Gene 93904.m00257 (T.vaginalis)

93904.m00257

Species: T.vaginalis
Alias: TvagK0501, 93904.m00257
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
93904.m00257.AA Protein None 364 None Fasta, JSON
93904.m00257.kin_dom Protein Kinase Domain None 173 None Fasta, JSON

Protein domain

Protein domains of 93904.m00257.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93904.m00257.AA CK1 10-264 27 4.7e-83 282.24 In-house 1-339 (339) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-339/339
Sequence Identity: 27% (92 aa)

YMLGPQLGQGGFG-KIFAA-----RDVRDG-----KVYALKAESELSN-RKSLEFETKVLERIKT---------------------IRYFPQIREHGVYH
.... ..|.||||  |. .     .|. ..     . ||.|.|.. |. ..... |  .. ....                     . .....  ||  .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

NYH-WLTLELIGPSLSAILK-ERT-DHKFSLSTALRASIHVLRSIKSLHALGFIHRDIKPANILVRV-------------SHGLP-LCLIDFGLVR-VYR
.|. .. ..| ||.|. ..| .|  ..|||..|.|.  |  | ... .|  |||||||||.|... .             .  .  . .||||..|  ||
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DQ-----------KTHAHIPPRQ---HTGFRG-TKTYASVNAHVLSDLSRRDDLISWVYFTICLMVGG--LPWQGVNDNSE-----VMRMKHEF--NVKE
|            ||. |.|||    ..|||| |  |.|.|.|   ...||||| || |  | ...|.  ||||...|...     |..|| ||  . | 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

AVKNV--CP--------EFVEVWPLVVGLRFEDDPNYDAL
 ..    ||        || .... . .|...| |.|...
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 93904.m00257.AA Worm6 10-264 28 1.2e-68 234.38 In-house 1-279 (279) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-279/279
Sequence Identity: 28% (81 aa)

YMLGPQLGQGGFGKIFAARDVRDGK--VYALKAES--ELSNRKSLEFETKVLERIKTIR--YFPQIREHGVYHN--YHWLTLELIGPSLSAILKERTDHK
. ..  .|.|||| .. . |  |.|   .|.|.|.  | . |. | .|  || ..| ..  .|..| ..| . |  .... ..|.|..|. . |.| | |
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSLSTALRASIHVLRSIKSLHALGFIHRDIKPANILVRV------SHGLPLCLIDFGLVR--VYRDQKTHAHIPPR-QHTGFRGTKTYASVNAHVLSDLS
||..|.|. .|  |..|  ||  ||||||.||.|  . .           ....|||. |  .|.....   ..|| .. |||||  ||....|   ...
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNEL-RTPRWTACGFRGTVRYAPLACHKGQEQC

RRDDLISWVYFTICLMVGGLPWQGVNDNSEVMRMKHEF---N----VKEAVKNVCP-EFVEVWPLVVGLRFEDDPNYDAL
|.||. || |  . . ||.|||....| ..| . |..    .     ..  ..... ||...   . .....|.|.|. .
RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 93904.m00257.AA TTBKL 10-268 29 1.5e-67 227.14 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-268
Range on HMM: 1-288/288
Sequence Identity: 29% (85 aa)

YMLGPQLGQGGFGKIFAARDVRD-GKVYALKAESEL-SN-RKSLEFETKVLERIK--TIRYFPQIREHGVYHNYHWLTLELIGPSLSAILKERTDHK-FS
.|   ..|.||||... ..|. | ....|.|.|.   ..  . ...| .|| .      ..||.. . | ...|... ..| ||.|... |     | ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LSTALRASIHVLRSIKSLHALGFIHRDIKPANILVRVS-H----GLPLCLIDFGLVRVYR----------DQKTHAHIPPRQ---HTGFRGTKTYASVNA
 .|..| .| .| ..| .|  ||||||.||.|. . .. |       . |||||..| |.           ...  . .||    ...||||  |.|.|.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HVLSDLSRRDDLISWVYFTICLMVGGLPWQGVNDNSEVMRMKHEFNVKEAVKN------VCPEFVEVWPLVVGLRFEDDPNYDALEEIL
|   ...| ||| || | .| |..| |||....|  |.. || . . .   |.        .|| .. . .  ||. | |.|. . |..
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 93904.m00257.AA CK1-A 10-264 33 8.2e-49 168.48 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-261/261
Sequence Identity: 33% (88 aa)

