GL50803_17216

Species: G.lamblia
Alias: GL50803_17216, GK228
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_17216.AA Protein None 844 None Fasta, JSON
GL50803_17216.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of GL50803_17216.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_17216.AA S_TKc 26-285 24 1e-15 53.59 SMART 1-231 (231) Show / Hide
Range on Protein: 26-285
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

FASIQCVGSSTAGKTYLAIKVDQGCPVILKEVDLSNLSSDQIDLLEGYVTAIKELTCPNIVRYKAIHKGSMGDKVYLESEYCSL--GSVQDMVINHKA--
.  .. .|. . || |...... |  | .|...         . ..  .   |.  .||||... .      |..|.  |||.   |.. |.  ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

SRRIIREDFIWRVAAVIVFVLEYLHTHLTPQYCSIKSYRCLRPSNILLTEDDIIKIDNFSATRLLGDYSSESLRIYIAPELLAGAAYGP-AADAWSLGCI
 |. . |  ...... |.  |||.| |          .| | |.||||.|   |||  |   |.|  ..    . |.|||.|    ||. ..| ||.|||
LRFPFPE-HARFYMYQICCALEYCHSHG-------IIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LLTMCTLLEPLSVIDPRASNEPLDLSTLHGLEHYSNELLELIKNCLYISVNMRSTISQLRS-------HPRI
|  |..   | .        ..  .  . |    | |....|..||    . | |. ..         || .
LYEMLCGYPPFP--------QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_17216.AA STE 197-285 22 2e-12 40.27 In-house 228-359 (359) Show / Hide
Range on Protein: 197-285
Range on HMM: 228-359/359
Sequence Identity: 22% (30 aa)

YIAPELLAG------AAYGPAADAWSLGCILLTMCTLLEPLSV-IDPRASNEPL-----------------DLSTLHG-----------------LEHYS
. ||| . .        |.  .| ||||| .. |.|   |..   ..||  . .                 .  .|                    ...|
WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWS

NELLELIKNCLYISVNMRSTISQLRS--HPRI
 |. . |..|| .  | | | ||| .  || |
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase GL50803_17216.AA Pkinase 197-285 23 6.2e-12 43.27 Pfam 177-293 (293) Show / Hide
Range on Protein: 197-285
Range on HMM: 177-293/293
Sequence Identity: 23% (28 aa)

YIAPELLA-GAAYGPAADAWSLGCILLTMCTLLEPLSVID----PRASNEPLDLSTLHGLEHYS-------------------------NELLELIKNCL
|.|||..  |  |||..| ||.||||  |..   | .  .    . ..   .   ....  |..                          |....||.||
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

YISVNMRSTISQLRSHPRI
    . | |. |.  || .
CKDPKKRPTAEQILQHPWF

Kinase GL50803_17216.AA STE 26-148 16 2e-11 36.76 In-house 1-171 (359) Show / Hide
Range on Protein: 26-148
Range on HMM: 1-171/359
Sequence Identity: 16% (29 aa)

FASIQCVGSSTAGKTYLAIKVD---------------QGCPVILKEVDLSNLSS---------------DQIDLLEGYVTAIKELT--CPNIVRYKAIHK
.  |...|. . |..|.|....               .|. .  |...|.| ..               .... ..  .   |..   .||||.|   . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GS-----MGDKVYLESEYCSLGSVQDMVI-NHKASR---------RIIREDFIWRVAAVIVFV-LEYLHTH
        .|....  ||.. ||. |..  ...  .           . |. | ...  |.   |.||| |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSH

Kinase GL50803_17216.AA Ciliate-E2 162-285 19 8.7e-10 29.76 In-house 187-365 (365) Show / Hide
Range on Protein: 162-285
Range on HMM: 187-365/365
Sequence Identity: 19% (37 aa)

LRPSNILLTEDDIIKIDNFS-ATRLLGDYSSES-----------------------------------LRIYIAPELLAGAA---------YGPAADAWS
. |.|||.     |||  |  ....  |.  ..                                      | ||| | |           |. ..| ||
IKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS

LGCILLTMCTLLEPLSVIDPRASNE--PLDLSTLH-------------GLEHYSNELLELIKN----CLYISVNMRST-ISQLRSHPRI
||.||  |..   |         ..  ..|..  .               .. |.|   |||.    .|    . | | ..|.  || .
LGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase GL50803_17216.AA NEK10 74-227 27 2.1e-09 26.94 In-house 63-216 (279) Show / Hide
Range on Protein: 74-227
Range on HMM: 63-216/279
Sequence Identity: 27% (44 aa)

VTAIKE-LTCPNIVRYKAIHKGSMGDKVYLESEYCSLGSVQDMVINHKASRRIIREDFIWRVAAVIVFVLEYLHTHLTPQYCSIKSYRCLRPSNILLTED
.. ||| .  ||||||  .      .. |   |     . .. ..  |  .    |. ||..   ..  | |||         |   | |.| ||.....
LKIIKEQMRHPNIVRYYRTFVEPQNHRMYIVMELIEGCPLYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLH-----KEKQI-VHRDLTPNNIMMGDK

DIIKIDNFSATRLLG-DYSSESLR------IYIAPELLAGAAYGPAADAWSLGCILLTMCTL
| . |  |   .  . |  .. ..      .|  || .    ||  || |. ||.|  ||||
DRVTITDFGLAKQKQPD--PSKMTSVVGTILYSCPEIVQSEPYGEKADVWAFGCCLYQMCTL

Kinase GL50803_17216.AA MELK 26-224 25 4.4e-09 26.87 In-house 1-193 (254) Show / Hide
Range on Protein: 26-224
Range on HMM: 1-193/254
Sequence Identity: 25% (53 aa)

FASIQCVGSSTAGKTYLAIKVDQGCPVILKEVDLSNLSSDQIDLLEGYVTAIKELTCPNIVRYKAIHKGSMGDKVYLESEYCSLGSVQDMVINHKASRRI
..  . .|.   .|  ||  .  .  | .| .|  .| .| .  ..  . |.|.|   .| .    |     ||...  |||. | . | .|    ..  
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHD-LPRVKTEMDALKNLRHQHICQL--YHYIETEDKIFMVMEYCPGGEMFDYII----RQDR

IREDFIWRVAAVIVFVLEYLHTHLTPQYCSIKSYRCLRPSNILLTEDDIIKIDNFS-ATRLLGDYSSESLRI------YIAPELLAGAAY-GPAADAWSL
. |.    .   ||  . |.|      |     .| |.| |.|..||  .|. .|    .  |      |        | ||||. |  | |  || ||.
LEEEETRHFFRQIVSAIAYVHSQ---GYA----HRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSM

GCILLTM
| .| ..
GILLYVL

Kinase GL50803_17216.AA NEK 38-146 21 1.6e-08 26.56 In-house 13-131 (286) Show / Hide
Range on Protein: 38-146
Range on HMM: 13-131/286
Sequence Identity: 21% (26 aa)

GKTYLAIKVDQGCP-----VILKEVDLSNLSSDQIDLLE-GYVTAIKELTCPNIVRYKAIHKGSMGDKVYLESEYCS-LGSVQDM---VINHKASRRIIR
|| |.. .   |       ...|.....|.|. . . .    |   |.| .||||.|.       ... . . |||   |  ...     ..| ..  . 
GKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFE

EDFIWRVAAVIVFVLEYLH
|. ||.. . ..  | |.|
EEQIWDWFIQMCLALKYMH

Kinase GL50803_17216.AA STE-Unique 196-285 21 2.4e-08 25.16 In-house 513-616 (616) Show / Hide
Range on Protein: 196-285
Range on HMM: 513-616/616
Sequence Identity: 21% (22 aa)

IYIAPELLAGA-----AYGPAADAWSLGCILLTMCTLLEPLSVIDPRAS-NEPLDLSTLHGL--------EHYSNELLELIKNCLYISVNMRSTISQLRS
.|..|| . ..      |.  .| |||||... ||... | .   .. .  | .....   .        . .. |. ..|  ||    . |....||. 
CYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLH

HPRI
|.  
HFWL

Kinase GL50803_17216.AA AGC 197-221 51 2.5e-08 16.12 In-house 273-295 (395) Show / Hide
Range on Protein: 197-221
Range on HMM: 273-295/395
Sequence Identity: 51% (14 aa)

YIAPELLAGAAYGPAADAWS--LGCIL
|.||| |    ||.|.| ||  |||..
YMAPEIL----YGKACDWWSFGLGCLM

Kinase GL50803_17216.AA RAD53 197-221 30 4.2e-08 19.69 In-house 192-231 (305) Show / Hide
Range on Protein: 197-221
Range on HMM: 192-231/305
Sequence Identity: 30% (12 aa)

YIAPELLAG---------------AAYGPAADAWSLGCIL
| ||| ...               ..|... |.||.||||
YVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCIL

Kinase GL50803_17216.AA Ciliate-E2-Unclassified 162-226 22 1e-07 22.87 In-house 170-265 (352) Show / Hide
Range on Protein: 162-226
Range on HMM: 170-265/352
Sequence Identity: 22% (22 aa)

LRPSNILLTED----DIIKIDNFSATRLLGDYSSESLR--------------------IYI----APELLAGAAYG----PAADAWSLGCILLTMCT
. |.|||....     |  || ... ..  .. ..  .                    .|.    |||.| |  |.     ..| ||||.||  |..
IKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF

Kinase GL50803_17216.AA TyrKc 26-285 15 1e-06 -115.68 SMART 1-280 (280) Show / Hide
Range on Protein: 26-285
Range on HMM: 1-280/280
Sequence Identity: 15% (49 aa)

FASIQCVGSSTAGKTYLAIKVDQGCPVILKEVDLSNLSSDQIDLLEGYVTAIKEL--TCPNIVRYKAIHKGSMG-----DKVYLESEYCSLGSVQDMVIN
   ..  |.   |. |...      .|  | .  .      .  .       ..|    |||||  ..   . .     . ...  ||...|. .|   .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HKASRRIIREDFIWRVAAVIVFVL------EYLHTHLTPQYCSIKSYRC----LRPSNILLTEDDIIKIDNFSATRLLGDY-----SSESLRI-------
|.             ..  . | .      |||| .           .|    |   |.|..|. ..||  |  .| ..|.     |..  |        
HRPK---------LCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

------YIAPELLAGAAYGPAADAWSLGCIL---LTMCTLLEPLS----VIDPRASNEPLDLSTLHGLEH--------YSNELLELIKNCLYISVNMRST
        ||| .    . .. | || |  .   .| .    |      . . .. .   .   .   ..         . |. ...| |     ..| |
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

ISQLRSHPRI
 |..  | ..
FSEI--HECF

Kinase GL50803_17216.AA NEK 197-227 48 1.8e-05 15.63 In-house 190-220 (286) Show / Hide
Range on Protein: 197-227
Range on HMM: 190-220/286
Sequence Identity: 48% (15 aa)

YIAPELLAGAAYGPAADAWSLGCILLTMCTL
|..||.. .  |.  .| |||||.|  ||||
YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTL

Kinase GL50803_17216.AA STE20 26-116 23 2.5e-05 15.74 In-house 1-99 (288) Show / Hide
Range on Protein: 26-116
Range on HMM: 1-99/288
Sequence Identity: 23% (23 aa)

FASIQCVGSSTAGKTYLAIKVDQGCP----VILKEVDLSNLSS--DQIDLLEGYVTAIKELTCPNIVRYKAIHKGSMG--DKVYLESEYCSLGSVQDMV
.  ....|. . || |.|.... |      |  | ..|.. .   |......  .   |.. .||||.|   .  .    |. ..  |||. ||..|..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

Kinase GL50803_17216.AA NEK 252-285 30 9.6e-05 13.08 In-house 251-286 (286) Show / Hide
Range on Protein: 252-285
Range on HMM: 251-286/286
Sequence Identity: 30% (11 aa)

EH--YSNELLELIKNCLYISVNMRSTISQLRSHPRI
.|  ||..| .|| ..|  .  .| ...|. ..| |
SHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase GL50803_17216.AA Pkinase 26-121 24 0.000531 15.23 Pfam 1-102 (293) Show / Hide
Range on Protein: 26-121
Range on HMM: 1-102/293
Sequence Identity: 24% (26 aa)

FASIQCVGSSTAGKTYLAIKVDQGCPVILKEVDLSNLSS--DQIDLL--EGYVTAIKELTCPNIVRYKAIHKGSMGDKVYLESEYCSLG----SVQDMVI
.  ....|| . |. |...... |. | .|...... .|  ||....  | ..   |.| .|||||.. .     .|..|.  |||  |    .  |.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQI--MKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIS

--NHKA
  .|..
TWRHGC

Kinase GL50803_17216.AA STE20 197-218 33 0.003267 7.94 In-house 188-214 (288) Show / Hide
Range on Protein: 197-218
Range on HMM: 188-214/288
Sequence Identity: 33% (9 aa)

YIAPELLAG-----AAYGPAADAWSLG
. |||....       |.  .| ||||
WMAPEVIQCMEGPDKGYDYKCDIWSLG

Kinase GL50803_17216.AA Ciliate-E2-Unclassified 255-285 28 0.028504 3.71 In-house 318-352 (352) Show / Hide
Range on Protein: 255-285
Range on HMM: 318-352/352
Sequence Identity: 28% (10 aa)

SNELLELIK----NCLYISVNMRSTISQLRSHPRI
|.|  ..|.     .|    | | |..|.  || .
SPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase GL50803_17216.AA RAD53 255-285 35 0.029026 1.96 In-house 275-305 (305) Show / Hide
Range on Protein: 255-285
Range on HMM: 275-305/305
Sequence Identity: 35% (11 aa)

SNELLELIKNCLYISVNMRSTISQLRSHPRI
|.| . |||. | . .. |.|| .. .|| .
SEEAKDLIKWMLCVDPEKRYTIDEALNHPWM

Kinase GL50803_17216.AA STE20 247-285 34 0.043038 3.8 In-house 248-288 (288) Show / Hide
Range on Protein: 247-285
Range on HMM: 248-288/288
Sequence Identity: 34% (14 aa)

TLHG--LEHYSNELLELIKNCLYISVNMRSTISQLRSHPRI
|| .   ...| |. .....|| . .. | | ||| .|| |
TLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI

Ank GL50803_17216.AA Ank 471-485 26 8.157292 3.59 Pfam 1-15 (33) Show / Hide
Range on Protein: 471-485
Range on HMM: 1-15/33
Sequence Identity: 26% (4 aa)

SDDTALMIAVRNRNM
  .|.|..|.|. ..
DGFTPLHLACRCGHT

Ank GL50803_17216.AA Ank 501-523 34 0.007955 14.45 Pfam 1-23 (33) Show / Hide
Range on Protein: 501-523
Range on HMM: 1-23/33
Sequence Identity: 34% (8 aa)

DNTTALMIAAETGNSEALSYLLG
|  |.|..|.. |. | ...||.
DGFTPLHLACRCGHTEVVKMLLQ

Ank GL50803_17216.AA Ank 531-551 47 8.2e-05 21.62 Pfam 1-21 (33) Show / Hide
Range on Protein: 531-551
Range on HMM: 1-21/33
Sequence Identity: 47% (10 aa)

DGKTALMLAILNGHVDVARVL
|| |.|.||...||..|.. |
DGFTPLHLACRCGHTEVVKML

Ank GL50803_17216.AA Ank 562-592 36 3.1e-05 23.14 Pfam 1-33 (33) Show / Hide
Range on Protein: 562-592
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

DGRTALMYACERGMSELINVLLD--AESGMTDV
||.|.|..||..|  | .  ||.  |.  ..| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_17216.AA Ank 593-625 24 0.00982 14.12 Pfam 1-33 (33) Show / Hide
Range on Protein: 593-625
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

NGYSALMLALQRNNIDGVRALAKREAMITLSDG
.|...|.|| ...... |. | .. | . . | 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_17216.AA Ank 726-746 33 0.039748 11.93 Pfam 1-21 (33) Show / Hide
Range on Protein: 726-746
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

KGWTALMKAAFYGKSECIPLL
 |.|.|. |...|  |.. .|
DGFTPLHLACRCGHTEVVKML

Ank GL50803_17216.AA Ank 756-777 36 0.020594 12.96 Pfam 1-22 (33) Show / Hide
Range on Protein: 756-777
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

AKYTALMSAAGNGHSACVRLLL
  .|.|. |. .||  .|..||
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_17216.AA Ank 786-818 24 0.001128 17.51 Pfam 1-33 (33) Show / Hide
Range on Protein: 786-818
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

KNETALMLAIMNEQEECIKLLMDKEGSLRTHDG
  .|.|.||... ..|..|.|...  ..  .| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD