Gene 86792.m00065 (T.vaginalis)

86792.m00065

Species: T.vaginalis
Alias: 86792.m00065, TvagK0392
External Links:
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: Fused

Sequence

Name Sequence Type Origin Length Description Download
86792.m00065.AA Protein None 966 None Fasta, JSON
86792.m00065.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of 86792.m00065.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86792.m00065.AA Fused 4-254 49 5.8e-122 411.49 In-house 1-251 (251) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-251/251
Sequence Identity: 49% (124 aa)

YYQIAQIGEGSFGRVYKARRKYTGRLVAIKMIHKLGQSQDSLASLRREINILQKVDHPNIMRLLEVFETNTDVCLVTELGRGDLFQVIQDQQTLPESVLK
|     .|.||||.||||||||  . ||||.| |.| |.  | .||||..| ..  ||.|  ... ||| ..|  ||.   ..|.|.  .  ..||   .
YHVSEMVGQGSFGCVYKARRKYDSKVVAIKFIPKRGRSDKELKNLRRECEIMRRMHHPHIIHMIDSFETDKEVVVVTDYAEMELHQYLEYDGKMPEEQVR

SVAAQLVSALLYLHQQRIIHRDIKPQNVLISLNNTVKLCDFGFARALSNTTLVLNSIKGTPLYMAPELVQEQQYNEKVDIWSLGAILYELYYGKTPFSAK
 .|..||||| |||  || |||.||||.|   |  .|||||||||..|  |.|| |||||||||||||| || |    |.|||| |||||  |. || | 
RIACHLVSALYYLHSHRILHRDMKPQNILLDKNMHIKLCDFGFARNMSINTHVLTSIKGTPLYMAPELVEEQPYDHHADMWSLGCILYELMVGQPPFCAN

SIYKLIQMIVNDQIAWSEPISPEFKGFLSIMLQKNPDRRASCEDLVKHPFI
||..|..||. | . |   |..... ||  .| | |  | |  .|  |||.
SIFHLVSMIKHDDVKWPSTITSCCRNFLQGLLTKDPRHRISWPQLLCHPFV
Kinase 86792.m00065.AA S_TKc 4-254 36 8.70000000001e-109 368.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-231/231
Sequence Identity: 36% (98 aa)

YYQIAQIGEGSFGRVYKARRKYTGRLVAIKMIHKLGQSQDSLASLRREINILQKVDHPNIMRLLEVFETNTDVCLVTELGRG---DLFQVIQDQQT----
|  . .||.|.||.|||.| | |||.||||.|.          ..||||.||.| .|||| .|..||.. .....|.|.  |   |||..|.....    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LPESVLKSVAAQLVSALLYLHQQRIIHRDIKPQNVLISLNNTVKLCDFGFARALSNTTLVLNSIKGTPLYMAPELVQEQQYNE-KVDIWSLGAILYEL
  .|| . .....|...|| |.|...|||||.||.|.|..   ..|.||||.|| |       ... ||| |||||..   .|.  |.|.||.| ||||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

YYGKTPFSAKSIYKLIQMIVNDQIAWSEPISPEFKGFLSIMLQKNPDRRASCEDLVK-------HPFI
..|..||.   .......|.          |||.| |.. .|||.|..| .. .. .       ||..
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 86792.m00065.AA AGC 4-254 22 5.8e-104 269.1 In-house 1-395 (395) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-395/395
Sequence Identity: 22% (89 aa)

YYQIAQIGEGSFGRVYKARRK------YTGRLVAIKMIHKLG--------QSQDSLAS--------LRREINILQKVD----------HPNIMR-LLEVF
.  .  ||.||||.|| .|.|       ||.. |.|.. |          . .  ..         ...| |||.|..          ||.| . |   |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETNTD--VCLVTEL----------GRG-DLFQVIQ---DQQTLPESVLKSVAAQ-------LVSALLYLHQ-QRIIHRD-IKPQNVLISLNNTVKLCDFG
....   ...| |.          | | .||. .|   ......|.. .  ||.       .|.|| |||. . ||||| .|| |.|.  .  .||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FARALSN--------------------------------------------------TTLVLNSIKG--TPLYMAPELVQEQQYNEKVDIWS--LGAILY
..  . |                                                   .   ... |  || ||||| .    |.  .|.||  ||...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELYYGKTPFSAK-------------SIYKLIQMIV---NDQIAWS----------EPISPEFKGFLSIMLQKNPDRRASC----------EDLVKHPFI
|. .|..||...              ....|.      |... .           . .||| | ... .|.|.|..|  |          |.. .||. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 86792.m00065.AA ULK 4-254 31 1e-98 334.28 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-329/329
Sequence Identity: 31% (105 aa)

YYQIAQIGEGSFGRVYKARRKYT----GRLVAIKMIHKLGQSQDSLA--------SLRREINILQKVD--------HPNIMRLLEVFETNTD--VCLVTE
|. . ..|.||||.|||.| | |    . .||.||| |  ..|..          .|..|| |..| .        |||| .|...||| ..  . ...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LGRG-DLFQVIQDQQTLPESV----------LKSVAAQLVSALLYLHQQRIIHRDIKPQNVLISLNN------------TVKLCDFGFARALSNT-----
.  | ||.| |. ...|||..           ...  |..... .||...||||||||||.||. ..            ..|..|||||. ..|      
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

TLVLNS----IKGTPLYMAPELVQ----EQQYN-EKVDIWSLGAILYELYYGKTPFSAKSIYKLIQMIVNDQIAW--------------------SEPIS
 ..  .    ..||||||||...|    ...|.  |.|||||| |.||. |||.||.|  ..... .|... | .                    . .||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

PEFKGFLSIMLQKNPDRRASCEDLVKHPFI
||.| ... |||.... | | |.| .||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 86792.m00065.AA Pkinase 4-254 32 1.1e-98 339.0 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

YYQIAQIGEGSFGRVYKARRKYTGRLVAIKMIHKLGQSQDSLASLRR--EINILQKVDHPNIMRLLEVFETNTDVCLVTELGRG-----DLFQVIQ--DQ
|  . .||.||||.|||...| ||..||.| | | ... . . ..||  || |.....|||| ||...||.......|.|. .|     ||| .|.  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QTL--PESVLKSVAAQLVSALLYLHQQRIIHRDIKPQNVLISLNNTV----KLCDFGFARAL-SNTTLVLNSIKGTPLYMAPELVQ-EQQYNEKVDIWSL
 ..  .| ..|... |....| |.|...|||||.||.|.||. |...    |.||||.|. .       .... ||| |||||...  | |  |||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GAILYELYYGKTPFSAK------SIYKLIQMIVNDQIAWSEPIS---------------------PEFKGFLSIMLQKNPDRRASCEDLVKHPFI
| ||||.. |..||. .      . ...|..|   .. ...| .                     .|.| |.. .|.|.| .| ..|....||..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 86792.m00065.AA ULK 4-254 32 1.6e-97 330.27 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-324/324
Sequence Identity: 32% (107 aa)

YYQIAQIGEGSFG-RVYKARRKYT---GRLVAIKMIHKLGQSQDSLA--------SLRREINILQKVD---HPN--IMRLLEVFETNTD--VCLVTELGR
|. . ..|.||||  |||.| | |   . .||.||| | .......         .|..||.|..| .   |||  | .|...||| ..  .....|.  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

G-DLFQVIQDQQTLPESV----------LKSVAAQLVSALLYLHQQRIIHRDIKPQNVLISLNN------------TVKLCDFGFARALSNTTL---VLN
| ||.| |. ...||| .           ...  |..... .||.. |||||||||| ||. ..            ..|..|||||. . | ..   .. 
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

SIK------GTPLYMAPELVQ----EQQYN-EKVDIWSLGAILYELYYGKTPFSAK--SIY----KLIQM-------IVNDQIAWS-----EPISPEFKG
...      ||||||||...|    ...|.  |.|||||| |.||. |||.||..   . |    |||..       | | .| .       .||||.| 
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FLSIMLQKNPDRRASCEDLVKHPFI
... |||.... | | |.. .||..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 86792.m00065.AA CAMK 9-254 22 2.2e-94 304.53 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-254
Range on HMM: 1-425/425
Sequence Identity: 22% (96 aa)

QIGEGSFGRVYKARRKYTG------------RLVAIKMIHK--LGQ------------------------SQDSLASLRREINILQK-------VDHPNI
..|.|||| |.....| |.            . ||||.| |  |                          .. .....||||.|..|       .|||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

MRLLEVFE------------TNTD--------VCLVT---ELGRG-----DLFQVIQDQ---------------QTLPESVLKSVAAQLVSALLYLHQQR
 .|.||.|            | ..        ...|.   |.  |     |||. |...                 ..|.  . .  |..||. |.|.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPQNVLISLN-----------------NTVKLCDFGFARALSN-----------------------TTLVLNSIKGTPLYMA-PELVQEQQ---
|.|||.|| |.|.. |                 |..|..|||||. .                         ..  ..   ||| ||| ||... ..   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YNEKVDIWSLGAILYELYYGKTPFSAK-------------SIYKLIQMIVNDQIAWSEP----------------ISPE--------FK
           |..|.|.||.| ||| .  |. || ..             ..|.| ..| . .  . .|                || |         |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

GFLSIMLQKNPDRRASCEDLVKHPFI
 ... |||..|..|...|.  .||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 86792.m00065.AA CAMKL 5-254 31 1.6e-88 282.59 In-house 1-297 (297) Show / Hide 
Range on Protein: 5-254
Range on HMM: 1-297/297
Sequence Identity: 31% (94 aa)

YQIAQ-IGEGSFGRVYKARR-KYTGRLVAIKMIH--KLGQSQDSLAS-----------LRREINILQKVD---HPNIMRLLEVF-------ETNTDVCLV
|.| . .|.|||| |  |.  ..||. ||||.|.  |.   . ...            .||||.|.....   ||||..|.||.       || ....||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

TELGRGD---LFQVIQDQ----QTLPESVLKSVAAQLVSALLYLHQQRIIHRDIKPQNVLISLNN--TVKLCDFGFARA---L-SNTTLVLNSIKGTPLY
.|.  |    ||. |. .    . .||.  .    |.|||. |.|...|.|||||| |.|.. |.  ..|..||||.        ..   |.   |.| |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

MAPELVQE--QQYN-EKVDIWSLGAILYELYYGKTPFSAKS---------IYKLIQMIVNDQIAWSEPISPEFKGFLSIMLQKNPDRRASCEDLVKHPFI
||||..|   ..|.  ||||||.| ||| . .|. || . .          .....|.   ..     .| . . ... |||.||..|........||. 
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 86792.m00065.AA STE 5-254 25 1.5e-81 277.27 In-house 1-359 (359) Show / Hide 
Range on Protein: 5-254
Range on HMM: 1-359/359
Sequence Identity: 25% (92 aa)

YQI-AQIGEGSFGRVYKARRKY---------------TGRLVAIKMIHKLGQSQ---------------DSLASLRREINILQKVD--HPNIMRLLEVFE
...  .||.|.|| ||||...                ||...||| ...  ...               . . .. .||.|..| .  |||| . .  ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TN-------TDVCLVTELGR-GDLFQVIQ----DQQTLP----------ESVLKSVAAQLVSA-LLYLHQQRIIHRDIKPQNVLISLNNTVKLCDFGFAR
 .       ...... |.   | | ..|.     ...|.          ||... .. |.. . | |||...||||||||.|.|.     |||||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

ALSN---------------TTL-VLNSIKGTPLYMAPELVQE------QQYNEKVDIWSLGAILYELYYGKTPFSA-KSIYKLIQMIVNDQIAW------
 |..               |.    |.. ||| .|||| .|       ..|..|.||||||  . |.  || |..  .  . . ... |  ...      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---------SEPIS-------------------PEFKGFLSIMLQKNPDRRASCEDLVK--HPFI
          ...|                   |||| |..  |||.|. |.. ..| |  ||||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 86792.m00065.AA NEK 4-254 34 5.5e-81 275.37 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-286/286
Sequence Identity: 34% (100 aa)

YYQIAQIGEGSFGRVYKARRKYTGRL-----VAIKMIHKLGQSQDSLASLR-REINILQKVDHPNIMRLLEVFETNT--DVCLVTELGR--GDLFQV---
|  | .||.||||.|||.||| .|.      ...| |   . |.     .   |..||.. .|||| .  . |. .     | | |     |||.|    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IQDQQ----TLPESVLKSVAAQLVSALLYLHQQ-----RIIHRDIKPQNVLISLNNT----VKLCDFGFARALSNTTLVLNS-IKGTPLYMAPELVQEQQ
|. |.     ..|..   . .|...|| |.|..     .|.||||||||. .. ||.    ||. ||| .. |..||  ...   ||| ||.||..|.. 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNEKVDIWSLGAILYELYYG--KTPFSAK--SIYKLIQMIVND-QIA-WSEP--ISPEFKGFLSIMLQKNPDRRASCEDLVKHPFI
||.|.|||||| .|||.     | || |.  ... |.  |..  | .  ..    |.. . ..| ||||.|. | ||... ..|||
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 86792.m00065.AA Ciliate-E2 4-254 24 1.2e-79 270.94 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-365/365
Sequence Identity: 24% (94 aa)

YYQIAQIGEGSFGRVYKARRKYTGRL------------------VAIKMIHKLGQSQDSLASLRREINILQ----------------KVDHPNIMRLLEV
|  | .||.|.|| |||.... ....                  |.||.. .  .... . .. .||.|..                ...||||... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--TNTDVCLVTELGRG-DLFQVIQDQQTLP-----------ESVLKSVAAQLVS---------------ALLYLHQQR-IIHRDIKPQNVLISLNNTV
|.  ... . ||.|.  | |||. |.....             |   | . .|...               || |||..  ||||||||.|.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLCDFGFAR----------------ALSNTT----------------LVLNSIKGTPLYMAPELVQEQQ---------YNEKVDIWSLGAILYELYYGKT
|..|||...                 . .                   . |.| ||| ||||| .. ..         |..|.|||||| ||||. .||.
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFSAKSIYKLIQMIVNDQIAWSEP------------------ISPEFKGFLSI----MLQKNPDRRAS-CEDLVKHPFI
||        .| | . .|  ..|                  .|.| | ...     ||||.|. | .  |.. .||..
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 86792.m00065.AA MARK 4-254 36 1e-78 256.93 In-house 1-262 (262) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-262/262
Sequence Identity: 36% (95 aa)

YYQIAQIGEGSFGRVYKARRKYTGRLVAIKMIHKLGQSQ-DSLASLRREINILQKVDHPNIMRLLEVFE--TNTD-VCLVTEL-GRGDLFQVIQDQ--QT
|  . .||.||.. |..|. | ||| ||||.. |   .   .. ...|||.|..|.||||| .|..|.|  |..  ..|. |. ..|.|.. |. .    
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LPESVLKSVAAQLVSALLYLHQQRIIHRDIKPQNVLISLNN--TVKLCDFGFARALSNTTLVLNSIKGTPLYMAPELVQEQQYN-EKVDIWSLGAILYEL
|.|.  .    |.|||. |.|...|.||||||.|.||  |.   .|..||||..   . .. ||.  ||| |||||... . |.  |||||||| .|| .
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK-LNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

YYGKTPFSAKS--IYKLIQMIVNDQIAWSEPISPEFKGFLSIMLQKNPDRRASCEDLVKHPFI
  |. || ...  . .| . |.. .      .|.| . ... .|. ||..|...|...|||..
VCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 86792.m00065.AA Pkinase_Tyr 4-212 30 2.1e-33 113.77 Pfam 1-228 (270) Show / Hide 
Range on Protein: 4-212
Range on HMM: 1-228/270
Sequence Identity: 30% (69 aa)

YYQIAQIGEGSFGRVYKARRK----YTGRLVAIKMIHKLGQSQDS--LASLRREINILQKV-DHPNIMRLLEVFE-TNTD--VCLVTEL-GRGDLFQVIQ
   . ..|||.||.|||.. |     |.  ||.||. | | ...   .... ||..|. .  .|||| ||. |         ...|.|.   |||    .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

D----QQTLPESVLKSVAAQLVSALLYLHQQRIIHRDIKPQNVLISLNNTVKLCDFGFARAL-SNTTLVLNSIKGTPL---YMAPELVQEQQYNEKVDIW
.    .| |. . | . ..|  ... ||.....||||.   |.|.. ||.|| |||| ||.. .  .  . . .|..|    ||||  ..  ...| |.|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SLGAILYELYY-GKTP-FSAKSIYKLIQMI
| |  ..|..  |..| .   | . ....|
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase 86792.m00065.AA TyrKc 4-254 25 1.7e-26 95.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-280/280
Sequence Identity: 25% (73 aa)

YYQIAQIGEGSFGRVYKARRKYTGRLVAIKMIHKLGQSQDSLASLRREINILQKV--DHPNIMRLLEVFETN-------TDVCLVTEL-GRGDLFQVIQD
   . ..||| ||.|||.. |   . ||.||...       .. ..||..|. |.  .|||| ||. |  .          ...|.|.   ||| . ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QQT-LPESVLKSVAAQLVSALLYLHQQRIIHRDIKPQNVLISLNNTVKLCDFGFARALSNT--------TLVLNSIKGTP--L---YMAPELVQEQQYNE
 .  |. . | | . |  .   |||....||||.   |.|.. |.||| .||| .|.. .         . .  . ||.   |    ||||  ..  ...
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KVDIWSLGAILYELY-YGKTPFSA-----KSIYKLIQMIVNDQIAWSEPI---------SPEFKGFLSIMLQKNPDRRASCEDLVKHPFI
| |.|| |  ..|.. ||..| .      .| . .|. . .       |          ..|     .   . .|. | . ...  | ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF