Gene 93440.m00446 (T.vaginalis)

93440.m00446

Species: T.vaginalis
Alias: TvagK0498, 93440.m00446
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
93440.m00446.AA Protein None 408 None Fasta, JSON
93440.m00446.kin_dom Protein Kinase Domain None 221 None Fasta, JSON

Protein domain

Protein domains of 93440.m00446.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93440.m00446.AA CK1-Unclassified 17-249 46 1e-131 390.98 In-house 1-244 (244) Show / Hide 
Range on Protein: 17-249
Range on HMM: 1-244/244
Sequence Identity: 46% (114 aa)

YQVTKRIGAGSFGAIYEVQELESGKMLAVKLERPTSPSPQLQYEHRLYQILDGAY-------AIPRVYDFWTE--ENWRGMAMDRLGCSLGYYFRKCGKI
|.|...||.|||| ||..  .....  |.|||. .| .|||.|| ...|.| .          ||..| . .|  ..   | || || || ..| .|.. 
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

LSMKTTIMCGIQMLSRLEYLHERSFIHRDIKPDNFVFG-VGKNSNLLFLIDLGLAKKYRDL-ISHAHITYSEDKGLAGTARYVSINVHYGVEQSCRDDLE
.|.||. | . ||..|.||||...|||||||||||. |  |||.. ...||.||.|.|.|    . ||.| |.|.| ||||| ||| |.|.||| |||||
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE

SVGYVLISLINGTLPWQGMEACSNNEKYELIQQSKVNTTLETLC
|.||||| .. |.||||.  | .  |||| |   | .|..| ||
SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 93440.m00446.AA CK1 17-275 46 8.8e-129 434.14 In-house 1-271 (271) Show / Hide 
Range on Protein: 17-275
Range on HMM: 1-271/271
Sequence Identity: 46% (127 aa)

YQVTKRIGAGSFGAIYEVQELESGKM--LAVKLERPTSPSPQLQYEHRLYQILDG------AYAIPRVYDFWTE--ENWRGMAMDRLGCSLGYYFRKCGK
|.|...||.|||| ||..  . .|.    |.|||. .|  |||.|| ..|.|| |      .  ||..| . .|  ..   | || || ||  .| .|..
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNR

ILSMKTTIMCGIQMLSRLEYLHERSFIHRDIKPDNFVFGV-GKNSNLLFLIDLGLAKKYRDLISHAHITYSEDKGLAGTARYVSINVHYGVEQSCRDDLE
 .|.||..| . ||..|.||.|...|||||||||||. |. ||... ...|| ||||.|||  .| || | |.|.| ||||| ||| |.|.||| |||.|
KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDME

SVGYVLISLINGTLPWQGMEACSNNEKYELIQQSKVNTTLETLCEN-LPNEFLVYMMKVRSLLFDERPPYA
|.||||. .. |.|||||. | .. .||| |   | .|..|.||.. .||||  |.  .|.| |.|.| |.
SLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 93440.m00446.AA CK1-D 17-277 47 4.1e-108 365.47 In-house 1-261 (261) Show / Hide 
Range on Protein: 17-277
Range on HMM: 1-261/261
Sequence Identity: 47% (123 aa)

YQVTKRIGAGSFGAIYEVQELESGKMLAVKLERPTSPSPQLQYEHRLYQILDGAYAIPRVYDFWTEENWRGMAMDRLGCSLGYYFRKCGKILSMKTTIMC
| . ..||.|||| ||  ......   |.|||   .  |||..| ..|... |   ||..  .  | ..  | || || ||   |  |..  |.|| .| 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

GIQMLSRLEYLHERSFIHRDIKPDNFVFGVGKNSNLLFLIDLGLAKKYRDLISHAHITYSEDKGLAGTARYVSINVHYGVEQSCRDDLESVGYVLISLIN
. ||..|.||.| |.|||||||||||. |.||  |. ..|| ||||.|||  .| || | |.| | ||||| ||| | |.||| ||||||.||||.    
ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR

GTLPWQGMEACSNNEKYELIQQSKVNTTLETLCENLPNEFLVYMMKVRSLLFDERPPYALF
|.|||||. |    .||| | . |..| ..|||. .|.||  ||  .|.| ||..| |. .
GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 93440.m00446.AA CK1-A 17-277 49 7.50000000001e-106 357.96 In-house 1-261 (261) Show / Hide 
Range on Protein: 17-277
Range on HMM: 1-261/261
Sequence Identity: 49% (128 aa)

YQVTKRIGAGSFGAIYEVQELESGKMLAVKLERPTSPSPQLQYEHRLYQILDGAYAIPRVYDFWTEENWRGMAMDRLGCSLGYYFRKCGKILSMKTTIMC
|.. ..||.|||| ||   ....|. .|.|.|.     ||| || ..|.||.|.  ||..  . .| ..  | || || ||   |  | .  .||| .| 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

GIQMLSRLEYLHERSFIHRDIKPDNFVFGVGKNSNLLFLIDLGLAKKYRDLISHAHITYSEDKGLAGTARYVSINVHYGVEQSCRDDLESVGYVLISLIN
  ||..|.||.||..|||||||||||. |.|.  | ||||| ||||||||  .. || | ||| | ||||| ||| | |.||| |||.||.|||..    
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR

GTLPWQGMEACSNNEKYELIQQSKVNTTLETLCENLPNEFLVYMMKVRSLLFDERPPYALF
|.||||||.|     ||| |   |. |..| ||   | || .||  .|.| |.| | |   
GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 93440.m00446.AA CK1 17-277 33 2.2e-100 339.78 In-house 1-339 (339) Show / Hide 
Range on Protein: 17-277
Range on HMM: 1-339/339
Sequence Identity: 33% (115 aa)

YQVTKRIGAGSFG-AIYEV-----QELESG-----KMLAVKLERPTSP--SPQLQYEHRLYQILDGA-------------------YAIPRVYDFWTEEN
..|.| || |.|| .||.|       ....     .  |.|.|. .|   .|||..|...|..| |                      .|..|.. .||.
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--WRGMAMDRLGCSLGYYFR---KCGKILSMKTTIMCGIQMLSRLEYLHERSFIHRDIKPDNFVFGV------GKNSN--------LLFLIDLGLAK-KY
  .. | |..|| .|. ...    |.. .||||..|..||||..|||.|.. |||||||||||..|.      ||. .         ...|| |.|. ||
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY

RDL-----------ISHAHITYSE---DKGLAG-TARYVSINVHYGVEQSCRDDLESVGYVLISLINGT--LPWQGMEACSN-------NEKYELIQQSK
||              . |... |    ||. | ||||.|||.| |.||. ||||.|..|.|| .. ||  ||||.|.. ..        .||| |   |
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

VNTTLETLCEN-----LPNEFLVYMMKVRSLLFDERPPYALF
 .|... ||..     .| ||  .|  .||| ...||.|. .
MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 93440.m00446.AA CK1-G 17-277 43 2.1e-91 309.96 In-house 1-266 (266) Show / Hide 
Range on Protein: 17-277
Range on HMM: 1-266/266
Sequence Identity: 43% (115 aa)

YQVTKRIGAGSFGAIYEVQELESGKMLAVKLERPTSPSPQLQYEHRLYQILDGAY-AIPRVYDFWTEENWRGMAMDRLGCSLGYYFRKCGKILSMKTTIM
|.| |.|| |.|| ..| . .  .   |.|.|   |  |||. | | |.|| |.   ||.|| |  .  .  | || || ||   |  |.   |.||..|
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

CGIQMLSRLEYLHERSFIHRDIKPDNFVFG--VGKNSNLLFLIDLGLAKKYRDLISHAHITYSEDKGLAGTARYVSINVHYGVEQSCRDDLESVGYVLIS
  |||..|.||.|... | ||.|||||  |    |. .....|| |.||.|.|.    || | | | | ||||| ||| | | ||| |||.|. | . . 
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

LINGTLPWQGMEACSNNEKYELIQQSKVNTTLETLCEN--LPNEFLVYMMKVRSLLFDERPPYALF
   | |||||. |  | |.|. | . | .|  | ||.|  .| .|  |.  ||.| |.| | |  .
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 93440.m00446.AA TTBKL 17-281 27 3.2e-42 140.36 In-house 1-288 (288) Show / Hide 
Range on Protein: 17-281
Range on HMM: 1-288/288
Sequence Identity: 27% (80 aa)

YQVTKRIGAGSFGAIYEVQELES-GKMLAVKLERPT--SPSPQLQYEHRLYQILD--GAYAIPRVYDFWTEENWRGMAMDRLGCSLGYYFRKCGKI--LS
....| || | ||..|.|  ... ... |.| |  .    .  .. |. .   |   |.  .|.... . ... . |.|  .| .|.   ..      .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

MKTTIMCGIQMLSRLEYLHERSFIHRDIKPDNFVFGVGKN----SNLLFLIDLGLAKKYRDLISH----------AHITYSE---DKGLAGTARYVSINV
  |.  .||| |  | ..|.  |||||.|| |...|. ..    . ...||| |.|..|..  .            . .  .     .. || ||.|.|.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HYGVEQSCRDDLESVGYVLISLINGTLPWQGMEACSNNEKYELIQQSKVNTTLETLCEN------LPNEFLVYMMKVRSLLFDERPPYALFRALF
| . ||.  ||| |. |..| |  | |||..||      . . | . |.|...|.|. .      .| ||.  |  .||| . .||.|  ....|
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNME------DKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 93440.m00446.AA Worm6 105-233 33 3.2e-29 102.07 In-house 98-233 (279) Show / Hide 
Range on Protein: 105-233
Range on HMM: 98-233/279
Sequence Identity: 33% (46 aa)

GKILSMKTTIMCGIQMLSRLEYLHERSFIHRDIKPDNFVFGV-----GKNSNLLFLIDLGLAK--KYRDLISHAHITYS-EDKGLAGTARYVSINVHYGV
.. .|| |.. ..||.| ..| ||   |||||.|| || .|.      ...  ....| |...  ||..      .|   .. |  || || ... |.| 
DRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNK-GNELRTPRWTACGFRGTVRYAPLACHKGQ

EQSCRDDLESVGYVLISLINGTLPWQGMEACSNNEKY
||. .||.||  |... .| |.|||..|.. .. ||.
EQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKH
Kinase 93440.m00446.AA Pkinase 17-223 24 1e-28 102.65 Pfam 1-214 (293) Show / Hide 
Range on Protein: 17-223
Range on HMM: 1-214/293
Sequence Identity: 24% (56 aa)

YQVTKRIGAGSFGAIYEVQELESGKMLAVKLERPTSPSPQLQY------EHRLYQILDGAYAIPRVYDFWTEENWRGMAMDRLGC-----SLGYYFR-KC
|.. ..||.||||  |. ..  .||. |||  .  . ... ..      | .. . |.  . | | ||.......  | |. ...     .|  | . . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

GKIL--SMKTTIMCGIQMLSRLEYLHERSFIHRDIKPDNFVFGVGKNSNL---LFLIDLGLAKKYRDLISHAHITYSEDKGLAGTARYVSINVHY-GVEQ
.. .  |... ...  |.|. |||.|....||||.||.|. .   .| ..   . ..| ||||...      .  .|  ....|| .|..  |.  | . 
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

SCRDDLESVGYVLISLINGTLPWQG
. . |  |.| .|. ...| .|..|
GPKVDMWSCGCILYEMLCGRPPFPG
Kinase 93440.m00446.AA TTBK 109-277 33 1.6e-25 87.21 In-house 95-257 (257) Show / Hide 
Range on Protein: 109-277
Range on HMM: 95-257/257
Sequence Identity: 33% (57 aa)

SMKTTIMCGIQMLSRLEYLHERSFIHRDIKPDNFVFG-VGKNSNLLFLIDLGLAKKYRDLISHAHI-TYSEDKGLAGTARYVSINVHYGVEQSCRDDLES
|. ||.  |.|.|  .|  |.  | |||||| ||  | . .. .  ...| ||| .|  . ..  . .  |  |  ||.|| ||| |   |   .||| |
SLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQY--TNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWS

VGYVLISLINGTLPWQGMEACSNNEKYELIQQSKVNTTLETLCENLPNEFLVYMMKVRSLLFDERPPYALF
. |.|.  ..| |||  .       | . . . |    .  | ...| || ..|  ..|| . .|| |.|.
LFYMLVEFVQGQLPWRKIK-----DK-DQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 93440.m00446.AA VRK 88-232 36 1.8e-18 56.16 In-house 106-251 (284) Show / Hide 
Range on Protein: 88-232
Range on HMM: 106-251/284
Sequence Identity: 36% (54 aa)

MAMDRLGCSLGYYFR-KCGKILSMKTTIMCGIQMLSRLEYLHERSFIHRDIKPDNFVFGVGKNSNLLFLIDLGLAKKYRDLISHAHITYSEDKGLA--GT
| |.|.| .|       .|. .||||    ...||  ||||||    | |||  |   |  || .  .|.| ||| .| .  .  |  | ||.  .  ||
MVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCP--NGKHRQYKEDPRRCHNGT

ARYVSINVHYGVEQSCRDDLESVGYVLISLINGTLPWQGMEACSNNEK
  . |.  | |.  | | |||. || ..    |.|||   .  .. ||
CEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEK
Kinase 93440.m00446.AA S_TKc 17-299 16 6.9e-15 41.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-299
Range on HMM: 1-231/231
Sequence Identity: 16% (50 aa)

YQVTKRIGAGSFGAIYEVQELESGKMLAVKLERPTSPSPQLQYEHRLYQILDGAYAIPRVYDFWTEENWRGMAMDRLGC---SLGYYFRKCGKI-----L
|.. . || |.||  | ... ..|.  |.|  .      ... | .. .   .   | . ||.. . .   | |. ..    .|  | .|.|.      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SMKTTIMCGIQMLSRLEYLHERSFIHRDIKPDNFVFGVGKNSNLLFLIDLGLAKKYRDLISHAHITYSEDKGLAGTARYVSINVHYGVEQSC-RDDLESV
.  ..     |... |||.|.. .||||.||.|  .        . ..| |||...              . . ||  |..  |      .. . |  |.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GYVLISLINGTLPWQGMEACSNNEKYELIQQSKVNTTLETLCENLPNEFLVYMMKVRSLLFDERPPYALFRALFAKVMT---DNNYAYDYK-----YDWI
| .|. .. |  |..        . ...... .                              ..   . | .. |  .       |  .        |.
GCILYEMLCGYPPFP--------QMQMMFKKIG-----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 93440.m00446.AA Worm6 17-61 34 2.1e-14 48.38 In-house 1-49 (279) Show / Hide 
Range on Protein: 17-61
Range on HMM: 1-49/279
Sequence Identity: 34% (17 aa)

YQVTKRIGAGSFGAIYEVQELESGK--MLAVKLER--PTSPSPQLQYEH
..||| || |.|||.|.|.. . .|  . |.|.|.  .......|. |.
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMEC
Kinase 93440.m00446.AA TTBK 17-48 39 6e-06 17.01 In-house 1-33 (257) Show / Hide 
Range on Protein: 17-48
Range on HMM: 1-33/257
Sequence Identity: 39% (13 aa)

YQVTKRIGAGSFGAIYEVQELESG-KMLAVKLE
 .|.|.|| | || ||| ...       |.|.|
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVE
Kinase 93440.m00446.AA TyrKc 17-281 16 0.000489 -157.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-281
Range on HMM: 1-280/280
Sequence Identity: 16% (54 aa)

YQVTKRIGAGSFGAIYEVQELESGKMLAVKLERPTSPSPQLQYEHRLYQILDGAYAIPRV----------YDFWT---------EENWRGMAMDRLGCSL
 .  | .| | || .|. .      . |||  .. .          .  ... |    ..          |   |         |  .  |    .|. |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD-L

GYYFRKCGKILSMKTTIMCGIQMLSRLEYLHERSFIHRDIKPDNFVFGVGKNSNLLFLIDLGLAKKYRDLISHAHITYSEDKGLAGTARYVSIN------
  | ||... |.||. .   .|  .  ||||.. .||||.   |   | ..                     .. |.        | .|..         
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------------------TVKISDF------GLSRDIYDDDQQGES

-VHYGVEQ-SCRDD--------LESVGYV-----------------LISLINGTLPWQGMEA--CSNNEKYELIQQSKVNTTLETLCENL-----PNEFL
   | . . .....        .|.  |                  . ..  |  |. ||.   .|| | .|...| .     .  .. .     | |  
KDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMY

VYMMKVRSLLFDERPPYALFRALF
  | .      ..||  .  . .|
QIMKQCWHEDPEDRPTFSEIHECF
Kinase 93440.m00446.AA VRK 17-33 47 0.037107 3.21 In-house 1-17 (284) Show / Hide 
Range on Protein: 17-33
Range on HMM: 1-17/284
Sequence Identity: 47% (8 aa)

YQVTKRIGAGSFGAIYE
. . | || | || ||.
WRLGKPIGQGGFGCIYL