Gene 96145.m00177 (T.vaginalis)

96145.m00177

Species: T.vaginalis
Alias: TvagK0692, 96145.m00177
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
96145.m00177.AA Protein None 421 None Fasta, JSON
96145.m00177.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of 96145.m00177.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 96145.m00177.AA NEK 6-259 42 4.7e-130 438.35 In-house 1-286 (286) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-286/286
Sequence Identity: 42% (121 aa)

YQVIQTIGTGSYGKVVLAKEKKSGTK-----YAIKKVKLSGMTVEQRQKAL-EEVNLLLKLNHPNIVRCYKSFIKKC--TLHIVMDYVD-GGNLDNV---
|..|..|| ||.||| ... |. | .     |..||.....|. ...|.|. .||..| .|.|||||. | ||| .   .|.|||.| . ||.|..    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IEKTHE---YMSEMDVLSFFIQIVIALSYIHKK-----NIIHRDIKPENVFLMKNGI----AKLGDFGISKTLESSIGLATT-VIGTPYYLAPEVWSGEQ
|.|  .   |..|. .. .|||...|| |.|..     .|.|||||| |.|| ||..    .|.||||||| |...  .|.| ..|||||..|||.... 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNTKADMWSLGCILYEMCAL--EKPFTGE--NQKELFDKILAG-HHKEIPSM--YSNDLRHLVDGLLSMDPSFRPTSAQILQLPFI
|| |.|.|||||.|||||.|  ..|| ..  |...|. ||  | . . |||.  ||.||. |.  .|  ||. ||.  |||..|||
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 96145.m00177.AA NEK8 6-259 35 9.1e-118 337.83 In-house 1-278 (278) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-278/278
Sequence Identity: 35% (99 aa)

YQVIQTIGTGSYGKVVLAKEKKSG--TKYAIKKVKLSGMTVEQRQKALEEVNLLLKLNHPNIVRCYKSFIKKCTLHIVMDYVDGGNLDNVIEKTHE-YMS
|  | ..| |. | ..|   |  .   .  .| . ...|. ..|| |. |...| .|.||||.  | .|..  || |.| | |||.|   | ..     .
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

EMD-----------------VLSFFIQIVIALSYIHKKNIIHRDIKPENVFLMKN-GIAKLGDFGISKTLESSIGLAT--TVIGTPYYLAPEVWSGEQYN
|.                  .| .|.|...|....|..|| |||.|. |.|. .  .. |.||||||| . . .  .|  ||.|||||. ||  .| .||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

TKADMWSLGCILYEMCALEKPFTGENQKELFDKILAG-HHKEIPSMYSNDLRHLVDGLLSMDPSFRPTSAQILQLPFI
 | |||.|||.||||| |.. | ..|. .|  || ..  .  |.. |||..| ||  .|. ||  ||. .||.  | .
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 96145.m00177.AA NEK1 6-259 42 7.29999999999e-112 377.93 In-house 1-276 (276) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-276/276
Sequence Identity: 42% (116 aa)

YQVIQTIGTGSYGKVVLAKEKKSGTKYAIKKVKLSGMTVEQRQKALEEVNLLLKLNHPNIVRCYKSFIKKCT--LHIVMDYVDGGNLDNVIEKT---HEY
| .|..|| ||.||..|.|.| .|  |.||  ... |  . |.....||..| |. |||||. . ||.      | |||.| ||| |   |..       
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

MSEMDVLSFFIQIVIALSYIHKKNIIHRDIKPENVFLM--KNG---------------IAKLGDFGISKTLESSIGLATTVIGTPYYLAPEVWSGEQYNT
 ||   ...|.||..|| .||...|.|||||. |.||   |||               ..|||||||...| ..  .| |.||||||| || .    || 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KADMWSLGCILYEMCALEKPFTGENQKELFDKILAGHHKEIPSMYSNDLRHLVDGLLSMDPSFRPTSAQILQLPFI
| |.|||||.||| |.|  || . | | |  ||. |.   ||. ||..|. ||  ... .|. ||   |||. |||
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 96145.m00177.AA S_TKc 6-259 34 3.6e-100 340.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

YQVIQTIGTGSYGKVVLAKEKKSGTKYAIKKVKLSGMTVEQRQKALEEVNLLLKLNHPNIVRCYKSFIKKCTLHIVMDYVDG--GNLDNVIEKTHE----
|.....|| |..||| ....||.| ..|||..|         .... |...| | .|||||..| .|     |..||.|.||  |.|  .|.|       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

-YMSEMDVLSFFIQIVIALSYIHKKNIIHRDIKPENVFLMKNGIAKLGDFGISKTLESSIGLATTVIGTPYYLAPEVWSGEQYNT-KADMWSLGCILYEM
 ...| .. ... ||. || |.|...|||||.||||..| .    |..|||... |       ||..|||.|.||||    .|.. |.|.||.|||||||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CALEKPFTGENQKELFDKILAGHHKEIPSMYSNDLRHLVDGLLSMDPSFRPTSAQILQ-------LPFI
.. . ||   .....|.||.           | .........| .||. |||  ..||        |..
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 96145.m00177.AA Pkinase 6-259 33 3e-94 324.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-293/293
Sequence Identity: 33% (98 aa)

YQVIQTIGTGSYGKVVLAKEKKSGTKYAIKKVKLSGMTVEQRQKALE--EVNLLLKLNHPNIVRCYKSFIKKCTLHIVMDYVDGG----NLDNVIE-KTH
|.....|| ||.|.| ....|..| ..|.|..|...   ...| ..   |. ....||||||||.| .|  |  ...||.|..||     |  .|. . |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EYM--SEMDVLSFFIQIVIALSYIHKKNIIHRDIKPENVFLMKNGIA----KLGDFGISKTL-ESSIGLATTVIGTPYYLAPEVWS-GEQYNTKADMWSL
  .  || .. ... ||. .| |.|...|||||.||||... .||      |..|||..| . . . . .||. |||.|.||||   |. | .|.||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILYEMCALEKPFTGE------NQKELFDKILAGHHKEI-PSMYS-------------------NDLRHLVDGLLSMDPSFRPTSAQILQLPFI
|||||||.  . || |.      .|......|. .  ..  |  .|                    .........| .||. ||| .|||| |..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 96145.m00177.AA NEK4 6-259 38 5e-87 295.44 In-house 1-257 (257) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-257/257
Sequence Identity: 38% (100 aa)

YQVIQTIGTGSYGKVVLAKEKKSGTKYAIKKVKLSGMTVEQRQKALEEVNLLLKLNHPNIVRCYKSFIKKCT--LHIVMDYVDGGNL-DNVIEKTHEYMS
|. .. .| |||| | | .... . .| .||..|     ..|. |. |..|| .| |||||    |.       | ||| . .|| |     ..  . ..
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EMDVLSFFIQIVIALSYIHKKNIIHRDIKPENVFLMKNGIAKLGDFGISKTLESSIGLATTVIGTPYYLAPEVWSGEQYNTKADMWSLGCILYEMCALEK
|  |.  |.|| .|| |.|.|.|.||| |  |.|| |  | |.||||||. |. .  .| |.||||||. ||...   |. | |.||||| .|||  |  
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

PFTGENQKELFDKILAGHHKEIPSMYSNDLRHLVDGLLSMDPSFRPTSAQILQLPFI
 |   .   |  .|. |.   .|  || ||  ||  .|.  |  ||   .|.| |.|
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 96145.m00177.AA CAMK 11-259 21 9.6e-86 276.17 In-house 1-425 (425) Show / Hide 
Range on Protein: 11-259
Range on HMM: 1-425/425
Sequence Identity: 21% (93 aa)

TIGTGSYGKVVLAKEKKSG------------TKYAIKKVKLSGMT--------------------------VEQRQKALEEVNLLLK-------LNHPNI
|.|.||.||| |...|...            .|.||| .. . ..                           . |.. . |.... |       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRCYKSFI------------KKCT--------LHIVM---DYVDGG----N-LDNVIEKTH-------------EYMSEMDVLSFFIQIVIALSYIHKKN
...|  .                .        ...||   .|..||      .| ..|...              ...| ..  .| ||. |. |.|..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPENVFLMKN-----------------GIAKLGDFGISKTLESSIG-----------------------LATTVIGTPYYLA-PEVWSG-----
|.|||.||||. | .|                 .  |. ||| .. .... .                       . .|. |||.| | ||| .|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EQYNTKADMWSLGCILYEMCALEKPFTGE-------------NQKELFDKILAGHHKEIPSMYSN-----------------------DLR
         . |. |.||||.|.||| |   . || |.             |..||| ||..|    .|.. |.                       . .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

HLVDGLLSMDPSFRPTSAQILQLPFI
.|. ..|  ||. |.| .|.|. |..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 96145.m00177.AA STE 6-259 25 9.8e-80 271.21 In-house 1-359 (359) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-359/359
Sequence Identity: 25% (94 aa)

