Gene GL50803_11390 (G.lamblia)

GL50803_11390

Species: G.lamblia
Alias: GK209, GL50803_11390
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_11390.AA Protein None 777 None Fasta, JSON
GL50803_11390.kin_dom Protein Kinase Domain None 274 None Fasta, JSON

Protein domain

Protein domains of GL50803_11390.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_11390.AA NEK 206-283 30 3.7e-18 60.88 In-house 202-286 (286) Show / Hide 
Range on Protein: 206-283
Range on HMM: 202-286/286
Sequence Identity: 30% (26 aa)

TEKVDIWSLGTTLFFIAAFQS--VWISS--DYASIVAEIKHG-KIQRLPDR--YSCELDGFIARCLQVDPMYRPSILELLLEPQI
..|.||||||  |. ......     ..  .  | .  |. | . ...|..  || .|  .| ..||.||  |||. ..|  |.|
NNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_11390.AA NRBP 148-284 28 2.6e-15 50.0 In-house 125-261 (261) Show / Hide 
Range on Protein: 148-284
Range on HMM: 125-261/261
Sequence Identity: 28% (40 aa)

PVVHGYLTPSDIFISRDGKCKVGGISPTQSAWEIRSGNADLGRLFLQAPEIL-DMQPNITEKVDIWSLGTTLFFIAAFQSV--WISSDYASIVAEIKHGK
|..|| ||   ||| . |  |.| . | .   ..| .  ..  .. .|||       ..|  |||.| |     .|...       ..   .  |. .  
PIIHGNLTCDTIFIQHNGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEMAVLEIQSGCQNGESEYVTEEAIQRA

IQRLPDRYSCELDGFIARCLQVDPMYRPSILELLLEPQIN
|. | |    .   || .||| ||  |||  |||  . . 
IHSLEDPMQRD---FIRKCLQKDPARRPSARELLFHQILF
S_TKc GL50803_11390.AA S_TKc 10-283 17 8.9e-14 25.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-283
Range on HMM: 1-231/231
Sequence Identity: 17% (54 aa)

YVWTADICRTTLGCICQAMDTSNNTEVTVKVVNYSQLSQEEANALAHEARALLYLNHDHVVKTYNTIIAPETYTIYIIMEPCLGTLGTAIQVMSAYGQQ-
|     | . . |. ... ... . .| .|...         . .  | . |   .|...|| | ..       .|..|| | | ||.  ...  .| . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----IPEEHIWYIAAEVGSALKYLHEPH---------------EKMMIDWYSAEIPIGPVVHGYLTPSDIFISRDGKCKVGGISPTQSAWEIRSGNADLG
    .|| |........ .||.|.|. .               . . .|  .| .                                        .   |
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL---------------------------------------TTFCG

RLFLQAPEILDMQPNITE-KVDIWSLGTTLFFIAAFQSVWISSDYASIVAEIKHGKIQRLPDRYSCELDGFIARCLQVDPMYRPSILELLL-------EP
 ..  |||.|      .  |.|.||.| .|.  .. .  .   ... .   |.           | |.  || .|||.||  ||.. |.|         |
TPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

QI
 .
WF
Kinase GL50803_11390.AA NEK2 207-283 37 9.2e-14 42.61 In-house 243-319 (319) Show / Hide 
Range on Protein: 207-283
Range on HMM: 243-319/319
Sequence Identity: 37% (29 aa)

EKVDIWSLGTTLFFIAAFQSVWISSDYASIVAEIKHGKIQRLPDRYSCELDGFIARCLQVDPMYRPSILELLLEPQI
|| ||||.|  ..  .|         .|     || |. .|.| .|| .|   |.. . ||.  |||| |.| .|||
EKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_11390.AA NZAK 195-278 27 6.7e-13 39.16 In-house 240-329 (329) Show / Hide 
Range on Protein: 195-278
Range on HMM: 240-329/329
Sequence Identity: 27% (25 aa)

APEILDMQPNITEKVDIWSLGTTLFFIAAFQSV---WISSDYASIVAEIKHGKIQRLPDRYSCELDGFIARCLQVDPMYR----PSILELL
||| .   . |.|| |.||.| | . ..  ..    .   . ||.|.. |   |   |.  .  .  || .|.  ||  |      . |.|
APENKNNHR-INEKSDVWSFGCTVWQMFGYNPPNTIYSPKEMASMVSDQKFNYIPQIPFHVPDKMKDFITQCWDIDPKKRPKDFSHMIEKL
Kinase GL50803_11390.AA Ciliate-E2 194-283 22 5.8e-12 37.34 In-house 254-365 (365) Show / Hide 
Range on Protein: 194-283
Range on HMM: 254-365/365
Sequence Identity: 22% (27 aa)

QAPEILDMQPN--------ITEKVDIWSLGTTLFFIAAFQSVWISSDYASIVAEIKHGKIQRL-----------------PDRYSCELDGFIAR----CL
.||||| ....         ..|.|||||| .|..    .  .          .|| .||.                   ..  | |   .| .    .|
MAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRML

QVDPMYRPS-ILELLLEPQI
|.||  |.. . ..|  | .
QKDPEKRITGWEQILNHPWF
Kinase GL50803_11390.AA STE 195-283 25 1.1e-11 37.68 In-house 230-359 (359) Show / Hide 
Range on Protein: 195-283
Range on HMM: 230-359/359
Sequence Identity: 25% (33 aa)

APEILDM-----QPNITEKVDIWSLGTTLFFIAAFQSVW--ISSDYASIVAEIKH-------------GKIQRLPD-------------------RYSCE
|||...       .  ..|.|||||| |.   |  .  |   .  .|   . ...             |.. .|||                   ..| |
APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE

LDGFIARCLQVDPMYRPSILELLL--EPQI
.  ||..||| ||  ||.  .||    | |
FKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_11390.AA Pkinase 22-130 19 1.2e-11 42.26 Pfam 13-126 (293) Show / Hide 
Range on Protein: 22-130
Range on HMM: 13-126/293
Sequence Identity: 19% (23 aa)

GCICQAMDTSNNTEVTVKVVNYSQLSQEEANALAH--EARALLYLNHDHVVKTYNTIIAPETYTIYIIMEPCLG-----TLGTAIQVMSAYGQQI--PEE
|| ..... ... .| ||.....  . ..  ....  |.. .. |||...|..| .        ||..|| | |      | . |..   ..  .  .|.
GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEW

HIWYIAAEVGSALKYLHE
..  .. .. ..|.|.|.
ECKFYMYQILRGLEYCHS
Kinase GL50803_11390.AA CAMK 195-283 19 5.3e-11 30.97 In-house 288-425 (425) Show / Hide 
Range on Protein: 195-283
Range on HMM: 288-425/425
Sequence Identity: 19% (27 aa)

APEILDM-------------QPNITEKVDIWSLGTTLFFIAAFQSVWISS-------------DYASIVAEIKHGKIQRLPDRYSC--------------
|||.|               .| ...|.|.||.|  |..     . . ..             ..  .   |. || .  |.  |               
APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDIS

---------ELDGFIARCLQVDPMYRPSILELLLEPQI
         |   .| ..|||||  |..| . |  | .
DEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_11390.AA STE 22-130 17 1.5e-09 29.99 In-house 13-170 (359) Show / Hide 
Range on Protein: 22-130
Range on HMM: 13-170/359
Sequence Identity: 17% (28 aa)

GCICQAMDT------SNNTE---------VTVKVVNYSQLSQ---------------EEANALAHEARALLYLN--HDHVVKTYNTII-----APETYTI
|  ..||.       ... .         . .|..|... ..               || . . .| . .  .|  |...|| | . .       .  ..
GTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDEL

YIIMEPCL-GTLGTAIQ-VMSAYG---------QQIPEEHIWYIAAEVGSA-LKYLHE
.|.|| .  |.|   |. ...  .         . .||. | ||. ..  . |.|||.
WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS
Kinase GL50803_11390.AA STE20 24-130 24 3.2e-09 30.14 In-house 15-135 (288) Show / Hide 
Range on Protein: 24-130
Range on HMM: 15-135/288
Sequence Identity: 24% (30 aa)

ICQAMDTSNNTE----VTVKVVNYSQLSQ--EEANALAHEARALLYLNHDHVVKTYNTIIAPET--YTIYIIMEPCLGTLGTAIQVMS---AYGQ-----
.. | ..... .    | .|..|... .   .| . .  | . .  ..| ..|| |.. .   |    ..|.|| | |  |.. ..|.     |.     
VYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGG--GSLTDIMKHCMKCGKNHKGH

QIPEEHIWYIAAEVGSALKYLHE
 . ||.| ||  ||  .|.|||.
PMNEEQIAYICREVLQGLDYLHS
Kinase GL50803_11390.AA NEK 39-130 30 4.9e-09 28.36 In-house 35-132 (286) Show / Hide 
Range on Protein: 39-130
Range on HMM: 35-132/286
Sequence Identity: 30% (30 aa)

KVVNYSQLSQEEANALA-HEARALLYLNHDHVVKTYNTIIAPETYTIYIIMEPCL--GTLGTA---IQVMSAYGQQIPEEHIWYIAAEVGSALKYLHE
| .|.. .|..|  ..  .|.| |  |.|...|| |. .|  .  ...|.|| |   |.|      |.     |. ..|| || . .   .||||.|.
KKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHD
Kinase GL50803_11390.AA CAMKL 194-283 24 6.8e-09 24.36 In-house 200-297 (297) Show / Hide 
Range on Protein: 194-283
Range on HMM: 200-297/297
Sequence Identity: 24% (24 aa)

QAPEILDM--QPNITEKVDIWSLGTTLFFIAAFQSVWISSDY--------ASIVAEIKHGKIQRLPDRYSCELDGFIARCLQVDPMYRPSILELLLEPQI
.||||.    .| .  ||||||.| .|...   .  .   .|             .... .  . . . | ..  .| . |||.|..||.| ...  |  
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase GL50803_11390.AA Ciliate-E2-Unclassified 193-283 21 4e-08 24.29 In-house 232-352 (352) Show / Hide 
Range on Protein: 193-283
Range on HMM: 232-352/352
Sequence Identity: 21% (26 aa)

LQAPEILDMQPNIT---EKVDIWSLGTTLFFIAAFQSVWISSDYAS----------------IVAEIKHGKIQRLP-------DRYSCELDGFIA----R
..|||.|. | . .   .|.||||||  |...   .    . .. .                .  .|| ..||  .       .. | |   ||     .
YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQK

CLQVDPMYRPSILELLLEPQI
.|...| .|... ..|  | .
MLKKNPNKRITFEQILNHPWF
Kinase GL50803_11390.AA Pkinase 195-283 19 7.1e-08 28.92 Pfam 179-293 (293) Show / Hide 
Range on Protein: 195-283
Range on HMM: 179-293/293
Sequence Identity: 19% (23 aa)

APEILDMQPNITEKVDIWSLGTTLFFIAAFQSVWISS------DYASIVAEIKHGKIQRLPDRYS---------------------CELDGFIARCLQVD
|||..  .. .. |||.||.| .|.  .  .  . ..      |   ....|..... . .  ..                      |.  || .||..|
APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPL-HFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD

PMYRPSILELLLEPQI
|  ||.. ..|  | .
PKKRPTAEQILQHPWF
Kinase GL50803_11390.AA TyrKc 15-281 15 5.1e-07 -109.13 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-281
Range on HMM: 1-280/280
Sequence Identity: 15% (48 aa)

DICRTTLGC-----ICQAMDTSNNTEVTVKVVNYSQLSQEEANALAHEARALLYL--NHDHVVKTYNTIIAP-----ETYTIYIIMEPC-LGTLGTAIQV
     .||.     ..... .   ..| ||... .        .. .||| .  |  .|...|. |  .. .     .   ..|.|| . .| |   .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MSAYGQQIPEEHIWYIAAEVGSALKYLHEPHEKMMIDWYSAEIPIGPVVHGYLTPSDIFISRDGKCKVG--GISPTQSAW--------EIRSGNADLGR-
       .. ..  ...  . .   |||.                 ...|  |    . ..... .|..  | |               .|.   . |. 
HRPK---LCMKDLLSFCWQIACGMEYLHSK----------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

---LFLQAPEILDMQPNITEKVDIWSLGTTLFFIAAF-QSVWIS-----SDYASIVAEIKHGKIQRLPDR--------YSCELDGFIARCLQVDPMYRPS
   .   ||| . .    |.| |.|| | ... |  . |. .        . . ... .|.|.  . |.          . |.   . .| . ||  ||.
MLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

ILELLLEP
  |.  . 
FSEIHECF
Kinase GL50803_11390.AA Ciliate-E2 61-130 24 9e-06 15.71 In-house 86-178 (365) Show / Hide 
Range on Protein: 61-130
Range on HMM: 86-178/365
Sequence Identity: 24% (23 aa)

LLYLNHDHVVKTYNTIIAPETYTIYIIMEPCLG-TLGTAIQVM---------SAYGQQIPEEHIWYIAAEVGS---------------ALKYLHE
|  |||....| | . .   . .||..|| | | .|   |. .         . . ... |..| || ... .               ||.|||.
LEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS
Kinase GL50803_11390.AA CAMK 15-89 10 1.5e-05 13.06 In-house 1-140 (425) Show / Hide 
Range on Protein: 15-89
Range on HMM: 1-140/425
Sequence Identity: 10% (15 aa)

DICRTTLGCICQAMDTSNN------------TEVTVKVVNYSQLS--------------------------QEEANALAHEARALLY-------LNHDHV
 . | . |    .......            ..| .|... ..|.                          ..    . .| . .         |.| ..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKTYNTIIAPE---------TYT---------IYIIM---E
.| | ..  |.         | .         .|..|   |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIME
Kinase GL50803_11390.AA NEK2 39-129 32 2.2e-05 13.95 In-house 30-121 (319) Show / Hide 
Range on Protein: 39-129
Range on HMM: 30-121/319
Sequence Identity: 32% (30 aa)

KVVNYSQLSQEEANALAHEARALLYLNHDHVVKTYNTIIAPETYTIYIIMEPCL-GTLGTAIQVMSAYGQQIPEEHIWYIAAEVGSALKYLH
|  .| ..   |  .|  |   |  | |  .|. |. ||  .. |.||.|| |  | |.  |.      | ..|| || | .   .||.  |
KEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQYMEEEFIWRIMFQLCTALQECH
Kinase GL50803_11390.AA Ciliate-E2-Unclassified 64-130 22 4.8e-05 13.47 In-house 76-161 (352) Show / Hide 
Range on Protein: 64-130
Range on HMM: 76-161/352
Sequence Identity: 22% (19 aa)

LNHDHVVKTYNTIIAPETYTIYIIMEPCLG-TLGTAIQVMSA-------------YGQQIPEEHIW-----YIAAEVGSALKYLHE
|||.| .. .   .   . .|||.|| | | .|   |. ..              ......|...      ...|.. ..|.|||.
LNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH
Kinase GL50803_11390.AA STE20 249-283 42 5e-05 14.66 In-house 254-288 (288) Show / Hide 
Range on Protein: 249-283
Range on HMM: 254-288/288
Sequence Identity: 42% (15 aa)

PDRYSCELDGFIARCLQVDPMYRPSILELLLEPQI
|...| |.  |...|||.||  ||.  .||  | |
PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase GL50803_11390.AA CAMKL 27-89 19 5.5e-05 11.69 In-house 18-101 (297) Show / Hide 
Range on Protein: 27-89
Range on HMM: 18-101/297
Sequence Identity: 19% (16 aa)

AMDTSN-NTEVTVKVVNYSQLS-QEEANA------------LAHEARALLYLN---HDHVVKTYNTIIAPET----YTIYIIME
|..... ...| .|... . ..  . ...            .  |.. .  ||   | ...| | .|  ||.      ||..||
ATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVME
Kinase GL50803_11390.AA STE20 195-215 40 0.016392 5.35 In-house 190-214 (288) Show / Hide 
Range on Protein: 195-215
Range on HMM: 190-214/288
Sequence Identity: 40% (10 aa)

APEILDMQ----PNITEKVDIWSLG
|||..  .     . ..|.||||||
APEVIQCMEGPDKGYDYKCDIWSLG
Ank GL50803_11390.AA Ank 614-641 32 0.000694 18.27 Pfam 1-28 (33) Show / Hide 
Range on Protein: 614-641
Range on HMM: 1-28/33
Sequence Identity: 32% (9 aa)

FGKTALMRAAELGNSELVELLVGYEACL
 | |.|. |.. |. | |..|... |..
DGFTPLHLACRCGHTEVVKMLLQHGADV
Ank GL50803_11390.AA Ank 645-665 42 0.000213 20.12 Pfam 1-21 (33) Show / Hide 
Range on Protein: 645-665
Range on HMM: 1-21/33
Sequence Identity: 42% (9 aa)

DGWTALMFAVHSRNTECVRLL
||.|.|. |... .||.|..|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_11390.AA Ank 676-696 28 0.001522 17.04 Pfam 1-21 (33) Show / Hide 
Range on Protein: 676-696
Range on HMM: 1-21/33
Sequence Identity: 28% (6 aa)

NGQTALMMASFWNNSDAVSIL
.|.|.|..|..... . |. |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_11390.AA Ank 713-734 50 1.5e-05 24.25 Pfam 1-22 (33) Show / Hide 
Range on Protein: 713-734
Range on HMM: 1-22/33
Sequence Identity: 50% (11 aa)

EGFTALMEAARWGRHDIVKLLL
.|||.|. |.|.|....||.||
DGFTPLHLACRCGHTEVVKMLL