GL50803_4977

Species: G.lamblia
Alias: GL50803_4977, GK282
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_4977.AA Protein None 385 None Fasta, JSON
GL50803_4977.kin_dom Protein Kinase Domain None 322 None Fasta, JSON

Protein domain

Protein domains of GL50803_4977.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_4977.AA S_TKc 30-353 12 1.8e-08 -52.64 SMART 1-231 (231) Show / Hide
Range on Protein: 30-353
Range on HMM: 1-231/231
Sequence Identity: 12% (45 aa)

YTRKALLHKGSDVSLYLTVLTTSMEQVISKEIYYQEENEDLVFALTDELRYISYMNNRCLQPILDVFFQRPEKRIIAVYASVNG--LSLRQIITYNTKHN
|.   .. ||.  . |. . . . ..|  |.|            .  |..  .  .   .  ..|||     ...  |   ..|   .|...|  . .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

VR--ISESDMWRIAGQLVSVLYYMHFVQSLHRLVKSAN---------------TDAFTESAREEDFAVMYRLYKNRPENFCSDDIHYKNFQLEELARVSN
 |  ..| . .... |... | |.|  . .|| .| .|               .                                              
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL--------------------------------------------

HLVREKSMELYEYACQIIPILHREITPDNLIVDSAGYLVLCNANPYRVLSQEYGPYD--SPELQKFGIFSE-ATDLYSVGLVLYELLTCRKYLERSVDSH
                                                 .   |  .  .||.     ..  . | .|.| .|||.|. .   .   .  
-------------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQM

WCPRQLPNTLYFDGYSTHLRNLIRGLLHPDPALRPLLTDIMR-------LPRL
   . .         |  ....||..|. ||. ||   ....        | .
MFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_4977.AA WEE 311-353 28 2.6e-08 24.05 In-house 246-297 (297) Show / Hide
Range on Protein: 311-353
Range on HMM: 246-297/297
Sequence Identity: 28% (15 aa)

R---------QLPNTLYFDGYSTHLRNLIRGLLHPDPALRPLLTDIMRLPRL
|         |.|.   ....|. |..||.  .|||| .||   .... | |
RQGDLSFDKNQIPFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL

Kinase GL50803_4977.AA NEK 322-353 40 9.5e-08 23.78 In-house 255-286 (286) Show / Hide
Range on Protein: 322-353
Range on HMM: 255-286/286
Sequence Identity: 40% (13 aa)

YSTHLRNLIRGLLHPDPALRPLLTDIMRLPRL
||. |.|||. .|..|| .||  ..|. .| .
YSQDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase GL50803_4977.AA NEK8 320-353 38 8.1e-07 15.36 In-house 245-278 (278) Show / Hide
Range on Protein: 320-353
Range on HMM: 245-278/278
Sequence Identity: 38% (13 aa)

DGYSTHLRNLIRGLLHPDPALRPLLTDIMRLPRL
|.||  .| |.. .|  ||. || .  ||  | .
DHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC

Kinase GL50803_4977.AA AGC 278-353 16 1e-06 11.58 In-house 281-395 (395) Show / Hide
Range on Protein: 278-353
Range on HMM: 281-395/395
Sequence Identity: 16% (19 aa)

SEATDLYS--VGLVLYELLTC------------------RKYLERSVDSHWCPRQLPNTLYF---------DGYSTHLRNLIRGLLHPDPALRPL-----
. | | .|  .| ..||.||                   .. .  .. .. .  . . .. |         .  |  ...||..||..||. |.      
GKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGND

-----LTDIMRLPRL
       .|.. |  
FGDKGAEEIKNHPWF

Kinase GL50803_4977.AA NEK4 322-353 37 4e-06 18.21 In-house 226-257 (257) Show / Hide
Range on Protein: 322-353
Range on HMM: 226-257/257
Sequence Identity: 37% (12 aa)

YSTHLRNLIRGLLHPDPALRPLLTDIMRLPRL
||. | ||.. .|   |  || . ||.. | .
YSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI

Kinase GL50803_4977.AA Ciliate-E2-Unclassified 230-295 18 1e-05 15.89 In-house 165-265 (352) Show / Hide
Range on Protein: 230-295
Range on HMM: 165-265/352
Sequence Identity: 18% (19 aa)

ILHREITPDNLIVDSAG---YLVLCN----------------------ANPYRVLSQEYGPYD------SPELQKFGIFS----EATDLYSVGLVLYELL
|.|| |.|.|...|. |   |. ..                        ...  ...  | .       .||. .    .    .. | .|.| .|||.|
IIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEML

T
.
F

Kinase GL50803_4977.AA MARK 323-353 41 2e-05 13.89 In-house 232-262 (262) Show / Hide
Range on Protein: 323-353
Range on HMM: 232-262/262
Sequence Identity: 41% (13 aa)

STHLRNLIRGLLHPDPALRPLLTDIMRLPRL
|...||||. || ..|  || ...||. | .
SKECRNLIQRLLTVNPEERPTIEEIMKHPWM

Kinase GL50803_4977.AA MLK 269-295 44 4.3e-05 12.53 In-house 195-221 (280) Show / Hide
Range on Protein: 269-295
Range on HMM: 195-221/280
Sequence Identity: 44% (12 aa)

PELQKFGIFSEATDLYSVGLVLYELLT
||  | ...|.. |  | | .| ||||
PEVIKESTWSKGSDVWSYGVLLWELLT

Kinase GL50803_4977.AA NEK1 322-353 28 0.000122 12.21 In-house 245-276 (276) Show / Hide
Range on Protein: 322-353
Range on HMM: 245-276/276
Sequence Identity: 28% (9 aa)

YSTHLRNLIRGLLHPDPALRPLLTDIMRLPRL
||. |..|.  ..  .| .||  ..|   | .
YSYELQSLVSQMFKRNPRHRPSVNQILERPFI

Kinase GL50803_4977.AA NEK 116-150 26 0.002043 8.35 In-house 94-131 (286) Show / Hide
Range on Protein: 116-150
Range on HMM: 94-131/286
Sequence Identity: 26% (10 aa)

LRQI---ITYNTKHNVRISESDMWRIAGQLVSVLYYMH
| |    |  ... .  ..|.  |..  |... |.|||
LYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMH

Kinase GL50803_4977.AA NEK6 320-344 48 0.002812 6.36 In-house 228-252 (252) Show / Hide
Range on Protein: 320-344
Range on HMM: 228-252/252
Sequence Identity: 48% (12 aa)

DGYSTHLRNLIRGLLHPDPALRPLL
| ||..||.|.   .|||| .|| .
DHYSEQLRQLVCMCIHPDPEWRPDI

Kinase GL50803_4977.AA NEK6 116-163 33 0.003139 6.2 In-house 86-133 (252) Show / Hide
Range on Protein: 116-163
Range on HMM: 86-133/252
Sequence Identity: 33% (16 aa)

LRQIITYNTKHNVRISESDMWRIAGQLVSVLYYMHFVQSLHRLVKSAN
. ..| .  |    | |  .|.   || | |  ||    .|| .| ||
MSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMHSKRVMHRDIKPAN

Kinase GL50803_4977.AA AGC 230-251 34 0.016837 0.68 In-house 175-197 (395) Show / Hide
Range on Protein: 230-251
Range on HMM: 175-197/395
Sequence Identity: 34% (8 aa)

ILHRE-ITPDNLIVDSAGYLVLC
| ||  . |.|.  |. |.. |.
IIHRDYLKPENILLDEDGHIKLT

Kinase GL50803_4977.AA WEE 115-150 23 0.071001 2.16 In-house 91-128 (297) Show / Hide
Range on Protein: 115-150
Range on HMM: 91-128/297
Sequence Identity: 23% (9 aa)

S--LRQIITYNTKHNVRISESDMWRIAGQLVSVLYYMH
|  | ..|..... | ...|.  | |  ...  | ..|
SNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIH

Kinase GL50803_4977.AA NEK1 281-295 60 0.205674 0.87 In-house 202-216 (276) Show / Hide
Range on Protein: 281-295
Range on HMM: 202-216/276
Sequence Identity: 60% (9 aa)

TDLYSVGLVLYELLT
.|  | | |||||.|
SDIWSLGCVLYELCT