GL50803_41369

Species: G.lamblia
Alias: GK234, GL50803_41369
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_41369.AA Protein None 1136 None Fasta, JSON
GL50803_41369.kin_dom Protein Kinase Domain None 267 None Fasta, JSON

Protein domain

Protein domains of GL50803_41369.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_41369.AA ULK 187-276 25 2.8e-15 49.89 In-house 217-329 (329) Show / Hide
Range on Protein: 187-276
Range on HMM: 217-329/329
Sequence Identity: 25% (29 aa)

YLAPEVIA----EQTVSDK-SDVWSMGVIFYELCT-LTP----LLPLL-QGN-ELIDN-------INILRTHISVPG----YSFDMCDVINGMLSREPLH
| ||...     ..  .|. .|.||.|.||||. .  .|      ..  |.. .||.|       |.   . .  .|     | .. | | .|| ...  
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKD

RFSTYELLHHERI
|.|  ||..|. .
RISWEELFNHPWF

S_TKc GL50803_41369.AA S_TKc 25-276 21 1.3e-14 37.14 SMART 1-231 (231) Show / Hide
Range on Protein: 25-276
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

YDAVRIDGPGTFTYLELCYAKA----------FQISVLPTLDALEDFQRLRHPSIVPILEIVYDPSSGIVGILVEQITD--MTLRDLMDDFIRHKLS--L
|. .|. | |.|    .|. |             ....  .. |.     .|| || .... .|   . . .  | .     .|.|....  ||.|   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGTVRVG-------FPELSFLLGCIKASDLSPGIQRYLAPEVIAEQTVSD-KS
|| ... ...|...|..|||          ...||| | | ||...   .. ..       .             .   |   |.||||.     .  |.
PE-HARFYMYQICCALEYCH---------SHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKC

DVWSMGVIFYELCTLTPLLPLLQGNELIDNINILRTHISVPGYSFDMCDVINGMLSREPLHRFSTYELLH-------HERI
|.|| |.|.||...  |. |  | ......|            | ...| |...| ..| .| .  |.|.       |. .
DWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_41369.AA ULK 187-276 21 1.5e-13 44.53 In-house 213-324 (324) Show / Hide
Range on Protein: 187-276
Range on HMM: 213-324/324
Sequence Identity: 21% (24 aa)

YLAPEVIA----EQTVSDK-SDVWSMGVIFYELCT-LTP----LLPLL------------QGNELIDNINILRTHI--SVPGYSFDMCDVINGMLSREPL
| ||...     ..  .|. .|.||.|.||||. .  .|      ..             |  ... . . ..  .  . |  | .. | | .|| ... 
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQ--QIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEK

HRFSTYELLHHERI
 |.|  |...|. .
DRISWEEIFNHPWF

Kinase GL50803_41369.AA Ciliate-E2-Unclassified 89-276 16 1e-12 40.43 In-house 101-352 (352) Show / Hide
Range on Protein: 89-276
Range on HMM: 101-352/352
Sequence Identity: 16% (46 aa)

EQITDMTLRDLMDDFIR----------HKLS---LPEEQVW-----DIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGTVRVGFPELSF
|.. . .|.. . ..            ....   ..|.|.      .. ||.... .|.|       ...  .||| . |.||... .|           
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH-------HKN-NIIHRDIKPENILFDNNGK----------

LLGCIKASDLSP------------------------------GIQRYL----APEVIAEQTVSDK----SDVWSMGVIFYELCTLTPLLPLLQGNE----
  ..|| .|..                               |  .|.    ||||. .|  ...    .|.||.|||.||... ..  .  . ..    
-NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQL

------------LIDNINILRTHISV-------PGYSFDMCDVIN----GMLSREPLHRFSTYELLHHERI
            |..||.   . ..         . |.   | ||     ||   |  | .  ..| |  .
ITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase GL50803_41369.AA Pkinase 186-276 23 1.5e-12 45.48 Pfam 176-293 (293) Show / Hide
Range on Protein: 186-276
Range on HMM: 176-293/293
Sequence Identity: 23% (28 aa)

RYLAPEVIA-EQTVSDKSDVWSMGVIFYELCTLTPLLPLL------QGNELIDNINILRTHISVPGYS--------------------FDMCDVINGMLS
.|.|||||   |  . |.|.||.|.|.||...  |. |          ...|..|   ..| . |  .                     ...|.|...| 
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

REPLHRFSTYELLHHERI
. |  | .  ..|.|. .
KDPKKRPTAEQILQHPWF

Kinase GL50803_41369.AA NEK6 103-217 31 2.4e-12 36.7 In-house 93-199 (252) Show / Hide
Range on Protein: 103-217
Range on HMM: 93-199/252
Sequence Identity: 31% (37 aa)

FIRHKLSLPEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGTVRVGFPELS-FLLGCIKASDLSPGIQRYLAPEVIAEQTVSDK
| . |  .||  .|    |. .|..  |          .||.|| . | |.|. | | |..|   |  |      |     |   |..|| | |.    |
FKKQKRLIPERTIWKYFVQLCSALEHMH---------SKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFK

SDVWSMGVIFYELCTL
||.||.| . ||.  |
SDIWSLGCLLYEMAAL

Kinase GL50803_41369.AA NEK1 187-276 32 9e-12 37.27 In-house 187-276 (276) Show / Hide
Range on Protein: 187-276
Range on HMM: 187-276/276
Sequence Identity: 32% (30 aa)

YLAPEVIAEQTVSDKSDVWSMGVIFYELCTLTPLLPLLQGNELIDNIN-ILRTHIS--VPGYSFDMCDVINGMLSREPLHRFSTYELLHHERI
|| || .  .    |||.|| |.. ||||||.  .|  ..| .   .. |.. ...  .| || .    .  |..| | ||.|.  .|    |
YLSPEICQNKPYNNKSDIWSLGCVLYELCTLK--HP-FEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI

Kinase GL50803_41369.AA CDC2 64-164 25 1.5e-11 31.27 In-house 57-145 (301) Show / Hide
Range on Protein: 64-164
Range on HMM: 57-145/301
Sequence Identity: 25% (26 aa)

LR-HPSIVPILEIVYDPSSGIVGILVEQITDMTLRDLMDDFIRHKLSLPEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGTVR
|. || || . ....         .|    || |. .||  |  . ..|.. | ..  | .... .||          ||..|| | | ||.....|...
LKDHPNIVKLHDVIHQ----NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCH---------QRRIMHRDLKPQNILIDKKGNIK

VG
..
IA

Kinase GL50803_41369.AA NEK-Unclassified 187-221 45 1.7e-10 30.66 In-house 163-197 (258) Show / Hide
Range on Protein: 187-221
Range on HMM: 163-197/258
Sequence Identity: 45% (16 aa)

YLAPEVIAEQTVSDKSDVWSMGVIFYELCTLTPLL
...|||. .|   ..|||||.| | ||.||  | .
WMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFF

Kinase GL50803_41369.AA NEK2 187-219 45 6.3e-10 29.48 In-house 230-262 (319) Show / Hide
Range on Protein: 187-219
Range on HMM: 230-262/319
Sequence Identity: 45% (15 aa)

YLAPEVIAEQTVSDKSDVWSMGVIFYELCTLTP
|  ||..  |  ..|||.||.| . ||.|.| |
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHP

Kinase GL50803_41369.AA NEK 187-219 42 2.8e-09 29.24 In-house 190-224 (286) Show / Hide
Range on Protein: 187-219
Range on HMM: 190-224/286
Sequence Identity: 42% (15 aa)

YLAPEVIAEQTVSDKSDVWSMGVIFYELCTL--TP
|..|||. ..  . |||.|| |.. ||.|||   .
YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKH

Kinase GL50803_41369.AA PEK 185-276 26 1.2e-08 25.45 In-house 553-655 (655) Show / Hide
Range on Protein: 185-276
Range on HMM: 553-655/655
Sequence Identity: 26% (29 aa)

QRYLAPEVIAEQ-----TVSDKSDVWSMGVIFYELCTLTPLLPLLQGN-ELIDNINILRT-HISVPGYSF---------DMCDVINGMLSREPLHRFSTY
..| .||..  |         |.|..|.|.|| |..      |  .   | .. ...||.  |  ||  .         . .| |. |||. |  | |. 
CLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMW-----YPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQ

ELLHHERI
..| || .
QILQHEFF

Kinase GL50803_41369.AA NEK 100-164 25 6.6e-08 24.34 In-house 94-165 (286) Show / Hide
Range on Protein: 100-164
Range on HMM: 94-165/286
Sequence Identity: 25% (19 aa)

MDDF---IRHKL----SLPEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGT----VRVG
....   | ..      ..|||.||. .| ..|..|.|     .    |...|| . |.||| .....    |..|
LYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GP---QRKILHRDIKPQNIFLTKNNNDYHNVKIG

Kinase GL50803_41369.AA NEK2 110-157 28 8.7e-08 22.17 In-house 101-160 (319) Show / Hide
Range on Protein: 110-157
Range on HMM: 101-160/319
Sequence Identity: 28% (17 aa)

LPEEQVWDIVAQVVKAMQYCHL------------AYKPGSQNLRRVIHRCLHPNNIFVSA
..|| .| | .|   | | ||               || . . . ..|| . | ||| ..
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDY

Pkinase GL50803_41369.AA Pkinase 62-164 23 9.6e-08 28.47 Pfam 55-154 (293) Show / Hide
Range on Protein: 62-164
Range on HMM: 55-154/293
Sequence Identity: 23% (27 aa)

QRLRHPSIVPILEIVYDPSSGIVGILVEQITDMTLRDLMDDF--IR--HKLSL--PEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFV
.||.|| || ......| .. |   .|    ...|  .|| |  |.   . ..  .|... ... |......|||           ..||| | | ||..
KRLNHPNIVRLYDWFED-KDHIY--MVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---------GIIHRDLKPENILI

SASGTV----RVG
.  |..    ...
DNNGHIDACVKIC

TyrKc GL50803_41369.AA TyrKc 25-276 20 4.2e-07 -107.77 SMART 1-280 (280) Show / Hide
Range on Protein: 25-276
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YDAVRIDGPGTFTYLELCYAKAFQISVL------PTLDALEDFQR-------L--RHPSIVPILEIVYDP-----SSGIVGILVEQITDMTLRDLMDDFI
    .. | | |    .. .|   | |        .   .||| |       |  .|| || .. .. ..     ... . |..|    | . || .|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY---MPHGDL-KDYL

-RHKLSLPEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGTVRVGFPELSFLLGCI----------KASD--LSP--GIQRYLA
 .|.  |. ..  ..  |. . |.| |           ..||| |   |. |.. .||...   ||  ..            ...    .      | .|
RKHRPKLCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEVIAEQTVSDKSDVWSMGVIFYELCTLTPLLPL------LQGNELIDNINILRTHISVPG--------YSFDMCDVINGMLSREPLHRFSTYELLHHER
||.| . . . |||||| ||  .|..|.    .       .   |.| ..   .     |          . .| ...     ..|  | .  |.  ||.
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HEC

I
.
F

Kinase GL50803_41369.AA PEK 95-164 19 1.4e-05 14.58 In-house 369-474 (655) Show / Hide
Range on Protein: 95-164
Range on HMM: 369-474/655
Sequence Identity: 19% (22 aa)

TLRDLMDD----------------------------------------FIRHKLSLPEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIF
||||..|.                                        . .  ......|.|.| .|......| |          . .||| | | |||
TLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIH---------SQGMIHRDLKPSNIF

VSASGT-----VRVG
.. .|.     |..|
LDCDGQHHQMQVKIG

Kinase GL50803_41369.AA Pkinase_Tyr 186-217 43 0.000143 16.1 Pfam 179-210 (270) Show / Hide
Range on Protein: 186-217
Range on HMM: 179-210/270
Sequence Identity: 43% (14 aa)

RYLAPEVIAEQTVSDKSDVWSMGVIFYELCTL
. .|||.|..   . |||||| ||  .|..|.
KWMAPECINYGKFTTKSDVWSFGVLMWEIFTY

Kinase GL50803_41369.AA NEK-Unclassified 245-276 37 0.000515 8.84 In-house 227-258 (258) Show / Hide
Range on Protein: 245-276
Range on HMM: 227-258/258
Sequence Identity: 37% (12 aa)

YSFDMCDVINGMLSREPLHRFSTYELLHHERI
|| |. .||  || |..  | |  |..  . |
YSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI

Kinase GL50803_41369.AA NEK2 245-276 34 0.000828 8.57 In-house 288-319 (319) Show / Hide
Range on Protein: 245-276
Range on HMM: 288-319/319
Sequence Identity: 34% (11 aa)

YSFDMCDVINGMLSREPLHRFSTYELLHHERI
|| .  ..|  |.   . || |. |.| | .|
YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI

Kinase GL50803_41369.AA NEK-Unclassified 121-164 38 0.001109 7.72 In-house 105-139 (258) Show / Hide
Range on Protein: 121-164
Range on HMM: 105-139/258
Sequence Identity: 38% (17 aa)

QVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGTVRVG
| . |.|| |          |..||| | | |||   . ||  |
QMIMAVQYIH---------QRKIIHRDLKPQNIFLTDDDTVSMG

Kinase GL50803_41369.AA CDC2 203-220 47 0.003779 4.94 In-house 188-208 (301) Show / Hide
Range on Protein: 203-220
Range on HMM: 188-208/301
Sequence Identity: 47% (10 aa)

DVWSMGVIFYEL---CTLTPL
|.|| | ||.|.   .|  ||
DMWSIGCIFAEMFMDVTKKPL

Kinase GL50803_41369.AA NEK 242-276 31 0.010758 5.78 In-house 249-286 (286) Show / Hide
Range on Protein: 242-276
Range on HMM: 249-286/286
Sequence Identity: 31% (12 aa)

VP-G--YSFDMCDVINGMLSREPLHRFSTYELLHHERI
.|    || |. ..|. || ..| .| |. ..| .  |
IPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase GL50803_41369.AA NEK1 141-164 21 0.019575 4.46 In-house 123-163 (276) Show / Hide
Range on Protein: 141-164
Range on HMM: 123-163/276
Sequence Identity: 21% (9 aa)

RRVIHRCLHPNNIFVS--ASG---------------TVRVG
|...|| . . ||| .   .|               .|..|
RKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLG

Ank GL50803_41369.AA Ank 801-822 45 0.000351 19.34 Pfam 1-22 (33) Show / Hide
Range on Protein: 801-822
Range on HMM: 1-22/33
Sequence Identity: 45% (10 aa)

HGVTALMFAAAAGHLSVVETLL
.| |.|. |.  ||..||. ||
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_41369.AA Ank 770-800 25 10.198843 3.24 Pfam 1-31 (33) Show / Hide
Range on Protein: 770-800
Range on HMM: 1-31/33
Sequence Identity: 25% (8 aa)

IEYTNLMKAATLGDIDKVKLLISLEANITTR
  .| |. |.  |... ||.|..  |..  .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQ

Ank GL50803_41369.AA Ank 832-852 38 1.179141 6.62 Pfam 1-21 (33) Show / Hide
Range on Protein: 832-852
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

DGLPALSYAVKGGHAEISRVL
||  .| .|.. ||.|. . |
DGFTPLHLACRCGHTEVVKML

Ank GL50803_41369.AA Ank 863-887 28 0.008533 14.34 Pfam 1-25 (33) Show / Hide
Range on Protein: 863-887
Range on HMM: 1-25/33
Sequence Identity: 28% (7 aa)

NGLSPLMIACDYNQVAIASILKEYG
.| .||..|| .... ... | ..|
DGFTPLHLACRCGHTEVVKMLLQHG

Ank GL50803_41369.AA Ank 894-924 21 0.113248 10.29 Pfam 1-33 (33) Show / Hide
Range on Protein: 894-924
Range on HMM: 1-33/33
Sequence Identity: 21% (7 aa)

SGTTALMRAAQRNSYPLCKTLFD--VEAAMQNN
 | |.|. |......  .| | .   .  .|..
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_41369.AA Ank 925-945 23 0.237494 9.13 Pfam 1-21 (33) Show / Hide
Range on Protein: 925-945
Range on HMM: 1-21/33
Sequence Identity: 23% (5 aa)

AGETAMLIAAKQNYVQIVELL
 |.|.  .|.. .....|..|
DGFTPLHLACRCGHTEVVKML

Ank GL50803_41369.AA Ank 956-976 33 0.003793 15.61 Pfam 1-21 (33) Show / Hide
Range on Protein: 956-976
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

QGTTALMIAASKNFVEIVRLL
 | |.|..|.... .|.|..|
DGFTPLHLACRCGHTEVVKML

Ank GL50803_41369.AA Ank 987-1012 26 0.075263 10.93 Pfam 1-26 (33) Show / Hide
Range on Protein: 987-1012
Range on HMM: 1-26/33
Sequence Identity: 26% (7 aa)

YNETALMKAAKAGALDAAALLLEAEA
. .|.|. |.. | .. . .||.. |
DGFTPLHLACRCGHTEVVKMLLQHGA

Ank GL50803_41369.AA Ank 1018-1041 33 0.001891 16.7 Pfam 1-24 (33) Show / Hide
Range on Protein: 1018-1041
Range on HMM: 1-24/33
Sequence Identity: 33% (8 aa)

DGKTAMMCAAEMDRMEMVDLLLKK
|| |. ..|......|.| .||..
DGFTPLHLACRCGHTEVVKMLLQH

Ank GL50803_41369.AA Ank 1049-1069 42 9.3e-05 21.42 Pfam 1-21 (33) Show / Hide
Range on Protein: 1049-1069
Range on HMM: 1-21/33
Sequence Identity: 42% (9 aa)

DGTTALMLAAQKGHRRIIQLL
|| |.|.||...|| .....|
DGFTPLHLACRCGHTEVVKML

Ank GL50803_41369.AA Ank 1080-1112 24 1e-05 24.9 Pfam 1-33 (33) Show / Hide
Range on Protein: 1080-1112
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

SGETALMLAIRHQNVDAIEDLINYEGDIDMYNG
 |.|.|.||.|. ... ...|...  |... . 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD