Gene 90936.m00066 (T.vaginalis)
90936.m00066
Species: T.vaginalis
Alias: TvagK0084, 90936.m00066
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 90936.m00066.AA | Protein | None | 439 | None | Fasta, JSON |
| 90936.m00066.kin_dom | Protein Kinase Domain | None | 249 | None | Fasta, JSON |
Protein domains of 90936.m00066.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 90936.m00066.AA | CAMK | 23-266 | 18 | 1.9e-58 | 186.64 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 23-266
Range on HMM: 1-425/425
Sequence Identity: 18% (77 aa)
EIARGAFSSIREAFRTDSPGS------------YAMKLISKKKIRQ------------------------YITSKEMIFSDSVIAPLLF-------HPNI
.. ||.|. ...... ..| .|.| |.|||.. ....... | .| ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
ARVYQTIE------------SVAQ--------HFQIM---DLFQKN----TLLYYIQYN----------------SLTTEQLLTYLDQILSAIEYLHLHD
. |...| . . . .| .. . |. ||. . .| .. .| ||.||..|.| |.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
LCHRDIKPENILMTDG-----------------NEVKLTDFGFLTFSFDGKNSG-------------------------TCGSPGYAA-PEVFLF-----
.|||.||||||..| | .|..|||| .. ..|.|. ||.|.|.| |||..
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
--------NVYDGKKADIWSIGVLVYSLFAGTCPFPSD-------------LKQSPHIYLDQVDFTKIPDC---------------------------VQ
. |.|.|.|.||.||. | . |. || .| . . . ... .|. ..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK
SFVKDCLKLDPNERPTVSQLREYTCF
.... .|. ||..|.|..| . .
DLIRKMLQVDPEKRMTIEQCLNHPWM
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| S_TKc | 90936.m00066.AA | S_TKc | 18-266 | 26 | 4.7e-52 | 180.17 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 18-266
Range on HMM: 1-231/231
Sequence Identity: 26% (69 aa)
YVVGVEIARGAFSSIREAFRTDSPGSYAMKLISKKKIRQYITSKEMIFSDSVIAPLLFHPNIARVYQTIESVAQHFQIMDLFQK--NTLLYYIQYNS---
| .. .| .|||.. . . ... .|.| |. |.| . | |||| . | .... . .|.. .|. ||. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----LTTEQLLTYLDQILSAIEYLHLHDLCHRDIKPENILMTDGNEVKLTDFGFLTFSFDGKNSGTCGSPGYAAPEVFLFNVYDGKKADIWSIGVLVYSL
.. . |. ||..|.||.| | .|||.||||||... ..|..|||. .. . ||.| | ||||. |...|.|.||.|...| .
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM
FAGTCPFPSDLKQSPHIYLDQVDFTKIPDCVQSFVKDCLKLDPNERPTVSQLRE-------YTCF
..| ||| .. .... .. . .|.. ||. ||..|||. .. . |
LCGYPPFP-----QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 90936.m00066.AA | Ciliate-E2-Unclassified | 18-266 | 20 | 1.6e-51 | 177.0 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 18-266
Range on HMM: 1-352/352
Sequence Identity: 20% (74 aa)
YVVGVEIARGAFSSIREAFRTDSPGSYAMKLISKKKIRQ--YITSKEMIFSDSVIAPLLF--------------------HPNIARVYQTIESVAQHFQI
| .. | .|.|...... . . |||| ..|..|. .| .|. ... . .. ||.| . . . .. . .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV
MDLFQKNTLLYYIQY------------------NSLTTEQLL-----TYLDQILSAIEYLHLHD-LCHRDIKPENILMTDGN---EVKLTDFGFLT----
|.... ..|..||. . .| .| . .|. |||...|||| .||||||||||..... ..|..|||.
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
-------------FSFDGKNSGTCGSPGYA----APEVFLFNVYDG---KKADIWSIGVLVYSLFAGTCPFPS-DLKQ----------------SPHIYL
. . . . .||.|.| ||||. . ||. .|.|||| ||. | . |..||.. . .| . .
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK
DQ------VDF----TKIPDCVQSFVK----DCLKLDPNERPTVSQLREYTCF
.. .. ....... |.. .|| .||.|.| .|. . |
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | 90936.m00066.AA | Ciliate-E2 | 18-266 | 20 | 3.7e-51 | 173.87 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 18-266 Range on HMM: 1-365/365 Sequence Identity: 20% (78 aa) YVVGVEIARGAFSSIREAFRTDSPGSYAMKLISKKKIRQY----------------ITSKEMIFSDSVIAPL------------------LFHPNIARVY | . | .|.|.|.... . . .|.|.| .|. |. . .. .. ..| . | |||| . | YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY QTIE--SVAQHFQIMDLFQKNTLLYYIQYN------------SLTTEQLLTYLDQILS---------------AIEYLHLHD-LCHRDIKPENILMTDGN . . . . .|...| ..|..||. | ..| .. ... |||. |.|||| .||||||||||. ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- EVKLTDFGF-----------------LTFSFDG-----------------KNSGTCGSPGYAAPEVFLFNVYDG--------KKADIWSIGVLVYSLFAG .|..|||. . | . .||.||| |||.. ||. .|.||||.||. | . | -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG TCPFPSDLKQSPHIYLDQV--------------DFTKIPDCVQSFVKD----CLKLDPNERPT-VSQLREYTCF || . .. | ... .. |... .. . | .|. ||..|.| .|. . | KPPF-QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 90936.m00066.AA | Pkinase | 18-266 | 25 | 9.2e-50 | 176.44 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 18-266 Range on HMM: 1-293/293 Sequence Identity: 25% (76 aa) YVVGVEIARGAFSSIREAFRTDSPGSYAMKLISKKKIRQYITSKEMIFS--DSVIAPLLFHPNIARVYQTIESVAQHFQIMDLFQKN----TLLYYIQ-- |..| | .|.|.. ... . ... .|.| |.|. .. .. . | | |||| | | . |. .|.. .. | ||. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW -YNSL--TTEQLLTYLDQILSAIEYLHLHDLCHRDIKPENILMTDGNEV----KLTDFGFLT---FSFDGKNSGTCGSPGYAAPEVFLFNVYDGKKADIW .... . ... |. |||...||.| . .|||.||||||. . ... |..|||. .. ... ||.|.|.|||| ... |.|.|.|.| RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW SIGVLVYSLFAGTCPFPSD-------------LKQSPHIYLDQVDFTKIP-----------------DCVQSFVKDCLKLDPNERPTVSQLREYTCF |.|...| .. | |||.. .. .| . | |. . ..|.|.||..||..||| |. . | SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 90936.m00066.AA | CAMKL | 18-266 | 27 | 4.4e-48 | 151.45 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 18-266 Range on HMM: 1-297/297 Sequence Identity: 27% (82 aa) YVVGVEIARGAFSSIREAFR-TDSPGSYAMKLISKKKIR--QYITSKEM---------IFSDSVIAPLLF---HPNIARVYQTI-------ESVAQHFQI | .| .. .|.|. . | .|.| | ||||. ...... |. | .| |||| . |..| |. . . . YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV MDLFQKNT--LLYYIQYNS-----LTTEQLLTYLDQILSAIEYLHLHDLCHRDIKPENILMT-DGN-EVKLTDFGFLTFSF------DGKNSGTCGSPGY | . . |. ||. . .. .. | ||.||..|.| |. .|||||||||| . .|| .|..|||| .. . | . |||| | MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY AAPEVFLF--NVYDGKKADIWSIGVLVYSLFAGTCPFPSD------------LKQSPHIYLDQVDFTKIPDCVQSFVKDCLKLDPNERPTVSQLREYTCF .|||.|. |||.|.||||.||. | . |. || | ... . ... .... . |. .|..|||. |... . MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 90936.m00066.AA | AMPK | 73-266 | 34 | 3.1e-41 | 120.23 | In-house | 55-254 (254) | Show / Hide |
