GL50803_15035

Species: G.lamblia
Alias: GK210, GL50803_15035
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_15035.AA Protein None 533 None Fasta, JSON
GL50803_15035.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of GL50803_15035.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_15035.AA NEK 229-298 28 1.5e-09 30.25 In-house 209-286 (286) Show / Hide
Range on Protein: 229-298
Range on HMM: 209-286/286
Sequence Identity: 28% (22 aa)

SLGVVIYTLVML--RKPFSLH--TAENLLQSMKVR-EYTPIC-G--VSEELTTLIEDLLNPQIDERPSLDYLLSLPQV
|||.|.| ...|  ..||  .    ..|    .   .| ||      |..|  ||. .|..  ..||| . .|..|..
SLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase GL50803_15035.AA Ciliate-E2-Unclassified 212-298 19 4.3e-08 24.19 In-house 234-352 (352) Show / Hide
Range on Protein: 212-298
Range on HMM: 234-352/352
Sequence Identity: 19% (23 aa)

APELFDSFIPD----VRSDLYSLGVVIYTLVMLRKPFSLHTAEN----------------LLQSMKVREYTPIC--------GVSEELTTLIE----DLL
|||....  .|      .| .||||..| ... . ||.  . |                 |.|  | ...   .        ..|.|   .|.     .|
APEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKML

NPQIDERPSLDYLLSLPQV
. ....|.... .|  |  
KKNPNKRITFEQILNHPWF

Kinase GL50803_15035.AA PLK1 226-298 24 4.4e-08 22.38 In-house 181-253 (253) Show / Hide
Range on Protein: 226-298
Range on HMM: 181-253/253
Sequence Identity: 24% (18 aa)

DLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGVSEELTTLIEDLLNPQIDERPSLDYLLSLPQV
|..|.| ..|.|.. . ||  .. ..  . .|  ||.    .|.    ||. .|.|. ..||  . .|.   .
DIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF

Kinase GL50803_15035.AA SAK 223-298 32 4.8e-08 23.19 In-house 179-254 (254) Show / Hide
Range on Protein: 223-298
Range on HMM: 179-254/254
Sequence Identity: 32% (25 aa)

VRSDLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGVSEELTTLIEDLLNPQIDERPSLDYLLSLPQV
..||..||| ..|||.. | ||   . .| |  . . ||     .| |   ||. .|  .  || .|.  |  | .
LQSDVWSLGCMLYTLLIGRPPFDTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM

S_TKc GL50803_15035.AA S_TKc 35-298 11 6.8e-07 -75.85 SMART 1-231 (231) Show / Hide
Range on Protein: 35-298
Range on HMM: 1-231/231
Sequence Identity: 11% (36 aa)

YSIETVLSENSIKTELLLAAVDGDDRVAVHAFKLGSLQDAIMTEIRRTAQDLSGVSLEGFLPISEIVWDESSSQLYILQNINKL--VPLSVLVEASEK--
| |  .. . .  .  .   .. . .||.   |     . |. ||.   .       .    . ..  |   . ||.           |  . .   .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LPEDYLWAVVSQVVQAIKTL----------------------------SRQQEALGAHMSISITNIFVTDTRGTDDPSAEFLVFLGLPCLDQALHP
    .||   . .. |...|.. .                            .||                                             
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL--------------------------------------------

CMLSGDVFQKSMC------APELFDSFIPDV-RSDLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGVSEELTTLIEDLLNPQIDERPSLDY
         ...|      |||..     .  ..| .|.|...| ..  . ||.  . . ... ..          |.|.  .|. .|.   ..||.   
---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-E

LLS-------LPQV
.|         | .
ALQDEWDIKCHPWF

Kinase GL50803_15035.AA Ciliate-E2 212-298 17 1e-06 18.57 In-house 255-365 (365) Show / Hide
Range on Protein: 212-298
Range on HMM: 255-365/365
Sequence Identity: 17% (21 aa)

APELFD---------SFIPDVRSDLYSLGVVIYTLVMLRKPFSLHTAENLLQSMK-VREYTPIC----------------GVSEELTTLIED----LLNP
||| .          .   |  .|..||||..| ... . ||       . | ..   .. . .                 .|.|   ||      .|. 
APEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQK

QIDERPS-LDYLLSLPQV
. ..|..  . .|  |  
DPEKRITGWEQILNHPWF

Kinase GL50803_15035.AA MARK 226-298 33 2e-06 16.9 In-house 188-262 (262) Show / Hide
Range on Protein: 226-298
Range on HMM: 188-262/262
Sequence Identity: 33% (25 aa)

DLYSLGVVIYTLVMLRKPFSLHT--AENLLQSMKVREYTPICGVSEELTTLIEDLLNPQIDERPSLDYLLSLPQV
| .||||| |..|  . ||   |   ..| . .   .|.  | || |.  ||  ||..  .|||... ... | .
DIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM

Kinase GL50803_15035.AA NEK4 213-298 26 4e-06 18.38 In-house 171-257 (257) Show / Hide
Range on Protein: 213-298
Range on HMM: 171-257/257
Sequence Identity: 26% (23 aa)

PELFDSFIPDVRSDLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGV-SEELTTLIEDLLNPQIDERPSLDYLLSLPQV
||.| .   | .||..|||  .| .. |.  |       |.  .      |.  . |..|  |.  .|. | ..|||.  ..  | .
PECFGNRPYDYKSDIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI

Kinase GL50803_15035.AA NEK1 225-298 33 4e-06 17.42 In-house 202-276 (276) Show / Hide
Range on Protein: 225-298
Range on HMM: 202-276/276
Sequence Identity: 33% (25 aa)

SDLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGV-SEELTTLIEDLLNPQIDERPSLDYLLSLPQV
||  |||.| | |. |  ||  .   ||        |.||    |.||  |.  ...     |||   .|. | .
SDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI

Kinase GL50803_15035.AA PASK 226-298 27 4e-06 14.6 In-house 192-260 (260) Show / Hide
Range on Protein: 226-298
Range on HMM: 192-260/260
Sequence Identity: 27% (20 aa)

DLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGVSEELTTLIEDLLNPQIDERPSLDYLLSLPQV
.. .|||  |||.    ||     | |   ... .      ||||.  ||  .||.. . |. .. .   | .
EMWALGVTLYTLMFKENPF-CNIEETLEAEIHFPN---AEHVSEECMSLIKSMLNRCPEKRCTMHQIITDPWL

Kinase GL50803_15035.AA SNRK 226-298 32 6e-06 15.09 In-house 182-254 (254) Show / Hide
Range on Protein: 226-298
Range on HMM: 182-254/254
Sequence Identity: 32% (24 aa)

DLYSLGVVIYTLVMLRKPFSLHTAENLLQSMKVREYTPICGVSEELTTLIEDLLNPQIDERPSLDYLLSLPQV
|..||||..| ||  . ||      . |  .    ||    ||.|   ||. .|  .   | ||. . | . |
DIWSLGVILYMLVCGQAPFQEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV

Kinase GL50803_15035.AA Pkinase 222-298 17 8.7e-05 18.01 Pfam 190-293 (293) Show / Hide
Range on Protein: 222-298
Range on HMM: 190-293/293
Sequence Identity: 17% (18 aa)

DVRSDLYSLGVVIYTLVMLRKPFSLH----TAENLLQSMKVREYTPICGVS------------------------EELTTLIEDLLNPQIDERPSLDYLL
. ..| .|.|...| ..  | ||. |    .  . .| .. . ..|.   .                        ||.  .|...|..   .||. . .|
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

SLPQV
  | .
QHPWF

Ank GL50803_15035.AA Ank 375-395 47 0.00232 16.38 Pfam 1-21 (33) Show / Hide
Range on Protein: 375-395
Range on HMM: 1-21/33
Sequence Identity: 47% (10 aa)

EGVTALMLAARLGFVNIVKEL
.| |.|.||.| | ...||.|
DGFTPLHLACRCGHTEVVKML

Ank GL50803_15035.AA Ank 441-462 45 8.7e-05 21.52 Pfam 1-22 (33) Show / Hide
Range on Protein: 441-462
Range on HMM: 1-22/33
Sequence Identity: 45% (10 aa)

VGRTALMLAAANSHLECIKLLL
 |.|.|.||. . |.|..|.||
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_15035.AA Ank 410-440 21 0.000268 19.76 Pfam 1-33 (33) Show / Hide
Range on Protein: 410-440
Range on HMM: 1-33/33
Sequence Identity: 21% (7 aa)

EGYTAMMFAVQRNSPECVRLLMD--AESGLVTK
.|.|. . |......|.|..|..  |.  ....
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_15035.AA Ank 472-492 23 17.767721 2.37 Pfam 1-21 (33) Show / Hide
Range on Protein: 472-492
Range on HMM: 1-21/33
Sequence Identity: 23% (5 aa)

EGWTSLMNAVIVCSLDAIDVL
.|.| |. |..  ... .  |
DGFTPLHLACRCGHTEVVKML