Gene GL50803_11364 (G.lamblia)

GL50803_11364

Species: G.lamblia
Alias: GL50803_11364, GK001
External Links: GiardiaDB ,
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
GL50803_11364.AA Protein None 586 None Fasta, JSON
GL50803_11364.kin_dom Protein Kinase Domain None 268 None Fasta, JSON

Protein domain

Protein domains of GL50803_11364.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH_Akt_basal GL50803_11364.AA PH_Akt_basal 12-96 37 8.6e-44 151.8 In-house 1-90 (90) Show / Hide 
Range on Protein: 12-96
Range on HMM: 1-90/90
Sequence Identity: 37% (34 aa)

VTKTSSRGKKQPRSLVLTSKSVQNVMGN---SIQWERPVQEIYGIHRSTKEPKAFVISFLQTYR--FDVESADQVSSIVSAFQRLNLGEV
|.|.....|.|.|.|..|||.|.|...|   ||.|..|.|.|||||.||.|...|||.....|.  ....|.||...|.....|......
VIKYNRYNKRQERNLMITSKHVYNCKPNKKHSIKWCIPLQKIYGIHQSTTEGCEFVIHVPDEYDYRYCMHSEDQRQCIIMVLCRAYCCYC
Kinase GL50803_11364.AA AGC 221-488 29 4.8e-147 383.07 In-house 1-395 (395) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-395/395
Sequence Identity: 29% (120 aa)

FELVSVVGKGSFGKVFLVRRV------EDNRFFAMKVLKKRN-VLDRR--QLEHLKAE------------HNILQSFN----------HPNMIK-LYHSF
||.. |.||||||||.|||..        ....|||||||.  .....  ..|| ..|             |||.  |          ||. .| |..||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTRTR--LFLVTTFAT---------GG-ELFYHLK---KIGRFPEPLAVFYLAQ-------IVLVIEYLHK-HDIVFRD-MKPENLLLDNHGNILLTDFG
|. ..  |..|  ..          || |||.||.   | |||.|. | ||.|.       ||| .||||. ..|. || .||||.|||..|.| |||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKTGISADNSGGAGVC---------------------------------------------SGSFCG--TPDYLSGEIISGVPHGKMVDIWA--LGALL
|.| |.. .. |..                                                  .|||  ||.|.. ||.    .|| .|.|.  ||.|.
LCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

FEMLVGSAPFSYASSTS---THGGNARSELYRRIL------KNIIVFP----------VFISAECKSFIAKCLSRRPKDRPN----------FDEIKKHE
.|||.|  || |. ..      . . . |.. .|.      .. . ||          ...| |.|..| |.| . |..|.           ..|||.|.
YEMLTGYPPF-YGDNPQENRH-PFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHP

VF
 |
WF
Kinase GL50803_11364.AA SGK 221-488 36 1.5e-111 345.86 In-house 1-283 (283) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-283/283
Sequence Identity: 36% (109 aa)

FELVSVVGKGSFGKVFLVRRVED------------------NRFFAMKVLKKRNVL-------DRRQLEHLKAEH-NILQSFNHPNMIKLYHSFQTRTRL
|.. .|.||||||||..|....|                    |.|||||.|  ..        . .  | .||  .||. ..||  ..|  .||| . |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FLVTTFATGGELFYHLKKIGRFPEPLAVFYLAQIVLVIEYLHKHDIVFRDMKPENLLLDNHGNILLTDFGLSKTGISADNSGGAGVCSGSFCGTPDYLSG
..|  .. |||.||||.. ..|||. | || |.||. .||||. ||..|| ||||.|||  |.. ||||||.| || . .         .||||| ||  
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDT------TFTFCGTPEYLAP

EIISGVPHGKMVDIWALGALLFEMLVGSAPFSYASSTSTHGGNARSELYRRILKNIIVFPVFISAECKSFIAKCLSRRPKDRPNFD----EIKKHEVF
|.. . ||.. || | ||..|.||..|  || |         . ....|  |..  . .| ..|..... |   | . ||.| .      |||.|  |
EVLRKQPHDRTVDWWCLGCVLYEMMYGLPPF-YS--------RNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase GL50803_11364.AA Akt 221-425 49 3.1e-104 334.1 In-house 1-203 (264) Show / Hide 
Range on Protein: 221-425
Range on HMM: 1-203/264
Sequence Identity: 49% (102 aa)

FELVSVVGKGSFGKVFLVRRVEDNRFF-AMKVLKKRNVLDRRQLEHLKAEHNILQSFNHPNMIKLYHSFQTRTRLFLVTTFATGGELFYHLKKIGRFPEP
|... | |||||||||||.   ..... |||||||.  ....|.|| |.| ||||  |||  ..|..|||| ..|..|. .. ||||||||.. .||.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

LAVFYLAQIVLVIEYLHKHDIVFRD-MKPENLLLDNHGNILLTDFGLSKTGISADNSGGAGVCSGSFCGTPDYLSGEIISGVPHGKMVDIWA-LGALLFE
 | || |.|.| ||.||...|..|| .||||.|.|..|.| ||||||.| .|  |.         .||||| ||. ||..|. |.|.||.|. ||....|
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHD-----KTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYE

MLVGSAPF
|. |  ||
MMCGRPPF
Kinase GL50803_11364.AA AktR 221-488 37 3e-100 339.35 In-house 1-268 (268) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-268/268
Sequence Identity: 37% (108 aa)

FELVSVVGKGSFGKVFLVRRV-EDNRFFAMKVLKKRNVLDRRQLEHLKAEHNILQ-SFNHPNMIKLYHSFQTRTRLFLVTTFATGGELFYHLKKIGRFPE
|..  . ||| ||||.||..  ......|||..|| .  .|.| .|.  | ||..   ||| ..||...|||.. ||..  .  |||||.||||...| |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PLAVFYLAQIVLVIEYLHKH-DIVFRDMKPENLLLDNHGNILLTDFGLSKTGISADNSGGAGVCSG-----SFCGTPDYLSGEIISG-VPHGKMVDIWAL
  | || |||.| .||||.| .|..||.||||.||| .|.. .|||||||           .. .      |||||| |.. |.|   ..|.|.||.||.
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK---------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAF

GALLFEMLVGSAPFSYASSTSTHGGNARSELYRRILKNI---IVFPVFISAECKSFIA-KCLSRRPKDRP-----NFDEIKKHEVF
|....||..|  ||           . . ... .|..     . .|. .| .||..|  |.| ..|. |.     ...|||.|  |
GIFIYEMVTGCPPFY---------HKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase GL50803_11364.AA RSK 224-488 36 7.4e-98 331.4 In-house 1-278 (278) Show / Hide 
Range on Protein: 224-488
Range on HMM: 1-278/278
Sequence Identity: 36% (107 aa)

VSVVGKGSFGKVFLVRRV---EDNRFFAMKVLKKRNVLDRRQ-LEHLKAEHNILQSFN-HPNMIKLYHSFQTRTRLFLVTTFATGGELFYHLKKIGR---
..| |.|..|||||.|..     .. .|||||||. .  |   ..| ..| |||.  . ||. ..|...||| . |.|.. .  |||||.||.| ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPEPLAVFYLAQIVLVIEYLHKHDIVFRDMKPENLLLDN---HGNILLTDFGLSKTGISADNSGGAGVCS-----GSFCGTPDYLSGEIIS----GVPHG
| |  | ||.|.||| .|.||...|..|| |||| |.|.   .| | |||||..| .          .|.      .||.| .|.  |..     .. |.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF----------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHD

KMVDIWALGALLFEMLVGSAPFSYASSTSTHGGNARSELYRRILKNI--IVFP--VFISAECKSFIAKCLSRRPKDRPN-----FDEIKKHEVF
| .|.| ||.|..|||.|  ||   .       | |.|. .||.|.     .|   ..|.|.|..| |.| | |..|..      .|||.|. |
KACDWWSLGVLMYEMLTGCPPFQG-PND-----NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase GL50803_11364.AA S_TKc 221-488 34 2.2e-93 317.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-231/231
Sequence Identity: 34% (97 aa)

FELVSVVGKGSFGKVFLVRRVEDNRFFAMKVLKKRNVLDRRQLEHLKAEHNILQSFNHPNMIKLYHSFQTRTRLFLVTTFATG--GELFYHLKKIGR---
.|.. ..|||.||||...| ....| .|.|..|          ||.. | .||.. .||| .||| .||. ..|..|. .. |  |.|| ..|| ||   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPEPLAVFYLAQIVLVIEYLHKHDIVFRDMKPENLLLDNHGNILLTDFGLSKTGISADNSGGAGVCSGSFCGTPDYLSGEIISGVPHGK-MVDIWAL
   |||  | ||..||.. .||.|.| |. || ||||.|||.  .| ..||||..                .|||||.|.. |..   ..||  .|.|..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GALLFEMLVGSAPFSYASSTSTHGGNARSELYRRILKNIIVFPVFISAECKSFIAKCLSRRPKDRPNFDEIKK-------HEVF
| .|.|||.|  ||.              .....|.          | |.|.|| ||| . |..||   |. .       |. |
GCILYEMLCGYPPFP-----------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_11364.AA p70 221-488 33 2.1e-88 300.01 In-house 1-299 (299) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-299/299
Sequence Identity: 33% (104 aa)

FELVSVVGKGSFGKVFLVRRVE---DNRFFAMKVLKKRNVL-DRRQLEHLK-------------------------AEHNILQSFNHPNMIKLYHSFQTR
|||. |.||| .||||.|| |     .. .|||||.|. ..   . ..| .                         || ||| . .||....|  .||| 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

TRLFLVTTFATGGELFYHLKKIGRFPEPLAVFYLAQIVLVIEYLHKHDIVFRDMKPENLLLDNHGNILLTDFGLSKTGISADNS----GGAGVCSGSFCG
  |.|.  .  |||||.||.. | ..|  | |||. |.. .|.||.|.|..|| |||| .|.  | . ||||||.|  |  .              .|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TPDYLSGEIISGVPHGKMVDIWALGALLFEMLVGSAPFSYASSTSTHGGNARSELYRRILKNI--IVFPVFISAECKSFIAKCLSRRPKDRPN-----FD
|. |   ||.... |.. || |.||.|.. ||.|. ||          |  | .    |||.   .  |   ..| .  | | | | |. | .       
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFT---------GENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAA

EIKKHEVF
.|..|. |
DIQEHPFF
Kinase GL50803_11364.AA RSK-Unclassified 221-488 35 5e-86 270.15 In-house 1-283 (283) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-283/283
Sequence Identity: 35% (104 aa)

FELVSVVGKGSFGKVFLVRRVEDNRFFAMKVLKKRNVLDRRQLEHLKAEHNILQSFNHPNMIKLYHSFQTRTRLFLVTTFATGGELFYHLK--KIGRFPE
|.    .|.|.||||.|||. . .. .|||||.|  .. ..       | ||.   |||  ..|||||||. .|.|.  .  ||..| ||   |  .| |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

PLAVFYLAQIVLVIEYLHKHDIVFRDMKPENLLLDNHGNILLTDFGLSKTG--------------------ISADNSGGAGVCSGSFCGTPDYLSGEIIS
 .. ||.. ...  ||||| |...||.||.| .|.  | . ||||.||. .                    |  . ..       ||||| .||  |.| 
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTN-----SFCGTEEYLAPEMIR

GVPHGKMVDIWALGALLFEMLVGSAPFSYASSTSTHGGNARSELYRRILKNIIVFP--VFISAECKSFIAKCLSRRPKDRP-----NFDEIKKHEVF
.  |.| || | || ...|||.|  |.          || . |..  |.|| . ||   .|| .|.. | | | | |  |        |.||.|  |
RCGHTKAVDWWTLGIVMYEMLFGCPPYY---------GNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase GL50803_11364.AA PKC 221-488 33 6.7e-85 275.1 In-house 1-262 (262) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-262/262
Sequence Identity: 33% (94 aa)

FELVSVVGKGSFGKVFLVRRVEDNRFFAMKVLKKRNVLDRRQLEHLKAEHNIL-QSFNHPNMIKLYHSFQTRTRLFLVTTFATGGELFYHLKKIGRFPEP
|... | ||||||||.|..| . ....|.||||| ....    |   .|  .| .. .||   .|. .|||  ||| |  .  || | .|  ...||.|.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

LAVFYLAQIVLVIEYLHKHDIVFRDMKPENLLLDNHGNILLTDFGLSKTGISADNSGGAGVCSGSFCGTPDYLSGEIISGVPHGKMVDIWALGALLFEML
 |.|| | |..   .||...|. || | .| |||  | | ..|||..|...        |.   .|||||||.. ||... . || || ||.| |..||.
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMW------NGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMM

VGSAPFSYASSTSTHGGNARSELYRRILKNIIVFPVFISAECKSFIAKCLSRRPKDR------PN--FDEIKKHEVF
.| .||.              || . |..  ...|. .| | .| . . . . |..|      ..  ...|..|  |
AGQSPFHGE---------DEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase GL50803_11364.AA AGC-Unique 221-488 34 1.9e-82 280.2 In-house 1-270 (270) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-270/270
Sequence Identity: 34% (97 aa)

FELVSVVGKGSFGKVFLVRRV---EDNRFFAMKVLKKRNVLDRRQLEHLKAEHNILQSFNHPNMIKLYHSFQTRTRLFLVTTFATGGELFYHLKKIGRFP
||.  ..| ||.|.| .|||       .|.||||. ||  . ..|. |   |  ||    || ....  |||..  ||..  .. ||..| |... . |.
FEILKHIGVGSYGRVYAVRRKNGCDTEKFYAMKVMNKRDMSKHKQMVHHNTEWMILTTMHHPFFMRMHYSFQNKDHLFMCMDYVPGGDMFHHMQNAECFI

EPLAVFYLAQIVLVIEYLHKHDIVFRDMKPENLLLDNHGNILLTDFGLSKTGISADNS---GGAGVCSGSFCGTPDYLSGEIISGVPHGKMVDIWALGAL
| .| ||.. ..  | |||  .|..|| ||||.|.|| | | .||.||||||. .      || |     ||||..|.  ||. .  |||  | |. | .
EESAHFYICEVICSIHYLHENHIIHRDIKPENILIDNDGHIMITDYGLSKTGCDSVDAIQNGGEGGFATTFCGTRHYMAPEIHTEKKHGKSCDWWSVGIT

LFEMLVGSAPFSYASSTSTHGGNARSELYRRILKNIIVFPVFISAECKSFIAKCLSRRPKDRPN-----FDEIKKHEVF
...|. . .||          .  | . |    .     | | | . . |. | . | |  |       |.||| |. |
YCDMRTDRSPFD---------ASNRNDMYDSMIQKRPRMPMFLSPDEQDFVNKLIVRDPNQRLGNSPQGFEEIKSHDMF
Kinase GL50803_11364.AA Pkinase 221-488 30 2.5e-82 284.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

FELVSVVGKGSFGKVFLVRRVEDNRFFAMKVLKKRNVLDRRQLEHLK-AEHNILQSFNHPNMIKLYHSFQTRTRLFLVTTFATGG----ELFYHLK--KI
.......|.||||.|.. ... ... .|.|..|||.  .  . .|.. .|  |....|||| ..||..|...... .|. .. ||    .|| ...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRF--PEPLAVFYLAQIVLVIEYLHKHDIVFRDMKPENLLLDNHGNI----LLTDFGLSKTGISADNSGGAGVCSGSFCGTPDYLSGEIIS-GVPHGKMV
|.|  .|  . ||. ||.  .||.|.. |. ||.||||.|.||.|.|     ..||||.|           ..   .|||||.|.. |.|  | ..|. |
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWALGALLFEMLVGSAPFSYASSTSTHGGNARSELYRRILKNIIVFPVFIS---------------------AECKSFIAKCLSRRPKDRPNFDEIKKH
|.|..| .|.||| |  ||.  .   ... .   ....||.. .. |. . .                      |||.|| .|| . ||.||....|..|
DMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

EVF
. |
PWF
Kinase GL50803_11364.AA PKA 221-367 46 1.2e-67 231.03 In-house 1-149 (263) Show / Hide 
Range on Protein: 221-367
Range on HMM: 1-149/263
Sequence Identity: 46% (70 aa)

FELVSVVGKGSFGKVFLVRRVEDNRFFAMKVLKKRNVLDRRQLEHLKAEHNILQSFNHPNMI-KLYHSFQTRTRLFLVTTFATGGELFYHLKKIGRFPEP
||.. ..|.||||.| |.|  .. ...|||.|||. . ...| || . | ||||. .||. . |.| .||... |..|  .. |||.|..| | |||..|
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

LAVFYLA-QIVLVIEYLHKHDIVFRDMKPENLLLDNHGNILLTDFGLSK
 | || | |||| .||||...|. || ||||.|.|. |.| .|||| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase GL50803_11364.AA PKA 386-488 35 1.6e-19 71.22 In-house 159-263 (263) Show / Hide 
Range on Protein: 386-488
Range on HMM: 159-263/263
Sequence Identity: 35% (41 aa)

CGTPDYLSGEIISGV-PHGKMVDIWALGALLFEMLVGSAPFSYAS--STSTHGGNARSELYRRILKNIIVFPVFISAEC---KSFIAKCLSRRPKDRP-N
||||.||  |||..  .||| || |||| | .|||.|  || |..  ..         ..|..|..  | || ...      |..| | |.. .. |  |
CGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPF-YDHNRDP--------MQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGN

FDE----IKKHEVF
...    ||.|. |
MKNGVNDIKNHKWF
Kinase GL50803_11364.AA TyrKc 221-488 21 6.8e-13 -14.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 221-488
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

FELVSVVGKGSFGKVFLVRRVEDNRFFAMKVLKKRNVLDRRQLEHLKAEHNILQSF--NHPNMIKLYHSFQTR-------TRLFLVTTFATGGELFYHLK
 .|  . | | ||.|.. .     .  | |.||.        .| .  | .|. ..  .||| ..||    .          |..|. .. .| |  .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KIGR-FPEPLAVFYLAQIVLVIEYLHKHDIVFRDMKPENLLLDNHGNILLTDFGLSKTGISADNSGGAGVCSGSFC-----GTPD-----YLSGEIISGV
| .. .. .  . .  ||    ||||.. .. ||    | |... . .  .|||||. . . |..|   . .         |. .      .. | |   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECI---

PHG---KMVDIWALGALLFEML-VGSAPFSY-----ASSTSTHGGNARSELYRRILKNIIVFPVF----ISAECKSFIAKCLSRRPKDRPNFDEIKKHEV
 .|      |.|. | ...|..  |  | .       | .  .  . ..  .... .|.   |       ..|  . . .|  . |.|||.| ||  || 
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVI-EYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HEC

F
|
F
Kinase GL50803_11364.AA Akt 439-488 31 1.3e-11 33.31 In-house 208-264 (264) Show / Hide 
Range on Protein: 439-488
Range on HMM: 208-264/264
Sequence Identity: 31% (18 aa)

RSELYRRILKNIIVFP--VFISAECKSFIAKCLSRRPKDRPN--FD---EIKKHEVF
. ...  |. . . ||   .|| |||..| ..|.. || |.   ..   ||| |. |
HHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase GL50803_11364.AA Pkinase_Tyr 221-285 25 0.00348 11.41 Pfam 1-70 (270) Show / Hide 
Range on Protein: 221-285
Range on HMM: 1-70/270
Sequence Identity: 25% (18 aa)

FELVSVVGKGSFGKVFLVRRV----EDNRFFAMKVLKKRNVLDRRQ--LEHLKAEHNILQSF-NHPNMIKLY
 ..  . |.|.||.|.. .      ...   | |.||     . .|  .| . .| .|. .. .||| ..||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase GL50803_11364.AA Pkinase_Tyr 467-488 45 0.130415 6.08 Pfam 251-270 (270) Show / Hide 
Range on Protein: 467-488
Range on HMM: 251-270/270
Sequence Identity: 45% (10 aa)

KCLSRRPKDRPNFDEIKKHEVF
.|    |.||| | ||  || .
QCWHYDPEDRPTFSEI--HEQL
S_TK_X GL50803_11364.AA S_TK_X 491-576 25 4.5e-05 20.11 SMART 1-79 (79) Show / Hide 
Range on Protein: 491-576
Range on HMM: 1-79/79
Sequence Identity: 25% (26 aa)

NKIDFDKLYR--KEIQPPFKPKLEQSCILAVDGKLLKNPLDNIYRYIAPEALVVNFDAKFTSESPILPPSTQTDSVTMQ--------------EDKNFKD
 .||.||||.  |||.||||||. .                    |   .  . ||| .||.|.|     | .|.. ..              .  .|  
RGIDWDKLYNQQKEIEPPFKPKIKE-------------------VYA-SPTDTSNFDPEFTEETPM---LTPDDPPLSNSMWQNEMETEIPPDPFRGFTY

FA
..
VF