YMLGPQLGQGGFGKIFAARDVRDGKVYALKAESELSNRKSLEFETKVLERIKTIRYFPQIREHGVYHNYHWLTLELIGPSLSAILKERTDHKFSLSTALR
| |  ..| | || |. .  ...|.  |.| ||.      | .|.|| . ..    .|..| .|  ..|  . ..|.||||  .     . .|.. | | 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLF-NFCKRRFTMKTVLM

ASIHVLRSIKSLHALGFIHRDIKPANILVRVS-HGLPLCLIDFGLVRVYRDQKTHAHIPPRQHTGFRGTKTYASVNAHVLSDLSRRDDLISWVYFTICLM
    ..  |  .|  .|||||||| | |. .  |   | |||||| . |||..|. ||| |.     ||  |||.|||.  . |||||. |  |  .   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

VGGLPWQGVNDNSE------VMRMKHEFNVKEAVKNVCPEFVEVWPLVVGLRFEDDPNYDAL
 | |||||.  .        .   |    ...  |    ||      . .||||. |.|  |
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 93904.m00257.AA TTBK 10-264 32 7.4e-48 165.31 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-257/257
Sequence Identity: 32% (85 aa)

YMLGPQLGQGGFGKIFAARDVRDG-KVYALKAESELSNRKSLEFETKVLERIKTIRYFPQIREHGVYHNYHWLTLELIGPSLSAILKERTDHKFSLSTAL
       |.|||| |. | |.       |.| ||    .  |  |  || .     .  .    |   .. .. ..| | .|.    .  . .|||||.|
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RASIHVLRSIKSLHALGFIHRDIKPANILV-RVSHGLPLC-LIDFGLVRVYRDQKTHAHIPPRQHTGFRGTKTYASVNAHVLSDLSRRDDLISWVYFTIC
|  . .| ||.| | .|| |||||| |  . |..     | ..|||| | |   .     |||. .|||||  |||.|||   .. |.||| |  |  . 
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVR-PPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LMVGGLPWQGVNDNSEVMRMKHEFNVKEAVKNVCPEFVEVWPLVVGLRFEDDPNYDAL
 ..| |||  . |  .| .|| ... .  .|.. .||      .  | .|| |.|  .
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 93904.m00257.AA CK1-D 10-264 33 5.9e-46 158.99 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-261/261
Sequence Identity: 33% (87 aa)

YMLGPQLGQGGFGKIFAARDVRDGKVYALKAESELSNRKSLEFETKVLERIKTIRYFPQIREHGVYHNYHWLTLELIGPSLSAILKERTDHKFSLSTALR
| .| ..| | || |.   ..  .   |.| |.  .    |..| |.   ..     |.||  |   .|  . ..|.||||  .     . |||| | | 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLF-NYCHRKFSLKTVLM

ASIHVLRSIKSLHALGFIHRDIKPANILVRV-SHGLPLCLIDFGLVRVYRDQKTHAHIPPRQHTGFRGTKTYASVNAHVLSDLSRRDDLISWVYFTICLM
 .  ... |. .|.  |||||||| | |. .  .|    .||||| . ||| .|| ||| | .    ||  |||.| |   . |||||| |  |  .   
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

VGGLPWQGVNDNS------EVMRMKHEFNVKEAVKNVCPEFVEVWPLVVGLRFEDDPNYDAL
 | |||||.           ..  | . ....  |    ||..    .  |.|.| |.|  |
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 93904.m00257.AA CK1 10-262 33 3.5e-40 136.09 In-house 1-271 (271) Show / Hide 
Range on Protein: 10-262
Range on HMM: 1-271/271
Sequence Identity: 33% (92 aa)

YMLGPQLGQGGFGKIFAARDVRDGKV--YALKAESELSNRKSLEFETKVLERIKT------IRYFPQIREHGVY--HNYHWLTLELIGPSLSAILKERTD
|..|  .||| || |. . .. .|.   .| | |.. |    | .| |.. . .         ..|...  |     .|  . ..| ||||   |.   .
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSL-EDLFNFCN

HKFSLSTALRASIHVLRSIKSLHALGFIHRDIKPANILVRV--SHGLPLCLIDFGLVRVYRDQKTHAHIPPRQHTGFRGTKTYASVNAHVLSDLSRRDDL
 |||| | |      .. |  .|  .|||||||| |.|. .   |.  . .|||||   ||| ||| ||| | . .. ||  |||.|.|     |||||.
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM

ISWVYFTICLMVGGLPWQGVNDNSE------VMRMKHEFNVKEAVKNVCP-EFVEVWPLVVGLRFEDDPNYD
 |  |  . .  | |||||.  |.        | .|   .| .  |. .| ||..    . .|.||..|.|.
ESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 93904.m00257.AA CK1-Unclassified 10-217 35 8.2e-37 106.19 In-house 1-219 (244) Show / Hide 
Range on Protein: 10-217
Range on HMM: 1-219/244
Sequence Identity: 35% (77 aa)

YMLGPQLGQGGFGKIFAARDVRDGKVYALKAESELSNRKSLEFETKVLERIKTIR-------YFPQIREHGVY--HNYHWLTLELIGPSLSAILKERTDH
|...  .||| || |. . .. .....|.| |.. |  . | .| |.. . .          ..| . . |     .|  . ..| ||||   |.     
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSL-EDLFNMCNR

KFSLSTALRASIHVLRSIKSLHALGFIHRDIKPANILV--RVSHGLPLCLIDFGLVRVYRDQ-KTHAHIPPRQHTGFRGTKTYASVNAHVLSDLSRRDDL
|||| | |      .  |  ||  .|||||||| |.|.  .  .   . .|||||   |.|  ||. ||| |   .. ||  |||.|||     ||||||
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL

ISWVYFTICLMVGGLPWQGV
 |  |  | .  | ||||..
ESLGYVLIYFLKGSLPWQNI
Kinase 93904.m00257.AA CK1-G 10-264 29 2.9e-29 96.29 In-house 1-266 (266) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-266/266
Sequence Identity: 29% (80 aa)

YMLGPQLGQGGFGKIFAARDVRDGKVYALKAESELSNRKSLEFETKVLERIKTIR-YFPQIREHGVYHNYHWLTLELIGPSLSAILKERTDHKFSLSTAL
|  |.  | | || .|  . .  .   | | |   |.   |  | .      .     ||.   |    |  . ..| ||||     .  | |||. | .
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLF-DWCDRKFSVKTVC

RASIHVLRSIKSLHALGFIHRDIKPANILV-RVSHGLP--LCLIDFGLVRVYRDQKTHAHIPPRQHTGFRGTKTYASVNAHVLSDLSRRDDLISWVYFTI
  .|  .. .. .|.   | ||.|| | |. | |   .  . .||||. . |.| .|  ||| | |    ||  | |.| |     |||||. .     .
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

CLMVGGLPWQGVNDNSEVMR------MKHEFNVKEAVKN-VCP-EFVEVWPLVVGLRFEDDPNYDAL
  . | |||||        |       | . |..  ..|   | .|      |  | |...| || |
YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 93904.m00257.AA CK1-Unique 10-215 24 6.4e-23 76.3 In-house 1-233 (337) Show / Hide 
Range on Protein: 10-215
Range on HMM: 1-233/337
Sequence Identity: 24% (56 aa)

YMLGPQLGQGGFGKIFAARDVRDG------KVYALKAESELSNRK--SLEFETKVLERIKTIR-------YFPQIREHGVYHNYHWLTLELIGPSLSAIL
.     .| ||.|      .| .|      . |. | |     .    |  | .|.  | .          |....  ..   . |. . ..|||.  . 
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

KERTDHKFSLS------TALRASIHVLRSIKSLHALGFIHRDIKPANILVRVSH---GLPLCLIDFGL-VRVYRDQKTHAHIPPRQHTGFRGTKTYASVN
      .| |.      .|.. .  .|  |   |  ||.||..||.|.            .  .|.|  .||    . |   .||  | |||.| |..  
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

AHVLSDLSRRDDLISWVYFTICLMVG--GLPWQ
 | . ...||||. ||.|  . |  .  || |.
CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase 93904.m00257.AA Pkinase 10-182 21 7.2e-22 78.41 Pfam 1-179 (293) Show / Hide 
Range on Protein: 10-182
Range on HMM: 1-179/293
Sequence Identity: 21% (42 aa)

YMLGPQLGQGGFGKIFAARDVRDGKVYALKAESELSNRKSLEF-------ETKVLERI------KTIRYFPQIREHGVYHNYHWLTLELIGP-----SLS
| .| ..|.|.||. . .... .||..|.|  .   ..|| .        | ... |.      .....|         ... .. .|. .      .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-------KDHIYMVMEYCEGGLYVMDLF

AILKERTDHKF--SLSTALRASIHVLRSIKSLHALGFIHRDIKPANILVRVSHGLP---LCLIDFGLVRVYRDQKTHAHIPPRQHTGFRGTKTYAS
.... . . .|  |  .. .    .|| .. .|. |.||||.||.|||.  ..| .   ....|||| ....      . . .  |.| ||  |..
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMA
Kinase 93904.m00257.AA S_TKc 10-289 14 1.6e-14 35.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-289
Range on HMM: 1-231/231
Sequence Identity: 14% (44 aa)

YMLGPQLGQGGFGKIFAARDVRDGKVYALKAESELSNRKSLEFETKVLERIKTIRYFPQIREHGVYHNYHWLTLELIGP---SLSAILKERTDHK----F
| .. ..|.|.||| . .|....|...|.|  .     .... | ..|..     .  .. .. .  .. .. .|...    .|  ..|.|  |.    |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLSTALRASIHVLRSIKSLHALGFIHRDIKPANILVRVSHGLPLCLIDFGLVRVYRDQKTHAHIPPRQHTGFRGTKTYASVNAHVLSDLSRRDDLISWVY
.  .| .    ... .. .| .|.||||.||.|||.       . ..|||| |..              | | ||  | .                    
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL-------------GYG

F-----------TICLMVGGLPWQGVNDNSEVMRMKHEFNVKEAVKNVCPEFVEVWPLVVGLRFEDDPNYDALEEILIKACETRGYK---GTDPYDW---
.            . ...|  |..   .  .....                                   . . . .|. | ..  .   .         
KCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEW

----DEYV
    ....
DIKCHPWF
Kinase 93904.m00257.AA TyrKc 10-268 16 2.6e-05 -136.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-268
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

YMLGPQLGQGGFGKIFAARDVRDGKVY-----ALKAESELSNRKSLEFETKVLERI--KTIRYFPQIREHGVYH---------NYHWLTLELIGP-SLSA
  || .|| | ||... ..       .      ||...    |. .  | ... ..  .       .| .||             ... .|.    .|  
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNI---VRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

ILKERTDHKFSLSTALRASIHVLRSIKSLHALGFIHRDIKPANILVRVSHGLPLCLIDFGLVRVYRDQ-KTHAHIPPRQHTGFRGTKTYAS---VNAH--
 |... .. ..... |  .. . .    ||  ..||||.   |.||   |       |||| |   |  ..              ...| .    ...  
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQG-----------ESKDYYRKKEHKGGKTM

---------VLSDLSRRDDLISWVY-FTICL----MVGGLPWQGV----NDNSEVMRMKHEFNVKEAVKNV-------CPEFV-----EVWPLVVGLRFE
         ..    ..    | |. | .|.      |. |. |.     .|.||..   . .  .  .|.       ||. .     . |      |  
LPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR--

DDPNYDALEEIL
  |.  .. |..
--PTFSEIHECF