Gene 89588.m00024 (T.vaginalis)

89588.m00024

Species: T.vaginalis
Alias: 89588.m00024, TvagK0775
External Links:
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK1

Sequence

Name Sequence Type Origin Length Description Download
89588.m00024.AA Protein None 480 None Fasta, JSON
89588.m00024.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of 89588.m00024.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 89588.m00024.AA S_TKc 22-276 34 1.8e-92 314.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

YRKQEQIGSGGFSTVFRVVNVKTNQIYAMKVIPQSKLMTEEQKTLIDNEIKLHRSLNHSNIVKLYNTFCDAQNQYIILEHCKG--GNLKDKFKQKGR---
|.. ..||.|.|..|......||..|.|.|.|.            | .||..... .| |||||| .| | .. |...|.| |  |.|.|  |..||   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSESDVKLFLHQALSALDYIHTCGIVHRDIKLGNFLYADNNIIKICDFGLAVKNNPKHNYMVSGTQAYLSPELFTQKGLGTSP-KIDIWALGVCAFM
   |.| ... ...| ..||.|.|  ||.|||.|  | |  .   ||||||||| .      . . ||  |..||..     | .. |.|.|..|.. . 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYE

LLNGYAPFDAPTPQLQFERIKSDEFRFNPSVEISENMQDFISKTLIKDPALRPSASELLN-------HPLF
.| || ||.  ..|. |..|.            |. . |||.| | |||. ||.| |.|.       || |
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 89588.m00024.AA CAMK 27-276 22 1.7e-90 291.78 In-house 1-425 (425) Show / Hide 
Range on Protein: 27-276
Range on HMM: 1-425/425
Sequence Identity: 22% (94 aa)

QIGSGGFSTVFRVVNVKTN------------QIYAMKVIPQSKLM-------------------------TEEQKTLIDNEIKLHRS-------LNHSNI
..|.|.|..|..... .|.            | .|.|.|. .||                          ... .  . .||.....       |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLYNTFCD-------------------AQNQYIIL---EHCKGG----NLKDKFKQK---------------GRFSESDVKLFLHQALSALDYIHTCGI
.||| .. |                    .. |...   |.| ||     | |. ...               |||.|.... . .| .||..|.| ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKLGNFLYADN-----------------NIIKICDFGLAVKNNPKHNYM-------------------------VSGTQAYLS-PELFTQKG----
||||.|. | |. ||                 | |||.|||.| | .|..|..                         . || .| . ||.. .||    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------LGTSPKIDIWALGVCAFMLLNGYAPFDAP-------------TPQLQFERIKSDEFRFNP--------------SVEISEN--------MQD
         . .||.|.|..||  ...| || ||...             ...  ||.|.. ...| |                .||..         .|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FISKTLIKDPALRPSASELLNHPLF
.|.| | .||  |..... |||| .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 89588.m00024.AA AGC 22-276 20 3.6e-85 219.4 In-house 1-395 (395) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-395/395
Sequence Identity: 20% (82 aa)

YRKQEQIGSGGFSTVFRVVNV------KTNQIYAMKVIPQSK---LMT--EEQKTLID------------NEIKLHRSLN--------HSNIVK-LYNTF
..    || |.|..|. |  .       |...|||||.  ..   ..   ....|..              .|  . .          | .||| |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

CDAQN--QYIILEHCK---------GG-NLKDKFK---QKGRFSESDVKLFLHQ-------ALSALDYIHT-CGIVHRD-IKLGNFLYADNNIIKICDFG
 | ..   |...| ..         ||  |    .   ..|||.|. .. .. .        ..||.|.|   ||.||| .|. | |  ..  ||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAVKNNPKH----------------------------------------------------NYMVSG--TQAYLSPELFTQKGLGTSPKIDIWA--LGVC
|. ... ..                                                    ..   |  |  |..|| .       ..  |.|.  ||..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL------YGKACDWWSFGLGCL

AFMLLNGYAPFDAPTPQ----------LQFERIK------SDEFRFNPS--------VEISENMQDFISKTLIKDPALRPS----------ASELLNHPL
 . .| || || . .||            |..|.      ... .|..         ...|.. .|.|.| | |||. |.           |.|. ||| 
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

F
|
F
Pkinase 89588.m00024.AA Pkinase 22-276 32 3.8e-84 290.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-293/293
Sequence Identity: 32% (95 aa)

YRKQEQIGSGGFSTVFRVVNVKTNQIYAMKVIPQSKLMTEEQKTLID-NEIKLHRSLNHSNIVKLYNTFCDAQNQYIILEHCKGG----NLKDKFK--QK
|.. ..||||.|..|.. ....|..|.|.|.|. ..   ....|..  .||.....||| |||.|| .| | .. |...|.| ||     |.|  .  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRF--SESDVKLFLHQALSALDYIHTCGIVHRDIKLGNFLYADNNII----KICDFGLAV---KNNPKHNYMVSGTQAYLSPELFTQKGLGTSPKIDIWA
|.|  || ..| .. | |..|.|.| .||.|||.|. |.|. .|. |    ||||||||      |   .. . ||  |..||.  ..| . .||.|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-IRGGQYYGPKVDMWS

LGVCAFMLLNGYAPFDAP------TPQLQFERIKSDEFRFNPSVEIS-------------------ENMQDFISKTLIKDPALRPSASELLNHPLF
.|.  . .|.|. ||.        ...  ..||.. ...|. . ..|                   |...|||.. | |||. ||.| ..|.|| |
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 89588.m00024.AA CAMKL 22-276 28 9e-80 254.23 In-house 1-297 (297) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-297/297
Sequence Identity: 28% (84 aa)

YRKQEQIGSGGFSTVFRVVN-VKTNQIYAMKVIPQSKLMTEEQKTL------------IDNEIKLHRSLN---HSNIVKLYNTFCDAQN------QYIIL
||  ...| |.|..|   ..   |.. .|.|.|  .|.  .....             |  ||.....||   | ||.||| .. . ..       |...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EHCKGGN--LKDKFKQK----GRFSESDVKLFLHQALSALDYIHTCGIVHRDIKLGNFLYADNN--IIKICDFGLA-----V-KNNPKHNYMVSGTQAYL
|.| ||.  | |. ...    ||..|.. . .  | .||..|.| .||||||||. | |  .|.   |||.|||..     . ... .   .  |. .| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPELFTQ-KGLGTSPKIDIWALGVCAFMLLNGYAPFDAPTPQ-------LQFERIKSDEFRFNPSVEISENMQDFISKTLIKDPALRPSASELLNHPLF
.||.|   .     ||.|||..||  .... || |||..| .       . ...|... ..... ...|   .|.|.| | ..|  ||.. ...||| .
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 89588.m00024.AA PLK 22-276 35 3.5e-76 247.6 In-house 1-258 (258) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-258/258
Sequence Identity: 35% (91 aa)

YRKQEQIGSGGFSTVFRVVNVKTNQIYAMKVIPQSKLMTEEQKTLIDNEIKLHRSLNHSNIVKLYNTFCDAQNQYIILEHCKGGNLKDKFKQK-GRFSES
|.... .|.|||. .... ...|.|.|| ||.|.| .  . |.  ...||..||.|.| ||||... | |..| || || |... | .  |..  |..| 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

DVKLFLHQALSALDYIHTCGIVHRDIKLGNFLYADNNIIKICDFGLAVKNNPK--HNYMVSGTQAYLSPELFTQKGLGTSPKIDIWALGVCAFMLLNGYA
 |. ...|  ..| |.|  .|.|||.||||..  ||. .||.|||||.. ..     . . ||  | .||    .  | | ..|.|.||.    || |  
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFDAPTPQLQFERIKSDEFRFNPSVEISENMQDFISKTLIKDPALRPSASELLNHPLF
||.. . .   .|||  ...|  .. || . .|.| | | ..|. ||.....|.|| |
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 89588.m00024.AA Ciliate-E2-Unclassified 22-276 26 2e-75 256.86 In-house 1-352 (352) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-352/352
Sequence Identity: 26% (93 aa)

YRKQEQIGSGGFSTVFRVVNVKTNQIYAMKVIPQSKLMTEEQKTLIDNEIKLH-----------------------RSLNHSNIVKLYNTFCDAQNQYII
|....|||.|||..|..... |..|.|||| . ...     |.   | ||..                        ....| .|||.. .| | || ||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEHCKGGNLKDKFKQK-----------------GRFSESDVK-----LFLHQALSALDYIHTCG-IVHRDIKLGNFLYADNN---IIKICDFGLAVKNN-
.| |.||.|..  |..                  .|.|  .|      .. | |..|.|.|  . |.|||||. | |. .|.    |||.|||.. |.. 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----------------PKHNYMVSGTQAYL----SPELFTQKGLGTS--PKIDIWALGVCAFMLLNGYAPFDAPTPQL----------------QFERIK
                ... . ..||  |.    .||.. ... ..|   |.|||.|||... .| || ||....                   ... ||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

SDEFRFNPSVE------ISENMQDFIS----KTLIKDPALRPSASELLNHPLF
  .. |... .      .|.. .|||.    | | |.|  |......||||.|
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 89588.m00024.AA Ciliate-E2 22-276 25 1.1e-73 251.16 In-house 1-365 (365) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-365/365
Sequence Identity: 25% (95 aa)

YRKQEQIGSGGFSTVFRVVNVKT-----------------------NQIYAMKVIPQS--KLMTEEQKTL---------IDNEIKLHRSLNHSNIVKLYN
| ....||.|.|..|... . |.                       ..|||||.. ..  . .  |.. .         | || .. ..||| ||.|.| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

TFC--DAQNQYIILEHCKGGNLKD-------KFKQK----GRFSESDVKLFLHQALS---------------ALDYIHTCG-IVHRDIKLGNFLYADNNI
.|   | .| |...| |.||.|.|       |....    ..|.|  .| .  | |.               || |.|  . |.|||||. | |.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKICDFGLAVKNNPKHN----------------------YM-----------VSGTQAYLSPELFTQKGLG-------TSPKIDIWALGVCAFMLLNGYA
|||.||||. |......                      ||           . ||  |..|| .  |. .        . |.|||.|||. ...| |. 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFDAPTPQLQFERIKSDEFRFN----------------PSVEISENMQDFISK----TLIKDPALRPS-ASELLNHPLF
||        .. ||  ...|.                   ..|....|.|.|     | |||  |.. ....|||| |
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 89588.m00024.AA PLK-Unclassified 22-276 36 6.5e-72 245.22 In-house 1-264 (264) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-264/264
Sequence Identity: 36% (97 aa)

YRKQEQIGSGGFSTVFRVVNVKTNQIYAMKVIPQSKLMTEEQKTLIDNEIKLHRSLNHSNIVKLYNTFCDAQNQYIILEHCKGGNLKDKFKQK-------
|.. . .|.|||. .. | |..|..||| |.|| | |  . ..    .|||.| ||.| |||| .  | | .| || || | .| | .  | .       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

GRFSESDVKLFLHQALSALDYIHTCGIVHRDIKLGNFLYADNNIIKICDFGLAVK--NNPKHNYMVSGTQAYLSPELFTQKGLGTSPKIDIWALGVCAFM
 | .|  || .. | . || |.|  .| ||| |||| .  ||. .||||||||.|  |.    . . ||  | .||    |  | | ..|.|..|. .  
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLNGYAPFDAPTPQLQFERIKSDEFRFNPSVEISENMQDFISKTLIKDPALRPSASELLNHPLF
|| |  || ..  .  ...||. .. |   . || |  |.| . |  .|. ||. .....|| .
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase 89588.m00024.AA ULK 22-276 27 2.1e-68 233.54 In-house 1-329 (329) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-329/329
Sequence Identity: 27% (91 aa)

YRKQEQIGSGGFSTVFRVVNVKT----NQIYAMKVIPQSKLMTEEQKT-------LIDNEIKLHRSLN--------HSNIVKLYNTFCDA--QNQYIILE
| . ...|.| | .|..  |.||    |...| |.|...|.  ...         |..||||. . |.        | ||||||  | ..   | |||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

HCKGGNLKDKFKQKGR----------FSESDVKLFLHQALSALDYIHTCGIVHRDIKLGNFLYADNN------------IIKICDFGLAVKNNPK-----
 | ||.|..  |....          .||. .. |..| |... ..|  .|.|||||. | |  ...            ..||.|||.| . .       
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-HNYMVS-----GTQAYLSPELFTQK--GLGTS-PKIDIWALGVCAFMLLNGYAPFDAP-TPQL-----QFER--------IKSDEFRFN---PSVEISE
   ..|      ||  | .|... ..  .   .  | ||| ||.  . .| |. || |. ..|      .  .        ||.  ..|.   ... ||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

NMQDFISKTLIKDPALRPSASELLNHPLF
...|.|.. |..|.  | |  ||.|||.|
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 89588.m00024.AA ULK 22-276 27 8.9e-67 228.16 In-house 1-324 (324) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-324/324
Sequence Identity: 27% (89 aa)

YRKQEQIGSGGFS-TVFRVVNVKT---NQIYAMKVIPQSKLMTEEQK-------TLIDNEIKLHRSLN---HSN--IVKLYNTFCDA--QNQYIILEHCK
| . ...|.| |  .|..  |.||   ||..| |.|...|.   ...        |..|||.. . |.   | |  |||||  | ..   | |||.| | 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGNLKDKFKQK---------GRFSESDVKLFLHQALSALDYIHTCGIVHRDIKLGNFLYADNN------------IIKICDFGLAVK-NNPKHNYMVS--
||.|..  |..         .|.||. .. |..| .... ..|  .|.|||||. | |  ...            ..||.|||.| . .|.  . ..   
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

--------GTQAYLSPELFTQK--GLGTS-PKIDIWALGVCAFMLLNGYAPFDAPTPQLQFER--------------IKSDEFRFN---PSVEISENMQD
        ||  | .|... ..  .   .  | ||| ||.  . .| |. || .. .. |...              ||   ..|.   ... ||....|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FISKTLIKDPALRPSASELLNHPLF
.|.. |..|.  | |  |..|||.|
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 89588.m00024.AA CAMK-Unique 22-276 24 1.2e-66 218.98 In-house 1-363 (363) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-363/363
Sequence Identity: 24% (88 aa)

YRKQEQIGSGGFSTVFRVVNVKTNQIYAMKVIPQSKLMTEEQKT-----------------LIDNEIKLHRSLNHSNIVKLYNT----FCDAQ-------
|.. . ||.|.|. |... . .|  ..|.|..   .   . ||.                   ..|. . ....| ||.||| .    |||..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NQYIILEHCKGGNLKDKFKQ--------------------KGRFSE--SDVKLFLHQALSALDYIHTCGIVHRDIKLGNFLYADN-------
        . ||..|.| || |.|.. .                    .|.|||  .|. .   . |||. | |  .|||||.|| | ..  .       
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

---------NIIKICDFGLAVKNNPKHNY----MVSGTQAYLSP--------------ELFTQKGLGTSPKI----DIWALGVCAFMLLNGYAPFDAPTP
         . ||.|||||... | .. .     . ||  |..|              |.  . . .   .     |||.||| ....| |. |||... 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQ--QCSPASDIWSLGVIMYYMLCGCPPFDCECE

Q--------LQFERIKSDEF-RFNPSVE-----ISENMQDFISKTLIKDPALRPSASELLNHPLF
          .||.|.. .. .|  ...     ||..  ||. ...  ||. | ||.||| |. .
DRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 89588.m00024.AA TyrKc 22-276 21 8.4e-20 73.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

YRKQEQIGSGGFSTVFRVVNVKTNQIYAMKVIPQSKLMTEEQKTLIDNEIKLHRSL--NHSNIVKLYNTFCDA-------QNQYIILEHCKGGNLKDKFK
 .. ...|.| | .|.. .     .  | |..  ..      .  . .|... ..|  .| |||.||    .        .  .|..|....|.|||  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QKGR-FSESDVKLFLHQALSALDYIHTCGIVHRDIKLGNFLYADNNIIKICDFGLAVKNNPK------HNYMVS----GTQ-----AYLSPELFTQKGLG
 ... .. .|   | .|. .  .|.|  ...|||.   | |...|...||.||||. .   .      . | ..    |.        ..|| .  .   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGK

TSPKIDIWALGVCAF-MLLNGYAPFDA-----PTPQLQFERIKSDEFRFNPSV-------EISENMQDFISKTLIKDPALRPSASELLNHPLF
 ..| |.|. ||| . .. .|  |         ..|  .|..|. . .  |         . .. | . ...    ||. ||. ||.  | .|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 89588.m00024.AA Pkinase_Tyr 22-167 26 2.2e-16 56.08 Pfam 1-158 (270) Show / Hide 
Range on Protein: 22-167
Range on HMM: 1-158/270
Sequence Identity: 26% (43 aa)

YRKQEQIGSGGFSTVFRVVNV----KTNQIYAMKVIPQSKLMTEE--QKTLIDNEIKLHRSL-NHSNIVKLYNTFC-DAQN--QYIILEHCKGGNLKDKF
 .. ...|.| | .|.. .      .|..  | |..   . | |.  .. ..  |.|. ..| .| |||.||     . .    ||..|....|.|.|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KQ----KGRFSESDVKLFLHQALSALDYIHTCGIVHRDIKLGNFLYADNNIIKICDFGLA
..    |.... .|   . .|  ....| .  ...|||.   | | ..||..||||||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
POLO_box 89588.m00024.AA POLO_box 304-342 37 4.2e-07 29.82 Pfam 3-45 (74) Show / Hide 
Range on Protein: 304-342
Range on HMM: 3-45/74
Sequence Identity: 37% (16 aa)

NKIGLAYLLVDGSVGII-FNDGYKFIQDPHQQ-FVQYYL--PN
.| |. |.| .|.|..  |||. |.| .|... .|.|.   ||
TKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPN
POLO_box 89588.m00024.AA POLO_box 398-427 35 0.041746 11.38 Pfam 1-31 (74) Show / Hide 
Range on Protein: 398-427
Range on HMM: 1-31/74
Sequence Identity: 35% (11 aa)

MRDKDIAMFKFDNNDMQFN-FNDGMKLIVYS
.|.|   |. . |...|.| |||. |.|. .
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCP