.|.|.|..  . | .....  ||.|  .|||||..| .. .||... |. .|||.|     .  |...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RRL--PEKKVVEITKDILSGVCYLHDNRIIHRDLKLENYLVGADGKI----KVADFGLSAKL-DYDDEKKFTVCGTPNYLCPEILR-SKGHSYEVDVWAI
...  .|. .  . . ||.|. |.|...|||||||.|| |.  .| |    |..||||....    ..   |.||||.|. ||..| .......||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVSVYVMLFGKQPFDCI------KTKLLYEHIKNGNYVIPIEPQVS-------------------KNAKEFIKSTLQINPNLRPSVQQLLCHPFI
|. .| ||.|. ||.          . ... |. . .  ...   |                   ...|.|||. |. .|. ||. .|.|.||..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 83275.m00150.AA Ciliate-E2-Unclassified 23-277 26 2.6e-77 263.17 In-house 1-352 (352) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-352/352
Sequence Identity: 26% (95 aa)

YKRREELGRGGFAAVYRVQESETGQDFAIKVINKSKYTKPKSIEKLKGEISIQ-----------------------SSLNHPNVLRSFGHYEDSRYHYIL
||  . .|.|||. ||..|.....| .|.| ..|..  | |.|.. . ||. .                       ....||.... | . .|  . || 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYCPGKSVRDMVRGS-----------------RRLPEKKVV-----EITKDILSGVCYLHDN-RIIHRDLKLENYLVGADG---KIKVADFGLSAKLDY
.|||.|.. ... . .                 ....|....      ... ||.| .||| .  |||||.|.|| |.  .|   .||..|||.| |...
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

D---------------DEKKFTVCGTPNYL----CPEILRSKGHS----YEVDVWAIGVSVYVMLFGKQPFDCIKTKL----------------LYEHIK
.               ...  |.||||||.     ||.|......    |..|.|. ||  | ||||. ||.. . .                 ||. ||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

NGNYVIPIEP------QVSKNAKEFIK----STLQINPNLRPSVQQLLCHPFI
..|. .| .|      ..|..||.||.    . |. ||| |.. .|.|.||..
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 83275.m00150.AA STE 23-277 23 1.2e-75 257.66 In-house 1-359 (359) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-359/359
Sequence Identity: 23% (87 aa)

YKRREELGRGGFAAVYRVQESE---------------TGQDFAIKVINKSKYTK--------------PKSIEKLKGEISIQSSLN--HPNVLRSFGHYE
... |..|.|.|  ||.    .               ||. .|||..|... ..              .. ..... ||.| . .|  |||. . .|.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DSR-------YHYILLEYCPGKSVRDMVR---GS-----------RRLPEKKVVEITKDILSG-VCYLHDNRIIHRDLKLENYLVGADGKIKVADFGLSA
.         . .| .||..| |..|...   |             |.||. .  |...|| |   |||...|||||.|  | |.     .| .|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KLDYD----------------DEKKFTVCGTPNYLCPEILRS------KGHSYEVDVWAIGVSVYVMLFGKQPF-DCIKTKLLYEHIKNG----------
.|. .                ..|  |..||| .  ||...       ||... .|.| .|  .  |. || |. |   .. ... ..|.          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---NYVIPIEP-------------------QVSKNAKEFIKSTLQINPNLRPSVQQLLC--HPFI
   .   |...                   ..|.. |.||.  ||..|| ||...|||   ||||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 83275.m00150.AA ULK 23-277 27 9.1e-69 234.77 In-house 1-329 (329) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-329/329
Sequence Identity: 27% (91 aa)

YKRREELGRGGFAAVYRVQESET----GQDFAIKVINKSKYTKPKS-------IEKLKGEISIQSSLN--------HPNVLRSFGHYEDS--RYHYILLE
|  ...|| | |. ||.    .|    ....|.|.| |.|  . .        .. || || |.  |.        |||. . .  .|.|   ..|| .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCPGKSVRDMVR----------GSRRLPEKKVVEITKDILSGVCYLHDNRIIHRDLKLENYLVGA-DGK-----------IKVADFGLSAKLDYD-----
||.|   ..               .||.|...... |.||.|  .||...|||||.|..| |.   ..|           .|.||||.. ..|.|     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

DEKKFT----VCGTPNYLCPEILRSKG----HS-YEVDVWAIGVSVYVMLFGKQPFDC-IKTKLLYEHIKNGNY---------VIPIE-------PQVSK
... ..    .|||| | .|.|| ..|    .. |..|.| .|.  | ||.|| || . . .  |. ..|. |.          .|..       ||.|.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

NAKEFIKSTLQINPNLRPSVQQLLCHPFI
. |..|.  ||.... | | ..|. ||..
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 83275.m00150.AA TyrKc 23-277 23 1.5e-24 88.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

YKRREELGRGGFAAVYRVQESETGQDFAIKVINKSKYTKPKSIEKLKGEISIQSSL--NHPNVLRSFGHYEDS-------RYHYILLEYCPGKSVRDMVR
 .  ..||.| |  ||. . .   .. |.|......      .| .  |..| ..|  .|||..| .|   ..         ..|..||.|. . .|  |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

GSRR-LPEKKVVEITKDILSGVCYLHDNRIIHRDLKLENYLVGADGKIKVADFGLSAKLDYD-------DEKKFTV--CGTP----NYLCPEILRSKGHS
 .|. |. |. ...  .| .|  |||....|||||   | |||... .|..||||| ... |       | .. .   .|        . || .. .  .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

YEVDVWAIGVSVY-VMLFGKQPFDC-----IKTKLLYEHIKNGNYVIPIEP-------QVSKNAKEFIKSTLQINPNLRPSVQQLLCHPFI
 . |||. ||  . .. .|.||        .. . ..|..|.|..  . .          ..   . .|.  . .|. ||. ...  | ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 83275.m00150.AA Pkinase_Tyr 23-176 27 3.1e-20 69.15 Pfam 1-165 (270) Show / Hide 
Range on Protein: 23-176
Range on HMM: 1-165/270
Sequence Identity: 27% (46 aa)

YKRREELGRGGFAAVYRVQES----ETGQDFAIKVINKSKYTKPKS--IEKLKGEISIQSSL-NHPNVLRSFGHYE-DSRY--HYILLEYCPGKSVRDMV
 .  ..||.| |  ||.        .|... |.|...   .. ..   .|..  |..| ..| .|||..|  |    ...   .|| .||.|. . .|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RG----SRRLPEKKVVEITKDILSGVCYLHDNRIIHRDLKLENYLVGADGKIKVADFGLSAKLDYDDE
|      ..|. |  ...  .| .|  ||.....|||||   | ||. ....|..||||.  . |.|.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDD