Gene GL50803_16508 (G.lamblia)
GL50803_16508
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_16508.AA | Protein | None | 1146 | None | Fasta, JSON |
| GL50803_16508.kin_dom | Protein Kinase Domain | None | 411 | None | Fasta, JSON |
Protein domains of GL50803_16508.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_16508.AA | S_TKc | 8-418 | 10 | 1.3e-11 | -6.64 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 8-418
Range on HMM: 1-231/231
Sequence Identity: 10% (47 aa)
YHVVSLVSQTPFSSTHRVTSRDTKQNFLAETIDMRKLSSDEQHRFREYVELYRRCNCNNLMRIYKIVENKNKQRITIVMEQYGT--VTLADIYESYKKAG
|... .. . |.. .... ..|.. . |. ..| ... .. .. |. ..| . .. ... .||| .. .| |. ..... |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG
LA--VPEPVLWNTVAQITVALNALLEQDKSFQHANIHPSNCFIDQSTGILRLG-----LFLPFLLKYEKEEQSTRESITGLIERVQKKLHGTSVTHASCV
| || . . ..|| ||. . .. . | . |.| ..|. . .. .|
LRFPFPE-HARFYMYQICCALEYC--HSHGIIHRDLKPENILLDE---HIKICDFGLARQL---------------------------------------
QNFADYGQRLTLV-----LPPEVFQGQGILP-VSDMWMLGCLLFEGCNGSNPFLEGVSTISSVTNPPYNKRCDEASESFAKYNGAISDHTQYFISERPSA
|.. ..|||. | . .|.| .||.|.| . | || . .. .
---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------------------------
LLELNCNAKSKGVHDDCPDITLVDSQDTPRSIPTVPHTSLASMAILPSISFATASMNKDTSFESMLTETSHAQYNFEQFVQHVLTGKRAPTNPAYSRNLQ
|. .
-----------------------------------------------------------------------------------------------SPEAK
MMINLCLNQNIKTRVTLDTLCR-------HPLI
.|. ||. . . | | . . || .
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | GL50803_16508.AA | Ciliate-D1 | 227-245 | 47 | 1e-06 | 23.08 | In-house | 1-19 (19) | Show / Hide |
Range on Protein: 227-245 Range on HMM: 1-19/19 Sequence Identity: 47% (9 aa) DMWMLGCLLFEGCNGSNPF |.| .||.|.| ..|..|| DIWSFGCILYEMLFGQPPF |
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| Kinase | GL50803_16508.AA | NEK | 367-418 | 21 | 3.4e-05 | 14.71 | In-house | 232-286 (286) | Show / Hide |
Range on Protein: 367-418 Range on HMM: 232-286/286 Sequence Identity: 21% (12 aa) NFEQFVQHVLTG-KRAPTNPA--YSRNLQMMINLCLNQNIKTRVTLDTLCRHPLI |... . . | . .| .. ||. ||..|...|. . . | . . . .|.| NMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_16508.AA | NEK-Unclassified | 212-239 | 46 | 0.000616 | 8.58 | In-house | 164-191 (258) | Show / Hide |
Range on Protein: 212-239 Range on HMM: 164-191/258 Sequence Identity: 46% (13 aa) LPPEVFQGQGILPVSDMWMLGCLLFEGC . ||| | | || | |||...| | MSPEVCQDQPYNNRSDVWSLGCIIYEMC |
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| Kinase | GL50803_16508.AA | STE | 387-418 | 32 | 0.000879 | 9.38 | In-house | 326-359 (359) | Show / Hide |
Range on Protein: 387-418 Range on HMM: 326-359/359 Sequence Identity: 32% (11 aa) YSRNLQMMINLCLNQNIKTRVTLDTLCR--HPLI .| ... ||.||. . . | | . | . || | WSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | GL50803_16508.AA | STE20 | 387-418 | 28 | 0.00094 | 9.94 | In-house | 257-288 (288) | Show / Hide |
Range on Protein: 387-418 Range on HMM: 257-288/288 Sequence Identity: 28% (9 aa) YSRNLQMMINLCLNQNIKTRVTLDTLCRHPLI .| ... ....||... . | | . | .|| | WSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI |
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| Kinase | GL50803_16508.AA | NEK6 | 56-156 | 26 | 0.000941 | 7.95 | In-house | 50-145 (252) | Show / Hide |
Range on Protein: 56-156 Range on HMM: 50-145/252 Sequence Identity: 26% (27 aa) VELYRRCNCNNLMRIYKIVENKNKQRITIVMEQYGTVTLADIYESYKKAGLAVPEPVLWNTVAQITVALNALLEQDKSFQHANIHPSNCFIDQSTGILRL ..| .. | .|... | . |. . ||.| .. . .|| . .|| .| |.. ||. . | | | | | || ..|| .| IDLLKQLNHPNVIKYYASFIENNE--LNIVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHM--HSKRVMHRDIKPANVFI-TANGIVKL G | G |
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| Kinase | GL50803_16508.AA | NEK | 226-237 | 66 | 0.001203 | 9.17 | In-house | 205-216 (286) | Show / Hide |
Range on Protein: 226-237 Range on HMM: 205-216/286 Sequence Identity: 66% (8 aa) SDMWMLGCLLFE ||.|.|||.|.| SDIWSLGCVLYE |
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| Kinase | GL50803_16508.AA | Ciliate-E2-Unclassified | 388-418 | 25 | 0.001332 | 8.39 | In-house | 318-352 (352) | Show / Hide |
Range on Protein: 388-418 Range on HMM: 318-352/352 Sequence Identity: 25% (9 aa) SRNLQMMIN----LCLNQNIKTRVTLDTLCRHPLI | . . .|| .|. |.. | |.. .. ||.. SPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | GL50803_16508.AA | Ciliate-E2-Unclassified | 212-245 | 39 | 0.001432 | 8.28 | In-house | 233-270 (352) | Show / Hide |
Range on Protein: 212-245 Range on HMM: 233-270/352 Sequence Identity: 39% (15 aa) LPPEVFQGQGILPV----SDMWMLGCLLFEGCNGSNPF ..|||.|||. .|.| ||..|.| . | || TAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPF |
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| Kinase | GL50803_16508.AA | NEK2 | 214-239 | 46 | 0.00159 | 7.6 | In-house | 233-258 (319) | Show / Hide |
Range on Protein: 214-239 Range on HMM: 233-258/319 Sequence Identity: 46% (12 aa) PEVFQGQGILPVSDMWMLGCLLFEGC ||. .|| . || | .|||..| | PEQMHGQKYNEKSDIWSVGCLIYEMC |
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| Kinase | GL50803_16508.AA | Ciliate-E2 | 212-303 | 12 | 0.002876 | 7.05 | In-house | 254-306 (365) | Show / Hide |
Range on Protein: 212-303 Range on HMM: 254-306/365 Sequence Identity: 12% (13 aa) LPPEVFQGQG---------ILPVSDMWMLGCLLFEGCNGSNPFLEGVSTISSVTNPPYNKRCDEASESFAKYNGAISDHTQYFISERPSALLELNCNAKS ..||...|.. .|.| ||..|.| . | || .. ... | MAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------------------------------------------QQQIKQCKI K . D |
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| Kinase | GL50803_16508.AA | NEK2 | 387-418 | 31 | 0.005204 | 5.84 | In-house | 288-319 (319) | Show / Hide |
Range on Protein: 387-418 Range on HMM: 288-319/319 Sequence Identity: 31% (10 aa) YSRNLQMMINLCLNQNIKTRVTLDTLCRHPLI ||| |. | . .| . ..| . . .||.| YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI |
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| Kinase | GL50803_16508.AA | NEK6 | 214-245 | 43 | 0.012612 | 4.18 | In-house | 172-203 (252) | Show / Hide |
Range on Protein: 214-245 Range on HMM: 172-203/252 Sequence Identity: 43% (14 aa) PEVFQGQGILPVSDMWMLGCLLFEGCNGSNPF || . .| ||.| |||||.| || PERIHENGYNFKSDIWSLGCLLYEMAALQSPF |
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| Kinase | GL50803_16508.AA | STE | 214-237 | 36 | 0.016124 | 4.86 | In-house | 231-260 (359) | Show / Hide |
Range on Protein: 214-237 Range on HMM: 231-260/359 Sequence Identity: 36% (11 aa) PEVFQG------QGILPVSDMWMLGCLLFE ||| |. .| .|.| |||.. | PEVIQQNGQGRDKGYDTKCDIWSLGCTIIE |
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| Kinase | GL50803_16508.AA | STE | 56-132 | 20 | 0.022972 | 4.31 | In-house | 79-172 (359) | Show / Hide |
Range on Protein: 56-132 Range on HMM: 79-172/359 Sequence Identity: 20% (19 aa) VELYRRCN--CNNLMRIYKIVE-----NKNKQRITIVMEQYGTVTLADIYESYKKAGL----------AVPEPVLWNTVAQITVALNALLEQDK ... ..|| . | . | . .||.. . |.|| . .| ||...... | .||... . || .| ..|.. . IKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH |
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| Kinase | GL50803_16508.AA | Ciliate-E2 | 394-418 | 20 | 0.030868 | 3.46 | In-house | 336-365 (365) | Show / Hide |
Range on Protein: 394-418 Range on HMM: 336-365/365 Sequence Identity: 20% (6 aa) MINL----CLNQNIKTRVT-LDTLCRHPLI .|. .|. . . | | . . || . LIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | GL50803_16508.AA | Ciliate-E2 | 60-87 | 28 | 0.042115 | 2.99 | In-house | 87-114 (365) | Show / Hide |
Range on Protein: 60-87 Range on HMM: 87-114/365 Sequence Identity: 28% (8 aa) RRCNCNNLMRIYKIVENKNKQRITIVME .. |..|....| ..|... | .||| EQLNHPNIIKMYECFQEKDDNNIYLVME |
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| Kinase | GL50803_16508.AA | Ciliate-E2-Unclassified | 8-88 | 14 | 0.107623 | 1.68 | In-house | 1-102 (352) | Show / Hide |
Range on Protein: 8-88 Range on HMM: 1-102/352 Sequence Identity: 14% (15 aa) YHVVSLVSQTPFSSTHRVTSRDTKQNF----LAETIDMRK----LSSDEQHRFREYVELYRR---------------CNCNNLMRIYKIVENKNKQRITI |... | |.. ... ...| . . | ..| ...| .. . . . . |.... ..... . ..|| | | YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI VMEQ |||. VMEY |
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| Ank | GL50803_16508.AA | Ank | 574-593 | 25 | 1.831747 | 5.93 | Pfam | 1-20 (33) | Show / Hide |
Range on Protein: 574-593 Range on HMM: 1-20/33 Sequence Identity: 25% (5 aa) EPFTILMIAALKNDIDLIKE . || |..|....... .|. DGFTPLHLACRCGHTEVVKM |
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| Ank | GL50803_16508.AA | Ank | 605-630 | 46 | 0.000216 | 20.1 | Pfam | 1-25 (33) | Show / Hide |
Range on Protein: 605-630 Range on HMM: 1-25/33 Sequence Identity: 46% (12 aa) SGKTALMFAAQQGHTEAVQLLLKEAG | |.|. |.. |||| |..||. .| DGFTPLHLACRCGHTEVVKMLLQ-HG |
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| Ank | GL50803_16508.AA | Ank | 635-665 | 33 | 4e-05 | 22.73 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 635-665 Range on HMM: 1-33/33 Sequence Identity: 33% (11 aa) SGKTALMIAAELGHHSVVSLLVK--VEGGIQDK | |.|..|.. ||..||..|.. . .||. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_16508.AA | Ank | 666-687 | 31 | 0.03454 | 12.15 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 666-687 Range on HMM: 1-22/33 Sequence Identity: 31% (7 aa) DLWTALMRAAWFGHSLCCEYLV | .|.|. |. || ....|. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_16508.AA | Ank | 697-717 | 38 | 1.9e-05 | 23.89 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 697-717 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) NGWTALMCAAYRGHANVCRVL .|.|.|..|...||..|.. | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_16508.AA | Ank | 728-748 | 47 | 0.000108 | 21.18 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 728-748 Range on HMM: 1-21/33 Sequence Identity: 47% (10 aa) AGYTALMYAARYGHYECCKVL |.|.|..|.|.||.|..| | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_16508.AA | Ank | 759-791 | 24 | 0.230033 | 9.18 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 759-791 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) HRQTALTIAAERMHGDIAMLLLNAETEACEQRD . .|.| .|... | ... .||.. . . | | DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_16508.AA | Ank | 995-1025 | 27 | 0.0385 | 11.98 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 995-1025 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) RGRTCLMLCAEKGLAHSVRLLVG--REAGMQDN |.|.|.| ...| . |..|.. . .||. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_16508.AA | Ank | 1026-1046 | 38 | 0.147132 | 9.88 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 1026-1046 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) SGWTALMNAAVSGKENVVPLL |.|.|. |. .| ..|| .| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_16508.AA | Ank | 1057-1087 | 30 | 0.000647 | 18.38 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 1057-1087 Range on HMM: 1-33/33 Sequence Identity: 30% (10 aa) VGNTAMMFAARYGHINIVKALMC--YELGIKDR |.|. . |.|.||...|| |. .. ..|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_16508.AA | Ank | 1088-1118 | 27 | 0.002864 | 16.05 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 1088-1118 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) NGWTALLHAVDADQLECVKLLVG--GEFSMCDN .|.|.| |. ...|.||.|.. . . |. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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