Gene GL50803_14014 (G.lamblia)
GL50803_14014
Group:
Other
Family:
Other-Unique
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_14014.AA | Protein | None | 586 | None | Fasta, JSON |
| GL50803_14014.kin_dom | Protein Kinase Domain | None | 197 | None | Fasta, JSON |
Protein domains of GL50803_14014.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_14014.AA | Pkinase | 79-187 | 22 | 2.4e-16 | 58.9 | Pfam | 38-158 (293) | Show / Hide |
Range on Protein: 79-187 Range on HMM: 38-158/293 Sequence Identity: 22% (28 aa) SKQQQQEAVR--EFMFHQALQHPNLVRCLCTSQEGSELKILLEHCKYY----DLD-----HYTGVF--TAYTAGRIVAQLFSVLHYLHTLPYSSLFFVHG .....|...| | .. |.||| ||.... ...... . .|.| || .. |.| . .. ... |... | |.| ..| KSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM-----GIIHR DVKRSNCFLDQDRDQ----KLGDFGS |.| .|...|.. . |..|||. DLKPENILIDNNGHIDACVKICDFGL |
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| S_TKc | GL50803_14014.AA | S_TKc | 37-313 | 14 | 5.7e-10 | -30.73 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 37-313
Range on HMM: 1-231/231
Sequence Identity: 14% (45 aa)
FTSSRLLSINQNRRVEEGIAVFGDPARRAKSYPVVMKTLYFGSKQQQQEAVREFMFHQALQHPNLVRCLCTSQEGSELKILLEHCKY-----YDLDHYTG
.. |.. .| .. . | .| . . . || .. .|||.|... . |. ..| . .|.| .|. . |
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
V------FTAYTAGRIVAQLFSVLHYLHTLPYSSLFFVHGDVKRSNCFLDQDRDQKLGDFGSTHFQRYDAASLQQVPAEGHHGVTRSYLPYFRDGTP---
|. .| ....|... | |.| |. ..| |.| .| .||. |..|||. . . |||
RHGLRFPFPE-HARFYMYQICCALEYCH-----SHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------TTFCGTPWYM
-----VVSQ-CTDIWAATLVSISILGDLTSFFQFTNSASLTHYLQNYHIDLLDALSGHDPRYAEFLLYFSTDEAI-------EAYYSSRSTDHDAVR---
. |.|. . . | |. .. . ... . ..||. . . | | .| .
APEVLGYGKCKCDWWSCGCILYEMLC-GYPPFP--------QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW
-ARLRAFM
... ..
DIKCHPWF
|
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| Kinase | GL50803_14014.AA | PLK1 | 70-186 | 25 | 3e-06 | 16.16 | In-house | 31-144 (253) | Show / Hide |
Range on Protein: 70-186 Range on HMM: 31-144/253 Sequence Identity: 25% (31 aa) VVMKTLYFGSKQQQQEAVREFMFHQALQHPNLVRCLCTSQEGSELKILLEHCK---YYDLDHYTGVFTAYTAGRIVAQLFSVLHYLHTLPYSSLFFVHGD || |.| ..|... . .| |. |.|...|. . . . |.|| |. .|. . | . . . |. .||| . .| | VVPKSLLIKQHQRDKMT-QEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHN-----NKIIHRD VKRSNCFLDQDRDQKLGDFG .| | ||... . |.|||| LKLGNLFLNDHLQVKIGDFG |
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| Kinase | GL50803_14014.AA | TK | 70-129 | 19 | 6e-06 | 15.14 | In-house | 57-149 (486) | Show / Hide |
Range on Protein: 70-129 Range on HMM: 57-149/486 Sequence Identity: 19% (18 aa) VVMKTLYFGSKQQQQEA-----------------VREFMFHQALQHPNLVRCL--CTSQEG----------SELKILLEHCKYYD----LDHY | |... .. |..... ... | |....|||.||.. || .|. . |..|.... | |..| VKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDY |
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| Kinase | GL50803_14014.AA | TK-Unique | 79-129 | 28 | 1.7e-05 | 15.05 | In-house | 43-95 (294) | Show / Hide |
Range on Protein: 79-129 Range on HMM: 43-95/294 Sequence Identity: 28% (15 aa) SKQQQQEAVREFMFHQALQ-HPNLVRCLCTSQEGS-ELKILLEHCKYYDLDHY .....|. .|. ....| |||.|.|| ... . |..|.| . .|.|| TDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHY |
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| Kinase | GL50803_14014.AA | CAMK | 79-153 | 18 | 0.000145 | 9.84 | In-house | 71-196 (425) | Show / Hide |
Range on Protein: 79-153
Range on HMM: 71-196/425
Sequence Identity: 18% (23 aa)
SKQQQQEAVREFMFHQALQ-------HPNLVRCLC---------------TSQE-----GSELKILL---EHCKYY----DLDHYT--------------
. . ... || .. || |||..... | . ... . . |.| || |
RPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFD
----GVFTAYTAGRIVAQLFSVLHYLH
| || | |.. |. | .||.|
IVERGRFTEREARRYFRQICSAVHYCH
|
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| TyrKc | GL50803_14014.AA | TyrKc | 37-241 | 14 | 0.000211 | -151.45 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 37-241
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)
FTSSRLLSINQNRRVEEGIAVFGDPARRAKSYPVVMKTLYFGSKQQQQEAVREFMFHQAL--QHPNLVRCL--CTSQEG-----SELKILLEHCKYYDLD
| . | . .| .|.. ..| |.| .. ... || | .|||.||.. ||.|.. | |..|.... ||.
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK
HYT----GVFTAYTAGRIVAQLFSVLHYLHTLPYSSLFFVHGDVKRSNCFLDQDRDQKLGDFGSTHFQ----------RYDAA----SLQ----------
.| . .. . . | . ||| ..| | || .. .. | .||| . . | . .
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP
----------------------------QVPAEG-----------HHGVTRSYLPYFRDG----------TPVVSQCTDIWAA---------TLVSISIL
| | .| .. | . | . . . . . .. |.. .. ....
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | GL50803_14014.AA | TAO | 141-187 | 36 | 0.000355 | 9.22 | In-house | 104-145 (254) | Show / Hide |
Range on Protein: 141-187 Range on HMM: 104-145/254 Sequence Identity: 36% (17 aa) IVAQLFSVLHYLHTLPYSSLFFVHGDVKRSNCFLDQDRDQKLGDFGS | . . |.||| |. .| |.| .| | .. ||.|||| ICHGALQGLRYLH-----SHKMIHRDIKAGNILLTEHGQVKLADFGS |
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| Kinase | GL50803_14014.AA | NuaK | 163-186 | 45 | 0.000753 | 5.41 | In-house | 121-144 (252) | Show / Hide |
Range on Protein: 163-186 Range on HMM: 121-144/252 Sequence Identity: 45% (11 aa) VHGDVKRSNCFLDQDRDQKLGDFG .| | | | |||. . | ||| CHRDLKLENILLDQNCNAKIADFG |
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