Gene GL50803_40904 (G.lamblia)

GL50803_40904

Species: G.lamblia
Alias: GK264, GL50803_40904
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_40904.AA Protein None 967 None Fasta, JSON
GL50803_40904.kin_dom Protein Kinase Domain None 275 None Fasta, JSON

Protein domain

Protein domains of GL50803_40904.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_40904.AA S_TKc 10-284 18 1.1e-30 109.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-284
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

FYIGRTLGQGSYGAVRVLKDKVTSTVVLCKEFNLSDLDDAAFSSLMYDLSLASHLEYQFLLHYERLIIYDEGSTLFAISSQIGA--YNLADLISKHQCAK
. |.|..|.|..| |.  ..| |  .| .|. .          ...  ... ..    .. ..   .     . |. .   ..    .| |.| |... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--MSIPEACILTILRSVAQALAFLHKEARPLLFARIGGEYTETPVLHNDLKPSNVLVMSNNQLLVTDYGTARSYKLKRLASTFSSSLPYIAPEILHKKEP
    .||  .  ... ...||...|.  .               ..| ||||.|.|. .  .. ..| | || .      .||  .. |.|||.|     
LRFPFPE-HARFYMYQICCALEYCHSH-G---------------IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GY

TE-ASDVWSLGCLIYELCTLKRFVERANTVSEASSFIASLKDVTIPKSYSKHLAKLIKHMLSINADDRPSVDDILK-------DKLL
.  ..|.||.||..||... .   .   .. .    |            |. .  .|...|  . ..||.. ..|.       .  .
GKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_40904.AA TKL 115-280 16 1.5e-27 96.27 In-house 134-362 (364) Show / Hide 
Range on Protein: 115-280
Range on HMM: 134-362/364
Sequence Identity: 16% (39 aa)

ILTILRSVAQALAFLHKEARPLLFARIGGEYTETPVLHNDLKPSNVLVMSNNQ--------------LLVTDYGTARSYKLKR-----------------
.. . ...|.....|| .  .  .          |..| |||..|.|| .|..              . ..|.|..|. . .                  
RCRWALDIARGMNYLHSMNPKWCT--------KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQN

---LASTFSSSLPYIAPEIL----------------HKKEPTEASDVWSLGCLIYELCTLKRFVERANTVSEA---------SSFIASLKDVTIP-----
     .|   .. . |||.|                ...| .|..||.| | ...|..| .|  .  .  ..          .  .   .  .||     
NRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQN

-------KSYSKHLAKLIKHMLSINADDRPSVDDILK
       ..  ....||...  . ....||| ..|||
HHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK
Kinase GL50803_40904.AA Ciliate-E2 149-284 18 1.6e-26 88.07 In-house 181-365 (365) Show / Hide 
Range on Protein: 149-284
Range on HMM: 181-365/365
Sequence Identity: 18% (37 aa)

PVLHNDLKPSNVLVMSNNQLLVTDYGTARSYKLK--------------------------------RLASTFSSSLPYIAPEILHKKE---------PTE
...| |.||.|.|.     . ..| |... |. .                                 .. |.  ...| ||||| .|.          ..
NIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDY

ASDVWSLGCLIYELCTLKR-FVERANTVSEASSFIASLK-DVTIP------------------KSYSKHLAKLIKH----MLSINADDRPS-VDDILKDK
..|.||||...||... |. |            ..  .. .. .|                  |. |.    |||     ||  . . |..  ..||. .
KCDIWSLGVILYEMLFGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHP

LL
 .
WF
Kinase GL50803_40904.AA Pkinase 109-284 17 1.6e-24 87.78 Pfam 102-293 (293) Show / Hide 
Range on Protein: 109-284
Range on HMM: 102-293/293
Sequence Identity: 17% (37 aa)

SI--PEACILTILRSVAQALAFLHKEARPLLFARIGGEYTETPVLHNDLKPSNVLVMSNNQL----LVTDYGTARS--YKLKRLASTFSSSLPYIAPEIL
..  .|  .  ... ....|...|..                 ..| ||||.|.|. .|...     ..| | |.   |  .. ..||  ...|.|||..
CFYFSEWECKFYMYQILRGLEYCHSM----------------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVI

H-KKEPTEASDVWSLGCLIYELCTLKRFVERAN----TVSEASSFIASLKDVTIPKSYS-----------------------KHLAKLIKHMLSINADDR
   .. . ..|.||.||..||... .|.  .      .  .    |.  ..  .. ...                       . . ..|| .|  .  .|
RGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

PSVDDILKDKLL
|. ..||... .
PTAEQILQHPWF
Kinase GL50803_40904.AA Ciliate-E2-Unclassified 150-284 19 2.5e-24 81.31 In-house 165-352 (352) Show / Hide 
Range on Protein: 150-284
Range on HMM: 165-352/352
Sequence Identity: 19% (36 aa)

VLHNDLKPSNVLVMSNN---QLLVTDYGTARSYKL----------------KRLASTFSSSLPYI----APEILHKKEPT----EASDVWSLGCLIYELC
..| |.||.|.|. .|.   .. ..|.| .. |.                 . ...||. .. |.    |||.| ....     ...|.||||...||..
IIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEML

TLKRFVERANTVS----------------EASSFIAS-LKDVT-----IPKSYSKHLAKLIK----HMLSINADDRPSVDDILKDKLL
. ..  .  |  .                  . ...  ..        |||  |.. . .|.     ||  | . |.. ..||.  ..
FGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_40904.AA AGC 154-284 17 1e-23 56.83 In-house 179-395 (395) Show / Hide 
Range on Protein: 154-284
Range on HMM: 179-395/395
Sequence Identity: 17% (39 aa)

D-LKPSNVLVMSNNQLLVTDYGTARSYKLKR---------------------------------------------------LASTFSS--SLPYIAPEI
| ||| |.|  ..  .  || | .   . ..                                                   ...||    .  |.||||
DYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEI

LHKKEPTEASDVWS--LGCLIYELCTLKRFVERANTV-------SEASSFIASL-------KDVTIP----------KSYSKHLAKLIKHMLSINADDRP
|     . | | ||  ||||.||. | .      |..       ...  |   .       ..|..|          .. |. .  |||..|  . ..|.
L----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRL

S----------VDDILKDKLL
           ...| . .  
GCGGNDFGDKGAEEIKNHPWF
Kinase GL50803_40904.AA NEK4 150-284 30 3.2e-19 65.82 In-house 123-257 (257) Show / Hide 
Range on Protein: 150-284
Range on HMM: 123-257/257
Sequence Identity: 30% (41 aa)

VLHNDLKPSNVLVMSNNQLLVTDYGTARSYK-LKRLASTFSSSLPYIAPEILHKKEPTEASDVWSLGCLIYELCTLKRFVERANTVSEASSFIASLKDVT
.|| |||  |.     | . . |.| .|       .|.|      |. ||.   .     ||.||||| .||. |||   .  .  |     |   .   
ILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQG-QPPP

IPKSYSKHLAKLIKHMLSINADDRPSVDDILKDKLL
.|. ||. |. |.. ||.   ..|||. ||..   .
MPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase GL50803_40904.AA STE 150-284 16 5.6e-17 56.58 In-house 173-359 (359) Show / Hide 
Range on Protein: 150-284
Range on HMM: 173-359/359
Sequence Identity: 16% (32 aa)

VLHNDLKPSNVLVMSNNQLLVTDYGTAR---------------------SYKLKRLASTFSSSLPYIAPEILHK------KEPTEASDVWSLGCLIYELC
. | |.||.|.|.        .| |..                      . | . .. |      . |||.. .      |. .. .|.|||||.| |..
IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-----WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA

TLKRFVERANTVSEASSFIAS--------------LKDVTIPK-------------------SYSKHLAKLIKHMLSINADDRPSVDDILK--DKLL
| |      .  .    .. .               .  ..|                    ..|...   |.. | .. ..||.... ||   . .
TGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_40904.AA NEK 150-226 34 1.1e-13 44.88 In-house 140-224 (286) Show / Hide 
Range on Protein: 150-226
Range on HMM: 140-224/286
Sequence Identity: 34% (29 aa)

VLHNDLKPSNVLVMSNNQ----LLVTDYGTARSYKLKR-LAST-FSSSLPYIAPEILHKKEPTEASDVWSLGCLIYELCTL--KR
.|| |.||.|.   .||     . . | | ..  . .. .|.| .     |..||... |  .. ||.|||||..||.|||  |.
ILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKH
Kinase GL50803_40904.AA NEK2 194-225 53 9.3e-12 35.75 In-house 230-261 (319) Show / Hide 
Range on Protein: 194-225
Range on HMM: 230-261/319
Sequence Identity: 53% (17 aa)

YIAPEILHKKEPTEASDVWSLGCLIYELCTLK
|  || .|     | ||.||.||||||.|.|.
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALH
Kinase GL50803_40904.AA NEK2 248-284 35 1.6e-11 34.9 In-house 283-319 (319) Show / Hide 
Range on Protein: 248-284
Range on HMM: 283-319/319
Sequence Identity: 35% (13 aa)

TIPKSYSKHLAKLIKHMLSINADDRPSVDDILKDKLL
.||  ||.|| ..|  |. ..   |||.. ||.. ..
RIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_40904.AA NEK 249-284 36 6.7e-11 35.02 In-house 249-286 (286) Show / Hide 
Range on Protein: 249-284
Range on HMM: 249-286/286
Sequence Identity: 36% (14 aa)

IPKS--YSKHLAKLIKHMLSINADDRPSVDDILKDKLL
||.   ||. | .||  ||  . ..|||...||.. ..
IPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_40904.AA NEK1 249-284 38 1.9e-10 32.65 In-house 241-276 (276) Show / Hide 
Range on Protein: 249-284
Range on HMM: 241-276/276
Sequence Identity: 38% (14 aa)

IPKSYSKHLAKLIKHMLSINADDRPSVDDILKDKLL
||. ||. |  |.. |...|. .|||| .||.   .
IPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_40904.AA NEK1 194-226 57 2.5e-10 32.2 In-house 187-219 (276) Show / Hide 
Range on Protein: 194-226
Range on HMM: 187-219/276
Sequence Identity: 57% (19 aa)

YIAPEILHKKEPTEASDVWSLGCLIYELCTLKR
|. |||  .|  .  ||.|||||  |||||||.
YLSPEICQNKPYNNKSDIWSLGCVLYELCTLKH
Kinase GL50803_40904.AA TyrKc 10-283 15 4.5e-10 -59.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-283
Range on HMM: 1-280/280
Sequence Identity: 15% (49 aa)

FYIGRTLGQGSYGAVR--VLKDKVTSTVVLCKEFNLSDLDDAAF---SSLMYDL-----------SLASH-LEYQF---LLHYERLIIYDEGSTLFAISS
   |..|| | .| |.  ..|     . |  |  . .    ..|    ..|  |             ...  .  |     ..  .   . |. .  . .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRK

QIGAYNLADLISKHQCAKMSIPEACILTILRSVAQALAFLHKEARPLLFARIGGEYTETPVLHNDLKPSNVLVMSNNQLLVTDYGTARSYKLK-------
  .                 .. .  | .   .|.  ..||.                 .. | ||   |.|| .|..  ..| | .|  . .       
HRPK----------------LCMKDLLSFCWQIACGMEYLHSK----------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESK

-RLASTF--SSS--LPY--IAPEILHKKEPTEASDVWSLGCLIYELCTLKRFVERA-----NTVSEASSFIASLKDVTIPKS--------YSKHLAKLIK
    ..   ..   ||.   ||| . ... |..||||| | ...|..|.             . .|.  .. . .   .|..         .. . ...|
DYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK

HMLSINADDRPSVDDILKDKL
     ...|||.  .| ....
QCWHEDPEDRPTFSEI-HECF
Kinase GL50803_40904.AA CAMKL 150-215 31 1.4e-09 26.62 In-house 148-223 (297) Show / Hide 
Range on Protein: 150-215
Range on HMM: 148-223/297
Sequence Identity: 31% (24 aa)

VLHNDLKPSNVLVMSNN--QLLVTDYGTARSYK-L----KRLASTFSSSLPYIAPEILHK-KEPTE--ASDVWSLG
. | |.|| |.|. .|.  .. ..| | .  |.       .. .||  |.|| ||||. . ..| .  . |.||.|
IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCG
Kinase GL50803_40904.AA CAMKL 249-284 27 5.2e-09 24.74 In-house 263-297 (297) Show / Hide 
Range on Protein: 249-284
Range on HMM: 263-297/297
Sequence Identity: 27% (10 aa)

IPKSYSKHLAKLIKHMLSINADDRPSVDDILKDKLL
|... |  .  ||..||  | ..||....|.... .
IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase GL50803_40904.AA STE 10-131 14 2e-06 18.72 In-house 1-170 (359) Show / Hide 
Range on Protein: 10-131
Range on HMM: 1-170/359
Sequence Identity: 14% (25 aa)

FYIGRTLGQGSYGAVRVLKDK------VTSTV---------VLCKEFNLSDLD---------------DAAFSSLMYDLSLASHLE--YQFLLHYERLII
. . . .|.|..| |   ...       |  |         .  |. ||.. .               .  . ... .... ...    ..  .|    .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YD-----EGSTLFAISSQIGAYNLADLIS-KHQCAK-MS--------IPEACILTILRSVAQA-LAFLHK
..     ....|. .   ...  | |.|  |. | | ..        .||  | .|.|.. .. |..||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS
Kinase GL50803_40904.AA CAMKL 10-36 39 6e-06 14.9 In-house 1-28 (297) Show / Hide 
Range on Protein: 10-36
Range on HMM: 1-28/297
Sequence Identity: 39% (11 aa)

FYIGRTLGQGSYGAVRVLKD-KVTSTVV
. ||.|||.||.| |.  .. . | . |
YRIGKTLGKGSFGKVKLATHIRTTGEKV
Kinase GL50803_40904.AA Pkinase_Tyr 196-224 44 1e-05 19.97 Pfam 182-210 (270) Show / Hide 
Range on Protein: 196-224
Range on HMM: 182-210/270
Sequence Identity: 44% (13 aa)

APEILHKKEPTEASDVWSLGCLIYELCTL
||| .. .. |..||||| | |..|..|.
APECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase GL50803_40904.AA AGC 10-39 25 1.3e-05 8.91 In-house 1-36 (395) Show / Hide 
Range on Protein: 10-39
Range on HMM: 1-36/395
Sequence Identity: 25% (9 aa)

FYIGRTLGQGSYGAVRVLKDK------VTSTVVLCK
| . ...|.||.| |.  ..|       |  .  .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMK
Kinase GL50803_40904.AA Pkinase 10-48 30 0.000191 16.8 Pfam 1-39 (293) Show / Hide 
Range on Protein: 10-48
Range on HMM: 1-39/293
Sequence Identity: 30% (12 aa)

FYIGRTLGQGSYGAVRVLKDKVTSTVVLCKEFNLSDLDD
. |||..|.||.| |.  ..| |. .| .|...... ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKS
Kinase GL50803_40904.AA Ciliate-E2 10-30 28 0.002122 7.51 In-house 1-21 (365) Show / Hide 
Range on Protein: 10-30
Range on HMM: 1-21/365
Sequence Identity: 28% (6 aa)

FYIGRTLGQGSYGAVRVLKDK
. . . .|||..| |.  |..
YKFIKKIGQGNFGSVYKCKVW
Kinase GL50803_40904.AA Ciliate-E2-Unclassified 10-30 33 0.002615 7.36 In-house 1-21 (352) Show / Hide 
Range on Protein: 10-30
Range on HMM: 1-21/352
Sequence Identity: 33% (7 aa)

FYIGRTLGQGSYGAVRVLKDK
. |....|||..| |. ...|
YKIIKQIGQGGFGKVYKCQHK
Kinase GL50803_40904.AA NEK2 10-42 27 0.028022 3.34 In-house 1-33 (319) Show / Hide 
Range on Protein: 10-42
Range on HMM: 1-33/319
Sequence Identity: 27% (9 aa)

FYIGRTLGQGSYGAVRVLKDKVTSTVVLCKEFN
  .  |.|.||.| .|  ..| .  .   || .
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEIC
Kinase GL50803_40904.AA NEK 10-24 46 0.231735 1.03 In-house 1-15 (286) Show / Hide 
Range on Protein: 10-24
Range on HMM: 1-15/286
Sequence Identity: 46% (7 aa)

FYIGRTLGQGSYGAV
. | ...||||.| |
YEIIKKIGQGSFGKV
Kinase GL50803_40904.AA TKL 16-24 44 0.23847 0.63 In-house 1-9 (364) Show / Hide 
Range on Protein: 16-24
Range on HMM: 1-9/364
Sequence Identity: 44% (4 aa)

LGQGSYGAV
.|.|..| |
IGSGGFGEV
Kinase GL50803_40904.AA NEK4 10-30 28 0.363851 0.16 In-house 1-21 (257) Show / Hide 
Range on Protein: 10-30
Range on HMM: 1-21/257
Sequence Identity: 28% (6 aa)

FYIGRTLGQGSYGAVRVLKDK
. . .  |.|||| |   . .
YCHMKVVGKGSYGEVWLVRHR