GL50803_14044

Species: G.lamblia
Alias: GL50803_14044, GK215
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_14044.AA Protein None 593 None Fasta, JSON
GL50803_14044.kin_dom Protein Kinase Domain None 266 None Fasta, JSON

Protein domain

Protein domains of GL50803_14044.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_14044.AA S_TKc 23-274 17 7.4e-10 -32.34 SMART 15-231 (231) Show / Hide
Range on Protein: 23-274
Range on HMM: 15-231/231
Sequence Identity: 17% (48 aa)

VCLVRSQLSSKLFVIRGIYLHSMNSAQLNALAQLRKLVDQLEHPVLLRHFKIDQGIANKCFVHSEYCEL--GSLELELVQRREDG--EYINELLIWEYIA
|...|   . ... |  |          ...  .. |     || . . . . |   .. ..  |||.   |.|   ...|.  |   ...|  .. |..
VYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY

QLVDITLFIVSQVGVENMDGQFFLYRFFKPSNIFLCENGCIKTGDYGF---FSPPTRHTEVFRVGKWINYVAPEVFRGQSPTL-RSAIFSFGCVVYALCT
|...         ..| .  . ...|  ||.||.|.|  .|| .| |.   .         | .  |  |.||||.   . .  .. . |.||..| ...
QICC---------ALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPW--YMAPEVL---GYGKCKCDWWSCGCILYEMLC

CTDPHLFDVGETEIVPPRVSPSLVIPIQYSLALRTLMHDMLKVSPKDRITFSKIAR-------HKLV
   |   .. ..  .              |  .. ..  .|.. |..|.|  .. .       |  .
GYPPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_14044.AA SAK 184-274 27 1e-09 29.0 In-house 165-254 (254) Show / Hide
Range on Protein: 184-274
Range on HMM: 165-254/254
Sequence Identity: 27% (25 aa)

NYVAPEVFRGQSPTLRSAIFSFGCVVYALCTCTDPHLFDVGETEIVPPRVSPSLVIPIQYSLALRTLMHDMLKVSPKDRITFSKIARHKLV
||..||.    .  |.| ..| ||..| | . . |   |  .. .    ..   ..|   |.  . |.| ||.  |..||| | .  |  .
NYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPFDTDAVKNTLNKVMMA-EYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM

Kinase GL50803_14044.AA TKL 147-218 17 5e-09 28.66 In-house 167-288 (364) Show / Hide
Range on Protein: 147-218
Range on HMM: 167-288/364
Sequence Identity: 17% (21 aa)

KPSNIFLCENGC--------------IKTGDYGFFSPPTRHTEVFR--------------------VGKWINYVAPEVFRGQ----------------SP
|..||.. ||.               .| .|.|.    .....  .                    .. .... ||||.|||                . 
KSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEY

TLRSAIFSFGCVVYALCTCTDP
. .. ..||| | . ..|.  |
SEKCDVYSFGIVLWEILTRCRP

Kinase GL50803_14044.AA Pkinase 147-274 20 1.2e-08 31.63 Pfam 135-293 (293) Show / Hide
Range on Protein: 147-274
Range on HMM: 135-293/293
Sequence Identity: 20% (34 aa)

KPSNIFLCENGCI----KTGDYGF--F--SPPTRHTEVFRVGKWINYVAPEVFR-GQSPTLRSAIFSFGCVVYALCTCTDPHLFDV------GETEIVPP
||.||.. .|| |    | .| |.  .    . . . .| .  |  |.|||| | ||  . .. ..|.||..| ...   |   .        . ...  
KPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW--YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICR

RVSPSLVIPIQYS---------------------LALRTLMHDMLKVSPKDRITFSKIARHKLV
. .| |  .....                      ... .. ..|.. ||.|.|.  |  |. .
IMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase GL50803_14044.AA Ciliate-E2 147-274 16 1.3e-08 25.65 In-house 188-365 (365) Show / Hide
Range on Protein: 147-274
Range on HMM: 188-365/365
Sequence Identity: 16% (31 aa)

KPSNIFLCENGCIKTGDYGFFS----PPTRHTEVFRVGK-----------------------------WINYVAPEVFRGQS---------PTLRSAIFS
||.||..     ||  | |.      .  ..|. ..  |                               .|.|||...|..          .  . |.|
KPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS

FGCVVYALCTCTDPHLFDVGETEIVPPRVSPSLV--------------IPIQYSLALRTLMHD----MLKVSPKDRIT-FSKIARHKLV
.|.. | ...   |      . .|    .. .                .. . |.    |.      ||.. |. ||| ...|  |.  
LGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase GL50803_14044.AA BARK 131-212 38 3.4e-07 20.47 In-house 114-195 (264) Show / Hide
Range on Protein: 131-212
Range on HMM: 114-195/264
Sequence Identity: 38% (33 aa)

VGVENMDGQFFLYRFFKPSNIFLCENGCIKTGDYGF---FSPPTRHTEVFRVGKWINYVAPEVF-RGQSPTLRSAIFSFGCVVYAL
.|.| |  .|  ||  || || | ||| ..  | |    ||    |  |   |    |.||||  .| .       ||.||..| |
LGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDFSKKKPHASVGTHG----YMAPEVLQKGTAYDSSADWFSLGCMLYKL

Kinase GL50803_14044.AA Ciliate-E2-Unclassified 147-214 23 1e-06 19.13 In-house 171-265 (352) Show / Hide
Range on Protein: 147-214
Range on HMM: 171-265/352
Sequence Identity: 23% (23 aa)

KPSNIFLCENG---CIKTGDYGFFS--------PPTR---------HTEVFRVGKWINYV----APEVFRGQSPTLR----SAIFSFGCVVYALCT
||.||.. .||   .||  |.|...          |.         . .   .   .||     ||||..|| .  .    . |.|.|.. |....
KPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF

Kinase GL50803_14044.AA CZAK 183-218 33 1e-06 20.25 In-house 186-221 (279) Show / Hide
Range on Protein: 183-218
Range on HMM: 186-221/279
Sequence Identity: 33% (12 aa)

INYVAPEVFRGQSPTLRSAIFSFGCVVYALCTCTDP
. . |||.| | . |  . ..||| ... . || .|
LCWMAPECFKGENYTEKVDVYSFGMILWCIITCDQP

Kinase GL50803_14044.AA NEK-Unclassified 81-215 28 2e-06 17.01 In-house 67-193 (258) Show / Hide
Range on Protein: 81-215
Range on HMM: 67-193/258
Sequence Identity: 28% (39 aa)

KCFVHSEYCELGSLELELVQRREDGEYINELLIWEYIAQLVDITLFIVSQVGVENMDGQFFLYRFFKPSNIFLCENGCIKTGDYGFFS--PPTRHTEVFR
| |   .||. | |   .  .|   | ..|. |     |..    .| ..           . |  ||.|||| .   .  ||.|       ||      
KLFYTQDYCDGGNLDRRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRK---------IIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTC

VGKWINYVAPEVFRGQSPTLRSAIFSFGCVVYALCTC
||   .. .|||   |    || . | ||..| .|||
VGT-MCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTC

Kinase GL50803_14044.AA ULK 185-274 21 2e-06 18.8 In-house 217-329 (329) Show / Hide
Range on Protein: 185-274
Range on HMM: 217-329/329
Sequence Identity: 21% (25 aa)

YVAPEVFR----GQSPT-LRSAIFSFGCVVYALCTCTDP---HLFDVGE-----TEIVPPRVSPS------LVIP-----IQYSLALRTLMHDMLKVSPK
| ||...     .. ..   . |.|.||. | . .   |     |          .|  | ..|       | .|     .| |  .. |   ||.. .|
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK

DRITFSKIARHKLV
|||..  .  |...
DRISWEELFNHPWF

Kinase GL50803_14044.AA CAMKL 239-274 35 3e-06 15.9 In-house 261-297 (297) Show / Hide
Range on Protein: 239-274
Range on HMM: 261-297/297
Sequence Identity: 35% (13 aa)

IPIQYSL-ALRTLMHDMLKVSPKDRITFSKIARHKLV
.|| |..  .| | . ||.| |..|.|   | .|. .
PPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM

Kinase GL50803_14044.AA NEK 239-274 28 3.6e-05 14.62 In-house 249-286 (286) Show / Hide
Range on Protein: 239-274
Range on HMM: 249-286/286
Sequence Identity: 28% (11 aa)

IPIQ--YSLALRTLMHDMLKVSPKDRITFSKIARHKLV
|| .  ||  |. |.. ||...|..| . ..|  . ..
IPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase GL50803_14044.AA Ciliate-E2-Unclassified 250-274 44 0.000324 10.55 In-house 328-352 (352) Show / Hide
Range on Protein: 250-274
Range on HMM: 328-352/352
Sequence Identity: 44% (11 aa)

LMHDMLKVSPKDRITFSKIARHKLV
|.. |||. |. ||||..|  | . 
LLQKMLKKNPNKRITFEQILNHPWF

TyrKc GL50803_14044.AA TyrKc 28-273 17 0.000544 -158.1 SMART 1-280 (280) Show / Hide
Range on Protein: 28-273
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)

SQLSSKLF------VIRGIYLHSM--------NSAQLNALAQLRKLVDQL--EHP--VLLRHFKIDQG----IANKCFVHSEYCELGSLELELVQRREDG
 .|  ||       | .|..   .        ..| . .. .  ..  .|  .||  | |    ..||     .   ..  ||...|.|   |  .|.. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

EYINELLIW--------EYIAQLVDITLFIVSQVGVENMDGQFFLYRFFKPSNIFLCENGCIKTGDYGFFSPPTRHT-------EVFRV----GKW----
    .|| .        ||...                     .  |     |. . ||...| .| |  |    .        .. |.    |.     
LCMKDLLSFCWQIACGMEYLHSK-------------------NCIHRDLAARNCLVGENHTVKISDFG-LSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

INYVAPEVFRGQSPTLRSAIFSFGCVVYALCTCTDPHLFD-----VGETEIVPPRVSPSLVIPIQY---------SLALRTLMHDMLKVSPKDRITFSKI
|   |||...    |  | ..||| . . ..|  ..   .     .  .|..    .     . ..         . .. ..| .  .  |.|| ||| |
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

ARHKL
 ....
-HECF

Kinase GL50803_14044.AA NEK 87-121 30 0.000591 10.27 In-house 86-124 (286) Show / Hide
Range on Protein: 87-121
Range on HMM: 86-124/286
Sequence Identity: 30% (12 aa)

EYCE-LGSLELE---LVQRREDGEYINELLIWEYIAQLV
||||  | |.     . .... |.|. |  ||.. .|..
EYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMC

Kinase GL50803_14044.AA NEK 147-165 47 0.002004 8.38 In-house 146-168 (286) Show / Hide
Range on Protein: 147-165
Range on HMM: 146-168/286
Sequence Identity: 47% (11 aa)

KPSNIFLCENGC----IKTGDYG
||.||||  |..    .| || |
KPQNIFLTKNNNDYHNVKIGDFG

Kinase GL50803_14044.AA ULK 87-121 19 0.137416 1.42 In-house 100-140 (329) Show / Hide
Range on Protein: 87-121
Range on HMM: 100-140/329
Sequence Identity: 19% (8 aa)

EYCELGSLELELVQRRE------DGEYINELLIWEYIAQLV
|||. | ||  . ....       . ...|  . ... |..
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQIL

Ank GL50803_14044.AA Ank 403-435 27 0.025101 12.65 Pfam 1-33 (33) Show / Hide
Range on Protein: 403-435
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

DGRTALMICVEVGFMKGLKVLLEYEARKRCKNI
||.|.|.. .. | .. .| ||.. |    .. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_14044.AA Ank 448-473 42 1.297637 6.47 Pfam 5-29 (33) Show / Hide
Range on Protein: 448-473
Range on HMM: 5-29/33
Sequence Identity: 42% (11 aa)

ALTIAAIRGSLEFVKELYDVEGADKN
.| .|...|..| ||.| .  ||| |
PLHLACRCGHTEVVKMLLQ-HGADVN

Ank GL50803_14044.AA Ank 475-496 50 8e-06 25.27 Pfam 1-22 (33) Show / Hide
Range on Protein: 475-496
Range on HMM: 1-22/33
Sequence Identity: 50% (11 aa)

DGLTPLMCAAINGKLDVVKFLV
|| |||..|...| ..|||.|.
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_14044.AA Ank 537-569 27 9e-06 25.11 Pfam 1-33 (33) Show / Hide
Range on Protein: 537-569
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

NGMTALMLAAINGHLGCVRQLCNMEGNMRNKNN
.|.|.|.||...||. .|. | .   .   ...
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_14044.AA Ank 506-536 33 0.002957 16.0 Pfam 1-33 (33) Show / Hide
Range on Protein: 506-536
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

GNKTALMHAAEHGHTRCVETLCA--WEIGLQDD
   |.|. |...|||..|. |     .. .|||
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD