GL50803_36783

Species: G.lamblia
Alias: GK263, GL50803_36783
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_36783.AA Protein None 645 None Fasta, JSON
GL50803_36783.kin_dom Protein Kinase Domain None 244 None Fasta, JSON

Protein domain

Protein domains of GL50803_36783.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_36783.AA TKL 116-201 18 9.8e-11 34.89 In-house 137-283 (364) Show / Hide
Range on Protein: 116-201
Range on HMM: 137-283/364
Sequence Identity: 18% (28 aa)

ILSQISMGLAYLHT--P---AGKGVILHRNLTPANVLVVANGA--------------IKLSDIRLGPLFDDDE---------------------------
.  .|. |..|||.  |     |  |.||.|...|.||  |.               .|..|  |   .. ..                           
WALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCG

PTAFRAPELRS----------------SGSFSAKTDIYSMGRIIAELC
 ... |||.                  ....| |.|.||.| .. |..
TPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL

S_TKc GL50803_36783.AA S_TKc 9-252 21 3.3e-10 -27.25 SMART 1-231 (231) Show / Hide
Range on Protein: 9-252
Range on HMM: 1-231/231
Sequence Identity: 21% (57 aa)

YSDIHEVSQKRWWTSYYAYRADSTRKVVLKRIDLSNLKTRESNTLVWAYSQLRDLSNIYVVRCSVVHYAPGDSLLLESPFEEG--CNLIDYVKRSCA--S
|  . .. .    . | ..  .. |.| .|.|.  .   || . |             ..|..  | .   |.| .   . .|   .| || |.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--------HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

CEPVSEEALWPILSQISMGLAYLHTPAGKGVILHRNLTPANVLVVANGAIKLSD----IRLGPLFDDDEPTAFRAPELRSSGSFSA-KTDIYSMGRIIAE
. | .|   . .. ||  .|.|.|   |   |.|| | |.|.|.     ||..|     .|           ..|||.    ...  | |..| | |..|
RFPFPE-HARFYMYQICCALEYCHSH-G---IIHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LCIAGPLSAETITRSALESHGYTSVFATLLHACLDPDPSKRPTAWDIAE-------QSTL
..   |.         ..  | .. .  ..  ||. ||.||||| .. .          .
MLCGYPPFP--QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_36783.AA PEK 173-252 19 6.7e-09 26.35 In-house 555-655 (655) Show / Hide
Range on Protein: 173-252
Range on HMM: 555-655/655
Sequence Identity: 19% (20 aa)

FRAPELRSSG-----SFSAKTDIYSMGRIIAELCIAGPLSA-ETITRSALESH------GYTS---------VFATLLHACLDPDPSKRPTAWDIAEQST
...||. | .      .  |.|.||.| |..|...    .  | ..             |  .         ..|.... .|..||..||.| .| .. .
YMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEF

L
.
F

Kinase GL50803_36783.AA nmo 117-200 36 5.7e-08 19.94 In-house 108-197 (292) Show / Hide
Range on Protein: 117-200
Range on HMM: 108-197/292
Sequence Identity: 36% (34 aa)

LSQISMGLAYLHTPAGKGVILHRNLTPANVLVVANGAIKLSDIRLGPLFDDDEPTA---------FRAPE-LRSSGSFSAKTDIYSMGRIIAEL
| ||  || |||.      |||| . | |.|| .|  .|. |  |    . |.            .|||| |  .  ...  ||.|.| | |||
LYQILRGLKYLHSAN----ILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAEL

Kinase GL50803_36783.AA PEK 90-158 18 1.2e-07 21.95 In-house 366-475 (655) Show / Hide
Range on Protein: 90-158
Range on HMM: 366-475/655
Sequence Identity: 18% (21 aa)

EGCNLIDYVKRSC----------------------------------------ASCEPVSEEALWPILSQISMGLAYLHTPAGKGVILHRNLTPANVLVV
|...| |. ....                                        . |. .... .| |..||  ||.|.|   ..| . || |.|.|... 
EKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIH---SQG-MIHRDLKPSNIFLD

ANGA-----IKLSD
 .|      .|  |
CDGQHHQMQVKIGD

Kinase GL50803_36783.AA CDC2 92-158 26 1.2e-07 19.01 In-house 84-146 (301) Show / Hide
Range on Protein: 92-158
Range on HMM: 84-146/301
Sequence Identity: 26% (18 aa)

CNLIDYVKRSCASCEPVSEEALWPILSQISMGLAYLHTPAGKGVILHRNLTPANVLVVANGAIKLSD
..|  | ..|  . ........  .. ||  |....|.      |.||.| | | |. ..|.||..|
MDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRR----IMHRDLKPQNILIDKKGNIKIAD

Kinase GL50803_36783.AA Ciliate-E2 116-194 20 2e-06 17.96 In-house 150-283 (365) Show / Hide
Range on Protein: 116-194
Range on HMM: 150-283/365
Sequence Identity: 20% (29 aa)

ILSQIS---------------MGLAYLHTPAGKGVILHRNLTPANVLVVANGAIKLSDIRLGPLFDDDE-------------------------------
|  ||                 .| |||    |. |.||.. | |.|.     ||..|  |   .|||.                               
IMKQILQGFKTKAEFYIACIILALEYLHS---KNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQ

--------PTAFRAPELRSSGS---------FSAKTDIYSMG
           . |||  ....          . | ||.|.|
NMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG

Kinase GL50803_36783.AA NEK 106-158 27 4e-06 17.89 In-house 109-166 (286) Show / Hide
Range on Protein: 106-158
Range on HMM: 109-166/286
Sequence Identity: 27% (16 aa)

EPVSEEALWPILSQISMGLAYLH--TPAGKGVILHRNLTPANVLVVANGA----IKLSD
.. .||  | .. |....| |.|     ... |||| . |.|.   .|.     .|. |
KYFEEEQIWDWFIQMCLALKYMHDRK-GPQRKILHRDIKPQNIFLTKNNNDYHNVKIGD

Kinase GL50803_36783.AA NAK 221-250 30 5e-06 16.05 In-house 270-299 (299) Show / Hide
Range on Protein: 221-250
Range on HMM: 270-299/299
Sequence Identity: 30% (9 aa)

YTSVFATLLHACLDPDPSKRPTAWDIAEQS
|.. .  |  ..|.|||..||. ... .| 
YSQQMHDLIRYMLTPDPEQRPNIYQVLNQL

TyrKc GL50803_36783.AA TyrKc 25-252 16 7e-06 -127.59 SMART 16-280 (280) Show / Hide
Range on Protein: 25-252
Range on HMM: 16-280/280
Sequence Identity: 16% (47 aa)

YAYRADSTRKVVLKRIDLSNLKTRESNTLVWAYSQLRD-------L--SNIYVVRCSVVHYAPG------DSLLLESPFEEGCNLIDYVKRSCASCEPVS
|  ...  ..|  | .  .                ...       |  ..  .||.  |   .|      . |..   . .. .| || ...      ..
YKGTWK--IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LC

EEALWPILSQISMGLAYLHTPAGKGVILHRNLTPANVLVVANGAIKLSD------IRLG-------PLFD------DD--EPTAFRAPELRSSGSFSAKT
 . |  .  ||. | .|||       . || |   |.|| .|. .| ||      |  .          .       .   |    |||    | |. |.
MKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

D----------IYSMGRIIAEL-----CIAGPLSAETITRSALESHGY---------TSVFATLLHACLDPDPSKRPTAWDIAEQSTL
|          |.. |    .      . .  . .   ..  ..   .         ..   ..   | . ||..||| ..|   . .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase GL50803_36783.AA MLK 119-158 34 2e-05 14.93 In-house 132-176 (291) Show / Hide
Range on Protein: 119-158
Range on HMM: 132-176/291
Sequence Identity: 34% (16 aa)

QISMGLAYLHTPAGKGVILHRNLTPANVLVVA------NGAIKLSD
|.. |..|||  | |  | || | . |.|. .      .|  | .|
QCARGMHYLHSMAPK-PIIHRDLKSHNILIDEICHDMHHGTLKICD

Kinase GL50803_36783.AA GCN2 107-158 33 6.5e-05 12.67 In-house 303-351 (511) Show / Hide
Range on Protein: 107-158
Range on HMM: 303-351/511
Sequence Identity: 33% (18 aa)

PVSEEA-LWPILSQISMGLAYLHTPAGKGVILHRNLTPANVLVVANGAIKLSD
...... || ...||  ||.|.|    .|.| || | |.|... ..| .| .|
WCMDHDELWRYFRQILEGLNYIH---SQGMI-HRDLKPSNIFLDCCGNVKIGD

Kinase GL50803_36783.AA NEK 228-252 32 8.2e-05 13.32 In-house 262-286 (286) Show / Hide
Range on Protein: 228-252
Range on HMM: 262-286/286
Sequence Identity: 32% (8 aa)

LLHACLDPDPSKRPTAWDIAEQSTL
|.. .| .||..||....| |.. .
LISQMLQKDPEQRPSCNQILEMPFI

Kinase GL50803_36783.AA STE-Unique 110-158 32 0.000119 11.79 In-house 403-453 (616) Show / Hide
Range on Protein: 110-158
Range on HMM: 403-453/616
Sequence Identity: 32% (18 aa)

EEALWPILSQISMGLAYLHTPAGKG-VILHRNLTPANVLVVANG-----AIKLSD
.|..| .. ||  || |||.   ..  |.||.| |.|..    |      .|..|
TEVIW-YTYQILEGLEYLHS---QHNPIIHRDLKPHNIFCMQDGKGRVCKVKICD

Kinase GL50803_36783.AA NAK 107-158 25 0.000175 10.79 In-house 115-169 (299) Show / Hide
Range on Protein: 107-158
Range on HMM: 115-169/299
Sequence Identity: 25% (14 aa)

PVSEEALWPILSQISMGLAYLHTPA-GKGVILHRNLTPANVLVV---ANGAIKLSD
...|.  . |....  |....|..   |. | || ... |.|     ..| .|| |
CFTEDEILQIFCDVCEGVQAMHQCQPPKPII-HRDIKIENILLSESHHDGNYKLCD

Kinase GL50803_36783.AA GCN2 225-252 32 0.000184 11.06 In-house 484-511 (511) Show / Hide
Range on Protein: 225-252
Range on HMM: 484-511/511
Sequence Identity: 32% (9 aa)

FATLLHACLDPDPSKRPTAWDIAEQSTL
...... ||..||.|||.| .. . ..|
QQDMIRWCLNHDPQKRPSAQQLLQHEFL

Kinase GL50803_36783.AA STE-Unique 225-252 25 0.000263 10.55 In-house 589-616 (616) Show / Hide
Range on Protein: 225-252
Range on HMM: 589-616/616
Sequence Identity: 25% (7 aa)

FATLLHACLDPDPSKRPTAWDIAEQSTL
.. .. .||...|..||.| . ..  .|
QQQFIEKCLERNPHHRPSAHQLLHHFWL

Kinase GL50803_36783.AA Pkinase 173-243 17 0.000775 14.65 Pfam 177-284 (293) Show / Hide
Range on Protein: 173-243
Range on HMM: 177-284/293
Sequence Identity: 17% (19 aa)

FRAPELRS-SGSFSAKTDIYSMGRIIAELCIAGPLSAET----------ITRSALE-----SHGYT---------------------SVFATLLHACLDP
..|||.   .   . | |..|.| |..|..   |.  .           . .  ..     .  ..                     . .  ..  ||..
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

DPSKRPTA
||.|||||
DPKKRPTA

Kinase GL50803_36783.AA MLK 225-250 30 0.002717 7.43 In-house 266-291 (291) Show / Hide
Range on Protein: 225-250
Range on HMM: 266-291/291
Sequence Identity: 30% (8 aa)

FATLLHACLDPDPSKRPTAWDIAEQS
.. |.. | ..||.|||.   | .. 
WKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase GL50803_36783.AA TKL 225-250 34 0.005086 6.73 In-house 339-364 (364) Show / Hide
Range on Protein: 225-250
Range on HMM: 339-364/364
Sequence Identity: 34% (9 aa)

FATLLHACLDPDPSKRPTAWDIAEQS
.. |.  | |.||.|||.. .| .. 
MKKLMQDCWDHDPEKRPSFQEILKRL

Kinase GL50803_36783.AA Ciliate-E2 228-252 26 0.029085 3.55 In-house 336-365 (365) Show / Hide
Range on Protein: 228-252
Range on HMM: 336-365/365
Sequence Identity: 26% (8 aa)

LLHA----CLDPDPSKRPT-AWDIAEQSTL
|.      .|. ||.||.| ...| .   .
LIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase GL50803_36783.AA MLK 172-192 33 0.170523 1.11 In-house 198-221 (291) Show / Hide
Range on Protein: 172-192
Range on HMM: 198-221/291
Sequence Identity: 33% (8 aa)

AFRAPELR---SSGSFSAKTDIYS
|..||| .    .. .| | |..|
AWMAPEVIQQFRCEKYSEKCDVWS

Kinase GL50803_36783.AA Pkinase 116-158 38 0.949376 3.73 Pfam 113-155 (293) Show / Hide
Range on Protein: 116-158
Range on HMM: 113-155/293
Sequence Identity: 38% (18 aa)

ILSQISMGLAYLHTPAGKGVILHRNLTPANVLVVANGAI----KLSD
.. ||  ||.|.|       |.|| | |.|.|.. || |    |..|
YMYQILRGLEYCHS-M---GIIHRDLKPENILIDNNGHIDACVKICD