Gene GL50803_24321 (G.lamblia)

GL50803_24321

Species: G.lamblia
Alias: GL50803_24321, GK261
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_24321.AA Protein None 288 None Fasta, JSON
GL50803_24321.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of GL50803_24321.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_24321.AA Ciliate-E2b 142-222 31 1.8e-18 52.86 In-house 120-208 (272) Show / Hide 
Range on Protein: 142-222
Range on HMM: 120-208/272
Sequence Identity: 31% (28 aa)

TRAIIHRYIMPRRIFMVSETRCKLADIGWSRDLLSMEG---KMGYIQGTLQYYAPELIV-----NEGYGREVDIFALGCTMYEIMMKRV
.. ||.| | |  |   ..  .||.| | .  . . ..   .   | ||. | |||.|      . ||. .|||...| . ||.|...|
NQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYV
Kinase GL50803_24321.AA AGC 186-269 22 1.9e-18 42.85 In-house 267-376 (395) Show / Hide 
Range on Protein: 186-269
Range on HMM: 267-376/395
Sequence Identity: 22% (26 aa)

G--TLQYYAPELIVNEGYGREVDIFA--LGCTMYEIMMKRVLVEDNPEE--------PLEALKKIR-------LPLII-----------TTYSKKLVNLV
|  | .| ||| .    ||...|. .  ||| ||| .  .    ... .        | |  .||.        .. .              |. ...|.
GPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLI

SSMLNPDPKKRPTA
. .|..||.||...
KKLLCKDPEKRLGC
Kinase GL50803_24321.AA Pkinase 155-271 21 2.6e-18 65.83 Pfam 139-286 (293) Show / Hide 
Range on Protein: 155-271
Range on HMM: 139-286/293
Sequence Identity: 21% (33 aa)

IFMVSETRC----KLADIGWSRDL-LSMEGKMGYIQGTLQYYAPELIV-NEGYGREVDIFALGCTMYEIMMKRVLVE-D----NPEEPLEALKKIRLPLI
|.....  .    |..| | .. . .   . |  . ||. | |||.|  ...||..||....||..|| . .| .   .    |  .... ...|. | .
ILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPL

ITTYS-----------------------KKLVNLVSSMLNPDPKKRPTAFE
   ..                       . .  .....|..|||||||| .
HFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ
Kinase GL50803_24321.AA TKL 139-269 16 3.2e-18 62.24 In-house 149-357 (364) Show / Hide 
Range on Protein: 139-269
Range on HMM: 149-357/364
Sequence Identity: 16% (34 aa)

HRFT------RAIIHRYIMPRRIFMVSETR--------------CKLADIGWSRDLLSMEG-------------------KMGYIQGTLQYYAPELIVNE
|  .      ..|||| . .. |.  .  .              ||..| | ||..  ...                   . . . ||... |||.. ..
HSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQ

----------------GYGREVDIFALGCTMYEIMMKRVLVEDNPEEP-----------LEALKKIRLPLII------------TTYSKKLVNLVSSMLN
                 |   .|... |  ..||.  ..  .|.|..|             . .| . |.|             ..  . . .|     .
MNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWD

PDPKKRPTA
.||.|||..
HDPEKRPSF
Kinase GL50803_24321.AA Ciliate-E2 155-271 16 3.6e-17 55.49 In-house 192-358 (365) Show / Hide 
Range on Protein: 155-271
Range on HMM: 192-358/365
Sequence Identity: 16% (30 aa)

IFMVSETRCKLADIGWSRDLL-------------------SMEGKMGYI------------QGTLQYYAPELIVNEG---------YGREVDIFALGCTM
|..     .|..| | |...                     ...  ||.             ||. | ||| . ...         |. ..||..||...
ILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

YEIMMKRVLVEDNPEEPLEALKKIRL-PLIIT-------------------TYSKKLVNLVSS----MLNPDPKKRPT-AFE
|| ....             ...|   .. .                      |..  .| .     ||. ||.||.| . .
YEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQ
S_TKc GL50803_24321.AA S_TKc 10-278 20 1.3e-16 62.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-278
Range on HMM: 1-231/231
Sequence Identity: 20% (57 aa)

