Gene GL50803_3957 (G.lamblia)

GL50803_3957

Species: G.lamblia
Alias: GK212, GL50803_3957
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_3957.AA Protein None 741 None Fasta, JSON
GL50803_3957.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of GL50803_3957.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_3957.AA S_TKc 10-278 30 1.5e-67 231.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-278
Range on HMM: 1-231/231
Sequence Identity: 30% (87 aa)

FDQIATVGCGAFGTVYSAWETNKKRKVAIKEYKVRQLSSGVLRAMKTELEIIPRISHPNLVQHFEVFNEIPGKIMLSMEFLES--GSLSNLIDKYHQ--C
.. . ..| ||||.|| ..... .|.||||. |         . .. |..|  .  |||.|. ..|| .  ... . ||...   |.|  .|.|.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

RQNIPETFVWDITAQMVLALRYLHSPIKENASGIGRIIHRDLKPDNVFLSSTGAVKIGDFNLSRVIESADAKMTFAGTFSYMAPEILLRKPYNE-KVDIW
|. .||  .. ...|...|| |.||          .||||||||.|..|..   .||.|| |.|..      .|| ||  |||||.|   .|.  |.|.|
RFPFPE-HARFYMYQICCALEYCHS--------H-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWW

SLGCIVCEMCTNRPIFNFSHSTDYTTEFSKFSAQNLRLPQGMYSNDLIGFIYKILVVDHNARPSSSELAQ-------VPQI
|.|||. ||.. .| |      .. . | |             | ... || |.|..| . ||.  |. |        | .
SCGCILYEMLCGYPPFP-----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase GL50803_3957.AA Pkinase 10-278 26 7.1e-56 196.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-278
Range on HMM: 1-293/293
Sequence Identity: 26% (82 aa)

FDQIATVGCGAFGTVYSAWETNKKRKVAIKEYKVRQLSSGVLRAMKT--ELEIIPRISHPNLVQHFEVFNEIPGKIMLSMEFLESG----SLSNLID-KY
.  . ..| |.||.|| . . .  ..||.|. |.|  .|.....     |..|  |..||| |. ...| . ...| . ||..| |    .|. .|  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

HQCRQNIPETFVWDITAQMVLALRYLHSPIKENASGIGRIIHRDLKPDNVFLSSTGAV----KIGDFNLSRV--IESADAKMTFAGTFSYMAPEILL-RK
| |    .|  . ..  |.. .| |.||          .||||||||.|......| .    ||.|| |...  . .    .||.||  |||||... ..
HGCFY-FSEWECKFYMYQILRGLEYCHSM---------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ

PYNEKVDIWSLGCIVCEMCTNRPIFNFSH--STDYTTEFSKFSAQNLRLPQGMYS-----------------------NDLIGFIYKILVVDHNARPSSS
.|  |||.||.|||. ||.. ||.|  .|  . .  ..  ..     . .   ..                        ... ||...| .| . ||.  
YYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

ELAQVPQI
.. | | .
QILQHPWF
Kinase GL50803_3957.AA NEK 10-215 33 4e-54 186.12 In-house 1-219 (286) Show / Hide 
Range on Protein: 10-215
Range on HMM: 1-219/286
Sequence Identity: 33% (75 aa)

FDQIATVGCGAFGTVYSAWETNKKRK-----VAIKEYKVRQLSSGVLRAMK-TELEIIPRISHPNLVQHFEVFNEIP-GKIMLSMEFLE-SGSLSNL---
.. | ..| |.||.|| .  .. ...     ...|. ..  .|.   ..    |  |  .. ||| |  .. | |   ....  ||. |  | |...   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IDKYHQCRQNIPETFVWDITAQMVLALRYLHSPIKENASGIGRIIHRDLKPDNVFLSSTGA----VKIGDFNLSRVIESADAKM-T-FAGTFSYMAPEIL
| |. | .....|  .||. .||.|||.|.|. .       ..|.|||.|| |.||.. .     ||||||..|.| ..   .  | . ||  ||.||..
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GP---QRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVC

LRKPYNEKVDIWSLGCIVCEMCT
  ||||.|.|||||||.. ||||
QNKPYNNKSDIWSLGCVLYEMCT
Kinase GL50803_3957.AA STE 10-278 22 3.3e-49 169.78 In-house 1-359 (359) Show / Hide 
Range on Protein: 10-278
Range on HMM: 1-359/359
Sequence Identity: 22% (86 aa)

FDQIATVGCGAFGTVYSAWET------NKKRK---------VAIKEYKVRQLSS---------------GVLRAMKTELEIIPRIS--HPNLVQHFEVFN
.. |  .| ||||||| |          ....         .|||. .... ..                 .   . |..|  . .  ||| |. .  . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EIP------GKIMLSMEFLESGSLSNLIDKYHQCRQN----------IPETFVWDITAQMVLA-LRYLHSPIKENASGIGRIIHRDLKPDNVFLSSTGAV
         ... . ||... |||. .|.... | ..          .||. .  |. | . . | ||||          .|||||.||.|..|     |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS---------HHIIHRDIKPANILL-----V

KIGDFNLSRVIES---------------ADAKM--TFAGTFSYMAPEILLR------KPYNEKVDIWSLGCIVCEMCTNRPIFNFSHSTDYTTEFSKFS-
|. || ..  ...                 ...  ||.||  .||||....      |.|..|.||||||| ..||.| .| .   | .    .. . . 
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

------------AQNLRLPQG------------------MYSNDLIGFIYKILVVDHNARPSSSELAQ--VPQI
             .  .||.                    .| ... || | |. | | ||..|.| .   | |
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_3957.AA CAMK 15-209 18 1.6e-48 154.09 In-house 1-323 (425) Show / Hide 
Range on Protein: 15-209
Range on HMM: 1-323/425
Sequence Identity: 18% (63 aa)

TVGCGAFGTVYSAWETNKK------------RKVAIKEYKVRQLS--------------------------SGVLRAMKTELEIIPR-------ISHPNL
| | |.||.|. . ..| .            .||||| .. ..|.                             .. .. |.||  .       ..|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQHFEVFNE-----------IPGK--------IMLSM---EFLESG----SLSNLIDKYHQCRQN-----------IPETFVWDITAQMVLALRYLHSPI
.. .||.                |        . . |   |. . |     | . | .  ... .           ..|  .  .  |.. |..|.||  
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS--

KENASGIGRIIHRDLKPDNVFLSST-----------------GAVKIGDFNLSRVIES------------------------ADAKMTFAGTFSYMA-PE
       . |.||||||.|. |..                  . .|| || .......                         .   || || .||| ||
------HN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE

ILLR--------------KPYNEKVDIWSLGCI
.|..              ..|..|.|.||.|.|
VLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI
Kinase GL50803_3957.AA Ciliate-E2 10-278 22 7.7e-44 148.37 In-house 1-365 (365) Show / Hide 
Range on Protein: 10-278
Range on HMM: 1-365/365
Sequence Identity: 22% (87 aa)

FDQIATVGCGAFGTVYSA--WETNKKR----------------KVAIKEYKVRQLSSGVLRAMKTELEIIP----------------RISHPNLVQHFEV
.. |   | |.||.|| .  |...|.                 ||.||.| . ...   ....| |. |.                 ...|||... .|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FNE-IPGKIMLSMEFLESGSLSNLI-DKYHQCRQNIP------ETFVWDITAQMVL---------------ALRYLHSPIKENASGIGRIIHRDLKPDNV
| |    .| | ||... |.|  .| ...... ..|.      |  . .|..| .                ||.||||         ..|||||.||.|.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS--------KNNIIHRDIKPENI

FLSSTGAVKIGDFNLSR--------------VIESADAK-------------------MTFAGTFSYMAPEILLRKP---------YNEKVDIWSLGCIV
..     .|| || ||.                .  . |                    |..||  ||||||| .|.         |..|.||||||.| 
LF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

CEMCTNRPIFNFSHSTDYTTEFSKFSAQNLRLP-----------------QGMYSNDLIGFIYK----ILVVDHNARPS-SSELAQVPQI
 ||....| |           . .   .....|                     |.. . .| |    .|..| . |..  ... . | .
YEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_3957.AA CAMKL 10-207 30 2.3e-42 132.91 In-house 1-223 (297) Show / Hide 
Range on Protein: 10-207
Range on HMM: 1-223/297
Sequence Identity: 30% (72 aa)

FDQIATVGCGAFGTVYSAWETNK-KRKVAIKEYKVRQLS-SGVLRAM------------KTELEIIPRIS---HPNLVQHFEVFN------EIPGKIMLS
.. . | |.|.||.|  |. .   ..||||| .. . ..   . ...            . | .|  ...   ||| .. .||.       |  .|| | 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

MEFLESGS--LSNLIDKYHQCRQNIPETFVWDITAQMVLALRYLHSPIKENASGIGRIIHRDLKPDNVFLSSTG--AVKIGDFNLSRVIES-----ADAK
||  ..|.  | . |.|   .|. .||     .  |.| |. |.||         | |.|||.||.|. |.. |   .|| || .|  ..       .  
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHS--------HG-IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKL

MTFAGTFSYMAPEILLR--KPYN-EKVDIWSLG
.|| |. .||||||...  |||.  ||||||.|
KTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCG
Kinase GL50803_3957.AA Ciliate-E2-Unclassified 10-278 22 7.9e-41 139.35 In-house 1-352 (352) Show / Hide 
Range on Protein: 10-278
Range on HMM: 1-352/352
Sequence Identity: 22% (82 aa)

FDQIATVGCGAFGTVYSAWETNKKRKV-------AIKEYKVRQLSSGVLRAMKTELEIIPR------------------ISHPNLVQHFEVFNEIPGKIM
.  | . | |.||.|| . . ..| ..        |..||..|  .   . |  ..|.  .                  . ||..|  |..| .   .| 
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCF-QDKQNIY

LSMEFLESGSLSNLIDKYHQ-------------CRQNIPETFVW-----DITAQMVLALRYLHSPIKENASGIG-RIIHRDLKPDNVFLSSTG---AVKI
. ||..| |.|.. | |...             .|. ..|  .      ...|| ...| |||.            |||||.||.|..... |    .||
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH---------KNNIIHRDIKPENILFDNNGKNYYIKI

GDFNLSRVIESA---------------DAKM-TFAGTFSYM----APEILLRKPYN----EKVDIWSLGCIVCEMCTNRPIFNFSHSTDYTT--------
 || .|. ...                . .| ||.|| .||    |||.| .. |.    .|.||||||.|  ||..... |.   .... .        
IDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINN

-----EFSKFSAQNLRLPQ-------GMYSNDLIGFIY----KILVVDHNARPSSSELAQVPQI
      .... ..|.  |           |.  . ||     |.|... | |.. ... . | .
AYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_3957.AA NEK4 10-278 30 4.8e-40 139.37 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-278
Range on HMM: 1-257/257
Sequence Identity: 30% (84 aa)

FDQIATVGCGAFGTVYSAWETNKKRKVAIKEYKVRQLSSGVLRAMKTELEIIPRISHPNLVQHFEVFNEIPG-KIMLSMEFLESGSLSNLIDKYHQCRQN
.. .  || | .| |.   ..  |..  .|  . .. |.   .|   | ..  .  ||| |. .| .    |      | | |.| | .   .  |  | 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQ--QKNQF

IPETFVWDITAQMVLALRYLHSPIKENASGIGRIIHRDLKPDNVFLSSTGAVKIGDFNLSRVIE-SADAKMTFAGTFSYMAPEILLRKPYNEKVDIWSLG
..|  | .   |  .|| |.|           .|.|||||  |.||  .  .||||| .|||.. ..|   |  ||  || ||.   .||. | ||||||
LEEYQVVEWFVQIAMALQYMHEK---------HILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLG

CIVCEMCTNRPIFNFSHSTDYTTEFSKFSAQNLRLPQGMYSNDLIGFIYKILVVDHNARPSSSELAQVPQI
| | || | .  |.          .     | . .|.  || ||   .|..|    . |||  .. | | |
CCVYEMITLKHAFDAKDMNSLI--YQIIQGQPPPMPP-NYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase GL50803_3957.AA TKL 16-288 18 1.1e-39 138.2 In-house 1-345 (364) Show / Hide 
Range on Protein: 16-288
Range on HMM: 1-345/364
Sequence Identity: 18% (72 aa)

VGCGAFGTVYSAWETNKK--------RKVAIKEYKVRQLSSGVL----------------------RAMKTELEIIPRIS---HPNLVQHFEVFNEIPG-
.| |.||.|| .   .          . ||.| .|... ..  .                      .....| | |  .|   |||.||   . ...|. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------KIMLSMEFLESGS-LSNLIDKYHQCRQNIPETFVWDITAQMVLALRYLHS--P--IKENASGIGRIIHRDLKPDNVFLSSTGA------
           .... ||. . || |..|.                ..  .. ... ||||  |   .        |||||||..|... . .       
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT-----KPPIIHRDLKSKNILVDENWTNVSNYM

--------VKIGDFNLSRVIESAD--------------------AKMTFAGTFSYMAPEILLRK----------------PYNEKVDIWSLGCIVCEMCT
        .||.|| |||...                       ..||  ||. .||||.|  .                .|.||.|..| | . .|..|
YNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT

NRPIFNFSHSTDYTTEFSKFSAQNLRLPQGMYSNDLIGF----IYKILVVDHNARPSSSELAQV-------PQIVSAVKRLIER
 ..                         ... ... |..    .. ..|.|.. ||   .  |        |..   .|.|...
RCR-----------------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQD
Kinase GL50803_3957.AA ULK 10-278 22 3.3e-39 136.57 In-house 1-324 (324) Show / Hide 
Range on Protein: 10-278
Range on HMM: 1-324/324
Sequence Identity: 22% (76 aa)

FDQIATVGCGAFG-TVYSAW-ETNK--KRKVAIKEYKVRQLSSGVLR--------AMKTELEIIPRIS---HPN--LVQHFEVFNEIPG-KIMLSMEFLE
.  .   | |.|| .|| .  . ..  . .||.|     ...   ..          | | .|.  .    |||   |. ...|..     | . ||. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

SGSLSNLIDKYHQCR-----QNIPETFVWDITAQMVLALRYLHSPIKENASGIGRIIHRDLKPDNVFLSST------------GAVKIGDFNLSRVIES-
 | |...| |.. .      ....|  .  .  | . ....||.           |||||.||.|  ..              | .||.|| ....... 
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHK---------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNN

---ADAKMTFA------GTFSYMAPEILL----RKPYN-EKVDIWSLGCIVCEMCTNRPIFNFSHSTDYT----TEFSK-------FSAQNLRLPQGM--
   ..  .|.       ||  ||||.||     .|||.  |.||||||||  || .... |. .  .|.      .  .          |... | .   
NMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKD

--YSNDLIGFIYKILVVDHNARPSSSELAQVPQI
   |.... .|.. |..| . | |  |. . | .
PKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_3957.AA NEK2 66-218 30 1.8e-38 127.1 In-house 57-262 (319) Show / Hide 
Range on Protein: 66-218
Range on HMM: 57-262/319
Sequence Identity: 30% (62 aa)

HPNLVQHFE-VFNEIPGKIMLSMEFLESGSLSNLIDKYHQCRQNIPETFVWDITAQMVLALRYLHS------------PIKENASGIGRIIHRDLKPDNV
||| |.    ....    . . ||. | | || .| |. . || ..| |.| | .|. .||.  |              .|    | . |.|||.|| |.
HPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANI

FLSSTGA---------------------------------------VKIGDFNLSRVIE-SADAKMTFAGTFSYMAPEILLRKPYNEKVDIWSLGCIVCE
||.. .                                        || ||| | |. . .     || ||  || || . . .|||| ||||.||.. |
FLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYE

MCTNRP
||. .|
MCALHP
Kinase GL50803_3957.AA TyrKc 10-285 21 1.3e-14 13.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-285
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

FDQIATVGCGAFGTVYSAWETNKKRKVAIKEYKVRQLSSGVLRAMKTELEIIPRI--SHPNLVQHFEVFNEIP-------GKIMLSMEFLESGSLSNLID
   . . |.||||.|| .  .   ..||.|  |        ....  |..|  ..  .|||.|. . |    .       . .|. ||. . |.| . . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVC-TQQGRNFMYIEPLMIVMEYMPHGDLKDYL-

KYHQCRQNIPETFVWDITAQMVLALRYLHSPIKENASGIGRIIHRDLKPDNVFLSSTGAVKIGDFNLSRVIESA-------DAKMT-------FAGTFSY
..|. .  ..     ..  |     .||||          ..|||||   |. ... . |||.|| ||| |..        | ...       .      
RKHRPK--LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MAPEILLRKPYNEKVDIWSLGCIVCEMCTNRPIFNFS---HSTDYTTEFSKFSAQNLRLPQGMY---------SNDLIGFIYKILVVDHNARPSSSELAQ
|||| .  . ...| |.|| |    |..|.          .     .|  ..  |  |.||  .         . ..   . .    | . ||. ||.  
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--

VPQIVSAVKRL
       ....
-------HECF
Kinase GL50803_3957.AA Pkinase_Tyr 10-71 27 1.1e-07 26.67 Pfam 1-68 (270) Show / Hide 
Range on Protein: 10-71
Range on HMM: 1-68/270
Sequence Identity: 27% (19 aa)

FDQIATVGCGAFGTVYSAWET----NKKRKVAIKEYKVRQLSSGV--LRAMKTELEIIPRI-SHPNLVQ
   . . | ||||.|| .  .    |.| .||.|  |  . ..    ....  |..|   . .|||.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVR
Kinase GL50803_3957.AA NEK 241-278 35 5.1e-07 21.18 In-house 248-286 (286) Show / Hide 
Range on Protein: 241-278
Range on HMM: 248-286/286
Sequence Identity: 35% (14 aa)

RLPQG-MYSNDLIGFIYKILVVDHNARPSSSELAQVPQI
..|.  |||.||  .| . | .|.  ||| ... . |.|
PIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_3957.AA Pkinase_Tyr 141-215 32 2.3e-05 18.82 Pfam 131-209 (270) Show / Hide 
Range on Protein: 141-215
Range on HMM: 131-209/270
Sequence Identity: 32% (26 aa)

RIIHRDLKPDNVFLSSTGAVKIGDFNLSRVI-ESADA-KMTFAGTFSY--MAPEILLRKPYNEKVDIWSLGCIVCEMCT
..|||||   |. ..... |||.|| |.| | .     ...  | .    |||| .  . ...| |.|| |    |..|
NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFT
Kinase GL50803_3957.AA NEK2 247-278 46 7.6e-05 12.12 In-house 288-319 (319) Show / Hide 
Range on Protein: 247-278
Range on HMM: 288-319/319
Sequence Identity: 46% (15 aa)

YSNDLIGFIYKILVVDHNARPSSSELAQVPQI
|| .|   |   . |||  |||  |. | |||
YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_3957.AA CAMK 248-278 25 0.010139 3.79 In-house 395-425 (425) Show / Hide 
Range on Protein: 248-278
Range on HMM: 395-425/425
Sequence Identity: 25% (8 aa)

SNDLIGFIYKILVVDHNARPSSSELAQVPQI
| . . .| |.|.|| . |.. ..  . | .
SQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Ank GL50803_3957.AA Ank 592-613 36 9.6e-05 21.37 Pfam 1-22 (33) Show / Hide 
Range on Protein: 592-613
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

DGKTALMYAAISDSLNCVEILL
|| |.|..|........|. ||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_3957.AA Ank 623-646 25 0.001331 17.25 Pfam 1-24 (33) Show / Hide 
Range on Protein: 623-646
Range on HMM: 1-24/33
Sequence Identity: 25% (6 aa)

VGNTALMHAVLNKRFNCIQLLLRQ
 |.|.|. |... . .....|| .
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_3957.AA Ank 654-676 30 0.003721 15.64 Pfam 1-23 (33) Show / Hide 
Range on Protein: 654-676
Range on HMM: 1-23/33
Sequence Identity: 30% (7 aa)

KGRTALMKAAATGQLSIATLLLG
 |.|.|. |.  |.......||.
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_3957.AA Ank 685-705 33 0.015953 13.36 Pfam 1-21 (33) Show / Hide 
Range on Protein: 685-705
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

DGSTALTYAANHNDIDMVNLL
|| |.| .|. ......| .|
DGFTPLHLACRCGHTEVVKML