Gene GL50803_12095 (G.lamblia)

GL50803_12095

Species: G.lamblia
Alias: GL50803_12095, GK283
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_12095.AA Protein None 576 None Fasta, JSON
GL50803_12095.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of GL50803_12095.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_12095.AA NEK2 184-217 52 8.1e-12 35.96 In-house 230-263 (319) Show / Hide 
Range on Protein: 184-217
Range on HMM: 230-263/319
Sequence Identity: 52% (18 aa)

YLAPETVQSKSLSECSDIWMVGCLMYELCTLTPP
|  || ..  . .| |||| |||| ||.|.| ||
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPP
Kinase GL50803_12095.AA NEK 184-224 43 2.3e-11 36.69 In-house 190-233 (286) Show / Hide 
Range on Protein: 184-224
Range on HMM: 190-233/286
Sequence Identity: 43% (19 aa)

YLAPETVQSKSLSECSDIWMVGCLMYELCTLTP-PPFDSG--TL
|..|| .|.|. .. ||||..||. ||.||| | .||..    .
YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNM
Kinase GL50803_12095.AA TK 184-271 18 5.3e-09 25.52 In-house 351-486 (486) Show / Hide 
Range on Protein: 184-271
Range on HMM: 351-486/486
Sequence Identity: 18% (25 aa)

YLAPETVQSKSLSEC---------SDIWMVGCLMYELCTLT-PPPFDSGTLTE----TPTLPSLQQLVDAG--------------------AFSH-----
..|||.....  ||.         ||.|. |.||.|..|.   |.    .  .      ..  . ... .|                    .  .     
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRY

---------ELI-LCIKSCLHYLPELRPSASVLRDLC
         |.. . ...| || || ||. | |..  
RMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase GL50803_12095.AA NEK8 184-214 41 1e-08 20.86 In-house 188-218 (278) Show / Hide 
Range on Protein: 184-214
Range on HMM: 188-218/278
Sequence Identity: 41% (13 aa)

YLAPETVQSKSLSECSDIWMVGCLMYELCTL
|. || ...|.  . ||.| .||  ||.|.|
YMSPEMCEGKPYNQKSDMWALGCVLYEMCCL
S_TKc GL50803_12095.AA S_TKc 17-272 17 1.1e-08 -49.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-272
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)

LHTDER------GSLFEARRICDNEKVLVEAIALSYISAEERQELLKEYTQLLTLRHDCLLSVQDIYYDAGEGHCLLIELEYFHG---SMKALIHDAAG-
 .  .       |. . .| . ....| .  |          . ...|   |   .|. .    |...|    ..| . .||  |   ... .|..  . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRH

-ARIPFDEEYIWHLMERIVNSLTYLYTNESFSIKAHGQIWPSNILRTATN---------KFVLGEPILPAHFVSHLLPSEYKQAGFSYLAPETVQSKSLS
  | ||.|  ....|  |.. | |.  .  .    |  . |.||| .  .         ...                         |.||| .   . .
GLRFPFPE-HARFYMYQICCALEYCHSH-GI---IHRDLKPENILLDE-HIKICDFGLARQL-----------------TTFCGTPWYMAPEVL---GYG

E-CSDIWMVGCLMYELCTLTPPPFDSGTLTETPTLPSLQQLVDAGAFSHELILCIKSCLHYLPELRPSASVLR-------DLCA
   .|.| .||..||...   |||.        ..  . ...     |.|..  |. ||.. || ||.| .|.       .   
KCKCDWWSCGCILYEMLC-GYPPFP--------QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase GL50803_12095.AA NEK10 184-217 50 1.6e-08 23.96 In-house 186-219 (279) Show / Hide 
Range on Protein: 184-217
Range on HMM: 186-219/279
Sequence Identity: 50% (17 aa)

YLAPETVQSKSLSECSDIWMVGCLMYELCTLTPP
|  || |||.   |  |.| .|| .|..||| ||
YSCPEIVQSEPYGEKADVWAFGCCLYQMCTLQPP
Kinase GL50803_12095.AA STE 184-267 23 4.5e-08 24.74 In-house 228-351 (359) Show / Hide 
Range on Protein: 184-267
Range on HMM: 228-351/359
Sequence Identity: 23% (29 aa)

YLAPETVQS------KSLSECSDIWMVGCLMYELCTLTPPPFDSGTL-----------------------TETPTLPSLQQLVDA-----------GAFS
. ||| .|       |  .. .||| .||.. |..|  || .|   .                        . |.||.  . ..              .|
WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWS

HELILCIKSCLHYLPELRPSASVL
 |..  |. || . |. ||.|| |
PEFKDFINKCLQKDPNKRPTASQL
Kinase GL50803_12095.AA NEK-Unclassified 184-216 39 1.2e-07 21.11 In-house 163-195 (258) Show / Hide 
Range on Protein: 184-216
Range on HMM: 163-195/258
Sequence Identity: 39% (13 aa)

YLAPETVQSKSLSECSDIWMVGCLMYELCTLTP
...|| .| .   . ||.|  ||..||.||  |
WMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEP
Kinase GL50803_12095.AA Ciliate-E2 184-265 19 2.4e-07 21.25 In-house 253-357 (365) Show / Hide 
Range on Protein: 184-265
Range on HMM: 253-357/365
Sequence Identity: 19% (23 aa)

YLAPETVQSKS---------LSECSDIWMVGCLMYELCTLTPPPFDSGTLTETPTLPSLQQLVD-----------------------AGAFSHELILCIK
|.||| ...|.          .. .||| .|...||...  ||               .||  .                           | | .  ||
YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIK

S----CLHYLPELRPS-AS
     .| . || |.. ..
KFGKRMLQKDPEKRITGWE
Kinase GL50803_12095.AA PLK1 184-227 45 3.6e-07 19.34 In-house 165-207 (253) Show / Hide 
Range on Protein: 184-227
Range on HMM: 165-207/253
Sequence Identity: 45% (20 aa)

YLAPETVQSKSLSECSDIWMVGCLMYELCTLTPPPFDSGTLTET
|.||| .. |  |   ||| .||.|| |  .  |||.. .| ||
YIAPEVLNKKGHSFEVDIWSIGCIMYILL-FGQPPFETKCLKET
Kinase GL50803_12095.AA Ciliate-E2-Unclassified 184-221 30 4.2e-07 20.71 In-house 232-272 (352) Show / Hide 
Range on Protein: 184-221
Range on HMM: 232-272/352
Sequence Identity: 30% (13 aa)

YLAPETVQSKSLS----ECSDIWMVGCLMYELCTLTPPPFDS
|.|||  |..  .    ...||| .|...||... . .||..
YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY-YPFYD
TyrKc GL50803_12095.AA TyrKc 17-271 12 1e-05 -130.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-271
Range on HMM: 1-280/280
Sequence Identity: 12% (41 aa)

LHTDER------GSLFEARRICDNEKVLVEAIALSYISAEERQELLKEYTQLLTL--RHDCLLSVQDIYYDAG------EGHCLLIELEYFHGSMKALIH
.. ..       |  .... .   ..| |  .  .      |.....|   .  |  .|....    .  . |      | .... |.   ||. |  ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY-MPHGDLKDYLR

DAAGARIPFDEEYIWHLMERIVNSLTYLYTNESFSIKAHGQIWPSNILRTATNKFVLGEPILPAHFV-------------SH-----------LLPSE--
.  .    .  .   . .  | .   ||  .                                 ...              |            . ..  
KHRPK---LCMKDLLSFCWQIACGMEYLHSK---------------------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQ

------YKQA----GFS------YLAPETVQSKSLSECSDIWMVGCLMYELCTLTPPPFDSGTLTETPTLPSLQQLVDAG--------A-------FSHE
      |. .    |         .|||. . .  .. ||.|. | .|.|..|.  .|    ..    .   . ..|..|        .        . |
QGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDE

LILCIKSCLHYLPELRPSASVLRDLC
.   .|.| |. || ||. | .... 
MYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_12095.AA Pkinase 184-217 34 0.00709 11.25 Pfam 177-211 (293) Show / Hide 
Range on Protein: 184-217
Range on HMM: 177-211/293
Sequence Identity: 34% (12 aa)

YLAPETVQ-SKSLSECSDIWMVGCLMYELCTLTPP
|.||| .. ..  .  .|.| .||..||...  ||
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPP
Pkinase GL50803_12095.AA Pkinase 26-131 16 0.366886 5.19 Pfam 16-125 (293) Show / Hide 
Range on Protein: 26-131
Range on HMM: 16-125/293
Sequence Identity: 16% (19 aa)

FEARRICDNEKVLVEAIALSYISAEERQELLK--EYTQLLTLRHDCLLSVQDIYYDAGEGHCLLIELEYFHGSMKALIHDA----AGARIPF--DEEYIW
...... ....| |  | .. .. ...|....  |   .. |.|.. .   |...|  ..|. .. .||  |  . ..  .    . .. .|  .|. . 
YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMV-MEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECK

HLMERIVNSLTYLY
. |  |.  | |..
FYMYQILRGLEYCH
Ank GL50803_12095.AA Ank 407-421 33 5.022075 4.35 Pfam 1-15 (33) Show / Hide 
Range on Protein: 407-421
Range on HMM: 1-15/33
Sequence Identity: 33% (5 aa)

NSKTPLMTAALEGNV
.  |||. |.. |..
DGFTPLHLACRCGHT
Ank GL50803_12095.AA Ank 441-462 40 0.003447 15.76 Pfam 1-22 (33) Show / Hide 
Range on Protein: 441-462
Range on HMM: 1-22/33
Sequence Identity: 40% (9 aa)

GGETALYYAVLGCNPECVKLLL
 |.|.| .|..  ..|.||.||
DGFTPLHLACRCGHTEVVKMLL