Gene 85746.m00166 (T.vaginalis)

85746.m00166

Species: T.vaginalis
Alias: TvagK0467, 85746.m00166
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
85746.m00166.AA Protein None 389 None Fasta, JSON
85746.m00166.kin_dom Protein Kinase Domain None 183 None Fasta, JSON

Protein domain

Protein domains of 85746.m00166.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 85746.m00166.AA CK1 16-270 27 9.2e-84 284.59 In-house 1-339 (339) Show / Hide 
Range on Protein: 16-270
Range on HMM: 1-339/339
Sequence Identity: 27% (94 aa)

YRIIKPIGDGGFA-YVFFV-----RDESTN-----RAYAMKISK-DPMHN-QVIDLERDVMEEITGN-------------------SCFPVLVKSGYYRK
....|.||.|||   .. |     .|...|       ||||. . . |.   .   |  .... .|.                   ...|...  .  ..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

N-M-YIIMELLGMNLASIRK--LLDGKKFSLYTSLVVASQTINILEIFHNKGFVHRDVKPSNFLVKQ--------------KNVSELCLIDFGLSK-RYI
.   |..|.|||.|| ..||   . ..|||. |.| .| |... ||  |..||.|||.||.||..                ..   . .||||... .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DP-----------NTGKPHPKSD---KVRFVG-TSRYASINALKDNDVSVCDDLISWFYMIVEQYVGQ--LPWSSITDKEL-----ILAMKIR-------
|.           .|... |. .   |. |.| | ||.|||. .  . .  ||| |||||..|  .|.  |||. ..|..      .  ||         
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

-TPVEELCSD-----LPQEMINIYKYLETLQYDDVVDYTFI
 ||.. ||       .|||.  |.||...|.|.|  || .|
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 85746.m00166.AA Worm6 16-270 31 1.4e-62 214.26 In-house 1-279 (279) Show / Hide 
Range on Protein: 16-270
Range on HMM: 1-279/279
Sequence Identity: 31% (88 aa)

YRIIKPIGDGGFAYVFFVRDESTNR--AYAMKISK--DPMHNQVIDLERDVMEEITGNS--CFPVLVKSGYYRK--NMYIIMELLGMNLASIRKLLDGKK
. . |.||.|||  |. | |.|...   .|||  |    |. |. ..|  |. ...      |. ..  | ...    ||.|.|.|.||. .|| . ..|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSLYTSLVVASQTINILEIFHNKGFVHRDVKPSNFLVKQ------KNVSELCLIDFGLSK--RYIDPNTGKPHPKSDKVRFVGTSRYASINALKDNDVSV
||. |.| .|.|... .|  || ||.||||||.|| . .      .. . ....|||...  .|.. ..   .|. ... |.|| |||.... |  . . 
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

CDDLISWFYMIVEQYVGQLPWSSITDKELIL--AMKI--RTP---VEELCSDLPQ-EMINIYKYLETLQYDDVVDYTFI
 ||. |||||.||  ||.|||  ..|.      ....  ||     ...    |. |.  | .|. ...| | .||.||
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 85746.m00166.AA TTBKL 16-274 31 2.1e-62 209.48 In-house 1-288 (288) Show / Hide 
Range on Protein: 16-274
Range on HMM: 1-288/288
Sequence Identity: 31% (91 aa)

YRIIKPIGDGGFAYVFFVRDEST-NRAYAMKISKDPMH--NQVIDLERDVMEEIT--GNSCFPVLVKSGYYRKNMYIIMELLGMNLASIRKLLDGKK-FS
..|.| || |||. |. |.| .. .  .|||. |. .   .... .| .|. .    | . || .. || . .  ...|.|.|.||  .|| .  || ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LYTSLVVASQTINILEIFHNKGFVHRDVKPSNFLVKQKN--VSE---LCLIDFGLSKRYIDPNTGKP-----------HPKS--DKVRFVGTSRYASINA
  |..... |..  |   | .||.||||||.|. .  .    ..   . |||||....|.... . .            |..   |. | || ||.|.|.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

LKDNDVSVCDDLISWFYMIVEQYVGQLPWSSITDKELILAMKIRTPVEELCSD------LPQEMINIYKYLETLQYDDVVDYTFIHSQI
    . . .||| ||.|||.| ..| |||....||. | .||  .  | |..|      .|.|.  ..|.|..|.| |  ||. |   .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 85746.m00166.AA TTBK 16-270 33 7.7e-48 165.25 In-house 1-257 (257) Show / Hide 
Range on Protein: 16-270
Range on HMM: 1-257/257
Sequence Identity: 33% (87 aa)

YRIIKPIGDGGFAYVFFVRDESTN-RAYAMKISKDPMHNQVIDLERDVMEEITGNSCFPVLVKSGYYRKNMYIIMELLGMNLASIRKLLDGKKFSLYTSL
 ...| || |||  ..   |  ..    |.|. .     ||  .|  |.    |       .  |   |  |..|.|.| |||  |      .||| | |
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

VVASQTINILEIFHNKGFVHRDVKPSNFLV--KQKNVSELCLIDFGLSKRYIDPNTGKPHPKSDKVRFVGTSRYASINALKDNDVSVCDDLISWFYMIVE
 .  | .. .|  |. || |||.||||| .    ... .  ..||||  .|.   .|   |      | || ||||||| .  .    ||| | ||| ||
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

QYVGQLPWSSITDKELILAMKIRTPVEELCSDLPQEMINIYKYLETLQYDDVVDYTFI
  .|||||  | ||. .  || .     |  ..|.|.    . .. |.| |  || .|
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 85746.m00166.AA CK1-Unclassified 16-191 36 5.2e-46 133.79 In-house 1-187 (244) Show / Hide 
Range on Protein: 16-191
Range on HMM: 1-187/244
Sequence Identity: 36% (69 aa)

YRIIKPIGDGGFAYVFFVRDESTNRAYAMKISKDPMHNQVIDLERDVMEEITGNS-------CFPVLVKSGYY--RKNMYIIMELLGMNLASIRKLLDGK
||.|. || | | ... . .  ||. .|.|. |    .  .. |  .| .  ...        .| .  .|    .   ...|.||| .| .. ..  ..
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC-NR

KFSLYTSLVVASQTINILEIFHNKGFVHRDVKPSNFLV--KQKNVSELCLIDFGLSKRYIDP-NTGKPHPKSDKVRFVGTSRYASINA
||||.| |  | | |  .| .|||.|.||| || |||.   .||   . .|||||||||||. .|||  |  ..  ..|| |||||||
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINA
Kinase 85746.m00166.AA CK1-A 16-270 30 4e-42 146.28 In-house 1-261 (261) Show / Hide 
Range on Protein: 16-270
Range on HMM: 1-261/261
Sequence Identity: 30% (80 aa)

YRIIKPIGDGGFAYVFFVRDESTNRAYAMKISKDPMHNQVIDLERDVMEEITGNSCFPVLVKSGYYRKNMYIIMELLGMNLASIRKLLDGKKFSLYTSLV
||....|| | |  ..           |.|. ..  .   .  |  | . . |   .| .   |  . .  ..|.|||  |  .  . . ..|.. | |.
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCK-RRFTMKTVLM

VASQTINILEIFHNKGFVHRDVKPSNFLV-KQKNVSELCLIDFGLSKRYIDPNTGKPHPKSDKVRFVGTSRYASINALKDNDVSVCDDLISWFYMIVEQY
.| | |  .|  |.|.|.|||.|| |||.   .   .| ||||||.|.| |..| .  |  .    .|| |||||||    . |  ||. |  |...   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

VGQLPWSSITDK------ELILAMKIRTPVEELCSDLPQEMINIYKYLETLQYDDVVDYTFI
 |.|||  .. .      | |.  |. ||.|.||   | |.  . .|   |..... ||...
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 85746.m00166.AA CK1 16-191 32 7.2e-40 134.99 In-house 1-187 (271) Show / Hide 
Range on Protein: 16-191
Range on HMM: 1-187/271
Sequence Identity: 32% (62 aa)

YRIIKPIGDGGFAYVFFVRDESTNRA---YAMKI-SKDPMHNQVIDLERDVMEEITG------NSCFPVLVKSGYY--RKNMYIIMELLGMNLASIRKLL
||... || | | ... . .  ||.    .|.|. ...  |   .. |  .. .  |         .| .  .|    ..  ...|.||| .| .  .. 
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC

DGKKFSLYTSLVVASQTINILEIFHNKGFVHRDVKPSNFLV--KQKNVSELCLIDFGLSKRYIDPNTGKPHPKSDKVRFVGTSRYASINA
 ..||||.| | .| | |  .| .|||.|.|||.|| |||.  ..|.   . .|||||.|||.|..|..  |  ..  ..|| ||||||.
-NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINT
Kinase 85746.m00166.AA CK1-D 16-270 32 1.4e-37 130.06 In-house 1-261 (261) Show / Hide 
Range on Protein: 16-270
Range on HMM: 1-261/261
Sequence Identity: 32% (85 aa)

YRIIKPIGDGGFAYVFFVRDESTNRAYAMKISKDPMHNQVIDLERDVMEEITGNSCFPVLVKSGYYRKNMYIIMELLGMNLASIRKLLDGKKFSLYTSLV
||| . || | |  ...  . .||   |.|.     .   ...|  .   . |    | .   |       ..|.|||  |  .    . .|||| | |.
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCH-RKFSLKTVLM

VASQTINILEIFHNKGFVHRDVKPSNFLVK-QKNVSELCLIDFGLSKRYIDPNTGKPHPKSDKVRFVGTSRYASINALKDNDVSVCDDLISWFYMIVEQY
.| | |  .|  | . |.|||.|| |||.   |  .   .|||||.||| |..| .  |  ..    || ||||||  .  . |  ||| |  |...   
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

VGQLPWS---SITDK---ELILAMKIRTPVEELCSDLPQEMINIYKYLETLQYDDVVDYTFI
 | |||     .| .   | |   |. |....||. .|.|  .   |  .|..||  ||...
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 85746.m00166.AA CK1-G 87-270 32 7.4e-26 84.56 In-house 73-266 (266) Show / Hide 
Range on Protein: 87-270
Range on HMM: 73-266/266
Sequence Identity: 32% (64 aa)

IIMELLGMNLASIRKLLDGKKFSLYTSLVVASQTINILEIFHNKGFVHRDVKPSNFLVKQ---KNVSELCLIDFGLSKRYIDPNTGKPHPKSDKVRFVGT
..|.|||  |     . |  |||. | . || | |. .|  | .  . ||||| |||. .   |.   . .||||. | ||||.|..  |   .    ||
MVMDLLGPSLEDLFDWCD-RKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGT

SRYASINALKDNDVSVCDDLISWFYMIVEQYVGQLPWSSI---TDKEL---ILAMKIRTPVEELCSD--LPQEMINIYKYLETLQYDDVVDYTFI
 || |||       |  ||. .   |      |.|||      . ||    |   | .|..| ||    .|...    .|   |....  || ..
ARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 85746.m00166.AA Ciliate-E2-Unclassified 16-167 24 3.8e-25 84.2 In-house 1-201 (352) Show / Hide 
Range on Protein: 16-167
Range on HMM: 1-201/352
Sequence Identity: 24% (50 aa)

YRIIKPIGDGGFAYVFFVRDESTNRAYAMKISKDPMHNQVIDLER--------DVMEEITGNSCF----------------PVLVKSGYY---RKNMYII
|.||| || |||. |. ....... .||||. |. ... .   ..        . |... . . .                |..||  |.   ..|.||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MELL-GMNLASIRKLLDG---------------KKFSLYTSL-----VVASQTINILEIFHNKG-FVHRDVKPSNFLVKQKN-VSELCLIDFGLSKRYID
||.. | .|  . |   .               |.|. . ..       . | .. ||  | |. ..||| ||.| |.....   ....||||.||.|..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

PN
.|
NN
Kinase 85746.m00166.AA S_TKc 16-270 19 5.9e-16 57.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-270
Range on HMM: 1-231/231
Sequence Identity: 19% (53 aa)

YRIIKPIGDGGFAYVFFVRDESTNRAYAMKISKDPMHNQVIDLERDVMEEITGNSCFPVLVKSGYYRKNMYIIMELLGMNLASIRKLLDGKK-------F
|.|...|| |.|. |. .|. .|.| .|.|| |     . |  |......  .      |  . .  ...|..||... .| . ..... ..       |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLYTSLVVASQTINILEIFHNKGFVHRDVKPSNFLVKQKNVSELCLIDFGLSKRYIDPNTGKPHPKSDKVRFVGTSRYASINALKDNDVSVCDDLISWFY
.  .   .. |... ||  |..|..|||.||.| |. .    .. ..||||....                |.||  | .   |            .. .
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL------------GYGK

----------MIVEQYVGQLPWSSITDKELILAMKIRTPVEELCSDLPQEMINI-----YKYLETLQ-YDDVVDYTFI
          .. | ..|. |..     .  .  ||.    . . |. . . .      .   | ||   |.    ..
CKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 85746.m00166.AA Pkinase 80-188 23 4.7e-15 54.31 Pfam 70-179 (293) Show / Hide 
Range on Protein: 80-188
Range on HMM: 70-179/293
Sequence Identity: 23% (28 aa)

YYRKNMYIIMELLGMN--LASIRKLLD---GKKF--SLYTSLVVASQTINILEIFHNKGFVHRDVKPSNFLVKQKNVSE---LCLIDFGLSKRYIDPNTG
......|..||....   ...   ..    ...|  |  .   .. |..  ||  |..|..|||.||.|.|.. .|      ....||||.| .      
EDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-----

KPHPKSDKVRFVGTSRYAS
   ..|    |.||..|..
-Y-NNS-MTTFCGTPWYMA
Kinase 85746.m00166.AA CK1 227-268 34 4.4e-10 31.12 In-house 229-271 (271) Show / Hide 
Range on Protein: 227-268
Range on HMM: 229-271/271
Sequence Identity: 34% (15 aa)

ELILAMKIRTPVEELCSD-LPQEMINIYKYLETLQYDDVVDYT
| |. .|. ||||.||.. .| |...  .|   |....  ||.
EKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 85746.m00166.AA CK1-Unclassified 229-242 64 5e-06 13.8 In-house 231-244 (244) Show / Hide 
Range on Protein: 229-242
Range on HMM: 231-244/244
Sequence Identity: 64% (9 aa)

ILAMKIRTPVEELC
|. ||. ||||.||
IMEMKMSTPVEQLC
Kinase 85746.m00166.AA Pkinase 16-48 36 0.000266 16.29 Pfam 1-33 (293) Show / Hide 
Range on Protein: 16-48
Range on HMM: 1-33/293
Sequence Identity: 36% (12 aa)

YRIIKPIGDGGFAYVFFVRDESTNRAYAMKISK
|.|...|| |.|. |.  .. .|.. .|.|| |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK