GL50803_16805

Species: G.lamblia
Alias: GK009, GL50803_16805
External Links: GiardiaDB ,
Annotation:

Classification

Group: PKL
Family: PIKK
Subfamily: PIKK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_16805.AA Protein None 2633 None Fasta, JSON
GL50803_16805.kin_dom Protein Kinase Domain None 229 None Fasta, JSON

Protein domain

Protein domains of GL50803_16805.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_16805.AA ATR 2486-2583 30 8e-17 53.45 In-house 170-267 (267) Show / Hide
Range on Protein: 2486-2583
Range on HMM: 170-267/267
Sequence Identity: 30% (30 aa)

TLAHWCAVCIVTGLGDRHSCNILIDTDDGSVHFIDFEAVFEYPKLLSYAELVPFRLTALIAQLLGPTGIHGCFYWELVKMVSLIQENAPAFINVFYPL
. | || |  . ||||||. |||||   | .  .|.  .|   . .   |.||||||  .   .|| . .| |   .. .. .....    . |.   
SYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF

Kinase GL50803_16805.AA PIKK 2482-2559 40 1.5e-16 57.02 In-house 188-266 (290) Show / Hide
Range on Protein: 2482-2559
Range on HMM: 188-266/290
Sequence Identity: 40% (32 aa)

MFATTLAHWCAVCIVTGLGDRHSCNILIDTDDGSVHFIDFEAVFEYPKL-LSYAELVPFRLTALIAQLLGPTGIHGCFY
... ..| .| |  ..||||||  ||.|| . | .  |||   ||  .  |.  |.||||||  .  ..||.|. | |.
NYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFR

Kinase GL50803_16805.AA ATM 2493-2558 45 1.9e-12 35.67 In-house 150-215 (304) Show / Hide
Range on Protein: 2493-2558
Range on HMM: 150-215/304
Sequence Identity: 45% (30 aa)

VCIVTGLGDRHSCNILIDTDDGSVHFIDFEAVFEYPKLLSYAELVPFRLTALIAQLLGPTGIHGCF
|  . ||||||  ||||      .  ||    ||  |.|   | ||||||  |   .| ||. | |
VGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVF

PI3Kc GL50803_16805.AA PI3Kc 2354-2632 15 2.4e-07 -48.29 SMART 1-336 (336) Show / Hide
Range on Protein: 2354-2632
Range on HMM: 1-336/336
Sequence Identity: 15% (56 aa)

RLILKCGEDTVADYAVMQFTEELAKCSVNT--------FFKPYFVAVLINIPKNQVSIIEHIDGNVVPIDELLT--------------------------
..|.|||.|   |. .||. .   |.  .          ..|| . ..      .  .|| .  |.... ...                           
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTG----PKCGMIEWVP-NCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ

---------------------------------PVFMGAKTKAAEFINEQEPNEDGCFPTFDLFMASVTALSHMEMALSKTHPCRFIALSQKNQRMFATT
                                  ...  .   ...  |. |...                                   .. .. |.  
KNMYMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN--------------------------------EDWWEARDNFTRS

LAHWCAVCIVTGLGDRHSCNILIDTDDGSVHFIDFEAVFE-YPKLLSYA----ELVPFRLTALIAQLLG----PTGIHGCFYWELVKMVSLIQENAPAFI
.| .| |. . |.||||. ||..| ..| .  |||   |. .||.. .     |.||||||  .  . |    |.|  | |.   ..   .. ... ...
CAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIM

NVFYPLAIVRASLGYVRQ--VKEMLETQRAEE--IVNAALAQA--------ADSS------RLSCMFGGWMAF
|.|  ..          .   ...|. .  ..   .. |. ..          .|      |.  ||  |. .
NLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase GL50803_16805.AA DNAPK 2492-2559 36 2.4e-07 22.6 In-house 195-267 (301) Show / Hide
Range on Protein: 2492-2559
Range on HMM: 195-267/301
Sequence Identity: 36% (27 aa)

A-VCI---VTGLGDRHSCNILIDTDDGSVHFIDFEAVFE-YPKLLSYAELVPFRLTALIAQLLGPTGIHGCFY
| .||   . | ||||  | ..  . | .  |||   |      |   || |||||     |. | .| | .|
AVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMY

Kinase GL50803_16805.AA FRAP 2498-2556 38 1e-06 20.69 In-house 155-214 (251) Show / Hide
Range on Protein: 2498-2556
Range on HMM: 155-214/251
Sequence Identity: 38% (23 aa)

GLGDRHSCNILIDTDDGSVHFIDFEAVFEYP-KLLSYAELVPFRLTALIAQLLGPTGIHG
||||||  ||...   | .  |||   ||   .  .. |..||||| ..   .  .|| |
GLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEG

Kinase GL50803_16805.AA SMG1 2493-2535 46 3e-06 16.7 In-house 200-242 (242) Show / Hide
Range on Protein: 2493-2535
Range on HMM: 200-242/242
Sequence Identity: 46% (20 aa)

VCIVTGLGDRHSCNILIDTDDGSVHFIDFEAVFEYPKLLSYAE
|  . ||||||  |.|||   | |  ||.   ||  | |   |
VGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE

Kinase GL50803_16805.AA PI3_PI4_kinase 2483-2580 26 6e-06 23.58 Pfam 167-280 (300) Show / Hide
Range on Protein: 2483-2580
Range on HMM: 167-280/300
Sequence Identity: 26% (30 aa)

FATTLAHWCAVCIVTGLGDRHSCNILI--DTDDGSVHFIDFEAVFE--YPKLLSYAELVPFRLTA-------LIAQL-----LGPTGIHGCFYWELVKMV
|.. .| .| | .. |.||||. ||..  |...| .  |||   |.    | .   |.||||.|        .. ..     |.|.|  | |  ..... 
FVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAY

SLIQENAPAFINVF
 .. ... ...|..
RALRRHMNLCMNLL

Kinase GL50803_16805.AA FATC 2601-2633 27 1.1e-05 21.25 Pfam 1-33 (33) Show / Hide
Range on Protein: 2601-2633
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

ETQRAEEIVNAALAQAADSSRLSCMFGGWMAFL
|    |. |.   ..| | ..|. |. ||....
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW

PI3_PI4_kinase GL50803_16805.AA PI3_PI4_kinase 2352-2372 30 0.2779 6.44 Pfam 1-23 (300) Show / Hide
Range on Protein: 2352-2372
Range on HMM: 1-23/300
Sequence Identity: 30% (7 aa)

GTRLILKCGEDTV--ADYAVMQF
....|.|.|.| .   |  .||.
WYPFIFKGGDDLRCRQDMRMMQM