YQVIQTIGTGSYGKVVLAKEKK---------------SGTKYAIKKVKLSGMTV---------------EQRQKALEEVNLLLKLN--HPNIVRCYKSFI
.. |. || |..|.|..|. .|               .|. .|||...|.  .                |..|. |.|.... |.|  |||||..| ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KKC-------TLHIVMDYVDGGNLDNVIEKTH-------------EYMSEMDVLSFFIQIVIA-LSYIHKKNIIHRDIKPENVFLMKNGIAKLGDFGISK
|..       .|.|.| |.||| || .|....              ...|  .  .  ||. . |.|.|...|||||||| |..|     .|| |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

TLESSIG----------------LATTVIGTPYYLAPEVWSG------EQYNTKADMWSLGCILYEMCALEKPFTGENQK-ELFDKILA-----------
 |..|.                   .|..||| . |||| ..       .|.||.|.||||| . ||.  . |.  ..    .| ..             
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GHHKEIPS-------------------MYSNDLRHLVDGLLSMDPSFRPTSAQILQ--LPFI
   |..  .|.                    .| .... ..  | .||. |||. | |.   |||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 96145.m00177.AA NEK2 6-259 33 8.7e-78 261.51 In-house 1-319 (319) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-319/319
Sequence Identity: 33% (106 aa)

YQVIQTIGTGSYGKVVLAKEKKSGTKYAIKKVKLSGMTVEQRQKALEEVNLLLKLNHPNIVRCYKSFI--KKCTLHIVMDYVDGGNLDNVIEKT---HEY
|.| .|||.||.|..   . |  |   . |  .   |.   .|    |.|.| .| |||||| |   |  .. || ||| |  || |  .| |    . |
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

MSEMDVLSFFIQIVIALSYIHK------------------KN---IIHRDIKPENVFLMKNGI-------------------------------------
| |  ..  . |. .||  .|.                  ..   |.|||||| |.||  ..                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--AKLGDFGISKTLESSIGLATTVIGTPYYLAPEVWSGEQYNTKADMWSLGCILYEMCALEKPFTGENQKELFDKILAGHHKEIPSMYSNDLRHLVDGLL
  .||||||  . |. ..  |.| .|||||  ||. .|  || | | ||.||..||||||  ||.. ||..|  ||  ||   ||. || .|  ..   .
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

SMDPSFRPTSAQILQLPFI
  |.. ||    ||| |.|
NVDHYHRPSIEEILQHPQI
Kinase 96145.m00177.AA Ciliate-E2-Unclassified 6-259 27 1.9e-72 246.98 In-house 1-352 (352) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-352/352
Sequence Identity: 27% (97 aa)

YQVIQTIGTGSYGKVVLAKEKKSGTKYAIKKVKLSGMTVEQRQK-----------ALEEVN-------------LLLKLNHPNIVRCYKSFIKKCTLHIV
| .|..||.|..||| ....|| . .|...| . . . . |.|.           .... .             .|| ..||.||...  | .| .. ||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MDYVDGGNLDNVIEKTHE----------------YMSEMDVL-----SFFIQIVIALSYIHKKN-IIHRDIKPENVFLMKNG---IAKLGDFGISKTLES
|.|..||.| . |.| .                   .|  ..      .| ||. .|.|.|.|| ||||||||||... .||     |. |||||| ...
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

SIG---------------LATTVIGTPYYL----APEVWSGEQYN----TKADMWSLGCILYEMCALEKPFTGENQKE----------------LFDKIL
...               ...|..|||.|.    ||||  |..|.     |.|.||||.|||||.  . || ..|...                |...|.
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

AG-----HHKE--IPSMYSNDLRHLVD----GLLSMDPSFRPTSAQILQLPFI
..     ....  ||   |.   ...      .|  .|. |.|  |||. |..
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 96145.m00177.AA Ciliate-E2 6-259 25 1.8e-71 243.72 In-house 1-365 (365) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-365/365
Sequence Identity: 25% (93 aa)

YQVIQTIGTGSYGKVVLAKEKKSGTKYAIK---------------KVKLSGMTVE--QRQKALEEVNLLL-----------------KLNHPNIVRCYKS
| .|. ||.|..|.| ..| .| . ..|||               |.|.  | .   .  .... .. ..                 .||||||...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FI--KKCTLHIVMDYVDGGNLDNVIE-----KTHE-----YMSEMDVLSFFIQIV---------------IALSYIHKKN-IIHRDIKPENVFLMKNGIA
|.  .. .. .||.|..||.|   |.     ..||     |..|  .. .. ||.                || |.|.|| ||||||||||...      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGISKTLESSIG-------------------------------LATTVIGTPYYLAPEVWSGEQ---------YNTKADMWSLGCILYEMCALEKP
|. |||.|| .  .                                 .. |..|||.|.|||. .|..         |..|.|.||||.|||||.  . |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FTGENQKELFDKILAGHHKE-----------IPSMYSNDLRHLVDG----LLSMDPSFRPT-SAQILQLPFI
|  ..|..  .  .   ...           ..   |..  .|       .|  ||. |.|   |||. |..
F--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 96145.m00177.AA ULK 6-259 25 5.9e-71 242.04 In-house 1-329 (329) Show / Hide 
Range on Protein: 6-259
Range on HMM: 1-329/329
Sequence Identity: 25% (85 aa)

YQVIQTIGTGSYGKVVLAKEKKS----GTKYAIKKVKLSGMTVEQRQ-------KALE-EVNLLLKLN--------HPNIVRCYKSFIKK--CTLHIVMD
|.... .| ||.|||  .. ||.    . |.|.|.. .. |  .. .       . |. |. .. ||.        |||||. |. |  .  . . |.|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YVDGGNLDNVIEK---------THEYMSEMDVLSFFIQIVIALSYIHKKNIIHRDIKPENVFLMKN------------GIAKLGDFGISKTLESS---IG
| .||.|.. |.|         .. . ||. ...||.||. .. ..||.|||||||||.|. . ..            |..|..||| .|.....   . 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LATTVI------GTPYYLAPEVWS----GEQYN-TKADMWSLGCILYEMCALEKPFTGENQKELFDKILAGHHK--------------EIP-----SMYS
...|        |||.| ||....    ...|.  |.|.||||||.|||   . || .    .....|.    .              ..|        |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

NDLRHLVDGLLSMDPSFRPTSAQILQLPFI
.... |  ..|  |.. | .  .... |..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 96145.m00177.AA TyrKc 6-257 23 7.3e-27 96.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-257
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

YQVIQTIGTGSYGKVVLAKEKKSGTKYAIKKVKLSGMTVEQRQKALEEVNLLLKL--NHPNIVRCYKSFIKK-------CTLHIVMDYVDGGNLDNVIEK
 . ....| | .|.|.... |   .. |.|..| .      |.  ..| ... ||  .||||||.|   ...         | ||| |...|.|.. . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

THEYMSEMDVLSFFIQIVIALSYIHKKNIIHRDIKPENVFLMKNGIAKLGDFGISKTLESS--------IGLATTVIGTP-----YYLAPEVWSGEQYNT
...  .  | ||| .||    .|.|.||.||||.   |. . .|...| .||| |. ...            ...  |.        .|||..    ..|
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KADMWSLGCILYEMCALEKPFTGE------NQKELFDKILAGHHKEIPSM--------YSNDLRHLVDGLLSMDPSFRPTSAQILQLP
| | || |  ..|.. . ..   .      . .|.. .. .|.  ..|           . ..  .       ||. ||| ..| .. 
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 96145.m00177.AA Pkinase_Tyr 6-225 25 2.4e-24 83.06 Pfam 1-238 (270) Show / Hide 
Range on Protein: 6-225
Range on HMM: 1-238/270
Sequence Identity: 25% (61 aa)

YQVIQTIGTGSYGKVVLAKEK----KSGTKYAIKKVKLSGMTVEQ--RQKALEEVNLLLKL-NHPNIVRCYKSFI-KKCT--LHIVMDYVDGGNLDNVIE
 . ....| |..|.|.... |    . ... |.|..   | . ||  |.. ..|.... .| .||||||.|   . ..    . ||| |. .|.|..   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KT---HEYMSEMDVLSFFIQIVIALSYIHKKNIIHRDIKPENVFLMKNGIAKLGDFGISKTL-ESSIG-LATTVIGTPY-YLAPEVWSGEQYNTKADMWS
|     .  .  | |.. .||  ...| . ||.||||.   |. . .|...| .||| .... . .    ...    |   .|||...   ..|| | ||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

LGCILYEMCALE-KP-FTGENQKELFDKI-LAGHHKEIP
 |  ..|.. .  .| . |    |....|   |.  ..|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCP