Gene GL50803_16765 (G.lamblia)

GL50803_16765

Species: G.lamblia
Alias: GL50803_16765, GK219
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL3

Sequence

Name Sequence Type Origin Length Description Download
GL50803_16765.AA Protein None 640 None Fasta, JSON
GL50803_16765.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of GL50803_16765.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_16765.AA S_TKc 13-274 31 3.6e-73 250.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-274
Range on HMM: 1-231/231
Sequence Identity: 31% (87 aa)

YEIISRLGVGSFGVVYKVKRLSDERIVAVKEVRLESFASNKPSVEGEFSIFPHLTHPHIATYYLQTYDATTNCYLIEMECYDR--GNLKAYIQEYRRNKI
|||.  .| |.||.|||..  .. ||||.|...         ... | .|  .  ||.| ..|   .|   ... . ||. |   |.|. ||....|.. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

D--IPEEEIWRFSSEILLALDYLHTDDHQNKTKGVIIHRDIKPENILLTQDNHVKLCDFGASRLLKPSAMADSVVGSPLFMAPEVAYHKGYRE-PVDIWS
.  .|| .....  .|..||.|.|           |||||.|||||||..  |.|.|||| .|.|      ....|.| .|||||    ||   ..|.||
RFPFPE-HARFYMYQICCALEYCHSHG--------IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWS

LGCVIVNMCTRMAPQVIRNKSYDQLLDVRPNIPEIYSRDLADFIASCLKIDPSHRITVPQALR-------HPRI
.||..  |...  |       .......        |... |||  ||. ||..|.|. .||.       || .
CGCILYEMLCGYPPFP----QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase GL50803_16765.AA Pkinase 13-274 27 9.1e-66 229.6 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-274
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

YEIISRLGVGSFGVVYKVKRLSDERIVAVKEVRLESFASNKPSVE---GEFSIFPHLTHPHIATYYLQTYDATTNCYLIEMECYDRG----NLKAYIQ-E
|.|....| ||||.||| .. ....|||||......  |.|.       | .|  .| ||.|   .. ..   ...|.. ||. . |     |..||. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNI-VRLYDWFEDKDHIYMV-MEYCEGGLYVMDLFDYISTW

YRRNKIDIPEEEIWRFSSEILLALDYLHTDDHQNKTKGVIIHRDIKPENILLTQDNHV----KLCDFGASRL--LKPSAMADSVVGSPLFMAPEVAY-HK
.... .  .|.|. ..  .|| .|.|.|           |||||.||||||. ...|.    |.|||| ...  . ..  .....|.| .|||||   ..
RHGCFY-FSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ

GYREPVDIWSLGCVIVNMCTRMAPQVIR--------NKSYDQLLDVRPNIPEIYS---------------------RDLADFIASCLKIDPSHRITVPQA
.|  .||.||.||..  |...  |   .        .. ... .. ..  .. ..                     ... ||| .||. ||. |.| .|.
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

LRHPRI
| || .
LQHPWF
Kinase GL50803_16765.AA STE 13-274 26 2.3e-61 210.18 In-house 1-359 (359) Show / Hide 
Range on Protein: 13-274
Range on HMM: 1-359/359
Sequence Identity: 26% (99 aa)

YEIISRLGVGSFGVVYKVKRL------SDERI---------VAVKEVRLESFA----------------SNKPSVEGEFSIFPHLT--HPHIATYYLQTY
.|.|...| |.||.||| ..       .  ..         .|.|...||.                  ... ... | .|  ..   ||.| .||   .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DAT-----TNCYLIEMECYDRGNLKAYIQ-EYRRNKID---------IPEEEIWRFSSEILLA-LDYLHTDDHQNKTKGVIIHRDIKPENILLTQDNHVK
.        .   | ||  | | |   |.  | ..| .         .||..| ..  .|| . |.|||    ...    |||||||| ||||     ||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLH----SHH----IIHRDIKPANILL-----VK

LCDFGASRLLKPS----------------A-MADSVVGSPLFMAPEVAYH------KGYREPVDIWSLGCVIVNMCTRMAP----QVIRNKSYDQLL---
||||| .  | .|                . . ...||.| .|||||         ||| . .|||||||.|. |.|   |    .  |.  . .     
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM

-----------DVRPNIPE-------------------IYSRDLADFIASCLKIDPSHRITVPQALR--HPRI
           .  | .|.                    .| .. |||. ||..||..| |. | |.  || |
QQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_16765.AA NEK 13-217 37 3.1e-52 179.86 In-house 1-219 (286) Show / Hide 
Range on Protein: 13-217
Range on HMM: 1-219/286
Sequence Identity: 37% (84 aa)

YEIISRLGVGSFGVVYKVKRLSDERI-----VAVKEVRLES-FASNKPSVE-GEFSIFPHLTHPHIATYYLQTYDATTNCYLIEMECYD-RGNLKAY---
||||  .| ||||.||||.| ||...     .. |.. ...    .|      |  |  .| ||.| .||   ..   ||  |.||  .  |.|      
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IQEYRRNKIDIPEEEIWRFSSEILLALDYLHTD--DHQNKTKGVIIHRDIKPENILLTQDNH----VKLCDFGASRLLK-PSAMADS-VVGSPLFMAPEV
|....  .  ..||.||..   ..|||.|.|          .. |.|||||| || || .|     ||. ||| |..|.  . || . .|| | .|.|||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGP-----QRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEV

AYHKGYREPVDIWSLGCVIVNMCT
  .|.| . .||||||||.  |||
CQNKPYNNKSDIWSLGCVLYEMCT
Kinase GL50803_16765.AA Ciliate-E2-Unclassified 13-274 23 5.3e-51 175.14 In-house 1-352 (352) Show / Hide 
Range on Protein: 13-274
Range on HMM: 1-352/352
Sequence Identity: 23% (84 aa)

YEIISRLGVGSFGVVYKVKR-----------LSDERIVAVKEVRL---------ESFASNKPSVEGEFSIFPH-------LTHPHIATYYLQTYDATTNC
|.||  .| |.||.|||...           ... .|...| ..          | .  .| ..    ..          | |||.  ...  .. ....
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQR--KY--NKIMQQILLNHPHPFIVKMFYCFQDKQN

YLIEMECYDRGNLKAYIQEY-------------RRNKIDIPEEEIW-----RFSSEILLALDYLHTDDHQNKTKGVIIHRDIKPENILLTQDN---HVKL
  | ||  . |.|. ||...             ....  ..|...      ..  .||..|.|||        |. ||||||||||||.....   ..|.
IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH-------HKNNIIHRDIKPENILFDNNGKNYYIKI

CDFGASRLLK----------------PSAMADSVVGSPLFM----APEVAYHKGYREP----VDIWSLGCVIVNMCTRMAPQVIRN--------------
.||| |. ..                .. |.....|.| .|    ||||   ..| ..    .||||||...  |..   |   .|              
IDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINN

----KSYDQLLDVRPNIPE--------IYSRDLADFIA----SCLKIDPSHRITVPQALRHPRI
      |.. ..  ...|.        . |   .|||     ..|| .|. ||| .|.| || .
AYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_16765.AA ULK 13-274 24 1.4e-48 167.68 In-house 1-329 (329) Show / Hide 
Range on Protein: 13-274
Range on HMM: 1-329/329
Sequence Identity: 24% (83 aa)

YEIISRLGVGSFGVVYKVKRLSDE----RIVAVKEVRLESFASNK---------PSVEGEFSIFPHLT--------HPHIATYYLQTYDAT-TNCYLIEM
|... .|| ||||.||| .   ..     .||.| . ....  ..          ... |  |   |         ||.|  .|  ..... .|.|.| |
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII-M

ECYDRGNLKAYIQEYRR------NKIDIPEEEIWRFSSEILLALDYLHTDDHQNKTKGVIIHRDIKPENILLTQDN------------HVKLCDFGASRL
|  . |.|. ||.....      .|  ..|.|.  |   || .. .||           ||||||||.|||.. ..            ..|..||| .. 
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--------IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH

LKPS----AMADSVV------GSPLFMAPEVAY----HKGYREP-VDIWSLGCVIVNMCTRMAP---QVIRNKS---YDQLLDVRPNIP-----------
.  .    .|. . |      |.||.|||..      .| | .  .|||||||..  | .   |   . ..      . .|.. .|..|           
VDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFP

-----EIYSRDLADFIASCLKIDPSHRITVPQALRHPRI
      . | .. |.|  .|..|.. ||. .. . || .
KDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_16765.AA Ciliate-E2 13-274 23 1.5e-47 161.28 In-house 1-365 (365) Show / Hide 
Range on Protein: 13-274
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

YEIISRLGVGSFGVVYKVKRLSDERI------------------VAVKEVRLESF-ASNKPSVEGEFSIFP----------------HLTHPHIATYYLQ
|..|  .| |.||.|||.|. .. .                   |..|.. ....  ... ... | .|.                 .| ||.|  .|  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

TYDATTNCYLIEMECYDRGNLKAYIQ---EYRRNKID----IPEEEIWRFSSEILL---------------ALDYLHTDDHQNKTKGVIIHRDIKPENIL
 .. ..|.. . || .. |.|. ||.     | ..|.    . |.|| ... .||                || |||        |. ||||||||||||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS-------KNNIIHRDIKPENIL

LTQDNHVKLCDFGASRLLKPS--------------------------------AMADSVVGSPLFMAPEVAY---------HKGYREPVDIWSLGCVIVN
.     .|..||| |. ....                                 |.....|.| .||||.           .||| . .||||||...  
F-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

MCTRMAPQVIRNKSYDQLLDVRPNIP------------------EIYSRDLADFIAS----CLKIDPSHRIT-VPQALRHPRI
|..   |       ..| ..   ..|                  .  | .  |.|      .|. ||. |||   |.| || .
MLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_16765.AA ULK 13-274 23 1e-45 158.2 In-house 1-324 (324) Show / Hide 
Range on Protein: 13-274
Range on HMM: 1-324/324
Sequence Identity: 23% (80 aa)

YEIISRLGVGSFG-VVYKVKRLSDE---RIVAVKEVRLESFASNK------------PSVEGEFSIFPHLTHPH--IATYYLQTYDAT-TNCYLIEMECY
|... .|| |||| .||| .   ..    .||.| . . ..  .|             ..  .  .. .| ||.  |  .|  ..... .|.|.| ||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYII-MEYC

DRGNLKAYIQEYRR-----NKIDIPEEEIWRFSSEILLALDYLHTDDHQNKTKGVIIHRDIKPENILLTQDN------------HVKLCDFGASRLLKPS
. |.|. ||.....     .|  ..|.|.  |   |. .. .||           ||||||||.|||.. ..            ..|..||| .. .   
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN--------IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNN

----AMADSVV------GSPLFMAPEVAY----HKGYREP-VDIWSLGCVIVNMCTRMAP---QVIRNKS---------------YDQLLDVRPNIPE--
     |  . |      |.||.|||..      .| | .  .|||||||..  | .   |   . ...                 | .   .....|.  
NMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKD

-IYSRDLADFIASCLKIDPSHRITVPQALRHPRI
 . | .. |.|  .|..|.. ||. .. . || .
PKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_16765.AA NEK2 13-217 30 1.4e-40 134.33 In-house 1-259 (319) Show / Hide 
Range on Protein: 13-217
Range on HMM: 1-259/319
Sequence Identity: 30% (78 aa)

YEIISRLGVGSFGVVYKVKRLSDERIVAVKEVRLESFAS-NKPSVEGEFSIFPHLTHPHIATYYLQTYDATTNCYLIEMECYDRGNLKAYIQEYRRNKID
||.   .| ||||...||.| || .| . ||   ..  .  .     | .|   | || |  ||    | ..    | ||.  .| |   |. .|  .  
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

IPEEEIWRFSSEILLALDYLHT-----------DDHQNKTKG--VIIHRDIKPENILLTQDNH-------------------------------------
..|| |||    ...||   |            |  . . .|  .|.|||||| || | .|                                       
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VKLCDFGASRLLK-PSAMADSVVGSPLFMAPEVAYHKGYREPVDIWSLGCVIVNMCT
  ||| |||  | |.  .  | . || |  | ||.     | |  ||||.||.|  ||.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCA
Kinase GL50803_16765.AA CAMK 18-211 18 1.5e-40 127.93 In-house 1-323 (425) Show / Hide 
Range on Protein: 18-211
Range on HMM: 1-323/425
Sequence Identity: 18% (62 aa)

RLGVGSFGVVYKVKRLSDE------------RIVAVKEVRLESFAS---------------------------NKPSVEGEFSIFPH-------LTHPHI
 || ||||.|..... ..             . ||.| .  .   .                           .. .|. | .|  .       | ||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ATYYLQTYDAT-----------------TNCYLIEM---ECYDRG----NLKAYIQEYRRNK-----------IDIPEEEIWRFSSEILLALDYLHTDDH
   |    |..                 .... . |   |  . |     |  ||.| ...              ..|.|  |.   |. |..|.|    
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS---

QNKTKGVIIHRDIKPENILLTQD-----------------NHVKLCDFGASRLLKPSA------------------------MADSVVGSPLFMA-PEVA
    .. |.|||.|||||||...                 | .|..||| .. ..|.                         .   ..|.| .|| ||| 
----HN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVL

YH--------------KGYREPVDIWSLGCV
                ..| ...|.||.|..
NGKGHCNMQNATDEEKPYYGPKCDMWSCGVI
Kinase GL50803_16765.AA STE-Unique 112-274 26 1.9e-34 119.48 In-house 400-616 (616) Show / Hide 
Range on Protein: 112-274
Range on HMM: 400-616/616
Sequence Identity: 26% (59 aa)

IPEEEIWRFSSEILLALDYLHTDDHQNKTKG-VIIHRDIKPENILLTQDN-----HVKLCDFGASRLLKPS-----------------------------
.||.|. ..  .||..|.|||       ...  |||||.|| ||...||      .||.|||| .  . |                              
FPETEVIWYTYQILEGLEYLH-------SQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQ

----------AMADSVVGSPLFMAPEVAYHK-----GYREPVDIWSLGCVIVNMCTRMAPQVIRNKS-----YDQLLDVRPN------IPEIYSRDLADF
             .. .| |  |.|||   .     .|   ||||||||..  ||.   |.. |        .  ..   |.      ||. .. ....|
TPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQF

IASCLKIDPSHRITVPQALRHPRI
| .||. .|.|| .. | |.|.  
IEKCLERNPHHRPSAHQLLHHFWL
Kinase GL50803_16765.AA STE20 123-209 45 1.2e-24 87.19 In-house 125-214 (288) Show / Hide 
Range on Protein: 123-209
Range on HMM: 125-214/288
Sequence Identity: 45% (45 aa)

EILLALDYLHTDDHQNKTKGVIIHRDIKPENILLTQDNHVKLCDFGASRLLKPS---AMA---DSVVGSPLFMAPEVAYH-----KGYREPVDIWSLG
|.| .|||||        .  |||||||  |||||.|  |||.||| .  | .    .|.   ...||.| .|||||        ||| . .||||||
EVLQGLDYLH--------SNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLG
Kinase GL50803_16765.AA TyrKc 13-274 22 7.1e-14 1.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-274
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

YEIISRLGVGSFGVVYKVKRLSDERIVAVKEVRLESFASNKPSVEGEFSIFPHL--THPHIATYYLQTYDATT--------NCYLIEMECYDRGNLKAYI
 . .  || | ||.||| .     . |||| .. ..    .     | .|  .|   ||.|   |     .|.          ..| ||  . |.|| |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLY---GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QEYRRNKIDIPEEEIWRFSSEILLALDYLHTDDHQNKTKGVIIHRDIKPENILLTQDNHVKLCDFGASRLLKPS----AMADSVV------G---SPLF-
...|..   .. ..   |.  |    .|||           .||||.   |.|.. ...|| .||| || ..      .  |  .      |    |.  
RKHRPK---LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MAPEVAYHKGYREPVDIWSLGCV---IVNMCTRMAPQV----IRNKSYDQLLDVR--PNIPEI--------YSRDLADFIASCLKIDPSHRITVPQALRH
||||.  .. . .  |.|| | .   |   .    | .    . |.   .... .  . .|.          . .. . . .| . ||. | |  .   |
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--H

PRI
 ..
ECF
Kinase GL50803_16765.AA NEK 237-274 40 4.4e-11 35.66 In-house 247-286 (286) Show / Hide 
Range on Protein: 237-274
Range on HMM: 247-286/286
Sequence Identity: 40% (16 aa)

PNIPEI--YSRDLADFIASCLKIDPSHRITVPQALRHPRI
| ||.   ||.|| ..| ..|. ||..| .. | | .| |
PPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_16765.AA STE20 13-48 35 9.9e-10 32.04 In-house 1-40 (288) Show / Hide 
Range on Protein: 13-48
Range on HMM: 1-40/288
Sequence Identity: 35% (14 aa)

YEIISRLGVGSFGVVYKVKRLSDERI----VAVKEVRLES
||.. ..| ||.|.|||.   .  ..    ||.| . ||.
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEK
Kinase GL50803_16765.AA STE-Unique 14-75 26 5.3e-09 27.51 In-house 1-67 (616) Show / Hide 
Range on Protein: 14-75
Range on HMM: 1-67/616
Sequence Identity: 26% (18 aa)

EIISRLGVGSFGVVYKVKRLSDERIVAVKEVRLESFASNK-----PSVEGEFSIFPHLTHPHIATYY
... ..| ||||.|.. .. .| . .|.| ..|. |   .          |. |   |.|. |..||
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYY
Kinase GL50803_16765.AA NEK2 239-274 38 5.6e-09 26.25 In-house 284-319 (319) Show / Hide 
Range on Protein: 239-274
Range on HMM: 284-319/319
Sequence Identity: 38% (14 aa)

IPEIYSRDLADFIASCLKIDPSHRITVPQALRHPRI
||..|||.| . |.. ...|..||  .   |.||.|
IPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_16765.AA CAMK 244-274 38 6.7e-08 20.79 In-house 395-425 (425) Show / Hide 
Range on Protein: 244-274
Range on HMM: 395-425/425
Sequence Identity: 38% (12 aa)

SRDLADFIASCLKIDPSHRITVPQALRHPRI
| .  |.| ..|. ||..|.|. |.|.|| .
SQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_16765.AA STE20 240-274 42 3e-06 19.32 In-house 254-288 (288) Show / Hide 
Range on Protein: 240-274
Range on HMM: 254-288/288
Sequence Identity: 42% (15 aa)

PEIYSRDLADFIASCLKIDPSHRITVPQALRHPRI
|. .| .. ||...|| .||. | |. | |.|| |
PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase GL50803_16765.AA Pkinase_Tyr 153-212 30 0.000347 14.8 Pfam 141-204 (270) Show / Hide 
Range on Protein: 153-212
Range on HMM: 141-204/270
Sequence Identity: 30% (20 aa)

NILLTQDNHVKLCDFGASRLLKPSAMADSVVGS----PLF-MAPEVAYHKGYREPVDIWSLGCVI
|.|.| .|.|| |||| .|.. .     .....    | . ||||.  .. . .  |.|| | ..
NCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLM
Kinase GL50803_16765.AA Pkinase_Tyr 13-75 28 0.000471 14.35 Pfam 1-70 (270) Show / Hide 
Range on Protein: 13-75
Range on HMM: 1-70/270
Sequence Identity: 28% (20 aa)

YEIISRLGVGSFGVVYKVKRL----SDERIVAVKEVRLESFASN---KPSVEGEFSIFPHL-THPHIATYY
 ...  || |.||.||| .      ...  |||| .  |.  .    . .   | .|  .|  ||.|  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Ank GL50803_16765.AA Ank 421-442 36 0.151904 9.83 Pfam 1-22 (33) Show / Hide 
Range on Protein: 421-442
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

DGTTGLMLAAMANDIDAFHDLL
|| | |.||.. ....   .||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_16765.AA Ank 452-472 33 0.010269 14.05 Pfam 1-21 (33) Show / Hide 
Range on Protein: 452-472
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

RGRTALMRAAEYGHIDAIVIL
 |.|.|. |...||.. .  |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_16765.AA Ank 483-506 29 0.081256 10.81 Pfam 1-24 (33) Show / Hide 
Range on Protein: 483-506
Range on HMM: 1-24/33
Sequence Identity: 29% (7 aa)

DAHTALMYSAKFGKVHCISLLLQA
|  |.|.. .. | . ....|||.
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_16765.AA Ank 514-534 38 0.000221 20.06 Pfam 1-21 (33) Show / Hide 
Range on Protein: 514-534
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

NGWTALMTAIETGNLEIVSLL
.|.|.|. |.. |..|.|..|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_16765.AA Ank 545-570 42 2e-06 27.29 Pfam 1-26 (33) Show / Hide 
Range on Protein: 545-570
Range on HMM: 1-26/33
Sequence Identity: 42% (11 aa)

DGTTPLMVAAKVGNVACLQMLIDAGA
|| |||..|.. |.. ...||...||
DGFTPLHLACRCGHTEVVKMLLQHGA
Ank GL50803_16765.AA Ank 576-611 33 0.041565 11.86 Pfam 1-33 (33) Show / Hide 
Range on Protein: 576-611
Range on HMM: 1-33/33
Sequence Identity: 33% (12 aa)

SGFFALLWAIVCNNPPCVSFLLPYELHMADKNGKTA
 || .| .|. |... .|..||    | || | .. 
DGFTPLHLACRCGHTEVVKMLLQ---HGADVNAQDD