Gene GL50803_137733 (G.lamblia)

GL50803_137733

Species: G.lamblia
Alias: GK195, GL50803_137733
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_137733.AA Protein None 297 None Fasta, JSON
GL50803_137733.kin_dom Protein Kinase Domain None 281 None Fasta, JSON

Protein domain

Protein domains of GL50803_137733.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_137733.AA S_TKc 11-292 18 5.2e-10 -30.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-292
Range on HMM: 1-231/231
Sequence Identity: 18% (56 aa)

YMELNELGCNGKLSLHSARVRSSGDAVSFWRIGISGLPDSVLDAIVVEVQHVKDYQHPALIKVTNVYADVDDLYVYIEMEPVNC---TLKDYAKQHIS--
|  |...|  .  . . .| ...|  |   .|          . |  |.|  |  .|| ..|   |. |    ..|. || ..    .|.|| |.. .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

AQSKVPEQVVWDTASSLLEGLSYLH--------------LLENPTPFLSTSSSSLMDATNNSRSVNIVGVHASITSSTVLVTQEGHIKLGVFGLSATLDE
 ... || ...  .  ....| |.|              || .                                          |||.. |||.. |  
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------------------------------------HIKICDFGLARQL--

LYSLGYYDVPHCFRAPEVTKYKHSL-KSDVWALGATLVDMCVGTLSSRDDFPVNPGSLEHPDLSDYLAQYTPRLRKFLGVCLRFDVTKRHLTNGLMD-E-
      . .   ..||||   ...  |.|.|..| .|  |..|    .          ..  . . .   .| .. |.  ||..| .||     ..  | 
----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP----------QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

----LASL
       .
DIKCHPWF
Kinase GL50803_137733.AA Pkinase 170-279 19 5.3e-07 25.84 Pfam 139-281 (293) Show / Hide 
Range on Protein: 170-279
Range on HMM: 139-281/293
Sequence Identity: 19% (28 aa)

VLVTQEGHI----KLGVFGLSATLDELYSLGYYDVPHC---FRAPEV--TKYKHSLKSDVWALGATLVDMCVGTLSSRDD--------FPVNPGSLEHPD
.|. ..|||    |.. |||.. .| . . . .... .   ..||||  .  ... |.|.|..| .|  |. | .  ...          .    .. | 
ILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPL

LSDYLAQYT-------------------PRLRKFLGVCLRFDVTKR
 .|.   ..                   . ...|.  ||..| .||
HFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR
Kinase GL50803_137733.AA STE 206-279 21 1.3e-05 15.95 In-house 230-345 (359) Show / Hide 
Range on Protein: 206-279
Range on HMM: 230-345/359
Sequence Identity: 21% (25 aa)

APEVTKY-------KHSLKSDVWALGATLVDMCVGTLSSRDDFPV----NPGSL---------------EHPDLSDYLA----------------QYTPR
|||| .        ... |.|.| || |.. |. |     |  |     .                   ..| | | |                 ...| 
APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE

LRKFLGVCLRFDVTKR
.. |.  ||. |  ||
FKDFINKCLQKDPNKR
Kinase GL50803_137733.AA TK 170-227 17 2.6e-05 12.93 In-house 271-384 (486) Show / Hide 
Range on Protein: 170-227
Range on HMM: 271-384/486
Sequence Identity: 17% (20 aa)

VLVTQEGH-----------IKLGVFGLSA-----TLDELYSLGYYDVPHCFR------------------------------APEVTKY----------K
.||.....           .|.. ||||         ..|| ..| . .  .                              |||. ..          |
CLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGK

HSLKSDVWALGATL
.. |||||..| ..
FTTKSDVWSFGVLM
Kinase GL50803_137733.AA MEK1 161-233 31 2.9e-05 13.38 In-house 120-192 (297) Show / Hide 
Range on Protein: 161-233
Range on HMM: 120-192/297
Sequence Identity: 31% (23 aa)

VHASITSSTVLVTQEGHIKLGVFGLSATLDELYSLGYYDVPHCFRAPEVTKYKH-SLKSDVWALGATLVDMCVG
.|  .  | .||  .| |||  || |  | .     .      . .||  .  | ...||.|..|  ||.| .|
MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT-RSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIG
Kinase GL50803_137733.AA STE-Unique 170-234 16 3.3e-05 13.82 In-house 436-550 (616) Show / Hide 
Range on Protein: 170-234
Range on HMM: 436-550/616
Sequence Identity: 16% (19 aa)

VLVTQEG-----HIKLGVFGLSATLDEL---------------------------------------YSLGYYDVPHCFRAPEVTKYK------HSLKSD
.. .|.|     ..|.. ||.. .. .                                        |.. |     |  .|||.  .      ...|.|
IFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVD

VWALGATLVDMCVGT
.| ||...  ||.|.
IWSLGCMCFHMCCGC
Kinase GL50803_137733.AA SgK071 206-230 52 4.3e-05 13.63 In-house 190-214 (283) Show / Hide 
Range on Protein: 206-230
Range on HMM: 190-214/283
Sequence Identity: 52% (13 aa)

APEVTKYKHSLKSDVWALGATLVDM
|||| .  .| |||.| ||  . ||
APEVLEFPFSQKSDIWSLGCIILDM
Kinase GL50803_137733.AA MEK5 161-233 32 0.000143 12.52 In-house 115-187 (254) Show / Hide 
Range on Protein: 161-233
Range on HMM: 115-187/254
Sequence Identity: 32% (24 aa)

VHASITSSTVLVTQEGHIKLGVFGLSATLDELYSLGYYDVPHCFRAPE-VTKYKHSLKSDVWALGATLVDMCVG
.|  .  | .||  .|.|||  || |. | .  .  |      . ||| .   .  . ||||.||  ...| .|
MHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGT-NAYMAPERISGDQYGIHSDVWSLGIFFMEMATG
Kinase GL50803_137733.AA PLK 206-224 50 0.000173 10.65 In-house 168-189 (258) Show / Hide 
Range on Protein: 206-224
Range on HMM: 168-189/258
Sequence Identity: 50% (11 aa)

APEV---TKYKHSLKSDVWALG
||||   .|  ||...|.|.||
APEVLDGNKQGHSYEVDCWSLG
Kinase GL50803_137733.AA PLK2 204-224 54 0.000212 9.77 In-house 169-190 (257) Show / Hide 
Range on Protein: 204-224
Range on HMM: 169-190/257
Sequence Identity: 54% (12 aa)

FRAPEV-TKYKHSLKSDVWALG
. ||||  .  || .||.||||
YIAPEVLNRQGHSCESDIWALG
Kinase GL50803_137733.AA SAK 161-234 30 0.000215 10.57 In-house 122-197 (254) Show / Hide 
Range on Protein: 161-234
Range on HMM: 122-197/254
Sequence Identity: 30% (23 aa)

VHASITSSTVLVTQEGHIKLGVFGLSATLD--ELYSLGYYDVPHCFRAPEVTKYKHSLKSDVWALGATLVDMCVGT
.|  .| | .|.| . |.|.  ||| . |   .   .     |       .|.  | |.||||.||  |  . .|.
MHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGR
Kinase GL50803_137733.AA Ciliate-E2-Unclassified 170-224 18 0.000217 11.16 In-house 175-257 (352) Show / Hide 
Range on Protein: 170-224
Range on HMM: 175-257/352
Sequence Identity: 18% (15 aa)

VLVTQEG---HIKLGVFGLSATLDEL---------------YSLGYYDV-PHCFR----APEVTKY-KHSLK----SDVWALG
.|....|   .||.  ||.|  ...                . . .  .   ..     |||| .  ... .    .|.|.||
ILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG
TyrKc GL50803_137733.AA TyrKc 11-289 14 0.000714 -160.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-289
Range on HMM: 1-280/280
Sequence Identity: 14% (48 aa)

YMELNELG-------CNGKLSLHSARV---RSSGDAVSFWRIGISGLPDSVLDAIVVEVQHVKDY--QHPALIKVTNVYADV-------DDLYVYIEMEP
   . .||       . |...     |       ||               . ..  | .  . .  .|| ...   |  .        . |..  |  |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMP

VNCTLKDYAKQHISAQSKVPEQVVWDTASSLLEGLSYLHLLENPTPFLSTSSSSLMDATNNSRSVNIVGVHASITSST----------VLVTQEGHIKLG
    |||| . |      .. .   . .    .| .|||                                                 .||. ....| .
H-GDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK------------------------------------NCIHRDLAARNCLVGENHTVKIS

VFGLSATLDEL----YSLGYYDVPH--CFR--------APEVTKYK-HSLKSDVWALG------ATLVDMCVGT-----LSSRD--DFPVNPGSLEHPDL
 ||||  ...      |  ||..    . .        |||. .|.  . |||||. |       |. ..         .| ..   .  . . .. |. 
DFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPN

-----SDYLAQYTPRLRKFLGVCLRFDVTKRHLTNGLMDEL
     .      .. . .    | ..|  .|   . . ...
DYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_137733.AA Ciliate-E2-Unclassified 65-130 27 0.002026 7.75 In-house 76-160 (352) Show / Hide 
Range on Protein: 65-130
Range on HMM: 76-160/352
Sequence Identity: 27% (23 aa)

YQHPALIKVTNVYADVDDLYVYIEMEPV-NCTLKDYAKQ------------HISAQSK-VPEQVVW-----DTASSLLEGLSYLH
..|| ...|  .|.. |. ..|| || . . .|..| |.            |   |.| ..|| .      . .  .|.||.|||
LNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH