Gene GL50803_137706 (G.lamblia)

GL50803_137706

Species: G.lamblia
Alias: GL50803_137706, GK174
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_137706.AA Protein None 595 None Fasta, JSON
GL50803_137706.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of GL50803_137706.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_137706.AA S_TKc 15-263 19 1.2e-14 37.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-263
Range on HMM: 1-231/231
Sequence Identity: 19% (52 aa)

YIRSSQLGA-----VYKAERLSDGATVAVKEISLRNIPDDQYVALCRPYELSRYLAHPHLLVYHEAYVIPGERCLLEMELCEN--GALIDVLDDLYKRKE
|    ..|      |||.   ..|  ||.|.|.           ..|  .. .   ||..  ......   ..  . ||.|..  | | |....  ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

H--LEESFVWEIIAQIADALAYLHDADKPQGPVLHKAVRASSIFIGESGLKLAKLGSTRHASELTVFGTRHKHDMYLPPEATVRRTPTD-KWDIWGLGCL
.  . |  .. ...||..||.|.|.       ..|  .  . |.. |  .|..  |. |.    |. ||..    |..||       .  | |.| .||.
RFPFPE-HARFYMYQICCALEYCHSHG-----IIHRDLKPENILLDE-HIKICDFGLARQL--TTFCGTPW----YMAPEVL---GYGKCKCDWWSCGCI

AVEVCTLGTVYNDSSTMLSRLSFDLRPYSNALAFMVASCLSVCDRDRPSAVEIKG-------HIEI
  | ..  . .      . ..   ..  |  .  ..  || .  ..||.| |.         |  .
LYEMLCGYPPFP----QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_137706.AA TKL 16-261 13 3.2e-13 43.98 In-house 1-364 (364) Show / Hide 
Range on Protein: 16-261
Range on HMM: 1-364/364
Sequence Identity: 13% (52 aa)

IRSSQLGAVYKAERLS--------DGATVAVKEISLRN-----------------------IPDDQYVALCRPYELSRYLA--HPHLLVYHEAYVIPGER
| |   | |||..           .| .|||| .. .|                        |. .    .. .|.   .   ||... .  .   |. .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------CLLEMELCENGALIDVLDDLYKRKEHLEESFVWEIIAQIADALAYLHDAD----KPQGPVLHKAVRASSIFIGESG------------
            . . ||.|..| | ..|            .    .. .|| ...|||  .    .   |..|     . |.. | .            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---LKLAKLGSTRHASELT--------------------VFGTRHKHDMYLPPEATVRRTPTDKW----------------DIWGLGCLAVEVCTLGTVY
   .|.. .|  |  |. .                      .|.  .  ...||.    ......                |..  | .  |..|  ..|
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

--NDSS------------TMLS----RLSFDLRPY--------SNA---LAFMVASCLSVCDRDRPSAVEIKGHI
  ....             | .    |.  . ..         ...   ..     | .   ..|||. ||. ..
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_137706.AA NEK6 10-211 26 4.5e-11 32.42 In-house 1-199 (252) Show / Hide 
Range on Protein: 10-211
Range on HMM: 1-199/252
Sequence Identity: 26% (54 aa)

HKNSVYIRSSQLGAVYKAERLSDGATVAVKEISLRNIPDDQYVALC-RPYELSRYLAHPHLLVYHEAYVIPGERCLLEMELCENGALIDVLDDLYKRKEH
 .    |   |   ||.|. | |. .||.| . . .. | .  . | .  .| . | ||... | ....   |  .  .|| . | .  ..    | |  
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIENNELNIV-LELADAGDMSRMIKHFKKQKRL

LEESFVWEIIAQIADALAYLHDADKPQGPVLHKAVRASSIFIGESGL-KLAKLGSTR-HASELTVFGTRHKHDMYLPPEATVRRTPTDKWDIWGLGCLAV
. |  .|    |.. ||. .|        |.|. ..   .||   |  ||  ||  |  .|. |          |. ||         | ||| ||||  
IPERTIWKYFVQLCSALEHMHSKR-----VMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLY

EVCTL
|.  |
EMAAL
Kinase GL50803_137706.AA NEK 22-130 26 7.6e-11 34.81 In-house 13-132 (286) Show / Hide 
Range on Protein: 22-130
Range on HMM: 13-132/286
Sequence Identity: 26% (32 aa)

GAVYKAERLSDGAT-----VAVKEISLRNI-PDDQYVALCRPYELSRYLA---HPHLLVYHEAYVIPG-ERCLLEMELCE-NGALIDV---LDDLYKRKE
| |||..| |||       .. |.|.. |  . ..  |. .  .  | |.   ||.   |.....  . ..   .|| || .| | .    .    ....
GKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQ-N--NEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGK

HLEESFVWEIIAQIADALAYLHD
..||. .|.. .|.. || |.||
YFEEEQIWDWFIQMCLALKYMHD
Kinase GL50803_137706.AA CAMK 22-130 14 3.5e-10 28.28 In-house 8-197 (425) Show / Hide 
Range on Protein: 22-130
Range on HMM: 8-197/425
Sequence Identity: 14% (28 aa)

GAVYKAERLSDG------------ATVAVKEISLRNIPDDQ--------------------------YVALCRPYELSRYLA-------HPHLLVYHEAY
| |..... ...              ||.| |. . ..|.|                             . | .|. . |        ||...  .|.|
GKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVY

V------------IPGE-------RCLLEM---ELCENGAL-IDVLDDLYKRKE--------------HLEESFVWEIIAQIADALAYLHD
                        .. . |   |.|..| | .|..| . ...               ...|. .  .. ||..|..|.|.
EDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS
Kinase GL50803_137706.AA STE 22-207 18 1.5e-09 30.06 In-house 13-260 (359) Show / Hide 
Range on Protein: 22-207
Range on HMM: 13-260/359
Sequence Identity: 18% (49 aa)

GAVYKAERL------SDGAT---------VAVKEISLRNIP---------------DDQYVALCRPYELSRYLA--HPHLLVYHEAYVIPG------ERC
| |||| .       . | .         .|.|...|.|                 ...   . .  .. . .   ||.   |. .|.  |      . .
GTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDEL

LLEMELCENGALIDVLDDLYKRKEHLE----------ESFVWEIIAQIADA-LAYLHDADKPQGPVLHKAVRASSIFIGESGLKLAKLGSTRHASEL---
 . ||....| | |...  |.... |           || .  |. ||  . |.|||.       . |  . .. |..     ||.  |     ..    
WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-----IIHRDIKPANILL----VKLCDFGVCGQLTDSMAN

------------------TVFGTRHKHDMYLPPEATVRRTPTD-------KWDIWGLGCLAVE
                  |. ||      .  ||  ...  ..       | ||| |||...|
IQSNNIIDCIETMQQKRNTFVGTP-----WMAPE-VIQQNGQGRDKGYDTKCDIWSLGCTIIE
Kinase GL50803_137706.AA WEE 87-132 24 3.9e-09 26.87 In-house 84-132 (297) Show / Hide 
Range on Protein: 87-132
Range on HMM: 84-132/297
Sequence Identity: 24% (12 aa)

MELCENGA--LIDVLDDLYKRKEHLEESFVWEIIAQIADALAYLHDA-D
||.|..|   | . . . .. . .|.|. .| |. .|. .|...|.  .
MEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCG
Kinase GL50803_137706.AA TyrKc 15-261 17 5.8e-09 -77.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-261
Range on HMM: 1-280/280
Sequence Identity: 17% (53 aa)

YIRSSQL-----GAVYKAERLSDGATVAVKEISLRNIPDDQYVALCRPYELSRYL--AHPHLLVYHEAYVIPG-------ERCLLEMELCENGALIDVLD
     .|     | |||..      .|||| .           ...|  .. . |   ||...  . .... .       |  .. ||....|.| | | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

DLYKRKEHLEESFVWEIIAQIADALAYLHDADKPQGPVLHKAVRASSIFIGESG-LKLAKLGSTRHASEL-------TVFGTR-HKHDM------YLPPE
.  ..   |  .   ..  |||.  .|||.      .. |    |  . .|| .  | .  | .|   .         .  .. ||.         ..||
KHRPK---LCMKDLLSFCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

ATVRRTPTDKWDIWGLGCLAVEVCTLGTVYNDS--------STMLSRLSFD--LRPYSN--------ALAFMVASCLSVCDR---DRPSAVEIKGHI
.   .. | | |.|  | .  |..|.|              . .. ..     ...  |        . . |    .. ...   |||.  ||.  .
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_137706.AA Pkinase 22-140 24 2e-08 30.9 Pfam 13-131 (293) Show / Hide 
Range on Protein: 22-140
Range on HMM: 13-131/293
Sequence Identity: 24% (30 aa)

GAVYKAERLSDGATVAVKEISLRNIPDDQYVALCR--PYELSRYLAHPHLLVYHEAYVIPGERCLLEMELCENG-ALIDVLDDLY-KRKEHL--EESFVW
| |||. . ..| .||||.|..|.. ... ... |    .. . | ||. . .....  ... . . ||.||.|  ..|  | .  .|.  .  .|  . 
GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECK

EIIAQIADALAYLHDADKPQGPVLH
 .. ||. .|.|.|.       ..|
FYMYQILRGLEYCHSM-----GIIH
Kinase GL50803_137706.AA NAK 87-131 19 4.7e-08 22.89 In-house 93-138 (299) Show / Hide 
Range on Protein: 87-131
Range on HMM: 93-138/299
Sequence Identity: 19% (9 aa)

MELCENGALIDVLDDLYK-RKEHLEESFVWEIIAQIADALAYLHDA
||.|..| |.|...   .  . ...| ... |. ... .....|..
MEYCCHGSLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQC
Kinase GL50803_137706.AA KHS 10-161 24 1.9e-07 20.98 In-house 1-141 (258) Show / Hide 
Range on Protein: 10-161
Range on HMM: 1-141/258
Sequence Identity: 24% (37 aa)

HKNSVYIRSSQLGAVYKAERLSDGATVAVKEISLRNIPDDQYVALCRPYELSRYLAHPHLLVYHEAYVIPGERCLLEMELCENGALIDVLDDLYKRKEHL
.     . |   | |||| .   .  .||| | .   |.|.   . .   . .   || .. |. .|.   ..  . || |  |.| |.    |.   .|
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKME--PGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLR-RDKLWICMEYCGGGSLQDI----YHVTGPL

EESFVWEIIAQIADALAYLHDADKPQGPVLHKAVRASSIFIGESG-LKLAKLG
.|  .  .  ..  .|.|||   |     .|. ..   | . ..|  |||  |
SELQIAYVCRETLQGLHYLHSMGK-----MHRDIKGANILLTDQGDVKLADFG
Kinase GL50803_137706.AA Ciliate-E2-Unclassified 85-129 25 3.4e-07 21.05 In-house 98-160 (352) Show / Hide 
Range on Protein: 85-129
Range on HMM: 98-160/352
Sequence Identity: 25% (16 aa)

LEMELCENGALIDVLD----------DLYKRKEH---LEESFVW-----EIIAQIADALAYLH
. ||.||.| |.. .           ||......   ..|  .       ..||| ..| |||
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH
Kinase GL50803_137706.AA NEK 232-263 28 9e-06 16.66 In-house 255-286 (286) Show / Hide 
Range on Protein: 232-263
Range on HMM: 255-286/286
Sequence Identity: 28% (9 aa)

YSNALAFMVASCLSVCDRDRPSAVEIKGHIEI
||. |  .. ..| .   .|||. .|  .  |
YSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_137706.AA NEK2 87-129 37 0.000405 9.63 In-house 79-121 (319) Show / Hide 
Range on Protein: 87-129
Range on HMM: 79-121/319
Sequence Identity: 37% (16 aa)

MELCENGALIDVLDDLYKRKEHLEESFVWEIIAQIADALAYLH
|| || | |  .     | .  .||.|.| | .|.  ||   |
MEYCEGGDLSQMIKKCRKERQYMEEEFIWRIMFQLCTALQECH
Kinase GL50803_137706.AA NEK2 181-211 41 0.002013 7.25 In-house 230-260 (319) Show / Hide 
Range on Protein: 181-211
Range on HMM: 230-260/319
Sequence Identity: 41% (13 aa)

YLPPEATVRRTPTDKWDIWGLGCLAVEVCTL
|  ||   ..   .| ||| .|||  | |.|
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCAL
Kinase GL50803_137706.AA NEK2 232-263 34 0.003895 6.27 In-house 288-319 (319) Show / Hide 
Range on Protein: 232-263
Range on HMM: 288-319/319
Sequence Identity: 34% (11 aa)

YSNALAFMVASCLSVCDRDRPSAVEIKGHIEI
||  |   ... . | .. |||  || .|. |
YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_137706.AA Pkinase 197-261 13 0.005358 11.68 Pfam 194-293 (293) Show / Hide 
Range on Protein: 197-261
Range on HMM: 194-293/293
Sequence Identity: 13% (13 aa)

DIWGLGCLAVEVCTLGTVYNDS---------STMLSRLSFDLRPYS------------------------NALAFMVASCLSVCDRDRPSAVEIKGH--I
|.|..||.  |...  . . ..           .  ... .|.  .                         ..   . .|| ..  .||.| .|. |  .
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Ank GL50803_137706.AA Ank 424-439 50 0.259698 8.99 Pfam 1-16 (33) Show / Hide 
Range on Protein: 424-439
Range on HMM: 1-16/33
Sequence Identity: 50% (8 aa)

LGKTPLMFAAETGNTE
 | |||. |.. |.||
DGFTPLHLACRCGHTE
Ank GL50803_137706.AA Ank 475-496 40 0.005088 15.15 Pfam 1-22 (33) Show / Hide 
Range on Protein: 475-496
Range on HMM: 1-22/33
Sequence Identity: 40% (9 aa)

DEVTALMIAASANKVEAVKLLL
|  |.|..|.. . .| ||.||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_137706.AA Ank 505-526 31 0.00257 16.22 Pfam 1-22 (33) Show / Hide 
Range on Protein: 505-526
Range on HMM: 1-22/33
Sequence Identity: 31% (7 aa)

NGMTALMFAAMNDSVEAAKYLV
.|.|.|. |......| .|.|.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_137706.AA Ank 535-555 42 0.00043 19.02 Pfam 1-21 (33) Show / Hide 
Range on Protein: 535-555
Range on HMM: 1-21/33
Sequence Identity: 42% (9 aa)

EGKTALMLAVYNNATECVELL
.| |.|.||.... ||.|..|
DGFTPLHLACRCGHTEVVKML