YTEVGVIEEAEYQRLVEVQDKETGERYLCRQISLEEYTTKVCDLCKTDITLSTQVASPFFATVHEATYEAKSKKVFVLMEDFPM--GTLNDYLYGLPEDE
|. . .| .  . .   ...|.||... . .|.         .  .  | .  .   |.  . ... ..   ..... ||  .   |.| ||.   .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

F---LPEQTCWCLLACLVEAICQLHEPSRMKDIEHRFTRAIIHRYIMPRRIFMVSETRCKLADIGWSRDLLSMEGKMGYIQGTLQYYAPELIVNEGYGR-
    .|| ....... ...|.  .|.            . |||| . |  |.. .  . |..| | .| |         . ||. | |||..   |||. 
LRFPFPE-HARFYMYQICCALEYCHS------------HGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKC

EVDIFALGCTMYEIMMKRVLVEDNPEEPLEALKKIRLPLIITTYSKKLVNLVSSMLNPDPKKRPTAFEMRT-------IPEI
..|. ..||..|| .  . . .    .. . .|||.        |. . .... .|. ||.||||| |  .        | .
KCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_24321.AA Ciliate-E2-Unclassified 145-278 21 3.5e-14 45.6 In-house 165-352 (352) Show / Hide 
Range on Protein: 145-278
Range on HMM: 165-352/352
Sequence Identity: 21% (41 aa)

IIHRYIMPRRIFMVSET---RCKLADIGWSRDLLSMEGKMGYIQ----------------GTLQYY----APELIVNEGYGRE----VDIFALGCTMYEI
|||| | |  |.. ..    ..|..| | |. . .....  . |                ||..|     |||.. ...|. .    .||..||. .||.
IIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM

MMKRVLVEDNPEEP----------------LEALKKIR-----------LPLIITTYSKKLVN-LVSSMLNPDPKKRPTAFEMRTIPEI
.. .   .|| .|                 |.  .| .            | ..    | ..| | ..||. .|.||.|. .    | .
LFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_24321.AA PKR 134-275 31 1.2e-13 45.08 In-house 133-272 (272) Show / Hide 
Range on Protein: 134-275
Range on HMM: 133-272/272
Sequence Identity: 31% (46 aa)

MKDIEHRFTRAIIHRYIMPRRIFMVSETRCKLADIGWSRDLLSMEGK-MGYIQGTLQYYAPELIVNEGYGREVDIFALGCTMYEIMMKRVLVEDNPEEPL
.| ..    . .||| . |  ||.| | . |. | |     |  .||     .||||| .|| |  . ||.||||.|||  . |..     | .   |  
VKGVDYIHSKKLIHRDLKPSNIFLVDERHIKIGDFGLVT-ALKNDGKSRTRRKGTLQYMSPEQIFSQHYGKEVDIYALGLILAELLH----VCFTEFEKI

EALKKIRLPLII-TTYSKKLVNLVSSMLNPDPKKRPTAFE-MRTI
   . .|   .    . .|   |.  .|   || ||   | .||.
KFFEDLRDGDFSNDIFDNKEKTLLQKLLSKKPKDRPNTSEILRTL
Kinase GL50803_24321.AA STE 155-278 20 1.6e-13 44.18 In-house 183-359 (359) Show / Hide 
Range on Protein: 155-278
Range on HMM: 183-359/359
Sequence Identity: 20% (37 aa)

IFMVSETRCKLADIGWSRDLLS----------------MEGKMGYIQGTLQYYAPELIVN------EGYGREVDIFALGCTMYEIMMKRVLVED-NPE-E
|..     .||.| | .  | .                | .|   . ||  . ||| | .       ||.. .||  ||||. |    ..   | .|   
ILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRA

PLEALKKI--------------RLPLIIT-------------------TYSKKLVNLVSSMLNPDPKKRPTAFEMRT--IPEI
 .......                | . .                    .|... . ..  |. ||.||||| ..     | |
MFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_24321.AA CAMK 164-271 16 2.1e-13 38.82 In-house 236-418 (425) Show / Hide 
Range on Protein: 164-271
Range on HMM: 236-418/425
Sequence Identity: 16% (30 aa)

KLADIGWSRDLLSMEG-----------------------KMGYIQGTLQYYA-PELIVN--------------EGYGREVDIFALGCTMYEIMMKRVLVE
|..| | .. . . |.                       ||    ||. | | ||..                ..||...|. ..|. .|     .   .
KIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY

D--------------NPEEPLEALKKIRLPLIITTYSK-----------------------KLVNLVSSMLNPDPKKRPTAFE
.              |..| .|  .| .   .    |.                          .|...||..||.||.|. .
GDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQ
Kinase GL50803_24321.AA NEK6 137-217 34 4.3e-11 32.51 In-house 116-196 (252) Show / Hide 
Range on Protein: 137-217
Range on HMM: 116-196/252
Sequence Identity: 34% (28 aa)

IEHRFTRAIIHRYIMPRRIFMVSETRCKLADIGWSRDLLSMEGKMGYIQGTLQYYAPELIVNEGYGREVDIFALGCTMYEI
.||   . ..|| | |  .|. ..   || |.|  |   |       . ||  | .|| |  .||    ||..||| .||.
LEHMHSKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEM
Kinase GL50803_24321.AA WEE 237-278 30 3.1e-08 23.79 In-house 256-297 (297) Show / Hide 
Range on Protein: 237-278
Range on HMM: 256-297/297
Sequence Identity: 30% (13 aa)

KIRLPLIITTYSKKLVNLVSSMLNPDPKKRPTAFEMRTIPEI
.|. | ..  .|. | .|. .|..|||..|||. . .  |..
QIPFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase GL50803_24321.AA WEE 155-218 25 1.9e-07 21.09 In-house 143-230 (297) Show / Hide 
Range on Protein: 155-218
Range on HMM: 143-230/297
Sequence Identity: 25% (22 aa)

IFMVSET--------------------RCKLADIGWSRDLLSMEGKMGYI-QGTLQYYAPELIV-NEGYGRE--VDIFALGCTMYEIM
||. ..                     .||..| | . |. | . . ...  |   | |||..  .  |..    |||.||.|.||..
IFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNSNNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYELA
TyrKc GL50803_24321.AA TyrKc 58-279 16 1.6e-05 -133.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 58-279
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

ITLSTQVASPFFATVHEATYEAKSKKVFV--LMEDFPMGTLNDYLYGLPEDEFLPEQTCWCLL------------ACLV--------EAICQLHE-----
|||  .  . .| .|...|.     .| |  | ||              . .|. |    | |            .|.         | .. . |     
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

--PSRMKDIEHRFTRA--------------------IIHRYIMPRRIFMVSETRCKLADIGWSRDLLSM--------EGKM----GYIQ-GTLQYYAPEL
   .. .. ..... .                    .||| .  | .   .. ..| .| | |||. .           ..    |      .  .||| 
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

IVNEG-YGREVDIFALGCTMYEIMMK-RVLVED------NPEEPLEALKKIRLPLIITT--------YSKKLVNLVSSMLNPDPKKRPTAFEMRTIPEIA
| |.| .  . |... | .|.||.       ..      ...| .| .|. . . .            .... .. ..  . ||..|||   ...| |. 
I-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT---FSEIHECF
Kinase GL50803_24321.AA NEK6 241-269 41 0.000695 8.39 In-house 224-252 (252) Show / Hide 
Range on Protein: 241-269
Range on HMM: 224-252/252
Sequence Identity: 41% (12 aa)

PLIITTYSKKLVNLVSSMLNPDPKKRPTA
||    ||..| .||. ...|||..||  
PLPADHYSEQLRQLVCMCIHPDPEWRPDI