82569.m00140

Species: T.vaginalis
Alias: 82569.m00140, TvagK0619
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
82569.m00140.AA Protein None 2262 None Fasta, JSON
82569.m00140.kin_dom Protein Kinase Domain None 149 None Fasta, JSON

Protein domain

Protein domains of 82569.m00140.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82569.m00140.AA PIKK 1874-2142 36 3.9e-89 302.42 In-house 1-290 (290) Show / Hide
Range on Protein: 1874-2142
Range on HMM: 1-290/290
Sequence Identity: 36% (105 aa)

RIQYFVGQFSVYMSKQQPKDVIVRGEDGNFYQYLVKGHEDLRLDERIMQFFRLINSFLKKQ-TYFSGNL-IGTMGVIPLSMQHGLVQWVRGTDTLRHVVE
||. .     |  .|| ||  . || || .| ||.|||||||.|.|.||.|.|.|  | |  .  . .| | |  |||.|.. ||..|| ...||.    
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

TYRKLYS---RDPMQE----------------FKLLEEYSYSSYDYMLPIQKQQVLEKVMRNVPSNDIAKLFILKADSTSTWLKQQHTFAISTAMTSIVG
 ... .    ... |                  | ...    .|.     .| .|....| |.| .. .|.| .|. .  .|.     ...|.|  ..||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YVIGLGDRHPSNILIDRLSGKVIHIDFGDCFEKAAKRKFLPEVVPFRLTRMMVSAMGVTGTMGTFRTAFVQMANILRENRRVLVMVLSIF
|..|||||||.||.||...|...|||||.|||.| .|   || |||||||.|| |||..|. | || . .. . ..|..|  |  |.  |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF

Kinase 82569.m00140.AA FRAP 1904-2152 40 4.8e-78 265.6 In-house 2-251 (251) Show / Hide
Range on Protein: 1904-2152
Range on HMM: 2-251/251
Sequence Identity: 40% (101 aa)

YQYLVKGHEDLRLDERIMQFFRLINSFLKKQTYFS-GNL-IGTMGVIPLSMQHGLVQWVRGTDTLRHVVETYRKLYSRDPMQEFKLLEEYSYSSYDYMLP
| .| |||||.| |||.|| | |||  |. ..     || |    .|||||. ||. ||.  |||.  .  ||| |      |...... . . || .  
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDR-MCNDYDHLPL

IQKQQVLEKVMRNVPSNDIAKLFILKADSTSTWLKQQHTFAISTAMTSIVGYVIGLGDRHPSNILIDRLSGKVIHIDFGDCFEKAAKRKFLPEVVPFRLT
..|  . . .| |   .|..||  ||  .   |.     .  | |  |..||..||||||||||...|..||..||||||||| | .|  .|| .|||||
MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT

RMMVSAMGVTGTMGTFRTAFVQMANILRENRRVLVMVLSIFVHEPLVDPDS
||.| || ..|  |..| .     ...||..  .. ||  ||  ||     
RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL

Kinase 82569.m00140.AA PI3_PI4_kinase 1903-2152 23 5.9e-64 223.59 Pfam 1-300 (300) Show / Hide
Range on Protein: 1903-2152
Range on HMM: 1-300/300
Sequence Identity: 23% (75 aa)

FYQYLVKGHEDLR--LDERIMQFF-----------------------RLINSFLKKQTYFSGNL----IGTMGVIPLSMQHGLVQWVRGTDTLRHVVETY
 |....||..|||   |.|.||..                       ||.| ..||      .     . .  .||.. ..|...||  ..|....  ||
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGC--DRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTY

R----------------KLYSRDPMQEFKLLEEYSYSSYDYMLPIQKQQVLEKVMRNVPSNDIAKLFILKADST-STWLKQQHTFAISTAMTSIVGYVIG
.                |.. . .. .                 .||..| |... ..| ... ..|. .  .   .|..  ..|. | |  ..|.|..|
MVKCKHKHFNKEHKMWMKMWPDWWHLM----------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILG

LGDRHPSNILI--DRLSGKVIHIDFGDCFE-KAAKRKFLPEVVPFRLTR------MMVSAM------GVTGTMGTFRTAFVQMANILRENRRVLVMVL--
.||||..||..  |. .|...|||||.||.  . |. . || ||||.|.      .||.||      ...| .|.||.  ... ..||.. ......|  
NGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKK

-----SIFVHEPLVDPDS
     ...|| .|..  |
AVMRGECMVHDGLPMWRS

Kinase 82569.m00140.AA PI3Kc 1905-2220 22 3.8e-54 187.1 SMART 1-336 (336) Show / Hide
Range on Protein: 1905-2220
Range on HMM: 1-336/336
Sequence Identity: 22% (78 aa)

QYLVKGHEDLRLDERIMQFFRLINSFLKKQ-TYFSGNL-IGTMGVIPLSMQHGLVQWVRGTDTLRHVVETYRKLYS--------------------RDPM
. ..|...||| |.|.||.|||.|  ..|.   .  .| . ....||.. ..|...||  ..||. .  .|.|  .                    . .|
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

QEFKLLEEYSYSSYDYMLPIQKQQVLEKVMRNVPSNDIAKLFILKADSTS-TWLKQQHTFAISTAMTSIVGYVIGLGDRHPSNILIDRLSGKVIHIDFGD
 ...  ..    .|. |  ...... |..  ... ..... |. .  . .  | . . .|. |.|  ..|.|. |.||||..||..|. .|...|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

CFEKAAKRKFLP-----EVVPFRLTRMMVSAMG----VTGTMGTFRTAFVQMANILRENRRVLVMVLSIFVHEPLVDPDSIEDSNIDTVDMPESVPPDPP
.|... ..|...     |.||||||..|| .||    ..|  | |||  ..  ...|... ... .....|. |. .|.   .               . 
IFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPI-MPCWRMM---------------EK

QQGYAKERPQVN-NNLMLAGSIMEK----SRIMLANNPAAQSSLEMRHRVNQK
   | ..| ...  .  .|   ...      |   |.       .| |...| 
DIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase 82569.m00140.AA ATR 1874-2142 32 2e-47 159.46 In-house 2-267 (267) Show / Hide
Range on Protein: 1874-2142
Range on HMM: 2-267/267
Sequence Identity: 32% (88 aa)

RIQYFVGQFSVYMSKQQPKDVIVRGEDGNFYQYLVKGHEDLRLDERIMQFFRLINSFLKKQTYFSGNL--IGTMGVIPLSMQHGLVQWVRGTDTLRHVVE
 |  |     .  | |.|| . ..| || ||  . | ..||| | | |.|  |||  ..|.         . |  ||||  | ... ||  | ||| ...
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

TYRKLYSRDPMQEFKLLEEYSYSSYDYMLPIQKQQVL-EKVMRNVPSNDIAKLFILKA--DSTSTWLKQQHTFAISTAMTSIVGYVIGLGDRHPSNILID
   ||. ..  |  .  .    .        .||.|. | ..   |.  | . . ..   |... |   .  .  |.|  ..|||.|||||||  |||||
---KLW-KEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPP--IFHDWFNRRFPDPQQ-WYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILID

RLSGKVIHIDFGDCFEKAAKRKFLPEVVPFRLTRMMVSAMGVTGTMGTFRTAFVQMANILRENRRVLVMVLSIF
.. | ..|.|.   | .  . .  ||.||||||. || .||  .| | || | . .  ..|..|  .. |.  |
KINGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF

Kinase 82569.m00140.AA ATM 2034-2149 41 1.3e-28 88.26 In-house 133-247 (304) Show / Hide
Range on Protein: 2034-2149
Range on HMM: 133-247/304
Sequence Identity: 41% (48 aa)

WLKQQHTFAISTAMTSIVGYVIGLGDRHPSNILIDRLSGKVIHIDFGDCFEKAAKRKFLPEVVPFRLTRMMVSAMGVTGTMGTFRTAFVQMANILRENRR
|  .   .  | |  |||||..||||||  ||||   |  ..||| |  ||.  |    || ||||||| .|  ||.||  | ||    .   ..|    
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQ-GKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

VLVMVLSIFVHEPLVD
 |. .  . . .|| |
TLLTIVEVLLYDPLFD

Kinase 82569.m00140.AA SMG1 2007-2094 45 1.1e-19 61.8 In-house 156-242 (242) Show / Hide
Range on Protein: 2007-2094
Range on HMM: 156-242/242
Sequence Identity: 45% (40 aa)

VLEKVMRNVPSNDIAKLFILKADSTSTWLKQQHTFAISTAMTSIVGYVIGLGDRHPSNILIDRLSGKVIHIDFGDCFEKAAKRKFLPE
||| .|   | | .||           | .    .| |||. |.|||.|||||||  |.|||   | |.|||.  ||||  | .  ||
VLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLN-VPE

Kinase 82569.m00140.AA DNAPK 2028-2152 28 4.2e-18 62.32 In-house 177-301 (301) Show / Hide
Range on Protein: 2028-2152
Range on HMM: 177-301/301
Sequence Identity: 28% (35 aa)

ADSTSTWLKQQHTFAISTAMTSIVGYVIGLGDRHPSNILIDRLSGKVIHIDFGDCFEKAAKRKFLPEVVPFRLTRMMVSAMGVTGTMGTFRTAFVQMANI
. .  |.|  .  |. . |.  | ... | ||||  | ..    | .| ||||  |  |      ||  ||||||  .  |   .  | ..   .     
STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA

LRENRRVLVMVLSIFVHEPLVDPDS
.|  | .|.    .|. .|..|   
FRKDRNILTNFCDVFINDPSFDWKN

Kinase 82569.m00140.AA SMG1 1882-1928 48 7.2e-14 42.18 In-house 1-47 (242) Show / Hide
Range on Protein: 1882-1928
Range on HMM: 1-47/242
Sequence Identity: 48% (23 aa)

FSVYMSKQQPKDVIVRGEDGNFYQYLVKGHEDLRLDERIMQFFRLIN
  .   | .|| ..  | ||  | || || ||| ||||||||  ..|
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVN

Kinase 82569.m00140.AA DNAPK 1874-1967 33 3.5e-12 40.45 In-house 3-98 (301) Show / Hide
Range on Protein: 1874-1967
Range on HMM: 3-98/301
Sequence Identity: 33% (32 aa)

RIQYFVGQFSVYMSKQQPKDVIVRGEDGNFYQYLVKGHEDLRLDERIMQFFRLINSFLKKQTYFSGNLIG--TMGVIPLSMQHGLVQWVRGTDTLR
||  |     |  |   || .|.|| |     ...|| ||||.| || | |   |  .      .       |  .||.    ||. ||  | .|.
RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLK

Kinase 82569.m00140.AA ATM 1905-1963 37 2.5e-07 19.04 In-house 1-61 (304) Show / Hide
Range on Protein: 1905-1963
Range on HMM: 1-61/304
Sequence Identity: 37% (23 aa)

QYLVKGHEDLRLDERIMQFFRLINSFLKKQTYFSGN--LIGTMGVIPLSMQHGLVQWVRGT
  |||| .||| |  . | | . |  |.. |        | |  |.|||   | . |  ||
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGT

FATC 82569.m00140.AA FATC 2230-2262 48 4.4e-17 57.75 Pfam 1-33 (33) Show / Hide
Range on Protein: 2230-2262
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

TPLSVEEQAGLLISNSVSTYNLAMMYSGWCSFW
.|||||.|.  ||.  ....||..||.|||..|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW