Gene GL50803_3677 (G.lamblia)

GL50803_3677

Species: G.lamblia
Alias: GK085, GL50803_3677
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GL50803_3677.AA Protein None 844 None Fasta, JSON
GL50803_3677.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of GL50803_3677.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_3677.AA S_TKc 16-279 26 1.6e-54 188.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-279
Range on HMM: 1-231/231
Sequence Identity: 26% (75 aa)

NRFGHCIGQGVYGTVYSLSDNP---DEAVKEMRIDGMPEDVLEAFETEIRIMPQLSHPNILRYKAVHQEGDFVYIRMQRYAK---SLEDTIKVYKRKRKE
 ...  ||.| .|.||   ..      |.|...         | .. ||.|. .  |||| ... | |. |..|. |        .| | || ..|... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FPRDKIIEVLLQVTTGLMYLHSPNKHDTTGNPLSAVIIHRDLKPANILTNDDETQFVIADFGFCREALKDGSTTAGSPMYFAPEVLLKKKYSP-ASDM
  ||   .  .. |.  .| |.|| .            ||||||||.||| ..   .  |.|||..|.     .|  |.| | |||||   .|.. ..|.
FPFPE-HARFYMYQICCALEYCHSHG------------IIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDW

WSLGVIIYELASGVRPFFLSNVKSESDLSEAWRPDLNAINDGFIKSVLETLLVPNPSDRPSAEQLLK-----ELDEYL
||.|.|.||...|  ||       .  . .  .       . ..   .. .|. .|..||.| ..|.      .....
WSCGCILYEMLCGYPPFP-----QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase GL50803_3677.AA Pkinase 16-275 25 3.9e-52 184.3 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-275
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

NRFGHCIGQGVYGTVYSLSDNPDE---AVKEMRIDGMPEDVLEAFET--EIRIMPQLSHPNILRYKAVHQEGDFVYIRMQRYAK-----SLEDTIKVYKR
 ..| .||.| .|.||   .  ..   |||... ..  ......     ||.||  |.||||.|.. . ...| .|. |    .     .| | |..  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

KRKEF--PRDKIIEVLLQVTTGLMYLHSPNKHDTTGNPLSAVIIHRDLKPANILTNDDETQF----VIADFGFCRE--ALKDGSTT--AGSPMYFAPEVL
... |  . . .. ...|.  || |.|| .            ||||||||.||| . .. .      |.|||...     ... .|  .|.| | ||||.
RHGCFYFSEWECKFYMYQILRGLEYCHS-M-----------GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVI

L-KKKYSPASDMWSLGVIIYELASGVRPFFLS--------NVKSESDLSEAWRPDLNAIND-------------------GFIKSVLETLLVPNPSDRPS
.  ..|.|..||||.|.|.||...|  ||  .        ... . ...  .. |    ..                      |.... .| ..|..||.
RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

AEQLLKE--L
|||.|.   .
AEQILQHPWF
Kinase GL50803_3677.AA ULK 16-234 25 1.5e-40 139.26 In-house 1-271 (329) Show / Hide 
Range on Protein: 16-234
Range on HMM: 1-271/329
Sequence Identity: 25% (73 aa)

NRFGHCIGQGVYGTVYSL--SDNP---DEAVKEMRID-----GMP-----EDVLEAFETEIRIMPQLS--------HPNILRYKAVHQEGDF--VYIRMQ
    ||.|.| .|.||     ..    .|.|.   ||       .     .  .. .. ||.|| .|         |||| ... . .. ..  .|| ..
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI-IM

RYAKS--LEDTIKVYKR------KRKEFPRDKIIEVLLQVTTGLMYLHSPNKHDTTGNPLSAVIIHRDLKPANILTNDDETQ-----------FVIADFG
 |     ||. || .|.      . | .. ...|... |   |...||. |            |||||.||.||| ... ..           . |||||
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN------------IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG

FCREALKD------GSTTA------GSPMYFAPEVLL----KKKYSPA-SDMWSLGVIIYELASGVRPFFLSNVKSES-----DL
|..   .|        |.       |.|.| ||..|     .|.|. . .|.||||.|.||.  |  ||. .   ..      .|
FAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKL
Kinase GL50803_3677.AA STE 16-224 25 5.3e-39 135.37 In-house 1-269 (359) Show / Hide 
Range on Protein: 16-224
Range on HMM: 1-269/359
Sequence Identity: 25% (72 aa)

NRFGHCIGQGVYGTVYSLSDN-PD-----------------EAVKEMRIDGMP---------------EDVLEAFETEIRIMPQLS--HPNILRYKAVHQ
 ..  .||.| .||||   .. ..                  |.|.|...                  .. .. .. ||.|| ...  |||| .|   . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------DFVYIRMQRYA-KSLEDTIK-VYKRKR---------KEFPRDKIIEVLLQVTTG-LMYLHSPNKHDTTGNPLSAVIIHRDLKPANILTNDD
 .       | ..| |   .  ||.| || .|....         . || . |. .. |.  | | |||| .            |||||.||||||    
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH------------IIHRDIKPANILL---

ETQFVIADFGFCREALKDGS-------------------TTAGSPMYFAPEVLLK------KKYSPASDMWSLGVIIYELASGVRPFF
     ..|||.|    ....                   | .|.| . ||||...      |.|.  .|.||||  | |.| |  |..
---VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWH
Kinase GL50803_3677.AA ULK 16-234 25 1.4e-38 134.46 In-house 1-266 (324) Show / Hide 
Range on Protein: 16-234
Range on HMM: 1-266/324
Sequence Identity: 25% (72 aa)

NRFGHCIGQGVYG-TVYSL--SDNP--DEAVKEMRID---GMPEDVL-------EAFETEIRIMPQLS---HPN--ILRYKAVHQEGDF--VYIRMQRYA
    ||.|.| .| .||     ..   ...|.   ||         .       . .. ||.|| .|    |||  | ... . .. ..  .|| .. | 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYI-IMEYC

KS--LEDTIKVYKR-----KRKEFPRDKIIEVLLQVTTGLMYLHSPNKHDTTGNPLSAVIIHRDLKPANILTNDDETQ-----------FVIADFGFCRE
    ||. || .|.     . | .. ...|... |   |...||. |            |||||.||.||| ... ..           . ||||||.. 
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN------------IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH

AL------KDGSTTA------GSPMYFAPEVLL----KKKYSPA-SDMWSLGVIIYELASGVRPFFLSNVKSES----DL
         .  |.       |.|.| ||..|     .|.|. . .|.||||.|.||.  |  ||| .   ..     .|
VDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKL
Kinase GL50803_3677.AA Ciliate-E2 16-273 21 2.2e-37 125.9 In-house 1-361 (365) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-361/365
Sequence Identity: 21% (84 aa)

NRFGHCIGQGVYGTVYSLSDNPD---------------------EAVKEMRIDGMPEDVLEAFETEIRIMP----------------QLSHPNILRYKAV
  |  .|||| .|.||  ..  .                      ..|.  .  | .. .|... ||.||                 ||.||||.... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

HQ--EGDFVYIRMQRYAK-SLEDTIKVYKRKRKEFPR-------DKIIEVLLQVTT---------------GLMYLHSPNKHDTTGNPLSAVIIHRDLKP
 |    . .|. |  .   .|.| ||  | ||.. .         .|...  |..                .| |||| |            |||||.||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKN-----------NIIHRDIKP

ANILTNDDETQFVIADFGFCREALKD--------------------GSTT--------------AGSPMYFAPEVLLKKK---------YSPASDMWSLG
 |||         |.|||..... .|                    ....              .|.|.| |||.| .||         |. ..|.||||
ENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG

VIIYELASGVRPFFLSNVKSESDLSEAWRPDLNAINDGFIK----------------------------SVLET----LLVPNPSDRPS-AEQLLK
||.||. .| .||                  .. | .. |.                              .      .|. .|. |.. .||.|.
VILYEMLFGKPPF------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase GL50803_3677.AA TKL 22-275 19 9.5e-36 125.08 In-house 1-364 (364) Show / Hide 
Range on Protein: 22-275
Range on HMM: 1-364/364
Sequence Identity: 19% (73 aa)

IGQGVYGTVYSLSDN-----------PDEAVKEMRIDG-------------------------MPEDVLEAFETEIRIMPQLSHPNILRYKAVHQEGDF-
||.| .|.||    .            | ||| ....                          ...   . .| ||..| .|.||||...... ..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------VYIRMQRY-AKSLEDTIKVYKRKRKEFPRDKIIEVLLQVTTGLMYLHS--PNKHDTTGNPLSAVIIHRDLKPANILTNDDET------
             .| |. .   ||....            ....   |..  |. ||||  |  .          |||||||..||| ... |      
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT------KPPIIHRDLKSKNILVDENWTNVSNYM

-------QFVIADFGFCREALKDG----------------------STTAGSPMYFAPEVLLKK----------------KYSPASDMWSLGVIIYELAS
          |.|||..|.  ..|                      .|  |.| . ||||| ..                .||...|..| |....|...
YNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT

GVRPFF--LSNVKS---------ESDLSEAWRPDLN---------AINDGF---IKSVLETLLVPNPSDRPSAEQLLKEL
. ||..   ..            . . ..  || .            .. .   .|. ..    ..|..|||....||.|
RCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_3677.AA Ciliate-E2-Unclassified 17-273 21 9.2e-35 118.01 In-house 2-348 (352) Show / Hide 
Range on Protein: 17-273
Range on HMM: 2-348/352
Sequence Identity: 21% (78 aa)

RFGHCIGQGVYGTVYSLSD--NPDEA-------VKEMRIDGMPEDVLEAFETEIRIMPQLS-----------------HPNILRYKAVHQEGDF--VYIR
.....|||| .|.|| . .  .  ..       .. .. .   . .   .  |. .| ...                 ||.....| .... |   .|| 
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MQRY-AKSLEDTIKVYK-------------RKRKEFPRDKII-----EVLLQVTTGLMYLHSPNKHDTTGNPLSAVIIHRDLKPANILTNDDET--QFVI
|.    ..|.. || .|             ..||.|.  ...       . |.  || |||. |.           |||||.|| ||| ...    .  |
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN-----------IIHRDIKPENILFDNNGKNYYIKI

ADFGFCREALKD------------------GSTTAGSPMYF----APEVLLKKKYS----PASDMWSLGVIIYELASGVRPFF-----------------
.|||....  ..                   .|..|.|.|     ||||| ...|.     ..|.||||||.||.  | .||.                 
IDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINN

-----LSNVKSESDLSEAWRP------DLNAINDGFIKSVLETLLVPNPSDRPSAEQLLK
     | . . . ...  . |      ...     ||.  |  .|. ||. |...||.|.
AYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase GL50803_3677.AA NEK 22-218 30 6.4e-30 102.78 In-house 7-219 (286) Show / Hide 
Range on Protein: 22-218
Range on HMM: 7-219/286
Sequence Identity: 30% (67 aa)

IGQGVYGTVY---SLSDNPDEA-----VKEMRIDGMPEDVLEAFE-TEIRIMPQLSHPNILRYKAVHQEGD--FVYIRMQRYAKS---LEDT---IKVYK
|||| .|.||   . ||.  ..      |.. ...| |   ..    |.||  || |||| .|.   .| .  . .| |  |.     |..    || .|
IGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVME-YCEGGGDLYQKIKSIKKQK

RKRKEFPRDKIIEVLLQVTTGLMYLH--SPNKHDTTGNPLSAVIIHRDLKPANILTNDDETQ---FVIADFGFCREALKD---GST-TAGSPMYFAPEVL
 |.| |. ..| ... |   .| |.|  . .            |.|||.||.||  ... ..     | |||  ..  ..    .|   | | | .|||.
QKGKYFEEEQIWDWFIQMCLALKYMHDRK-GP--------QRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVC

LKKKYSPASDMWSLGVIIYELAS
  |.|.  ||.||||...||...
QNKPYNNKSDIWSLGCVLYEMCT
Kinase GL50803_3677.AA CAMK 146-273 21 1.8e-28 88.3 In-house 200-421 (425) Show / Hide 
Range on Protein: 146-273
Range on HMM: 200-421/425
Sequence Identity: 21% (48 aa)

IIHRDLKPANILTNDDE----------------TQFVIADFGFCREALKDGS--------------------------TTAGSPMYFA-PEVLLKKK---
|.|||||| ||| .|..                 .  |.|||| ..  .. .                          |  |.| | | ||||..|.   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YSPASDMWSLGVIIYELASGVRPFFLSNVK----------SESDLSE-----AWRPDLNAINDGF----------------------IK
           |.|..||||.||| | . .|  ||  .. .          ....| |      .. .   . .                         |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SVLETLLVPNPSDRPSAEQLLK
. .  .|...|..|...|| |.
DLIRKMLQVDPEKRMTIEQCLN
Kinase GL50803_3677.AA STE20 118-224 35 7.6e-18 62.04 In-house 122-228 (288) Show / Hide 
Range on Protein: 118-224
Range on HMM: 122-228/288
Sequence Identity: 35% (42 aa)

VLLQVTTGLMYLHSPNKHDTTGNPLSAVIIHRDLKPANILTNDDETQFVIADFGFCREALK-----DG---STTAGSPMYFAPEVLLK-----KKYSPAS
.. .|  || |||| .            |||||.| .||| ..|  .  .||||.|    |     ..    |  |.| . ||||...     |.|   .
ICREVLQGLDYLHSNH------------IIHRDIKADNILLTED-GEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKC

DMWSLGVIIYELASGVRPFF
| ||||  . |.| |  |.|
DIWSLGITAIEMAEGEPPYF
Kinase GL50803_3677.AA TyrKc 16-275 22 9.9e-16 31.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-275
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

NRFGHCIGQGVYGTVYS--LSDNPDEAVKEMRIDGMPEDVLEAFETEIRIMPQL--SHPNILRYKAVHQEG-------DFVYIRMQRYAK-SLEDTIKVY
 ..|. .| | .|.||   ..   . ||| .. |      .|.|  |.||| .|  .||||.|  .|  ..       . ..| |   .. .| | .. .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KRKRKEFPRDKIIEVLLQVTTGLMYLHSPNKHDTTGNPLSAVIIHRDLKPANILTNDDETQFVIADFGFCREALKD-------GSTTA----GSPM----
..|   .. .. ..  .|.  |  ||||              .|||||   |.| ...  .  |.||| .|.   |          ..    |. .    
RPK---LCMKDLLSFCWQIACGMEYLHSK------------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

-YFAPEVLLKKKYSPASDMWSLGVIIYELAS-GVRPFF------LSNVKSESDLSEAWRPDLNAI--------NDGFIKSVLETLLVPNPSDRPSAEQLL
   |||.. ..|....|| || || ..|. . |  |        .||     .. .  |..  .             . .. ..    .|.|||. ... 
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

KEL
...
ECF
Kinase GL50803_3677.AA STE11 146-223 31 8.2e-14 46.58 In-house 137-238 (303) Show / Hide 
Range on Protein: 146-223
Range on HMM: 137-238/303
Sequence Identity: 31% (32 aa)

IIHRDLKPANILTNDDETQFVIADFGFCREALKDG---------------------STTAGSPMYFAPEVLLKKK---YSPASDMWSLGVIIYELASGVR
|||||.|.|||| . | .   .|||| ..   ...                     ....|.||. ||||. . .   |. ..| |||| ...| |.| .
IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKP

PF
|.
PW
Kinase GL50803_3677.AA STE11 16-87 28 3.9e-11 36.8 In-house 1-90 (303) Show / Hide 
Range on Protein: 16-87
Range on HMM: 1-90/303
Sequence Identity: 28% (26 aa)

NRFGHCIGQGVYGTVY-SLSDNPDE--AVKEMRIDGMP------EDVLEA------FETEIRIMPQLSHPNILRYKAVHQ---EGDFVYI
 . |..||.| .||||  .  . .|  |||...|...       |. ...      .. ||..| .|.|.|| ||  . .   . |.|.|
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNI
Kinase GL50803_3677.AA CAMK 21-131 13 1.2e-09 26.5 In-house 1-197 (425) Show / Hide 
Range on Protein: 21-131
Range on HMM: 1-197/425
Sequence Identity: 13% (26 aa)

CIGQGVYGTVYSLSDNPDE---------------AVKEMRIDGMPED--------------------------VLEAFETEIRIMPQLS-------HPNI
 .|.| .|.|.   .  .                |.| .  . ....                           .. .. ||.|| .|.       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRYKAVHQEGDF-------------------VYIRM---QRYAK-----SLEDTIKVYKRKR-----------KEFPRDKIIEVLLQVTTGLMYLHS
..   | . ...                   .|. |              | | |.  ....           . |. .    .  |.  .. |.||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS
Kinase GL50803_3677.AA STE20 17-83 30 5.2e-09 29.37 In-house 2-81 (288) Show / Hide 
Range on Protein: 17-83
Range on HMM: 2-81/288
Sequence Identity: 30% (24 aa)

RFGHCIGQGVYGTVYSLSDN--PDE-----AVKEMRIDGMPE--DVLEAFETEIRIMPQLSHPNILRYKAVHQEG----D
 . ..|||| ||.||   ..   ..     |.| | ..   .  | .|  ..||.|| |. |||| .|   .. .    |
ELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDD
Kinase GL50803_3677.AA Pkinase_Tyr 104-223 24 4.8e-07 24.48 Pfam 99-216 (270) Show / Hide 
Range on Protein: 104-223
Range on HMM: 99-216/270
Sequence Identity: 24% (32 aa)

KRK---RKEFPRDKIIEVLLQVTTGLMYLHSPNKHDTTGNPLSAVIIHRDLKPANILTNDDETQFVIADFGFCREALKDGST-TAGSPMYF-----APEV
...   .. ..   ...  .|.  |. ||.| |            .|||||   |.| ...  .  |.||| .|   .|.   ....   .     |||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN------------CIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC

LLKKKYSPASDMWSLGVIIYELAS-GVRP-F
.  .|.. .|| || || ..|. . |  | .
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTY
Kinase GL50803_3677.AA Pkinase_Tyr 17-78 38 1e-06 23.09 Pfam 2-72 (270) Show / Hide 
Range on Protein: 17-78
Range on HMM: 2-72/270
Sequence Identity: 38% (27 aa)

RFGHCIGQGVYGTVYS--LSDNPDE-----AVKEMRIDGMPED-VLEAFETEIRIMPQL-SHPNILRYKAV
.||. .|.| .|.||   . . ||.     ||| .. . |.|.  .|.|  |..|| || .||||.|. .|
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGV
Kinase GL50803_3677.AA STE 254-300 23 0.000191 11.75 In-house 334-359 (359) Show / Hide 
Range on Protein: 254-300
Range on HMM: 334-359/359
Sequence Identity: 23% (11 aa)

LETLLVPNPSDRPSAEQLLKELDEYLTSKESKGTFRFKELEAEHSAL
..  |. .|..||.|.||||.                     ||. .
INKCLQKDPNKRPTASQLLKS---------------------EHPFI
Kinase GL50803_3677.AA NEK 251-273 30 0.004827 7.02 In-house 260-282 (286) Show / Hide 
Range on Protein: 251-273
Range on HMM: 260-282/286
Sequence Identity: 30% (7 aa)

KSVLETLLVPNPSDRPSAEQLLK
..... .| ..|..|||..|.|.
QNLISQMLQKDPEQRPSCNQILE
Kinase GL50803_3677.AA STE11 258-273 43 0.004942 7.15 In-house 284-299 (303) Show / Hide 
Range on Protein: 258-273
Range on HMM: 284-299/303
Sequence Identity: 43% (7 aa)

LVPNPSDRPSAEQLLK
....|..||.| |||.
FEHDPKKRPTANQLLQ
Kinase GL50803_3677.AA STE20 254-273 45 0.005977 6.97 In-house 265-284 (288) Show / Hide 
Range on Protein: 254-273
Range on HMM: 265-284/288
Sequence Identity: 45% (9 aa)

LETLLVPNPSDRPSAEQLLK
... |. .|..||.|.||||
VDKCLQKDPEKRPTASQLLK
Kinase GL50803_3677.AA Pkinase_Tyr 260-275 31 0.21864 5.32 Pfam 255-270 (270) Show / Hide 
Range on Protein: 260-275
Range on HMM: 255-270/270
Sequence Identity: 31% (5 aa)

PNPSDRPSAEQLLKEL
..|.|||. .... .|
YDPEDRPTFSEIHEQL
Ank GL50803_3677.AA Ank 453-473 52 0.000129 20.9 Pfam 1-21 (33) Show / Hide 
Range on Protein: 453-473
Range on HMM: 1-21/33
Sequence Identity: 52% (11 aa)

YGYTALMHAAYSGHTDVVKKL
.|.|.|. |...|||.||| |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_3677.AA Ank 422-452 27 0.095927 10.55 Pfam 1-33 (33) Show / Hide 
Range on Protein: 422-452
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

RSFTALMHAAQRGRTAFIPLLVD--KEKGIQDK
  ||.|. |...|.|  . .|..   .  .||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_3677.AA Ank 484-507 29 0.127039 10.11 Pfam 1-24 (33) Show / Hide 
Range on Protein: 484-507
Range on HMM: 1-24/33
Sequence Identity: 29% (7 aa)

QTLTALMVAAGKNHVDSVKILINY
   |.|..|. ..|.. || |...
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_3677.AA Ank 515-538 41 0.000417 19.07 Pfam 1-24 (33) Show / Hide 
Range on Protein: 515-538
Range on HMM: 1-24/33
Sequence Identity: 41% (10 aa)

KGETSLMIAAQHGHIETVKVLMDY
 |.| |..|...||.| || |...
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_3677.AA Ank 546-576 36 2.4e-05 23.56 Pfam 1-33 (33) Show / Hide 
Range on Protein: 546-576
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

LGYTALMEAARKGHTEVIRLLVE--VEENLRAN
 |.|.|. |.|.|||||...|..   . |.. .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_3677.AA Ank 577-598 31 0.002068 16.56 Pfam 1-22 (33) Show / Hide 
Range on Protein: 577-598
Range on HMM: 1-22/33
Sequence Identity: 31% (7 aa)

DGRTALMIAAENSNKEAAEVLM
||.|.|..|... ..| .. |.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_3677.AA Ank 605-623 21 20.444701 2.15 Pfam 1-19 (33) Show / Hide 
Range on Protein: 605-623
Range on HMM: 1-19/33
Sequence Identity: 21% (4 aa)

SNWTTLMCAAALGDVQLIE
  .| |..|.  |... ..
DGFTPLHLACRCGHTEVVK
Ank GL50803_3677.AA Ank 635-658 37 7.134104 3.8 Pfam 1-24 (33) Show / Hide 
Range on Protein: 635-658
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

LGRTSLIIAAQNNKIAAVKKLAQH
 |.| | .|.... .  || | ||
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_3677.AA Ank 663-680 33 0.694139 7.45 Pfam 1-18 (33) Show / Hide 
Range on Protein: 663-680
Range on HMM: 1-18/33
Sequence Identity: 33% (6 aa)

SGWTVLMYASCIGDAELA
 |.| |..|.. |..| .
DGFTPLHLACRCGHTEVV
Ank GL50803_3677.AA Ank 693-716 41 5e-06 25.94 Pfam 1-24 (33) Show / Hide 
Range on Protein: 693-716
Range on HMM: 1-24/33
Sequence Identity: 41% (10 aa)

TGMTALMWAAMHGHHELVELLVEH
 |.|.|..|...||.| |..|..|
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_3677.AA Ank 724-747 45 7.1e-05 21.84 Pfam 1-24 (33) Show / Hide 
Range on Protein: 724-747
Range on HMM: 1-24/33
Sequence Identity: 45% (11 aa)

DGHTAMMWASRNGHSKSVSLLLDH
|| |. ..|.|.|| . |..||.|
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_3677.AA Ank 786-813 46 0.000367 19.27 Pfam 1-28 (33) Show / Hide 
Range on Protein: 786-813
Range on HMM: 1-28/33
Sequence Identity: 46% (13 aa)

DLRTALMHAAMNGHVSVVKALAEHERDV
| .|.|. |...||..||| | .|  ||
DGFTPLHLACRCGHTEVVKMLLQHGADV
Ank GL50803_3677.AA Ank 755-785 39 0.000552 18.63 Pfam 1-33 (33) Show / Hide 
Range on Protein: 755-785
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

KGMTSLMLGAAAGYLEVVQILLD--VECNLQDA
 |.| |.| .  |..|||. ||.   . |.|| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_3677.AA Ank 817-837 38 0.937035 6.98 Pfam 1-21 (33) Show / Hide 
Range on Protein: 817-837
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

DCCTALQLAKQYGQQDVAEFL
| .|.| || ..|. .|...|
DGFTPLHLACRCGHTEVVKML