Gene GL50803_114469 (G.lamblia)

GL50803_114469

Species: G.lamblia
Alias: GK273, GL50803_114469
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_114469.AA Protein None 1093 None Fasta, JSON
GL50803_114469.kin_dom Protein Kinase Domain None 267 None Fasta, JSON

Protein domain

Protein domains of GL50803_114469.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_114469.AA S_TKc 10-276 23 1.5e-23 85.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

YRLGPLLTHGQHSRIHWAHDTWTSHDVVCKVIDYTQSATTLREHVDRQYQLTQRLQHPGILQIHNVFHDQFRHTYYVFMDAYLSQ---SLRQQIVDRFEA
|... .. .|  .. . .... | . | .|.|.         ||. |  |. .. .|| | ... ||.|   . .|..|. |...   .|.. |..|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVME-YCDGDLGDLFDYIKKRGRH

A--HLYDESTIWMVLAQLCDVLAYLHSPYKLNCPEVGIVIHRNIRPETIFLSNNTACVLGGMRQAVSLSQASEISEQVGDYVYMAPEMLLGHKYGA-KVD
   . ..| ... ...|.|. |.|.||  .        .||| . || |.|..     ..    |  |      . ..|   |||||.|   .||  |.|
GLRFPFPE-HARFYMYQICCALEYCHSH-G--------IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCD

MFMLGCVLHEMCTLRRYRETCANKQEAIQSLSSFVKTSYHGYSAELTRIINLLLDHNPRSRPPADELLK-------HPRI
.  .||.| ||.. .   .   . |. .. .           | |.  .|. .|. .|. || | |.|.       || .
WWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_114469.AA STE 143-276 20 6.1e-16 52.88 In-house 173-359 (359) Show / Hide 
Range on Protein: 143-276
Range on HMM: 173-359/359
Sequence Identity: 20% (40 aa)

VIHRNIRPETIFLSNNTACVLGGMRQAVSLSQ-----------------ASEISEQVGDYVYMAPEMLLG------HKYGAKVDMFMLGCVL-------H
.||| | |  |.|     . |     . .|..                 ...    ||   .||||....      ..|..|.|.  |||..       .
IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKP

EMCTLRRYRETCANKQE---------------AIQSLSS-------------FVKTSYHGYSAELTRIINLLLDHNPRSRPPADELLK--HPRI
.....   |   .  ..                . .| .                |. | .| |.   ||. |. .|. || |..|||  || |
PWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGT-TYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_114469.AA Ciliate-E2-Unclassified 143-276 22 4.6e-15 48.7 In-house 165-352 (352) Show / Hide 
Range on Protein: 143-276
Range on HMM: 165-352/352
Sequence Identity: 22% (43 aa)

VIHRNIRPETIFLSNNTA------CVLGGMR-------------QAVSLSQASEISEQVGDYVYM----APEMLLGHKYG----AKVDMFMLGCVLHEMC
.|||.| || |...||        . .|  .             |  .  .  ... ..| . ||    |||.| |..|.     |.|.. ||..|.||.
IIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEML

TLRRYRE--TCAN--------------KQEAIQSL---SSFVKTSY----HGYSAELTRIIN----LLLDHNPRSRPPADELLKHPRI
. ..  .  .|                ||   . .    .| | .     .. | |   .||     .|. || .|. ....|.|| .
FGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_114469.AA Ciliate-E2 143-276 19 1.3e-14 46.57 In-house 182-365 (365) Show / Hide 
Range on Protein: 143-276
Range on HMM: 182-365/365
Sequence Identity: 19% (38 aa)

VIHRNIRPETIFLSNNTACVLGGMR----------------QAVSLSQAS-----------------EISEQVGDYVYMAPEMLLGHK---------YGA
.|||.| || |..     . .  .                 |.  . . .                  .  ..| . |||||.| | |         |. 
IIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDY

KVDMFMLGCVLHEMCTLRRYRETCANKQEAIQS-LSSFVKT--------------SYHGYSAELTRIINL----LLDHNPRSRPP-ADELLKHPRI
|.|.. ||..|.||.. ..        |. |.    .| .               |..  | |   .|.     .|. .|  |.  ....|.|| .
KCDIWSLGVILYEMLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_114469.AA NEK8 187-219 60 8.9e-13 32.68 In-house 188-220 (278) Show / Hide 
Range on Protein: 187-219
Range on HMM: 188-220/278
Sequence Identity: 60% (20 aa)

YMAPEMLLGHKYGAKVDMFMLGCVLHEMCTLRR
|| |||  | .| .| ||  ||||| |||.|.|
YMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKR
Kinase GL50803_114469.AA Pkinase 179-276 23 4.9e-12 43.65 Pfam 169-293 (293) Show / Hide 
Range on Protein: 179-276
Range on HMM: 169-293/293
Sequence Identity: 23% (29 aa)

SEQVGDYVYMAPEMLL-GHKYGAKVDMFMLGCVLHEMCT--LRRYRE----TCANKQEAIQSLSSFVKTSYHGYS---------------------AELT
.  .| . ||||| .. | .|| ||||. .||.|.||..  .  . .    . ..... |.   .    .   ..                      |. 
TTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

RIINLLLDHNPRSRPPADELLKHPRI
 .|. .|. .| .|| |...|.|| .
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_114469.AA CDKL 143-216 38 2.2e-10 31.69 In-house 119-195 (286) Show / Hide 
Range on Protein: 143-216
Range on HMM: 119-195/286
Sequence Identity: 38% (31 aa)

VIHRNIRPETIFLS-NNTACVLGGMRQAVSLSQASEISEQVGDYV----YMAPEMLLG-HKYGAKVDMFMLGCVLHEMCT
.|||.| || |...  |    |.. . |  |.. .||   . |||    | ||| |.|  .||  ||.  .|||. || .
CIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEI---YTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMID
Kinase GL50803_114469.AA NEK 187-219 48 8.9e-10 31.01 In-house 190-224 (286) Show / Hide 
Range on Protein: 187-219
Range on HMM: 190-224/286
Sequence Identity: 48% (17 aa)

YMAPEMLLGHKYGAKVDMFMLGCVLHEMCTL--RR
||.||.. . .|. |.|. .||||| |||||  ..
YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKH
Kinase GL50803_114469.AA NEK 245-276 34 2.4e-09 29.5 In-house 255-286 (286) Show / Hide 
Range on Protein: 245-276
Range on HMM: 255-286/286
Sequence Identity: 34% (11 aa)

YSAELTRIINLLLDHNPRSRPPADELLKHPRI
|| .| ..|...|  .| .|| ....|..| |
YSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_114469.AA PEK 91-215 15 2.7e-09 27.72 In-house 364-588 (655) Show / Hide 
Range on Protein: 91-215
Range on HMM: 364-588/655
Sequence Identity: 15% (36 aa)

YLSQSLRQQIVDRFE-----------------------------------------AAHLYDESTIWMVLAQLCDVLAYLHSPYKLNCPEVGIVIHRNIR
| ..... .. |.                                           ...  |. ..|. ..|... |.|.||         | .||| ..
YCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHS--------QG-MIHRDLK

PETIFL-SNNT-------------ACVLG--------------------GMRQAVSLSQASEISEQ-----------------------------VGDYV
|  ||| ....             |. .                     .. .. .... . .|..                             || . 
PSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCL

YMAPEMLLGH-----KYGAKVDMFMLGCVLHEMC
||.|| | |      .|. ||||. || .. ||.
YMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMW
Kinase GL50803_114469.AA NEK2 245-276 37 3.9e-09 26.8 In-house 288-319 (319) Show / Hide 
Range on Protein: 245-276
Range on HMM: 288-319/319
Sequence Identity: 37% (12 aa)

YSAELTRIINLLLDHNPRSRPPADELLKHPRI
|| .|  || . .. ....||  .|.|.||.|
YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_114469.AA NEK2 187-218 46 8.8e-09 25.57 In-house 230-261 (319) Show / Hide 
Range on Protein: 187-218
Range on HMM: 230-261/319
Sequence Identity: 46% (15 aa)

YMAPEMLLGHKYGAKVDMFMLGCVLHEMCTLR
|| || . | ||  | |   .||.. |||.|.
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALH
Kinase GL50803_114469.AA GCN2 246-276 32 2.2e-08 25.01 In-house 481-511 (511) Show / Hide 
Range on Protein: 246-276
Range on HMM: 481-511/511
Sequence Identity: 32% (10 aa)

SAELTRIINLLLDHNPRSRPPADELLKHPRI
... ...|. .|.|.|..|| |..||.|. .
HKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase GL50803_114469.AA NEK8 244-276 27 7.8e-08 18.32 In-house 246-278 (278) Show / Hide 
Range on Protein: 244-276
Range on HMM: 246-278/278
Sequence Identity: 27% (9 aa)

GYSAELTRIINLLLDHNPRSRPPADELLKHPRI
.||.|.   .  .|.  |  ||.|..... | .
HYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase GL50803_114469.AA PEK 248-276 31 1e-07 22.13 In-house 627-655 (655) Show / Hide 
Range on Protein: 248-276
Range on HMM: 627-655/655
Sequence Identity: 31% (9 aa)

ELTRIINLLLDHNPRSRPPADELLKHPRI
..  .|...|.|.|. || |...|.|. .
KQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase GL50803_114469.AA NEK-Unclassified 143-216 29 6.2e-07 18.67 In-house 118-192 (258) Show / Hide 
Range on Protein: 143-216
Range on HMM: 118-192/258
Sequence Identity: 29% (22 aa)

VIHRNIRPETIFLSNNTACVLGGMRQAVSLSQASEISE-QVGDYVYMAPEMLLGHKYGAKVDMFMLGCVLHEMCT
.|||  .|  |||       .|    .  .  . .     ||   .|.|| .    |  . |   |||.. ||||
IIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCT
TyrKc GL50803_114469.AA TyrKc 10-276 16 2e-06 -117.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-280/280
Sequence Identity: 16% (49 aa)

YRLGPLLTHGQHSRIHWAHDTWTSHDVVCKVIDYTQSATTLREHVDRQYQLTQRL--QHPGILQIHNVFHDQFR-----HTYYVFMDAYLSQSLRQQIVD
 .||  | .|.  ... .. .    .|  |..         ||   |  ..  .|  .|| |.... |  .|.|     . ... |      .|.. . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RFEAAHLYDESTIWMVLAQLCDVLAYLHSPYKLNCPEVGIVIHRNIRPETIFLSNNT---------ACVLGGM-RQAVSLSQASEISEQ---VGD----Y
. .       ..      | ..  .||||           .||| .    . ...|          .  ..   .|       . .. .    |.    .
HRPK---LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPI

VYMAPEMLLGHKYGAKVDMFMLGCVLHEMCTL-RRYRETC----ANKQEAIQSLSSF-VKTSYHG--------YSAELTRIINLLLDHNPRSRPPADELL
  |||| .  .|.  | | .. | .. |..|.     .       . ||.|. . .       .          ..|. .|.    ...| .||   |. 
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-

KHPRI
 | ..
-HECF
Kinase GL50803_114469.AA GCN2 182-215 42 4e-06 16.99 In-house 414-447 (511) Show / Hide 
Range on Protein: 182-215
Range on HMM: 414-447/511
Sequence Identity: 42% (15 aa)

VGDYVYMAPEMLLGHKYGAKVDMFML-GCVLHEMC
|| ..||.|| .   .|. ||||. | | .. ||.
VGTPFYMCPEQQ-KSHYNQKVDMYSLGGIIFFEMW
Kinase GL50803_114469.AA NEK-Unclassified 245-276 34 1e-05 14.58 In-house 227-258 (258) Show / Hide 
Range on Protein: 245-276
Range on HMM: 227-258/258
Sequence Identity: 34% (11 aa)

YSAELTRIINLLLDHNPRSRPPADELLKHPRI
||. |  .|  .|  |.  || | |..  . |
YSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase GL50803_114469.AA Ciliate-E2 62-131 16 1.2e-05 15.31 In-house 87-178 (365) Show / Hide 
Range on Protein: 62-131
Range on HMM: 87-178/365
Sequence Identity: 16% (15 aa)

QRLQHPGILQIHNVFHDQFRHTYYVFMDAYLSQSLRQQIVDR---------------FEAAHLYDESTIW-------MVLAQLCDVLAYLHS
..|.|| |.... .| .. ....|  |. .  ..|.. | ..                . .  . .  .        . .|.... | ||||
EQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS
Kinase GL50803_114469.AA NEK2 111-158 26 4.2e-05 12.99 In-house 102-161 (319) Show / Hide 
Range on Protein: 111-158
Range on HMM: 102-161/319
Sequence Identity: 26% (16 aa)

DESTIWMVLAQLCDVLAYLHS----------PYKLNCPEVG--IVIHRNIRPETIFLSNN
.|. || ...|||  |   |             ..  .  |  ...|| | |  |||. .
EEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYD
Kinase GL50803_114469.AA CDKL 242-276 22 0.010265 5.11 In-house 251-286 (286) Show / Hide 
Range on Protein: 242-276
Range on HMM: 251-286/286
Sequence Identity: 22% (8 aa)

YHGYS-AELTRIINLLLDHNPRSRPPADELLKHPRI
| . | ...  ..  .|. .|. |. ...|..||  
YPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase GL50803_114469.AA GCN2 108-155 26 0.015195 4.23 In-house 302-341 (511) Show / Hide 
Range on Protein: 108-155
Range on HMM: 302-341/511
Sequence Identity: 26% (13 aa)

HLYDEST-IWMVLAQLCDVLAYLHSPYKLNCPEVGIVIHRNIRPETIFL
... ... .|....|. . |.|.||           .||| ..| .|||
GWCMDHDELWRYFRQILEGLNYIHSQG---------MIHRDLKPSNIFL
Kinase GL50803_114469.AA NEK 111-131 38 0.037941 3.83 In-house 112-132 (286) Show / Hide 
Range on Protein: 111-131
Range on HMM: 112-132/286
Sequence Identity: 38% (8 aa)

DESTIWMVLAQLCDVLAYLHS
.|..|| ...|.|  | |.|.
EEEQIWDWFIQMCLALKYMHD
Pkinase GL50803_114469.AA Pkinase 59-131 20 4.710929 1.27 Pfam 52-126 (293) Show / Hide 
Range on Protein: 59-131
Range on HMM: 52-126/293
Sequence Identity: 20% (17 aa)

QLTQRLQHPGILQIHNVFHDQFRHTYYVFMDAYLSQ----SLR----QQIVDRFEAAHLY--DESTIWMVLAQLCDVLAYLHS
|. .||.|| |.... .|.|  .  .|. |.         .|            ..   .  .| .. ... |..  |.|.||
QIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST------WRHGCFYFSEWECKFYMYQILRGLEYCHS