Gene GL50803_16988 (G.lamblia)
GL50803_16988
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_16988.AA | Protein | None | 278 | None | Fasta, JSON |
| GL50803_16988.kin_dom | Protein Kinase Domain | None | 249 | None | Fasta, JSON |
Protein domains of GL50803_16988.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_16988.AA | Pkinase | 38-249 | 22 | 2.7e-25 | 90.53 | Pfam | 46-293 (293) | Show / Hide |
Range on Protein: 38-249 Range on HMM: 46-293/293 Sequence Identity: 22% (57 aa) RL--ELTALLDLSHPGVLKYHQVIEDEGLIYVVTDRHSR-----TLDNLLAEHKRRKNLV--PIAMILSAMKQVAAALAYLHGVNGANNRGLVHCDLRPA |. |. .. |.|| ..... . ||.. ||.|.. . | .. .|.. . . . . |.|.. .|.|.| | .|.|| |. RRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM------GIIHRDLKPE NIFISADGER---FIIAGLGLCKDA-LWSESTLMGVAV---YMAPEVLL-RNESSPASDVWSLGAIIYELVTLRRPDFLGG------KEPAEVFVDGWRP ||.|. .|. . |. ||.| . . . | ...... ||||||.. ... .|..|.||.| |.||... .|| | | . . .. ....| NILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPP DLSGVADG----------------------FMQNVLERILVLDPGRRPTARKLVRL--L . .. .....| .|| .||||. .. . LHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | GL50803_16988.AA | TKL | 76-249 | 17 | 3.5e-24 | 83.96 | In-house | 126-364 (364) | Show / Hide |
Range on Protein: 76-249
Range on HMM: 126-364/364
Sequence Identity: 17% (44 aa)
LDNLLAEHKRRKNLVPIAMILSAMKQVAAALAYLHGVN---GANNRGLVHCDLRPANIFISADGE-------------RFIIAGLGLCKDALWSES----
|..|. . ... ....| ...||| | . ....|.|| ..||.. ... . |. .||... .|..
LHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDT
---------------TLMGVA---VYMAPEVLLRN----------------ESSPASDVWSLGAIIYELVTLRRPDF-LGGKEPA---------EVFVD-
|.| . .|||||| . | |...||.| | ...|..| .|| . .. .. .. .|
MTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDK
GWRPDLS------------GVADGFMQNVLERILVLDPGRRPTARKLVRLL
| || . .. | . ... || ||.. ... |
GLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| S_TKc | GL50803_16988.AA | S_TKc | 7-252 | 21 | 7.9e-21 | 76.44 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 7-252 Range on HMM: 1-231/231 Sequence Identity: 21% (58 aa) FSVIYSLRRGPHLTVEEIQLGG---------LDKNSADAIRLELTALLDLSHPGVLKYHQVIEDEGLIYVVTDRHSR---TLDNLLAEHKRRK--NLVPI . .. . .| .| . . .. . || |. | || . |.. |..| . .|.|.. . .| .. ...|.. | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE AMILSAMKQVAAALAYLHGVNGANNRGLVHCDLRPANIFISADGERFIIAGLGLCKDALWSESTLMGVAVYMAPEVLLRNESSP-ASDVWSLGAIIYELV .. . |.|.. ||.|.| ..| .|.|| |.||... . |. ||.. .|. | ||||||| .. ..|.||.| |.||.. -HARFYMYQICCALEYCH------SHGIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML TLRRPDFLGGKEPAEVFVDGWRPDLSGVADGFMQNVLERILVLDPGRRPTARKLVR------LLRIL . ..| | .....| . . . ....|. || .|||| .. . . . C-GYPPFP---QMQMMFKKIG-------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_16988.AA | Ciliate-E2 | 40-196 | 20 | 1.3e-19 | 63.93 | In-house | 82-295 (365) | Show / Hide |
Range on Protein: 40-196
Range on HMM: 82-295/365
Sequence Identity: 20% (47 aa)
ELTALLDLSHPGVLKYHQVIE--DEGLIYVVTDRHSR-TLDNLLAEH-KRRKNLVP------IAMILSAMKQVAA---------------ALAYLHGVNG
|. | |.|| ..|.. . . |. || |.. . .| .. .. | |.. . . |. |||.. || |||
EKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH----
ANNRG-LVHCDLRPANIFISADGERFIIAGLGLCKDA--------------LWSEST---------------------LMGVAVYMAPEVLLRNE-----
... .| |. | ||.. |. .||.|.. .. . . | . |||||.| . .
--SKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQ
----SSPASDVWSLGAIIYELVTLRRP
. ..|.|||| |.||... ..|
KQKGYDYKCDIWSLGVILYEMLFGKPP
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| Kinase | GL50803_16988.AA | Ciliate-E2-Unclassified | 44-196 | 22 | 2.1e-18 | 60.46 | In-house | 75-269 (352) | Show / Hide |
Range on Protein: 44-196 Range on HMM: 75-269/352 Sequence Identity: 22% (44 aa) LLDLSHPGVLKYHQVIEDEGLIYVVTDR--------HSRTL------DNLLAEHKRRKNLVPIAMIL-----SAMKQVAAALAYLHGVNGANNRGLVHCD ||.. || ..|.. . .|. || |.. . . |.| ....... .. .. ..|. .| ||| .| . .| | LLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH----HKN-NIIHRD LRPANIFISADGE--RFIIAGLGLCKDALWS------------------ESTLMGVAVYM----APEVLLRNESS----PASDVWSLGAIIYELVTLRRP . | ||... .|. . |...|..| . .| .| || ||||| ... . ..|.|||| |.||... ..| IKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP |
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| Kinase | GL50803_16988.AA | TK | 30-249 | 12 | 6.2e-17 | 52.57 | In-house | 64-486 (486) | Show / Hide |
Range on Protein: 30-249
Range on HMM: 64-486/486
Sequence Identity: 12% (53 aa)
DKNSADAIRL--------------ELTALLDLS-----HPGVLKYHQVIEDE------------GLIYVVTDRHSRT-----LDNLLAEHKRRKNL----
| .|... .. |. .. .. || ... . |. .. . ...|. . |.. | .......
DAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDC
--------------------------------------------------------------------VPIAMILSAMKQVAAALAYLHGVN--GANNRG
.. . | . |.|....||| | . .
PDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI--QN
LVHCDLRPANIFISADGER----------FIIAGLGLCKDALWSESTLMGVAVY-----------------------------------------MAPEV
.|| || |. .. .. . || ||... .. ..| ||||.
FVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGS-G---VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPEC
LLRNE---------SSPASDVWSLGAIIYELVTLRRPDFLGG------------KEPAEVFVDG---------------WRPDLSGVAD-----------
|. .. ...|||||.| ..|..|. . . || .| | ..| .| . |
LNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHC
--GFMQNVLERILVLDPGRRPTARKLVRLL
... .. . .|| .||| . |.. |
PPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | GL50803_16988.AA | CAMK | 47-192 | 17 | 1.4e-15 | 46.01 | In-house | 95-329 (425) | Show / Hide |
Range on Protein: 47-192 Range on HMM: 95-329/425 Sequence Identity: 17% (43 aa) LSHPGVLKYHQVIED-------------------EGLIYVVT---DRHSRT-----LDNLLAEHKRRKNL-----------VPIAMILSAMKQVAAALAY |.|| ..| ..|.|| . .| |. . | | . . ||... . .. . ..|.. |..| LDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHY LHGVNGANNRGLVHCDLRPANIFISADG----------------ERFIIAGLGLCKDALWSES--------------------------TLMGVAVYMA- .| ... ||.|| | || .. .. |. |. . .|. | | ||| CH------SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAA PEVLLR--------------NESSPASDVWSLGAIIYELVT ||||.. .|..|.||.| | | ... PEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLC |
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| Kinase | GL50803_16988.AA | NEK6 | 40-202 | 32 | 9.8e-15 | 44.68 | In-house | 49-207 (252) | Show / Hide |
Range on Protein: 40-202 Range on HMM: 49-207/252 Sequence Identity: 32% (55 aa) ELTALLDLSHPGVLKYHQ-VIEDEGLIYVVTDRHSRTLDNLLAEHKRRKNLVPIAMILSAMKQVAAALAYLHGVNGANNRGLVHCDLRPANIFISADGER |. | .| || |.|| . ||. | |. . .. |. | |.| | |.. ||. .| . ..| |..|||.|| |.| EIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMH------SKRVMHRDIKPANVFITANG-I FIIAGLGLCKDALWSEST----LMGVAVYMAPEVLLRNESSPASDVWSLGAIIYELVTLRRPDFLGGK . ||| . |. | |.| ||.|| . | ||.|||| ..||. | | | | | VKLGDLGLGR-FFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSP-FYGDK |
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| Kinase | GL50803_16988.AA | AGC | 101-192 | 22 | 4.5e-14 | 31.3 | In-house | 161-300 (395) | Show / Hide |
Range on Protein: 101-192
Range on HMM: 161-300/395
Sequence Identity: 22% (34 aa)
QVAAALAYLHGVNGANN-RGLVHCD-LRPANIFISADGERFIIAGLGLCKDALWSE--------------------------------------------
... || ||| . .| .| | | | || . .| .. |||| ..