Range on Protein: 73-266 Range on HMM: 55-254/254 Sequence Identity: 34% (70 aa) LLFHPNIARVYQTI-ESVAQHFQIMDLFQKNTLLYYI-QYNSLTTEQLLTYLDQILSAIEYLHLHDLCHRDIKPENILMTDGNEVKLTDFGFLTFSFDGK |. ||.| . |. | |. . | .| . . | || . . |. .. .. ||.|..||.| | ||| ||||.|. . ...|. ||| ||. LFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGE NSGT-CGSPGYAAPEVFLFNVYDGKKADIWSIGVLVYSLFAGTCPFPSDLKQSPHIYLDQV-DFTKIPDCVQSFVKD----CLKLDPNERPTVSQLREYT | |||| |||||. | | . |||| || | . |. || | . | | . . .||. . . .|| |. ||..| |....|. FLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF--DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHP CF | WF |
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| Kinase | 90936.m00066.AA | MARK | 76-260 | 33 | 4.4e-40 | 128.81 | In-house | 58-256 (262) | Show / Hide |
Range on Protein: 76-260 Range on HMM: 58-256/262 Sequence Identity: 33% (66 aa) HPNIARVYQTIE--SVAQ-HFQIMDLFQKNTLLYYIQYN---SLTTEQLLTYLDQILSAIEYLHLHDLCHRDIKPENILMTDGN--EVKLTDFGF-LTFS |||| . ...|| . . ||.. . |. ||. |. | .. ||.||..|.| .. .||||||||||. . . .|..|||| . HPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIP FDGKNSGTCGSPGYAAPEVFLFNVYDGKKADIWSIGVLVYSLFAGTCPFP--S--DLKQSPHIYLDQVD-FTKIPDCVQSFVKDCLKLDPNERPTVSQL . | . ||.| |.|||.|| |||.|.|||| ||. | . |. || . . . |. . | ...... ..... |...|.||||.... PGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEI |
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| Kinase | 90936.m00066.AA | CAMK-Unique | 18-266 | 19 | 2.4e-36 | 117.35 | In-house | 1-363 (363) | Show / Hide |
Range on Protein: 18-266
Range on HMM: 1-363/363
Sequence Identity: 19% (72 aa)
YVVGVEIARGAFSSIREAFRTDSPGSYAMKLISK---KKIRQYI------------------TSKEMIFSDSVIAPLLFHPNIARVYQT----IESVA--
| . | |.|. ..|.. . .|.|.. | . ..|.. . .| .| .. |||| ..|.. .
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREH-----QIWKMVDHPNIIKLYDWNNPIFCDRKYP
-------------QHFQIMDLFQKNTLLYYIQY--------------------NSLTTE---QLLTYLDQILSAIEYLHLHDLCHRDIKPENILMTDG--
. .|.. |...|. .|| . .| . ... ..|||..|.| | |||.|.|||.
LCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFK
--------------NEVKLTDFGFLTFSFDGKNSGT-----CGSPGYAAP--------------EVFLFNVYDGKKA---DIWSIGVLVYSLFAGTCPFP
. .||.||| | .... . . ||.| |.|| || . ||.. ||||.||. |... | ||
DNNHHRDFPYDWSNWHIKLCDFG-LCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFD
SDLKQ---------------SPHI-YLDQVDFTK---IPDCVQSFVKDCLKLDPNERPTVSQLREYTCF
.. . . . ..| . | .. .|||.|...||. | . ..| | .
CECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
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| Kinase | 90936.m00066.AA | QIK | 124-218 | 46 | 1.3e-35 | 124.68 | In-house | 126-221 (272) | Show / Hide |
Range on Protein: 124-218 Range on HMM: 126-221/272 Sequence Identity: 46% (45 aa) QILSAIEYLHLHDLCHRDIKPENILMTDGNEVKLTDFGFLTFSFDGK-NSGTCGSPGYAAPEVFLFNVYDGKKADIWSIGVLVYSLFAGTCPFPSD ||.||..|.| . |||.| ||||. ..|. |||| .. |. . |||| |||||.|. . ||| |.||||.||. |.| .| ||... QICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGK |
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| Kinase | 90936.m00066.AA | ULK | 107-254 | 23 | 7e-32 | 108.62 | In-house | 110-317 (329) | Show / Hide |
Range on Protein: 107-254 Range on HMM: 110-317/329 Sequence Identity: 23% (49 aa) YIQYN-----------SLTTEQLLTYLDQILSAIEYLHLHDLCHRDIKPENILMTDGN------------EVKLTDFGFLTFSFDG-----KNSGTC--- ||. | |. .. . .. |||.. .|| | ||||||.|||...|. .|..|||| . .. . . YIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEK ---GSPGYAAPEVFL----FNVYDGKKADIWSIGVLVYSLFAGTCP----FPSDL---KQSP---------HIYLDQVDFTK------IPDCVQSFVKDC |.| | ||... |. .|.||||.|.. | . | .| | .. .|. | . .| | | . .... . . RLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRM LKLDPNER |. |...| LQYDEKDR |
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| Kinase | 90936.m00066.AA | TKL | 24-264 | 15 | 4.4e-31 | 109.17 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 24-264
Range on HMM: 1-364/364
Sequence Identity: 15% (56 aa)
IARGAFSSIREAFRTDSP--------GSYAMKLISKKKIRQY---------------------ITSKEMIFSDSVIAPLLF--HPNIARVYQ-TIESVA-
| .|.|. . . . |.| .... .|... | .| .. |||| . . ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
-----------QHFQIMDLFQKNTLLYYIQYNSLTTEQLLTYLDQILSAIEYLHLHD--------LCHRDIKPENILMTDGNE--------------VKL
|.. .|.. .. .||.|.. .|.. .| ....||| .. . |||.|..||| . .. .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI
TDFGFLTFSFDGK---------------------NSGTCGSPGYAAPEVFLFNVYDGKKA---------------DIWSIGVLVYSLFAGTCPFPSDLKQ
.|||. .| . . .. ||.|.. ||||. . .. .|. |..| |.. . .... |. .|..
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY-YDYPY
SPHI---------YLDQVDF------------------TKIPDCVQSFVKDCLKLDPNERPTVSQLREYT
.|.| ... ... . .|. . . .|| . ||..||. ... ..
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 90936.m00066.AA | TyrKc | 18-266 | 22 | 2.5e-12 | -23.26 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 18-266 Range on HMM: 1-280/280 Sequence Identity: 22% (67 aa) YVVGVEIARGAFSSIREAFRTDSPGSYAMKLISKKKIRQYITSKEMIFSDSVIAPLL--FHPNIARVYQTIESV-------AQHFQIMDLFQKNTLLYYI . | .. .||| .... . | | . . . .|.. . | | |||| | | . . ... .| . . |. |. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL QYNS--LTTEQLLTYLDQILSAIEYLHLHDLCHRDIKPENILMTDGNEVKLTDFGFLTFSFDG------KNSGTC----GSPG-----YAAPEVFLFNVY ... |....|| . || . |||| . . |||. |.| .... || .||| . |. | . |. . |||.. .... RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF DGKKADIWSIGVLVYSLFA-GTCPFPS-----DLKQSPHIYLDQVDFTKIPDC------------VQSFVKDCLKLDPNERPTVSQLREYTCF | |.|| ||. . .| | | | | . |..| . ..|. . . |.| . ||..||| |.. . || T-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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