GL50803_17406

Species: G.lamblia
Alias: GK311, GL50803_17406
External Links: GiardiaDB ,
Annotation:

Classification

Group: PKL
Family: PI3K

Sequence

Name Sequence Type Origin Length Description Download
GL50803_17406.AA Protein None 1638 None Fasta, JSON
GL50803_17406.kin_dom Protein Kinase Domain None 518 None Fasta, JSON

Protein domain

Protein domains of GL50803_17406.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3K_C2 GL50803_17406.AA PI3K_C2 77-132 23 1e-05 22.81 Pfam 30-105 (168) Show / Hide
Range on Protein: 77-132
Range on HMM: 30-105/168
Sequence Identity: 23% (18 aa)

KKTQ----LTYVWNSQQLTFP-ISISNLPQAAHFHISIYVH----G-----------VLLGSTEFPLYNE-HFALRC
|...     ...|| ...||| | ...|| .|...|.|. .    .           ...| . .||...    |||
KPFNNHFFPRWNWN-EWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNMNEQNKKCPIGWCNLPLFDHEKCMLRC

PI3Ka GL50803_17406.AA PI3Ka 442-634 16 0.000512 -52.6 SMART 1-232 (232) Show / Hide
Range on Protein: 442-634
Range on HMM: 1-232/232
Sequence Identity: 16% (42 aa)

VPDNAS--AGKLAKLCDVLF----THQLRSQDKDLIWKYR-YYMRKYPRGLIKVISSIPQSYRNVLIRQRSVKDKGQDSGQNFGDSIDESTNQDLRHIVG
  | ..    .. ..   ..    | .| ...||||||.| || ...|. |                           |   |   .  ..| . .. | 
DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALP--------------------------SMC-F-PKFLRCVNWSWADEVK

ELKTLLYTW--NDPAIDQLLLLLSQEYSLYNLNTNVIREYAINKLNQFADSVLLQFLLELT----FK--------------------------IDLDESL
..  |.. |  .   ... | ||. ..  |  |. ..|.||. .|.|. |  ||..|| |     .                             .|  |
QAYQLMHQWWWPPIDPEDALELLDPKFPDY--NCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPL

C---------------------IVDL--------FNYKELYQSIEDQMIDQQ-ETLAREKKK
|                      ...         .|.. .... ....... ..  |. .|
CRFLLQRALCNPRIGHFFYWYLKSEMYDHCQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK

PI3Kc GL50803_17406.AA PI3Kc 1135-1635 11 1.8e-34 121.72 SMART 1-336 (336) Show / Hide
Range on Protein: 1135-1635
Range on HMM: 1-336/336
Sequence Identity: 11% (64 aa)

PVLLKINDDVRLDMLYVHLFSLMDSYMQTH----NLDMKFTIYSCFALSPSIGFIECILPSESQDDIYK-------------------------------
.|..| .|| | ||.   .|.||.   |.     ..|.....|.| ...| .|.||..  .|.   | |                               
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

---------------------------KKELGTITDYFNAMLCKYRSQVSPSVLSQALVKLPSLLSEISAKLLADESLCLSSLISESILDGKLPPQSPYA
                           ..   . .. ..  . ..  . .                                                  
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN--------------------------------------------------

FSEFSDKTIPSVAGKGSLPFGEESYQMVKKRTRPSNLSSTSVHIPNMSTSMDDLMGGIRSTKGAHKSVFSDDGVEKRQENSRGHSRHVSTSDCSYGGSEA
                                                                                                    
----------------------------------------------------------------------------------------------------

KGSGDKGSETIESDKVMSAGATPSIQSRHTRGVPSNLSLQIGNRPLTQDIVQKWLVEQLTVKGIESLPQKVYAIIGSVIDKVYRFNGPLNCMNDITAEAQ
                                                                                              .   . 
----------------------------------------------------------------------------------------------EDWWEA

MSNFVKSTAAYSVATYLLRAGDRHGENLLIR-PDGRMFHIDFGWCFGKDPKLMAPK--------MKVSKDLVKAMG--GEGSADFESYLNYVAEIFCMLR
..||..|.|.|...||.|  ||||..|...   .| .|||||| .||..||.. .|        ..  .|.| .||  |  | .|  .  .. ......|
RDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMR

QDVYIIISLLYILQGGGM-AYLDEAAQSHFYVIEDNYQLS-LERDAAIYYILD-----VVKASMKAIMGQFIDAFHRFTQG
..   |..|. .......   ..   .   .....  .|. |  . |. |. .     . ..|  .   .... ||...|.
KHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

PI3_PI4_kinase GL50803_17406.AA PI3_PI4_kinase 1473-1571 29 7.2e-23 86.26 Pfam 164-280 (300) Show / Hide
Range on Protein: 1473-1571
Range on HMM: 164-280/300
Sequence Identity: 29% (35 aa)

MSNFVKSTAAYSVATYLLRAGDRHGENLLI---RPDGRMFHIDFGWCFG-----KDPKLMAPKMKVSK------DLVKAMGG----EGSADFESYLNYVA
..|||.| | ..|..|.|. ||||..|...   ...| .|||||| ||.      ..|. .. ..  .      ..|.||||    . | |.. .  |  
RDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCW

EIFCMLRQDVYIIISLL
...  ||..  ....||
HAYRALRRHMNLCMNLL

PI3_PI4_kinase GL50803_17406.AA PI3_PI4_kinase 1133-1201 17 1.6e-11 44.32 Pfam 1-98 (300) Show / Hide
Range on Protein: 1133-1201
Range on HMM: 1-98/300
Sequence Identity: 17% (17 aa)

EIPVLLKINDDVR--LDMLYVHLF-----------------------SLMDSYMQTHNLDMK----FTIYSCFALSPSIGFIECILPSESQDDIYKKK
..|...| .|| |   ||. ....                       .||.   . ...| .    ...|.| ...|  |.||..  ... . | ...
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTY

Kinase GL50803_17406.AA ATR 1474-1574 21 7.3e-10 29.34 In-house 165-267 (267) Show / Hide
Range on Protein: 1474-1574
Range on HMM: 165-267/267
Sequence Identity: 21% (23 aa)

SNFVKSTAAYSVATYLLRAGDRHGENLLIRP-DGRMFHIDFGWCFGKDPKLMAPKM---KVSKDLVKAMGGEGSADFESYLNYVAEIFCMLRQDVYIIIS
.|...|.|....  |..  ||||..|.||    | . |.|.   |..  ..  | .   .. . .| .||  ..     .   . .|  ..|.    |.|
ENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGL--FRRACEVIMMCMRDHRDDIMS

LLYIL
..   
VWDCF

Kinase GL50803_17406.AA FRAP 1475-1517 47 1.6e-08 27.6 In-house 139-182 (251) Show / Hide
Range on Protein: 1475-1517
Range on HMM: 139-182/251
Sequence Identity: 47% (21 aa)

NFVKSTAAYSVATYLLRAGDRHGENLLI-RPDGRMFHIDFGWCF
|. .| |  |.| |.|  ||||  |... |  |.. ||||| ||
NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCF

Kinase GL50803_17406.AA PIKK 1474-1519 42 2.4e-08 26.89 In-house 187-233 (290) Show / Hide
Range on Protein: 1474-1519
Range on HMM: 187-233/290
Sequence Identity: 42% (20 aa)

SNFVKSTAAYSVATYLLRAGDRHGENLLIRPD-GRMFHIDFGWCFGK
.|.  |.|  ... | |  ||||.||..|  . |   ||||| ||..
ENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFES

Kinase GL50803_17406.AA SMG1 1476-1527 41 6.2e-07 18.85 In-house 190-242 (242) Show / Hide
Range on Protein: 1476-1527
Range on HMM: 190-242/242
Sequence Identity: 41% (22 aa)

FVKSTAAYSVATYLLRAGDRHGENLLI-RPDGRMFHIDFGWCFGKDPKLMAPK
. .|||  |.  |..  |||| .| ||    | . |||.  || |  || .| 
YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE