Gene 83456.m00049 (T.vaginalis)

83456.m00049

Species: T.vaginalis
Alias: 83456.m00049, TvagK0028
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
83456.m00049.AA Protein None 299 None Fasta, JSON
83456.m00049.kin_dom Protein Kinase Domain None 248 None Fasta, JSON

Protein domain

Protein domains of 83456.m00049.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 83456.m00049.AA CAMK 12-254 20 1.5e-84 272.25 In-house 1-425 (425) Show / Hide 
Range on Protein: 12-254
Range on HMM: 1-425/425
Sequence Identity: 20% (85 aa)

PIGRGVSSTVYVARNTDTD------------EVVCIKVIPKA-----------------------------EKEKCFLDTEIKVLPT-------LNHPNI
 .|||  ..|. .... |             . | ||.|.|                              .| . ..  ||... .       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFIDFLEDLEN-------------------YYLIE---EYCNGE----TLTQFVESGKL---------------LTERSILSIMQQLFSALMYIHAKGV
.|.... || ..                   .|..    ||| |      | ... . .                .|||    ...|. ||. |.| ...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

SHRDLKPDNIIIIDSS-----------------NIKVIDFGLSTDDNSS-------------------------LRSTFCGSVAFAS-PECINH------
 ||||||.|| . |..                 |||.||||...  ...                         . .||||. .... || .|       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------QKYDAKAADIWSCGVICFYLSTGQIPWKGN-------------NIVQLMRSISAVNYY-IPNSILI-----------------------PIKS
       ..|. ...|.||||||.. . .|  |. |              |. .|.. | . .|. .|  . .                         |.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

IITQCLCLDPSKRPTAEKLLESPFL
 | ..|. ||.||.|.|  |. |..
LIRKMLQVDPEKRMTIEQCLNHPWM
Pkinase 83456.m00049.AA Pkinase 7-254 30 4.8e-83 287.0 Pfam 1-293 (293) Show / Hide 
Range on Protein: 7-254
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

YTVIDPIGRGVSSTVYVARNTDTDEVVCIKVIPKAEKEKCFLDT-----EIKVLPTLNHPNIVKFIDFLEDLENYYLIEEYCNGE----TLTQFVE--SG
|... .||.| ...|| ... .| ..|..|.|.| ....... |     ||...  |||||||...|. ||  ..|.. |||.|      |  ...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KLL--TERSILSIMQQLFSALMYIHAKGVSHRDLKPDNIIIIDSSNI----KVIDFGLST---DDNSSLRSTFCGSVAFASPECINHQKYDAKAADIWSC
. .  .|. . ..| |....| |.|..|. ||||||.|| | .  .|    |..||||.      |.|  .||||.  ...|| |....|. ...|.|||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVICFYLSTGQIPWKGN----------NIVQLMRSISAVNYYIPNSIL-----------------IPIKSIITQCLCLDPSKRPTAEKLLESPFL
|.|.... .|. |..|            |.. |. .   ... ..||                   . |..|. |||.||.|||||| .|..|..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc 83456.m00049.AA S_TKc 7-254 30 6.5e-80 272.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 7-254
Range on HMM: 1-231/231
Sequence Identity: 30% (80 aa)

YTVIDPIGRGVSSTVYVARNTDTDEVVCIKVIPKAEKEKCFLDTEIKVLPTLNHPNIVKFIDFLEDLENYYLIEEYCNG--ETLTQFVESGKL------L
|.....||.|  ..|| .|...|...| ||.|.      . .  ||..|   .||||||..|. .| ...|.. |||.|   .| .. .. .       .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TERSILSIMQQLFSALMYIHAKGVSHRDLKPDNIIIIDSSNIKVIDFGLSTDDNSSLRSTFCGSVAFASPECINHQKYDAKAADIWSCGVICFYLSTGQI
.|  . ..|.|...|| |.| .|. ||||||.|| . .  .||..||||..       .||||.  . .|| .   .|. ...|.||||.| . . .|. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP

PWKGNNIVQLMRSISAVNYYIPNSILIPIKSIITQCLCLDPSKRPTAEKLLE-------SPFL
|.   .. .... |             . |..| .||. ||.||||| ..|.        |..
PFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 83456.m00049.AA CAMKL 7-254 28 4.7e-78 248.65 In-house 1-297 (297) Show / Hide 
Range on Protein: 7-254
Range on HMM: 1-297/297
Sequence Identity: 28% (86 aa)

YTVIDPIGRGVSSTVYVARN-TDTDEVVCIKVIPKAEKE-KCFLDT---------------EIKVLPTLN---HPNIVKFIDFLEDLEN------YYLIE
|.... .|.|  ..|  |..   | | | ||.| |  .  ... .                ||. .  ||   ||||.|. . .|. |.      .||. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCNGET--LTQFV--ESGKL--LTERSILSIMQQLFSALMYIHAKGVSHRDLKPDNIIIIDSS--NIKVIDFGLSTD-DN-----SSLRSTFCGSVAFA
||| |    | ...  . ..   ..|.    . .|. ||. |.| .|. |||.||.|| . ..   |||.||||.|.  ..       . .||||| ...
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPECINH--QKYDAKAADIWSCGVICFYLSTGQIPWKGN--------NIVQLMRSISAVNYYIPNSILI-PIKSIITQCLCLDPSKRPTAEKLLESPFL
.|| ..   ..||....|||||||| . . .|. |...         ||  |.. |    ||.|  . . . ...| . |  .|.||||.. ... |..
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 83456.m00049.AA MARK 7-254 30 1.3e-76 250.02 In-house 1-262 (262) Show / Hide 
Range on Protein: 7-254
Range on HMM: 1-262/262
Sequence Identity: 30% (81 aa)

YTVIDPIGRGVSSTVYVARNTDTDEVVCIKVIP---KAE-KEKCFLDTEIKVLPTLNHPNIVKFIDFLE--DLEN-YYLIEEYCNGETLTQFVESG--KL
| ..  || |  ..|..|... |.. |.||...   . . .... .  ||...  |.||||.|. .  |  . ..  ||| ||. |  | .....     
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LTERSILSIMQQLFSALMYIHAKGVSHRDLKPDNIIIIDSS--NIKVIDFGLSTDD-NSSLRSTFCGSVAFASPECINHQKYDAKAADIWSCGVICFYLS
|.|.    | .|. ||. | | |.. |||.||.|| | .    ||| ||||.|.   . .. .||||. ....|| .. ..||....||||.||. ... 
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

TGQIPWKGNN--IVQLMRSISAVNYYIPNSILIPIKSIITQCLCLDPSKRPTAEKLLESPFL
.|. |..| .  ...|.. | . .| ||  .   ....| . | ..|..|||.| ... |..
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 83456.m00049.AA Ciliate-E2 7-254 22 5.4e-68 232.21 In-house 1-365 (365) Show / Hide 
Range on Protein: 7-254
Range on HMM: 1-365/365
Sequence Identity: 22% (86 aa)

YTVIDPIGRGVSSTVYVARNTDTDE-----------------------VVCIKVIPKAEKEKCFLDTEIK--------------VLPTLNHPNIVKFIDF
| .|  ||.|  ..|| ...  ...                        . .|.. | ..|  .    |               .| .||||||.|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LE--DLENYYLIEEYCNGETLTQFVESGKL-----------LTERSILSIMQQLFS---------------ALMYIHAKG-VSHRDLKPDNIIIIDSSNI
 .  | .|.||. |||.| .| .. .. |.           .||. |. ||.|...               || |.| |. . |||.||.||..     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KVIDFGLSTDDNSS---------------------------------LRSTFCGSVAFASPECINHQKYDA--------KAADIWSCGVICFYLSTGQIP
|.||||||.. . .                                 .  |.||.  . .|| .| .|||         ...||||.||| ... .|. |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

WKGNNIVQLMRSISAVNYYIP------------------NSILIPIKSIITQ----CLCLDPSKRPT-AEKLLESPFL
.        .. |   .. .|                  ...    | .| .    .|. ||.||.| .|..|. |..
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 83456.m00049.AA ULK 7-254 24 3.8e-65 222.73 In-house 1-324 (324) Show / Hide 
Range on Protein: 7-254
Range on HMM: 1-324/324
Sequence Identity: 24% (78 aa)

YTVIDPIGRGVSS-TVYVARNTDT---DEVVCIKVIP-----KAEKE------KCFLDTEIKVLPTLN---HPN--IVKFIDFLEDL--ENYYLIEEYCN
| ... .| |    .|| .|| .|   ...| .|.|.     | ..|      ...|. ||... .|.   |||  |||..|..|.    |.|.| ||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GETLTQFVE---------SGKLLTERSILSIMQQLFSALMYIHAKGVSHRDLKPDNIIIIDSSN------------IKVIDFGLSTD-DNSSLRSTFC--
| .| |. .          .| |.|  ......|. ......| ... |||.||.|| | .               .|. |||..   || ..  . |  
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

--------GSVAFASPECIN----HQKYDAKAADIWSCGVICFYLSTGQIP---WKGNNIV-------------QLMRSISAVNYYIPN---SILIPIKS
        |.  . .|. ..    ...|. . .|||| |.| ... .|. |   |  |. .             |..     .....|.    |   .|.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

IITQCLCLDPSKRPTAEKLLESPFL
.| ..|. |...| . | ... |..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 83456.m00049.AA ULK 7-254 24 2e-62 213.72 In-house 1-329 (329) Show / Hide 
Range on Protein: 7-254
Range on HMM: 1-329/329
Sequence Identity: 24% (80 aa)

YTVIDPIGRGVSSTVYVARNTDT----DEVVCIKVIP---KAEKE--------KCFLDTEIKVLPTLN--------HPNIVKFIDFLEDL--ENYYLIEE
| ... .| |   .|| .|| .|    .|.| .|.|.   . .|.        ...|. |||.. .|.        ||||||..|..|.    |.|.| |
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCNGETLTQFVE----------SGKLLTERSILSIMQQLFSALMYIHAKGVSHRDLKPDNIIIIDSSN------------IKVIDFGLSTD-DNS----S
|||| .| |. .           .| |.|  ......|. ......| ... |||.||.|| | .               .|. |||..   ||.     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LRSTFC------GSVAFASPECIN----HQKYDAKAADIWSCGVICFYLSTGQIPWKGN-NIVQLMRSISAVNYY-------------IP-----NSILI
.  |.       |.  . .|. ..    ...|. . .|||| |.| ... .|. |.... |  .|.  .. .|..             .|     . |  
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

PIKSIITQCLCLDPSKRPTAEKLLESPFL
 .|..| ..|. |...| . | |.. |..
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 83456.m00049.AA Ciliate-E2-Unclassified 7-254 23 5.8e-62 212.17 In-house 1-352 (352) Show / Hide 
Range on Protein: 7-254
Range on HMM: 1-352/352
Sequence Identity: 23% (82 aa)

YTVIDPIGRGVSSTVYVARNTDTDEVV-----CIKVIPKAEKEKCF--------LDTEIK--------------VLPTLNHPNIVKFIDFLEDLENYYLI
|..|  ||.|  ..|| ... ...  .      .|.. .. | . .        .  ..|               |  ..||.|||...  .| .| |..
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

EEYCNGETLTQFVES-----------------GKLLTERSIL-----SIMQQLFSALMYIHAKG-VSHRDLKPDNIIIIDSS---NIKVIDFGLST----
 |||.| .| |. ..                 .| .||. ..      .. |. ..| |.| |. . |||.||.||.. ..    .||.||||.|     
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

-----DDN--------SSLRSTFCGSVAFA----SPECINHQKYDA---KAADIWSCGVICFYLSTGQIPWKGNNIVQ----------------LMRSIS
     ...        . . .||||.  .     .||..  |.||    ...||||.|||.... .|. | ..||  |                | . | 
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

AVNYYIPN--------SILIPIKSIIT----QCLCLDPSKRPTAEKLLESPFL
. |...|.         .    | .|.    ..|  .|.||.|.|..|. |..
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 83456.m00049.AA CAMK-Unique 7-254 21 3.2e-59 194.06 In-house 1-363 (363) Show / Hide 
Range on Protein: 7-254
Range on HMM: 1-363/363
Sequence Identity: 21% (79 aa)

YTVIDPIGRGVSSTVYVARNTDTDEVVCIKVIPK--AEKEKCFL-------------------DTEIKVLPTLNHPNIVKFIDF----LEDLE-------
|. . .|| |  . || . .  |     .|.. |  .. .|  .                   . |. .. ...||||.|. |.     .| .       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NYYLIEEYCNGETLTQFVES--------------------GKLLTE--RSILSIMQQLFSALMYIHAKGVSHRDLKPDNIIIIDS-------
        ..|.. |||.| .| . . .                       ..|  . ...|||.| ||. | | ... |||||..|| .  |       
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

---------SNIKVIDFGLSTDDNSSLRS----TFCGSVAFASP--------------ECINHQKYDAKAA---DIWSCGVICFYLSTGQIPWKGNNIV-
         ..||..||||... |..  .    |.||.  ...|              | || |.|| .     ||||.||| .|. .|  |  ....  
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------QLMRSISAVNY-YIPNSILIP-------IKSIITQCLCLDPSKRPTAEKLLESPFL
        . ..|.. .| . ...            |.....|. .||..| .|. |||....
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 83456.m00049.AA Ciliate-E2a 7-207 35 8.2e-56 162.77 In-house 1-223 (275) Show / Hide 
Range on Protein: 7-207
Range on HMM: 1-223/275
Sequence Identity: 35% (79 aa)

YTVIDPIGRGVSSTVYVARNTDTDEV-VCIKVIPKAEKEK---CFLDTEIKVLPTLNHPNIVKFIDFLEDLENYYLIEEYCNGETLT-QFVESGKLLTE-
| .|. || |    ||.|.  .| .  . .|.| |.. .|    ..  ||. . .|.|||| |.... ||  ||||. |||.| .|   ....... .| 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

RSILSIMQQLFS-ALMYIHAKGVSHRDLKPDNIII----IDS---SNIKVIDFGLSTDDNSSL---RSTFCGSVAFAS------PECINHQKYDAKAADI
  | .|||||.. .| |.| ... ||||||.||..     .|   |.||.|||||.|. ..     . . ||.  .        .| ..|..|| |  |.
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTK-CDM

WSCGVICFYLSTGQIPWKGNNIVQ
|||||| . | .|. | || .  .
WSCGVIFYILLCGKPPFKGKTYNE
Kinase 83456.m00049.AA STE 7-254 24 1.1e-54 187.98 In-house 1-359 (359) Show / Hide 
Range on Protein: 7-254
Range on HMM: 1-359/359
Sequence Identity: 24% (88 aa)

YTVIDPIGRGVSSTVYVARNT------DTDEV---------VCIKVIPKAEK-----------------EKC-FLDTEIKVLPTLN--HPNIVKFIDFLE
.. |. ||.| . ||| |.|       .|.||         . ||.... ..                 |.   .  |||..  .|  ||||||...  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DL-------ENYYLIEEYCNGETLTQFVE----SGKLLT----------ERSILSIMQQLFSA-LMYIHAKGVSHRDLKPDNIIIIDSSNIKVIDFGLST
.        .. ... ||..| .|.....     || |.          |  |  | .|.  . | |.| ... |||.||.|| .     .| .|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

DDNSS------------------LRSTFCGSVAFASPECINH------QKYDAKAADIWSCGVICFYLSTGQIPWKGNNIVQLMRSISAVN---------
  ..|                   | ||.|.  . .|| |.       ..||.| .|||| |  .  . ||. ||   .  . |  |   .         
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTK-CDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

-------YYIPNSIL-------------------IPIKSIITQCLCLDPSKRPTAEKLLE--SPFL
         .|. .                     . |  | .||  ||.|||||..||.   ||.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 83456.m00049.AA TyrKc 7-254 22 1.2e-14 14.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 7-254
Range on HMM: 1-280/280
Sequence Identity: 22% (64 aa)

YTVIDPIGRGVSSTVYVARNTDTDEVVCIKVIPKAEKEKCFLDTEIKVLPTL--NHPNIVKFIDFLEDL-------ENYYLIEEYCNGETLTQFVESGKL
 | .. .|.|   .|| .. .   . | .|.. .   .. |.. |....  |  .|||||...    .        | .... ||. .  | ..  . . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMR-EARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LTERSILSIMQQLFSALMYIHAKGVSHRDLKPDNIIIIDSSNIKVIDFGLSTDDNSS---------LRSTF--CGS----VAFASPECINHQKYDAKAA
 |. .  ||.. |  .   |.| |.. ||||   |. . .   .|. ||||| |  .           |..   .|     .   .|||||. |.   . 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKS

DIWSCGVICF-YLSTGQIPWKG-----NNIVQLMRSISAVNY-YIPNS--------ILIPIKSIITQCLCLDPSKRPTAEKLLESPFL
|.|| || ..  .. || |. |      .  .... . . ..  .| .            . .|..||   ||..||| . .    ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 83456.m00049.AA Pkinase_Tyr 7-150 24 2e-08 29.15 Pfam 1-160 (270) Show / Hide 
Range on Protein: 7-150
Range on HMM: 1-160/270
Sequence Identity: 24% (39 aa)

YTVIDPIGRGVSSTVYVARNT----DTDEVVCIKVI--PKAEKE---KCFLDTEIKVLPTL-NHPNIVKFIDFLE-DLEN--YYLIEEYCNGETLTQFVE
 | .  .|.|   .|| .. .    .|.  | .|..     ...   . |.  |.|.. .| .|||||...     . |   .|.. ||. .  |  .  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

S----GKLLTERSILSIMQQLFSALMYIHAKGVSHRDLKPDNIIIIDSSNIKVIDFGLSTD
.    .. ||   .|.. .|  ... | ..|.  ||||   |. . ..  .|. ||||. |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase 83456.m00049.AA Ciliate-E2a 238-254 47 1.7e-05 12.15 In-house 259-275 (275) Show / Hide 
Range on Protein: 238-254
Range on HMM: 259-275/275
Sequence Identity: 47% (8 aa)

DPSKRPTAEKLLESPFL
||.||.||. .|..|. 
DPKKRITAQQALNHPWF
Kinase 83456.m00049.AA Pkinase_Tyr 226-250 36 0.955972 3.15 Pfam 244-268 (270) Show / Hide 
Range on Protein: 226-250
Range on HMM: 244-268/270
Sequence Identity: 36% (9 aa)

PIKSIITQCLCLDPSKRPTAEKLLE
.| ....||   ||..||| . ..|
EIYDLMKQCWHYDPEDRPTFSEIHE