Gene GL50803_115786 (G.lamblia)
GL50803_115786
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_115786.AA | Protein | None | 880 | None | Fasta, JSON |
| GL50803_115786.kin_dom | Protein Kinase Domain | None | 265 | None | Fasta, JSON |
Protein domains of GL50803_115786.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_115786.AA | Pkinase | 179-273 | 24 | 8.4e-11 | 39.27 | Pfam | 179-293 (293) | Show / Hide |
Range on Protein: 179-273 Range on HMM: 179-293/293 Sequence Identity: 24% (28 aa) SPEVLHGGPGSTQSV-MWSLGCLLYRICNGSYPFGDD-------RSQVLPAILSTLGPSALPKR-------------ASTLVEKVPLTLRPLVAQLLAYR .|||. ||.. ...| |||.||.|| ..| || .. |.. |... .. |. ..|. ... ... .. .|.. APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKD PSDRPTPTKLLLHPKV |..|||.. .| || . PKKRPTAEQILQHPWF |
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| Kinase | GL50803_115786.AA | Ciliate-E2 | 179-273 | 19 | 2.8e-09 | 27.99 | In-house | 255-365 (365) | Show / Hide |
Range on Protein: 179-273 Range on HMM: 255-365/365 Sequence Identity: 19% (23 aa) SPEVLHGGP---------GSTQSVMWSLGCLLYRICNGSYPFGDDRSQVLPAILSTLGPSALPKRAST-----------LVEKVPLTLRPLVAQ----LL .||.| |.. .... .||||..||. . | .|| . .. .|. .. .|... | . .| APEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRML AYRPSDRPT-PTKLLLHPKV . |. |.| . ..| || QKDPEKRITGWEQILNHPWF |
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| Kinase | GL50803_115786.AA | PDK1 | 179-211 | 36 | 2.3e-08 | 21.16 | In-house | 207-239 (307) | Show / Hide |
Range on Protein: 179-211 Range on HMM: 207-239/307 Sequence Identity: 36% (12 aa) SPEVLHGGPGSTQSVMWSLGCLLYRICNGSYPF |||.| ... .... |.|||..|. | .|| SPELLTDKECTPSCDIWALGCIIYQMVAGQPPF |
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| Kinase | GL50803_115786.AA | Ciliate-E2-Unclassified | 178-273 | 21 | 4.8e-07 | 20.51 | In-house | 230-352 (352) | Show / Hide |
Range on Protein: 178-273
Range on HMM: 230-352/352
Sequence Identity: 21% (28 aa)
S---SPEVLHG-GPGS---TQSVMWSLGCLLYRICNGSYPFGD-DRSQ----------------VLPAILS--TLGPSALPKRASTLVEKVPLTLRPLVA
. .|||| | ... .. .||||..|| .. | |||.| .. | .. |. . |.. .. .| .. | ..
PQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQ-------IPKHWSPEAK
--------QLLAYRPSDRPTPTKLLLHPKV
..| ..|. |.|. ..| ||
DFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | GL50803_115786.AA | STE | 179-273 | 21 | 1e-06 | 19.39 | In-house | 230-359 (359) | Show / Hide |
Range on Protein: 179-273 Range on HMM: 230-359/359 Sequence Identity: 21% (28 aa) SPEVLHG------GPGSTQSVMWSLGCLLYRICNGSYPFGD-DRSQVLPAILST--------------LGPSALPKRAS------------TLVEKVPLT .|||. . .. .|.. .|||||.. ..| .|. | ... .|. .| || . | |. .|. APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE LRPLVAQLLAYRPSDRPTPTKLLL--HPKV .. ... | . |..|||...|| || . FKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | GL50803_115786.AA | Ciliate-D1 | 193-211 | 47 | 4e-06 | 21.52 | In-house | 1-19 (19) | Show / Hide |
Range on Protein: 193-211 Range on HMM: 1-19/19 Sequence Identity: 47% (9 aa) VMWSLGCLLYRICNGSYPF .||.||.|| ...|..|| DIWSFGCILYEMLFGQPPF |
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| Kinase | GL50803_115786.AA | NEK2 | 179-205 | 48 | 8e-06 | 15.47 | In-house | 232-258 (319) | Show / Hide |
Range on Protein: 179-205 Range on HMM: 232-258/319 Sequence Identity: 48% (13 aa) SPEVLHGGPGSTQSVMWSLGCLLYRIC |||..|| . . | ||.|||.| | SPEQMHGQKYNEKSDIWSVGCLIYEMC |
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| Kinase | GL50803_115786.AA | SCY1 | 194-273 | 23 | 9e-06 | 16.09 | In-house | 256-337 (337) | Show / Hide |
Range on Protein: 194-273 Range on HMM: 256-337/337 Sequence Identity: 23% (20 aa) MWSLGCLLYRICNGSYPFGDDRSQ-VLPAILSTLGPSALPKRASTLVEKVPLTLRPL----VAQLLAYRPSDRPTPTKLLLHPKV |.||||| . . || .|. .. |. .. . . . .. . . ...| |. . . ||. | ||.| ..|.|.. MFSLGCLIWWVYNGKKPQITCNSNPYSTFHRYM---EQWNAMSHCWWDHIPKELQEHLGHCYCHLLHQDPTCRPDPQQFLQHCYF |
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| Kinase | GL50803_115786.AA | SAK | 179-273 | 28 | 1.9e-05 | 14.22 | In-house | 168-254 (254) | Show / Hide |
Range on Protein: 179-273 Range on HMM: 168-254/254 Sequence Identity: 28% (27 aa) SPEVLHGGPGSTQSVMWSLGCLLYRICNGSYPFGDDRSQVLPAILSTLGPSALPKRASTLVEKVPLTLRPLVAQLLAYRPSDRPTPTKLLLHPKV |||. .. || .|||||.|| . | || | |. .|| . . . . . |. ..| | .| | | || . SPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPFDTD------AVKNTLNKVMMAEYI--MPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM |
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| Kinase | GL50803_115786.AA | NAK | 195-213 | 52 | 3.7e-05 | 13.09 | In-house | 225-243 (299) | Show / Hide |
Range on Protein: 195-213 Range on HMM: 225-243/299 Sequence Identity: 52% (10 aa) WSLGCLLYRICNGSYPFGD |.|||.||..| . ||.| WALGCMLYKMCFYTHPFED |
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| Kinase | GL50803_115786.AA | CAMK | 249-273 | 32 | 0.000621 | 7.77 | In-house | 401-425 (425) | Show / Hide |
Range on Protein: 249-273 Range on HMM: 401-425/425 Sequence Identity: 32% (8 aa) LVAQLLAYRPSDRPTPTKLLLHPKV |. ..| . |..|.| . | || . LIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | GL50803_115786.AA | CAMK | 179-214 | 31 | 0.018542 | 2.93 | In-house | 287-337 (425) | Show / Hide |
Range on Protein: 179-214 Range on HMM: 287-337/425 Sequence Identity: 31% (16 aa) S-PEVLHG-------------GPGSTQSV-MWSLGCLLYRICNGSYPFGDD . |||| | |. .... |||.|..|| | .|| .| AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGD |
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| S_TKc | GL50803_115786.AA | S_TKc | 342-606 | 14 | 1.5e-05 | -95.49 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 342-606 Range on HMM: 1-231/231 Sequence Identity: 14% (42 aa) YLPIAHCGFNGMCEGFVLKNRSTGIRVFCKVYRIGDDSVLQNAITEYFAELASISHPYIVPLSFGKISSLNTYAYEAVEAASL--HRLSDVVGTLDRGG- | . . | .. . . ....|| .| .|. . .... | ||.|| | . .. | | .. | |. |.| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---LCEQKVWSLLIAVVDVLCMLQTRSDGPLCHHAIRPWALYLTQEGDLRLLDTGSALRFAKKLTQPSRCGHLALDKGLD---PFTAPELRPGSAQSWVG . | ..... ... | . . .| . | . |.. . . | |.| .. . . . |||. | RFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL------GYG GSRADLWELAQTICHLCRGDIIACSTLDDAQAHLRGHFLGLSYSDELHGVLAGMLQPDPVARTALSMLAT-------HPCI . ..| | . .. .. | . ... ... |.|. . ..|| || | . . || . KCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_115786.AA | NAK | 575-594 | 45 | 0.002117 | 7.12 | In-house | 270-289 (299) | Show / Hide |
Range on Protein: 575-594 Range on HMM: 270-289/299 Sequence Identity: 45% (9 aa) YSDELHGVLAGMLQPDPVAR ||...| . .||.||| | YSQQMHDLIRYMLTPDPEQR |
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| Kinase | GL50803_115786.AA | CAMK | 576-606 | 28 | 0.024039 | 2.56 | In-house | 387-425 (425) | Show / Hide |
Range on Protein: 576-606 Range on HMM: 387-425/425 Sequence Identity: 28% (11 aa) SDE--------LHGVLAGMLQPDPVARTALSMLATHPCI ||| . .|||.|| | .. || . SDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | GL50803_115786.AA | SAK | 576-606 | 32 | 0.17767 | 0.48 | In-house | 224-254 (254) | Show / Hide |
Range on Protein: 576-606 Range on HMM: 224-254/254 Sequence Identity: 32% (10 aa) SDELHGVLAGMLQPDPVARTALSMLATHPCI | | . .. ||. .| | .|| || . SMEAQDLIHKMLRKNPHERITLSTVLCHPFM |
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| Kinase | GL50803_115786.AA | Ciliate-E2 | 585-606 | 36 | 0.303929 | 0.0 | In-house | 341-365 (365) | Show / Hide |
Range on Protein: 585-606 Range on HMM: 341-365/365 Sequence Identity: 36% (9 aa) G--MLQPDPVARTA-LSMLATHPCI | ||| || | . . || . GKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | GL50803_115786.AA | Ciliate-D1 | 537-555 | 15 | 3.084233 | 0.61 | In-house | 1-19 (19) | Show / Hide |
Range on Protein: 537-555 Range on HMM: 1-19/19 Sequence Identity: 15% (3 aa) DLWELAQTICHLCRGDIIA |.| . ...... | . DIWSFGCILYEMLFGQPPF |
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| Ank | GL50803_115786.AA | Ank | 650-680 | 27 | 0.001602 | 16.96 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 650-680 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) QGCTALFLAAQRGMHQLLNLLVG--AEADIADS |.|.| ||...| .. . .|.. |. .. | DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_115786.AA | Ank | 681-702 | 27 | 0.021673 | 12.88 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 681-702 Range on HMM: 1-22/33 Sequence Identity: 27% (6 aa) RGRTALMAAAANNRVGCIDRLL |.|.|. |. .... .. || DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_115786.AA | Ank | 712-732 | 38 | 0.215806 | 9.28 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 712-732 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) DGDTALIYAARFWATDALSLL ||.|.| .|.| |. ...| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_115786.AA | Ank | 742-763 | 36 | 0.011086 | 13.93 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 742-763 Range on HMM: 1-22/33 Sequence Identity: 36% (8 aa) RGETALMVAAASNYVEGVEALL |.|.|..|. ....| |. || DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_115786.AA | Ank | 773-803 | 24 | 0.173698 | 9.62 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 773-803 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) EGWTALMCAAVVGATAAVCQLVT--VEAGLRNN .|.|.|..|. | | | |. . .... DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_115786.AA | Ank | 804-824 | 38 | 0.730511 | 7.37 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 804-824 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) RGRTALIEAVLCGQMASVHVL |.|.| |..||.. | | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_115786.AA | Ank | 835-855 | 33 | 0.085513 | 10.73 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 835-855 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) AGRCALMYAASRGHTPAIRIL |. .|..|...||| .. | DGFTPLHLACRCGHTEVVKML |
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