CIVLALEYLH------SHMGIIHRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDD
---------STLMG--VAVYMAPEVLLRNESSPASDVWS--LGAIIYELVT
.|. | . |||||.| ..| | || ||...||..|
TTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLT
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| Kinase | GL50803_16988.AA | WEE | 76-192 | 23 | 6e-14 | 43.24 | In-house | 94-231 (297) | Show / Hide |
Range on Protein: 76-192 Range on HMM: 94-231/297 Sequence Identity: 23% (34 aa) LDNLLAEHKRRKNLVPIAMILSAMKQVAAALAYLHGVNGANNR-GLVHCDLRPANIFISADGE-------------------RFIIAGLGLCKDAL---- | ........ .. | .|| ... .|...| .. |.|| |. |.||||| ... .. |. .|...|. LQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIH------SNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNSNNN WSESTLMGVAVYMAPEVLL-RNESSPA--SDVWSLGAIIYELVT .... | . |||||.| . ... .|. |||. ||||.. NPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYELAC |
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| Kinase | GL50803_16988.AA | PLK1 | 46-251 | 27 | 3.6e-13 | 39.36 | In-house | 55-253 (253) | Show / Hide |
Range on Protein: 46-251 Range on HMM: 55-253/253 Sequence Identity: 27% (57 aa) DLSHPGVLKYHQVIEDEGLIYVVTDRHSRTLDNLLAEHKRRKNLVPIAMILSAMKQVAAALAYLHGVNGANNRGLVHCDLRPANIFISADGERFIIAGLG .|.|. . |.|. ||. .|.| . .| |. ||||| . |.|.. . ||| . ..| ||. |.|. | . | | QLHHRHIVKFHHFFEDKQNVYIVLELCRRR--SLMELHKRRKAITEPECRY-YMYQIVEGCQYLHNNK------IIHRDLKLGNLFL-NDHLQVKIGDFG LCKDALWS---ESTLMGVAVYMAPEVLLRNESSPASDVWSLGAIIYELVTLRRPDFLGGKEPAEVFVDGWRPDLS--GVADGFMQNVLERILVLDPGRRP | . || | |.||||| . | |.||.| |.| |. . .| | | | .. . . . . .......| || ||| LATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILL-FGQPPF-ETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRP TARKLVRLLRI |...... . TIEQVLNDEFF |
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| Kinase | GL50803_16988.AA | ULK | 99-196 | 23 | 4.8e-13 | 42.67 | In-house | 132-251 (324) | Show / Hide |
Range on Protein: 99-196 Range on HMM: 132-251/324 Sequence Identity: 23% (30 aa) MKQVAAALAYLHGVNGANNRGLVHCDLRPANIFISADGER-----------FIIAGLGLCKDALW--SESTLM----------GVAVYMAPEVLL----R .|| .... .|| ... .|.|. |.|| |. . . . || |..| | ... | ||||..| . FKQICNGFKELH------KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQ NESSPA-SDVWSLGAIIYELVTLRRP . . . .|.|||| |.||... . | KPYYDYKCDIWSLGCIFYEMLYGKYP |
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| TyrKc | GL50803_16988.AA | TyrKc | 20-249 | 17 | 3.3e-12 | -25.4 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 20-249 Range on HMM: 1-280/280 Sequence Identity: 17% (51 aa) TVEEIQLGG-------------------LDKNSADAIRLELTALLDL--SHPGVLKYHQVIEDE-------GLIYVVTD--RHSRTLDNLLAEHKRRKNL . . .|| | ... ... |. . | .|| ... . |. .. . ...|. | |.. | .|... ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRPK--- VPIAMILSAMKQVAAALAYLHGVNGANNRGLVHCDLRPANIFISADGERFIIAGLGLCKDALWS-------ESTLMG---VAV------YMAPEVLLRNE .. . || . |.|. .||| ...| || |. ..... . |. ||..| . . . ||||.. .. LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK SSPASDVWSLGAIIYELVTLRRPDFLGG----KEPAEVF---VDGWRPDLSGV--------ADGFMQNVLERILVLDPGRRPTARKLVRLL ...||||| | ..|. |. . | ....||. .| |.. . | .. .. || ||| . ..... FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | GL50803_16988.AA | Pkinase_Tyr | 164-193 | 40 | 0.000183 | 15.74 | Pfam | 181-210 (270) | Show / Hide |
Range on Protein: 164-193 Range on HMM: 181-210/270 Sequence Identity: 40% (12 aa) MAPEVLLRNESSPASDVWSLGAIIYELVTL ||||.. .. . .||||| | ..|..|. MAPECINYGKFTTKSDVWSFGVLMWEIFTY |
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| Kinase | GL50803_16988.AA | Pkinase_Tyr | 235-249 | 40 | 0.763854 | 3.48 | Pfam | 256-270 (270) | Show / Hide |
Range on Protein: 235-249 Range on HMM: 256-270/270 Sequence Identity: 40% (6 aa) DPGRRPTARKLVRLL || .||| . ... | DPEDRPTFSEIHEQL |
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| Kinase | GL50803_16988.AA | Pkinase_Tyr | 84-136 | 19 | 1.237775 | 2.77 | Pfam | 99-148 (270) | Show / Hide |
Range on Protein: 84-136 Range on HMM: 99-148/270 Sequence Identity: 19% (11 aa) KRR---KNLVPIAMILSAMKQVAAALAYLHGVNGANNRGLVHCDLRPANIFISADG ... |. ... ..|. |.|....||. | ..| ||. |. .. .. RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN------CIHRDLAARNCLVTENN |
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