Gene GL50803_13981 (G.lamblia)
GL50803_13981
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_13981.AA | Protein | None | 1109 | None | Fasta, JSON |
| GL50803_13981.kin_dom | Protein Kinase Domain | None | 267 | None | Fasta, JSON |
Protein domains of GL50803_13981.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_13981.AA | Ciliate-E2 | 189-278 | 25 | 1.8e-16 | 53.03 | In-house | 253-365 (365) | Show / Hide |
Range on Protein: 189-278 Range on HMM: 253-365/365 Sequence Identity: 25% (30 aa) YMAPEILRREK---------YTDKADVWSLGCVAYELCTLTL-FTKIPSSEVIRQSLDGSGKHI------------SLPNYSTSLEALVNK----MLTFN |||||||...| |. |.|.||||.. ||... . | . . . .| . .. | . | . | .| || . YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKD EKERIS-SHEILLWPEM ...||. .|| .| . PEKRITGWEQILNHPWF |
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| Kinase | GL50803_13981.AA | ULK | 189-278 | 28 | 1.8e-15 | 50.57 | In-house | 217-329 (329) | Show / Hide |
Range on Protein: 189-278 Range on HMM: 217-329/329 Sequence Identity: 28% (33 aa) YMAPEILR----REKYTDK-ADVWSLGCVAYELCTLTLFTKIP----SSEVI---RQSLDGSGKHI---------------SLPNYSTSLEALVNKMLTF ||||.|| ...|.|. .|.|||||. ||. |. | | .. . |.| .. . . |. | .. | .||.. YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEM----LYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQY NEKERISSHEILLWPEM .||.||| .|.. | . DEKDRISWEELFNHPWF |
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| Kinase | GL50803_13981.AA | Pkinase | 189-273 | 20 | 4.9e-15 | 54.26 | Pfam | 177-288 (293) | Show / Hide |
Range on Protein: 189-273 Range on HMM: 177-288/293 Sequence Identity: 20% (23 aa) YMAPEILR-REKYTDKADVWSLGCVAYELCT-LTLFTKI------PSSEVIRQSLDGSGKHISLPNYS-------------------TSLEALVNKMLTF |||||..| ...|. |.|.||.||. ||... ..| ..|.. ... . . .| .. .....|.. YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK NEKERISSHEIL . |.|.. ..|| DPKKRPTAEQIL |
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| Kinase | GL50803_13981.AA | NEK | 189-219 | 58 | 6.7e-15 | 49.26 | In-house | 190-220 (286) | Show / Hide |
Range on Protein: 189-219 Range on HMM: 190-220/286 Sequence Identity: 58% (18 aa) YMAPEILRREKYTDKADVWSLGCVAYELCTL ||.||... ..|. |.|.|||||| ||.||| YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTL |
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| Kinase | GL50803_13981.AA | NEK2 | 189-219 | 51 | 7.6e-15 | 46.31 | In-house | 230-260 (319) | Show / Hide |
Range on Protein: 189-219 Range on HMM: 230-260/319 Sequence Identity: 51% (16 aa) YMAPEILRREKYTDKADVWSLGCVAYELCTL || || . . || .| |.||.||. ||.|.| YMSPEQMHGQKYNEKSDIWSVGCLIYEMCAL |
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| Kinase | GL50803_13981.AA | ULK | 189-278 | 29 | 7.8e-14 | 45.53 | In-house | 213-324 (324) | Show / Hide |
Range on Protein: 189-278 Range on HMM: 213-324/324 Sequence Identity: 29% (34 aa) YMAPEILR----REKYTDK-ADVWSLGCVAYELCTLTLFTKIP----SSEVI--RQSL------------DGSGKHI---SLPNYSTSLEALVNKMLTFN ||||.|| ...|.|. .|.|||||. ||. |. | | .. . |.| . .. . |. | .. | .||... YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEM----LYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYD EKERISSHEILLWPEM ||.||| .||. | . EKDRISWEEIFNHPWF |
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| S_TKc | GL50803_13981.AA | S_TKc | 10-281 | 15 | 2e-13 | 20.03 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-281
Range on HMM: 1-231/231
Sequence Identity: 15% (50 aa)
YHILEPYSVEPHIQVSLAKNKETGELV-----DYHNICYEKLLVHPQEPDFIALERYMQL-RHPCLLNILDVYHNKPARKVVVITERSPS--HELADLIT
|.||.. .| ....|.||..| . . | |. . .|| . ...||... .. ...| . .| |.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKKHHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIK
NYKSSG--TLIPEEQIWAILYSVCAGLSYCHSN-------------------------SKHNCPKVPKLVHRHVSSFSILIGENTSMLTKLRFPDLFTLL
.... | .|| ... ..| .| .| ||||. ...
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL--------------------------------------
DIRSISESPASHLVYMAPEILRREKYTD-KADVWSLGCVAYELCT-LTLFTKIPSSEVIRQSLDGSGKHISLPNYSTSLEALVNKMLTFNEKERISSHEI
. . |||||.| .|. |.|.||.||. ||... ..| ..... . | .. ...|.|... ..|.. |.
------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EA
LL----WPEMQTV
| . .. .
LQDEWDIKCHPWF
|
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| Kinase | GL50803_13981.AA | STE | 189-273 | 18 | 2e-13 | 43.87 | In-house | 228-352 (359) | Show / Hide |
Range on Protein: 189-273 Range on HMM: 228-352/359 Sequence Identity: 18% (23 aa) YMAPEILRR------EKYTDKADVWSLGCVAYELCTLTLF-TKIPSSEVIRQSLDGS-------------GKHISLPN--------------------YS .||||.... .|. |.|.|||||.. |..| . . ... . .... |.. .||. .| WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWS TSLEALVNKMLTFNEKERISSHEIL .. .|| |. . ..| .... | PEFKDFINKCLQKDPNKRPTASQLL |
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| Kinase | GL50803_13981.AA | Ciliate-B1 | 188-218 | 53 | 9.9e-13 | 41.0 | In-house | 193-224 (290) | Show / Hide |
Range on Protein: 188-218 Range on HMM: 193-224/290 Sequence Identity: 53% (17 aa) VYMAPEILR-REKYTDKADVWSLGCVAYELCT .|||||||. . |. | | ||.|| .||. | NYMAPEILNFNQQYDKKVDIWSFGCIMYEIIT |
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| Kinase | GL50803_13981.AA | Ciliate-E2-Unclassified | 189-278 | 22 | 9.6e-12 | 37.03 | In-house | 228-352 (352) | Show / Hide |
Range on Protein: 189-278 Range on HMM: 228-352/352 Sequence Identity: 22% (28 aa) YM----APEILRREKYTDK----ADVWSLGCVAYELCTLTLFTKIPS-----------------SEVIRQSLDGSGKHISLPN----YSTSLEA--LVN- || |||.|....| .. .|.||||...||... .. . .. ...... ... . . |. . | || ..| YMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIND ---KMLTFNEKERISSHEILLWPEM ||| | ..||. .|| | . LLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | GL50803_13981.AA | NEK1 | 189-221 | 57 | 1.5e-11 | 36.54 | In-house | 187-219 (276) | Show / Hide |
Range on Protein: 189-221 Range on HMM: 187-219/276 Sequence Identity: 57% (19 aa) YMAPEILRREKYTDKADVWSLGCVAYELCTLTL | ||| |. | |.|||||| ||||||.. YLSPEICQNKPYNNKSDIWSLGCVLYELCTLKH |
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| Kinase | GL50803_13981.AA | CAMK | 189-214 | 31 | 3.6e-09 | 24.96 | In-house | 285-325 (425) | Show / Hide |
Range on Protein: 189-214 Range on HMM: 285-325/425 Sequence Identity: 31% (13 aa) YMA-PEILRR--------------EKYTDKADVWSLGCVAY ||| ||.|.. . |. |.|.||.|.. | YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY |
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| Kinase | GL50803_13981.AA | Pkinase | 64-146 | 20 | 8.7e-07 | 25.08 | Pfam | 57-132 (293) | Show / Hide |
Range on Protein: 64-146 Range on HMM: 57-132/293 Sequence Identity: 20% (18 aa) LRHPCLLNILDVYHNKPARKVVVITERSPSH----ELADLITNYKSSGTLI--PEEQIWAILYSVCAGLSYCHSNSKHNCPKVPKLVHR |.||. . ..|.... ... ...| . .|.|.|. .... . .|... ..| .. || ||||. . .|| LNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM---------GIIHR |
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| Kinase | GL50803_13981.AA | NEK | 96-132 | 32 | 3e-06 | 18.24 | In-house | 94-133 (286) | Show / Hide |
Range on Protein: 96-132 Range on HMM: 94-133/286 Sequence Identity: 32% (13 aa) LADL---ITNYKSSGTLIPEEQIWAILYSVCAGLSYCHSN |... | ..| .|....||||| ... | .| |.|.. LYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDR |
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| Kinase | GL50803_13981.AA | TyrKc | 23-276 | 16 | 1e-05 | -130.27 | SMART | 14-280 (280) | Show / Hide |
Range on Protein: 23-276 Range on HMM: 14-280/280 Sequence Identity: 16% (48 aa) QVSLAKNKETGELVDYHNICYE---KLLVHPQEPDFIALER----YMQL--RHPCLLNILDVYHNK-----PARKVVVITERSPSHELADLITNYKSSGT .| ... | .. | | . .. | ..| .||...... | . . . ...| | | | . ... EVYKGTWK------------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-- LIPEEQIWAILYSVCAGLSYCHSNSKHNCPKVPKLVHRHVSSFSILIGENTSM------LTKLRFPD-LF----TLLDIRS--ISE--SPASHLVYMAPE .. .. . . ...| .| ||. ...|| .|.||| . |.. | . .. . | . |||| -LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP---IRWMAPE ILRREKYTDKADVWSLGCVAYELCTL--TLFTK-----IPSSEVIRQSLDGSGKHISLPNY-------STSLEALVNKMLTFNEKERISSHEILLWP .. |.| | |||| | . .|..|. . .. .|||.. .| . .| .. . . . .. ..| . || CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | GL50803_13981.AA | Pkinase_Tyr | 190-219 | 46 | 1.4e-05 | 19.54 | Pfam | 181-210 (270) | Show / Hide |
Range on Protein: 190-219 Range on HMM: 181-210/270 Sequence Identity: 46% (14 aa) MAPEILRREKYTDKADVWSLGCVAYELCTL |||| .. |.| | |||| | . .|..|. MAPECINYGKFTTKSDVWSFGVLMWEIFTY |
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| Kinase | GL50803_13981.AA | CAMK | 63-132 | 16 | 2.2e-05 | 12.51 | In-house | 94-198 (425) | Show / Hide |
Range on Protein: 63-132 Range on HMM: 94-198/425 Sequence Identity: 16% (17 aa) QLRHPCLLNILDVYH------------NKP------ARKVVVIT---ERSPSHEL----ADLITNYKSSG-----------TLIPEEQIWAILYSVCAGL .|.||.......|| . .... .. | . || | |. .. | ..|.. . .| .. KLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAV SYCHSN ||||. HYCHSH |
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| Kinase | GL50803_13981.AA | NEK1 | 245-278 | 38 | 0.000394 | 10.42 | In-house | 243-276 (276) | Show / Hide |
Range on Protein: 245-278 Range on HMM: 243-276/276 Sequence Identity: 38% (13 aa) PNYSTSLEALVNKMLTFNEKERISSHEILLWPEM | ||. |. || .|. | . | | . || | . PHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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| Kinase | GL50803_13981.AA | NEK | 239-278 | 29 | 0.000526 | 10.45 | In-house | 243-286 (286) | Show / Hide |
Range on Protein: 239-278 Range on HMM: 243-286/286 Sequence Identity: 29% (13 aa) G-KHISLP-N--YSTSLEALVNKMLTFNEKERISSHEILLWPEM | . .| . ||. | |...||. . ..| | .|| | . GPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_13981.AA | CAMK | 246-273 | 25 | 0.00098 | 7.12 | In-house | 393-420 (425) | Show / Hide |
Range on Protein: 246-273 Range on HMM: 393-420/425 Sequence Identity: 25% (7 aa) NYSTSLEALVNKMLTFNEKERISSHEIL . |.. |..|||. . ..|.. ...| FVSQECKDLIRKMLQVDPEKRMTIEQCL |
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| Kinase | GL50803_13981.AA | Ciliate-E2 | 23-132 | 13 | 0.002876 | 7.05 | In-house | 14-179 (365) | Show / Hide |
Range on Protein: 23-132 Range on HMM: 14-179/365 Sequence Identity: 13% (23 aa) QVSLAKNKETGELV----------------DYHNICYEKLLVHPQEPDFIALERYMQ------------------LRHPCLLNILDVYHNKPARKVVVIT .| ..|........ . . |.. ..... .| | .. | || .... ... .| .. .. SVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVM ERSPSHELADLIT-NYKSSGTLIP------EEQIWAILYSVCA---------------GLSYCHSN | .| |.| |.|... |. |..| | . .. .| |.||. EYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK |
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| Kinase | GL50803_13981.AA | STE | 96-132 | 31 | 0.006023 | 6.39 | In-house | 124-171 (359) | Show / Hide |
Range on Protein: 96-132 Range on HMM: 124-171/359 Sequence Identity: 31% (15 aa) LADLIT-NYKSSGTL---------IPEEQIWAILYSVCAG-LSYCHSN | |.| .|. ..| .||.|| .|..... | |.| ||. LDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSH |
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| Kinase | GL50803_13981.AA | NEK2 | 96-130 | 31 | 0.006241 | 5.57 | In-house | 87-121 (319) | Show / Hide |
Range on Protein: 96-130 Range on HMM: 87-121/319 Sequence Identity: 31% (11 aa) LADLITNYKSSGTLIPEEQIWAILYSVCAGLSYCH |. .|. ... . ..|| || |. | | || LSQMIKKCRKERQYMEEEFIWRIMFQLCTALQECH |
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| Kinase | GL50803_13981.AA | Ciliate-E2-Unclassified | 59-132 | 16 | 0.009492 | 5.39 | In-house | 68-162 (352) | Show / Hide |
Range on Protein: 59-132 Range on HMM: 68-162/352 Sequence Identity: 16% (16 aa) ERYMQ---LRHPCLLNILDVYHNKPARKVVVITERSPSHELADLITNYKS-------------SGTLIPEEQIW-----AILYSVCAGLSYCHSN .. || | ||... . ..|. . .. ..| . .| . |...|. .. ..|.|. ... .. ||.|.|.. NKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHK |
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| Kinase | GL50803_13981.AA | NEK2 | 247-278 | 31 | 0.01429 | 4.34 | In-house | 288-319 (319) | Show / Hide |
Range on Protein: 247-278 Range on HMM: 288-319/319 Sequence Identity: 31% (10 aa) YSTSLEALVNKMLTFNEKERISSHEILLWPEM ||. | ... |. . . | | ||| | YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI |
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| Ank | GL50803_13981.AA | Ank | 744-765 | 31 | 0.017004 | 13.26 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 744-765 Range on HMM: 1-22/33 Sequence Identity: 31% (7 aa) NDSTPLMVAASADNVDQVRFLL . |||..|.. .... |..|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_13981.AA | Ank | 775-796 | 40 | 0.000479 | 18.85 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 775-796 Range on HMM: 1-22/33 Sequence Identity: 40% (9 aa) KGITALMMAASAGHVRSVKLLI | |.|..|.. ||.. ||.|. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_13981.AA | Ank | 806-836 | 36 | 5e-06 | 26.12 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 806-836 Range on HMM: 1-33/33 Sequence Identity: 36% (12 aa) DGMTALMYAAHFGKLEAVKELVE--AEHNKVNS ||.|.|..|.. | .| ||.|.. |. | .. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_13981.AA | Ank | 837-857 | 33 | 0.002233 | 16.44 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 837-857 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) AGLTALMIAAEFGNVDIVNFL | |.|..|.. |....| .| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_13981.AA | Ank | 868-890 | 34 | 0.0271 | 12.53 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 868-890 Range on HMM: 1-23/33 Sequence Identity: 34% (8 aa) SRETAMMRAAKLGHVDIVKELLG .|. . |.. ||...||.||. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_13981.AA | Ank | 899-919 | 33 | 0.000438 | 18.99 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 899-919 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) DGYTALMIAIQCNNSKIAALL ||.|.|..|..|.. ... .| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_13981.AA | Ank | 930-960 | 21 | 0.021812 | 12.87 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 930-960 Range on HMM: 1-33/33 Sequence Identity: 21% (7 aa) AGWTALMSCATNSNVEAARILVN--HEANMRDK |.|.|. . . ..| .. |.. . |..|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_13981.AA | Ank | 961-982 | 31 | 0.029445 | 12.4 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 961-982 Range on HMM: 1-22/33 Sequence Identity: 31% (7 aa) YDETALMKAAKSGAVNVARILL . .|.|. |...| ..|.. || DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_13981.AA | Ank | 992-1013 | 45 | 0.000121 | 21.01 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 992-1013 Range on HMM: 1-22/33 Sequence Identity: 45% (10 aa) DGKTALMCAAEAGHLPLVSLLL || |.|..|.. ||. |..|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_13981.AA | Ank | 1023-1044 | 40 | 0.000236 | 19.96 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 1023-1044 Range on HMM: 1-22/33 Sequence Identity: 40% (9 aa) DGTTALMCAAQSNCIEAVRLLL || |.|..|......| |..|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_13981.AA | Ank | 1054-1086 | 39 | 0.000749 | 18.15 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 1054-1086 Range on HMM: 1-33/33 Sequence Identity: 39% (13 aa) DGETALIRAIRWSRPEAVQELVKDEYDLNMYDD ||.|.| |.|. ..| |..|.. |.|. || DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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