Gene GL50803_12152 (G.lamblia)

GL50803_12152

Species: G.lamblia
Alias: GK194, GL50803_12152
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_12152.AA Protein None 334 None Fasta, JSON
GL50803_12152.kin_dom Protein Kinase Domain None 248 None Fasta, JSON

Protein domain

Protein domains of GL50803_12152.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_12152.AA Ciliate-E2 115-270 20 1.8e-23 77.44 In-house 138-360 (365) Show / Hide 
Range on Protein: 115-270
Range on HMM: 138-360/365
Sequence Identity: 20% (50 aa)

QRDKRELPLQEALGILRQVGK---------------ALEHLHTLNNGGSPTPHYNLKPSNIMFNSSKEQVIVTDFGI---------HCRYWKTAAISSTK
. |   . ..|.. | .|. .               |||.||  ||      | ..||.||.|      . ..|||.          ... |  .   . 
K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN----IIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF

ES--------------------------QYVAPEVDMDSG------GEAYTFSSDMWSLGVIAYELLTGKL-FHKESYNISDLSNLCNQRL---------
 .                           |.|||. .  .      .. |....|.|||||| ||.|.||. |         . . ... .         
-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQK

-------------------MTLIES----LLDKDPAKRPT-AKQFL
                   . ||      .|.||| ||.| ..| |
DTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase GL50803_12152.AA Ciliate-E2-Unclassified 109-270 21 1.9e-22 74.66 In-house 123-347 (352) Show / Hide 
Range on Protein: 109-270
Range on HMM: 123-347/352
Sequence Identity: 21% (51 aa)

NEMRKRQRDKRELPLQEAL-----GILRQVGKALEHLHTLNNGGSPTPHYNLKPSNIMFNSSKE--QVIVTDFGI----------------------HCR
|.. .... ..... |.|.      ...|. ..||.||  ||      |...||.||.|.....  .. ..||||                      ...
NDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN----IIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQM

YWKTAAISSTKESQYVAPEVDMDSGGEAYT----FSSDMWSLGVIAYELLTGKLFHK---------------------ESYNIS----------------
.| ..   ...  || ||||    .|. |     ...|.||||||.||.|.|..  .                     . |..                 
MWTFCGTPNYMP-QYTAPEV---LQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIP

-DLSNLCNQRLMTLIESLLDKDPAKRPTAKQFL
 ..|. .   .  |. ..|.|.| ||.|..| |
KHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase GL50803_12152.AA AGC 193-268 22 6.6e-19 44.09 In-house 272-378 (395) Show / Hide 
Range on Protein: 193-268
Range on HMM: 272-378/395
Sequence Identity: 22% (26 aa)

QYVAPEVDMDSGGEAYTFSSDMWS--LGVIAYELLTG--------------------KLFHKES------YNISDLS----------NLCNQRLMTLIES
.|.|||.        |... | ||  ||.. ||.|||                    ..|.|         .   .               . .. ||. 
EYMAPEIL-------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKK

LLDKDPAKRPTAKQ
|| |||.||.....
LLCKDPEKRLGCGG
Kinase GL50803_12152.AA TKL 106-273 14 7.6e-18 60.84 In-house 124-364 (364) Show / Hide 
Range on Protein: 106-273
Range on HMM: 124-364/364
Sequence Identity: 14% (37 aa)

SLHNEMRKRQRDKRELPLQEALGILRQVGKALEHLHTLNN--GGSP--TPHYNLKPSNIMFNSSKE-------------QVIVTDFGIHC--------RY
||.. .           ..  . . ... .....||. |   .. .    | .||..||. ..  .              . ..|||.            
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMND

WKTA-------------AISSTKESQYVAPEVDMDS-------------GGEAYTFSSDMWSLGVIAYELLTGK-LFHKESYN------------ISDLS
..|.              ..     .. |||| ...             .|. |. ..|..| |.. .|.||..  .... |.            . . .
TMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCD

--------------------NLCNQRLMTLIESLLDKDPAKRPTAKQFLALL
                    . | ...  |..   | || |||.... |  |
KGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc GL50803_12152.AA S_TKc 28-278 23 4.3e-15 44.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 28-278
Range on HMM: 1-231/231
Sequence Identity: 23% (62 aa)

DKNVDRI-FGPHGNVYRLLSTE--KEVA-KEMTVDLLTSDQLDKLLDKLDELKRINHPNLARIIMFGTNSKLLLIKIPAYTN---SLHNEMRKRQRDKRE
 . .. |  |  | ||.   ..  ..|| |..          ....  .. ||. .|||. ... .  . . | .      .   .|.  ..||.| .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LPLQEALGILRQVGKALEHLHTLNNGGSPTPHYNLKPSNIMFNSSKEQVIVTDFGIHCRYWKTAAISSTKESQYVAPEVDMDSGGEAYTF-SSDMWSL
  .|  .|  ...|. .|||..| ..       |  |||.||....   .. ..|||. ...  |  . .     |.||||        |.. ..|.||.
FPFPE-HARFYMYQICCALEYCHSHG-----IIHRDLKPENILLDE---HIKICDFGLARQL--TTFCGTP---WYMAPEVL------GYGKCKCDWWSC

GVIAYELLTGKL-FHKESYNISDLSNLCNQRLMTLIESLLDKDPAKRPTAKQFLA----LLDNSCL
|.| ||.|.|.  |. . . . ..     . .  .|. .|.|||.||||| . |.          .
GCILYEMLCGYPPFP-QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_12152.AA Pkinase 116-229 24 1.7e-12 45.27 Pfam 98-210 (293) Show / Hide 
Range on Protein: 116-229
Range on HMM: 98-210/293
Sequence Identity: 24% (32 aa)

RDKREL--PLQEALGILRQVGKALEHLHTLNNGGSPTPHYN-----LKPSNIMFNSSKEQV----IVTDFGI-----HCRYWKTAAISSTKESQYVAPEV
.... .  . .|.  ...|. ..||..|            .     |||.||... .. ..     ..|||.     . ..  .  .  | .  |.||||
WRHGCFYFSEWECKFYMYQILRGLEYCHSM----------GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW--YMAPEV

DMDSGGEAYTFSSDMWSLGVIAYELLTGKL
 .  ||. |. ..||||.|.| ||.|.|..
IR--GGQYYGPKVDMWSCGCILYEMLCGRP
Kinase GL50803_12152.AA CAMK 155-229 19 1.7e-12 35.9 In-house 205-332 (425) Show / Hide 
Range on Protein: 155-229
Range on HMM: 205-332/425
Sequence Identity: 19% (25 aa)

LKPSNIMFNSSK----------------EQVIVTDFGIHCRYWKTA-------------------------AISSTKESQYVA-PEVDMDSG--------
||| ||......                 .. ..|||  ... .                              .     |.| |||   .|        
LKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNAT

---GEAYTFSSDMWSLGVIAYELLTGKL
    . |....||||.||| | .|.|..
DEEKPYYGPKCDMWSCGVILYIMLCGYP
Kinase GL50803_12152.AA GIN4 117-240 33 1e-11 33.29 In-house 127-245 (293) Show / Hide 
Range on Protein: 117-240
Range on HMM: 127-245/293
Sequence Identity: 33% (43 aa)

DKRELPLQEALGILRQVGKALEHLHTLNNGGSPTPHYNLKPSNIMFNSSKEQVIVTDFGIHCRYWKTAAISSTKES-QYVAPEVDMDSGGEAYT-FSSDM
|. .|| .||. . ||.   .   |..|       |  ||| |..  .  ... . |||.     .   .     |  | |||. |   |  |  |.||.
DHGPLPEREAIHYFRQIIIGVSYCHAFN-----ICHRDLKPENLLLDHKYNRIKIADFGMAALETDNKLLETSCGSPHYAAPEIVM---GIPYHGFASDV

WSLGVIAYELLTGKL-FHKESYNISDL
|| ||| . ||||.| |  |  || .|
WSCGVILFALLTGHLPFDEEDGNIRKL
Kinase GL50803_12152.AA MSK 109-228 27 1.2e-11 35.66 In-house 86-207 (277) Show / Hide 
Range on Protein: 109-228
Range on HMM: 86-207/277
Sequence Identity: 27% (36 aa)

NEMRKRQRDKRELPLQEALGILRQVGKALEHLHTLNNGGSPTPHYNLKPSNIMFNSS--KEQVIVTDFGIHCRYWKTAAISSTKES-----QYVAPEVDM
.|.  . | ..   ..|.  |.|..  |..|.| .        |  ||| ||.| .     .| ..|||  .   ...  .    |     .| |||.  
GELFTHIRKREHFDESECRMIMRELVMAVDHMHQKG-----IIHRDLKPENILFDDEEDNGHVKLIDFGFAR--LFPQDEEWRMKSPCFTLHYMAPEMLR

D--SGGEAYTFSSDMWSLGVIAYELLTGK
.  .. . |  . |.|||||| |..|||.
RGYAQDGGYDEACDWWSLGVILYTMLTGQ
Kinase GL50803_12152.AA RSK 193-229 38 5.1e-09 29.47 In-house 173-210 (278) Show / Hide 
Range on Protein: 193-229
Range on HMM: 173-210/278
Sequence Identity: 38% (15 aa)

QYVAPEVDM--DSGGEAYTFSSDMWSLGVIAYELLTGKL
.|.|||. .  . ...... . | |||||. ||.|||..
EYMAPEMLKRAN-QQGGHDKACDWWSLGVLMYEMLTGCP
Kinase GL50803_12152.AA Ciliate-E2a 194-229 48 1.2e-08 21.65 In-house 176-214 (275) Show / Hide 
Range on Protein: 194-229
Range on HMM: 176-214/275
Sequence Identity: 48% (19 aa)

YVAPEVDMDSG---GEAYTFSSDMWSLGVIAYELLTGKL
||||||        .. |. . ||||.||| | ||.||.
YVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKP
TyrKc GL50803_12152.AA TyrKc 28-273 16 2.6e-08 -88.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 28-273
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

DKNVDRIF-GPHGNVYR-LLSTEKEVA-KEMTVDLLTSDQLDKLLDKLDELKRI--NHPNLARIIMFGTNS-------KLLLIKIPAYTN-SLHNEMRKR
 .  . .  |  | ||.  ..   .|| | .  |      .  ... .  ....  .|||. |..   | .       . |.|      . .|..  ||.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

QRDKRELPLQEALGILRQVGKALEHLHTLNNGGSPTPHY---NLKPSNIMFNSSKEQVIVTDFGIHCRYWKTA--------AISSTK--ESQ------YV
...   |.... | .  |. .  |.||          ..    |   |.. .. . .| ..|||  .|...           .....   .         
RPK---LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENH-TVKISDFGL-SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APEVDMDSGGEAYTFSSDMWSLGVIAYELLT-GKLFHKE----------------SYNISDLSNL--------CNQRLMTLIESLLDKDPAKRPTAKQFL
|||. ...    .|. || || ||  .|..| |.  . .                . .  .            | . . .....  . ||..||| ..  
APECINYG---KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

ALL
 ..
ECF
Kinase GL50803_12152.AA CAMK1 194-227 51 4.2e-08 19.58 In-house 179-212 (276) Show / Hide 
Range on Protein: 194-227
Range on HMM: 179-212/276
Sequence Identity: 51% (18 aa)

YVAPEVDMD-SGGEAYTFSSDMWSLGVIAYELLTG
||||||  . .  ..|  . |||| ||| | ||.|
YVAPEVLECKK-DKPYDKACDMWSIGVITYILLCG
Kinase GL50803_12152.AA CAMK1 251-271 42 4e-06 13.76 In-house 252-272 (276) Show / Hide 
Range on Protein: 251-271
Range on HMM: 252-272/276
Sequence Identity: 42% (9 aa)

LIESLLDKDPAKRPTAKQFLA
.|  .|..|| ||.|..|.|.
FIKHMLEVDPKKRYTCEQCLN
Kinase GL50803_12152.AA Pkinase 251-273 48 6.9e-05 18.37 Pfam 269-293 (293) Show / Hide 
Range on Protein: 251-273
Range on HMM: 269-293/293
Sequence Identity: 48% (12 aa)

LIESLLDKDPAKRPTAKQFLAL--L
.|...|.|||.|||||.| |    .
FIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_12152.AA CAMK 236-271 36 0.000188 9.47 In-house 385-421 (425) Show / Hide 
Range on Protein: 236-271
Range on HMM: 385-421/425
Sequence Identity: 36% (14 aa)

NISDL--SNLCNQRLMTLIESLLDKDPAKRPTAKQFLA
.|||   .  . |  . || ..| .|| ||.|..| |.
DISDEFHH-FVSQECKDLIRKMLQVDPEKRMTIEQCLN
Kinase GL50803_12152.AA RSK 155-175 39 0.000266 12.05 In-house 130-152 (278) Show / Hide 
Range on Protein: 155-175
Range on HMM: 130-152/278
Sequence Identity: 39% (9 aa)

LKPSNIMFNS--SKEQVIVTDFG
|||.||....  . . . .||||
LKPENILYDDESNEGHIKLTDFG
Kinase GL50803_12152.AA Ciliate-E2a 251-268 55 0.00173 6.16 In-house 251-268 (275) Show / Hide 
Range on Protein: 251-268
Range on HMM: 251-268/275
Sequence Identity: 55% (10 aa)

LIESLLDKDPAKRPTAKQ
|.  .|.||| ||.||.|
LMKKMLEKDPKKRITAQQ
Kinase GL50803_12152.AA MSK 251-278 35 0.006072 5.78 In-house 253-277 (277) Show / Hide 
Range on Protein: 251-278
Range on HMM: 253-277/277
Sequence Identity: 35% (10 aa)

LIESLLDKDPAKRPTAKQFLALLDNSCL
||. || |||.||...     |.... .
LIQWLLTKDPKKRLGMND---LRAHEWK
Kinase GL50803_12152.AA Ciliate-E2a 155-175 33 0.007576 4.24 In-house 128-154 (275) Show / Hide 
Range on Protein: 155-175
Range on HMM: 128-154/275
Sequence Identity: 33% (9 aa)

LKPSNIMFN---SSK---EQVIVTDFG
||| ||.|.   ...    .... |||
LKPENILFKNCSKNSIQNSDIKIIDFG
Kinase GL50803_12152.AA CAMK 117-144 25 0.024898 2.51 In-house 172-199 (425) Show / Hide 
Range on Protein: 117-144
Range on HMM: 172-199/425
Sequence Identity: 25% (7 aa)

DKRELPLQEALGILRQVGKALEHLHTLN
... .. .||  . ||.  |....| .|
ERGRFTEREARRYFRQICSAVHYCHSHN
Kinase GL50803_12152.AA RSK 251-268 34 0.033588 4.29 In-house 249-271 (278) Show / Hide 
Range on Protein: 251-268
Range on HMM: 249-271/278
Sequence Identity: 34% (8 aa)

LIESLLDKDPAKRPT-----AKQ
||  .| .||.||..     |..
LIRKMLHRDPHKRLGCGPQDAEE
Kinase GL50803_12152.AA RSK 129-143 33 0.38169 0.39 In-house 109-123 (278) Show / Hide 
Range on Protein: 129-143
Range on HMM: 109-123/278
Sequence Identity: 33% (5 aa)

ILRQVGKALEHLHTL
..... .|.||||..
YMAEIVLAVEHLHQQ