Gene GL50803_5358 (G.lamblia)

GL50803_5358

Species: G.lamblia
Alias: GK043, GL50803_5358
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
GL50803_5358.AA Protein None 311 None Fasta, JSON
GL50803_5358.kin_dom Protein Kinase Domain None 281 None Fasta, JSON

Protein domain

Protein domains of GL50803_5358.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_5358.AA Aur 20-300 39 5e-142 377.64 In-house 1-257 (257) Show / Hide 
Range on Protein: 20-300
Range on HMM: 1-257/257
Sequence Identity: 39% (113 aa)

FEIGRFLGRGKYGLVYLAREQSSKLVVALKVLYKSYIKSERVEGQVRRELDIHLNVRHINIIRLYTWFQDETRVFLVLEVAPYGELYQRLQQF--GKFPL
||||. ||.||.| |||||. ...  .||||. |. ||.. .| |.|||  |.   .| ||...|..|.|..|..|.|| || ||||. ||.   ..|. 
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

PVVSKIIRDVAQAIQYLHRKNIFHRDLKAENILICKGKETKEHTDAHNSDDSISVHEHELVRMAHYTYKIADFGWSVHHPTHGGRRRTQCGTLDYLPPEV
.   |...... |. |.|.||| |||.| ||||.                                . ||.||||||| |    ||.|.||||||.|||.
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQ---------------------------CNGNIKICDFGWSVHCPN-NNRRMTFCGTLDYMPPEM

MLGQSYDKACDIWSLGALCYELICGTAPFYH-DEIKITRQNIA-NVEYSFTKDFSPASKDFIQRMLIRSPEARISIEDILRHPFL
  ||..|.  |||.|| |||||. | .||.. .. . | ..|  .|...| . .|.  ||.|.. | . |. |.....|..||. 
VEGQMHDHKVDIWCLGVLCYELCHGCPPFESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase GL50803_5358.AA S_TKc 20-300 28 1.1e-88 301.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-300
Range on HMM: 1-231/231
Sequence Identity: 28% (84 aa)

FEIGRFLGRGKYGLVYLAREQSSKLVVALKVLYKSYIKSERVEGQVRRELDIHLNVRHINIIRLYTWFQDETRVFLVLEVAPY--GELYQRLQQFGK---
.||.| .|.| .| ||..|. ... .||.|..            ..|||..|. . .| ||..|| .||| .....|.| ..   |.|...... |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPLPVVSKIIRDVAQAIQYLHRKNIFHRDLKAENILICKGKETKEHTDAHNSDDSISVHEHELVRMAHYTYKIADFGWSVHHPTHGGRRRTQCGTLD
   ||  .. .... ...|..|.|...| ||||| ||||...                              . ||.||| . .        .|.|||..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------------------------HIKICDFGLARQL-------TTFCGTPW

YLPPEVMLGQSYDK-ACDIWSLGALCYELICGTAPFYHDEIKITRQNIANVEYSFTKDFSPASKDFIQRMLIRSPEARISIEDILR-------HPFL
|..|||.   .|.| .||.||.| . ||..||  ||.  ... . ..|           ||  ||||...| . || |... ..|.       ||..
YMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_5358.AA CAMK 25-300 20 8.8e-85 273.02 In-house 1-425 (425) Show / Hide 
Range on Protein: 25-300
Range on HMM: 1-425/425
Sequence Identity: 20% (93 aa)

FLGRGKYGLVYLAREQSSK------------LVVALKVLYKSYIKS-------------------------ERVEGQVRRELDIHLN-------VRHINI
 |||| .| |.|... ...              || |.. |. .|.                         .. . .||||..|. .       ..| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLYTWFQD-------------------ETRVFLVL---EVAPYGEL----YQRLQQF---------------GKFPLPVVSKIIRDVAQAIQYLHRKNI
|.|| ...|                   ......|.   | .. |||    ......                |.|.   .....| ...|..|.| .||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

FHRDLKAENILICKGKETKE-------HTDAHNSDDSISVHEHELVRMAHYTYKIADFGWSVHHPTH-----------------------GGRRRTQCGT
 ||||| ||||... .. ..         |                 .  .. ||.||| . . .                         |   .|.|||
VHRDLKPENILLDDNNDDSDPVEHDEIF-D-----------------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGT

LDYLP-PEVMLGQS--------------YDKACDIWSLGALCYELICGTAPFYHD-------------EIKITRQNIANVEYSFT---------------
. | . ||| .|..              |...||.||.| ..| . ||. |||.|             ... . ..| . .|.|                
PEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEW

KD---------FSPASKDFIQRMLIRSPEARISIEDILRHPFL
 |         .|.  ||.|..|| . || |..||..|.||..
WDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_5358.AA Pkinase 20-300 26 9.8e-82 282.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 20-300
Range on HMM: 1-293/293
Sequence Identity: 26% (84 aa)

FEIGRFLGRGKYGLVYLAREQSSKLVVALKVLYKSYIKSERVEGQVR-RELDIHLNVRHINIIRLYTWFQDETRVFLVLEVAPYG----ELYQRLQ--QF
..||| .|.| .| ||.......  .||.|.. |. .||.  .  .| .|. |.....| ||.||| ||.|.... .|.| .. |    .|. ...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKF--PLPVVSKIIRDVAQAIQYLHRKNIFHRDLKAENILICKGKETKEHTDAHNSDDSISVHEHELVRMAHYTYKIADFGWSVHH-PTHGGRRRTQCGT
|.|  .  .. .... ......|.|...| ||||| ||||| .  ....                        . ||.||| . ..   ...   | |||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------------------------CVKICDFGLAKQFDY-NNS-MTTFCGT

LDYLPPEVML-GQSYDKACDIWSLGALCYELICGTAPFYHD-------EIKITRQNIA-NVEYSFTKDFS-------------------PASKDFIQRML
..|..||| . || |....|.||.| ..||..||  ||...       .... ...    ..... .. |                   .. |||| ..|
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

IRSPEARISIEDILRHPFL
 . |. |...|.|| ||..
CKDPKKRPTAEQILQHPWF
Kinase GL50803_5358.AA Ciliate-E2 20-300 22 1.2e-66 227.69 In-house 1-365 (365) Show / Hide 
Range on Protein: 20-300
Range on HMM: 1-365/365
Sequence Identity: 22% (91 aa)

FEIGRFLGRGKYGLVYLARE-----------------------QSSKLVVALKVLYKSYIKSERVEGQVRRELD----------IHLNVRHINIIRLYTW
... . .|.| .| ||...                        .  .  .|.|.. |. |..   | .. ||..          |  .. | |||..| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DETRVFLVLEVAPYGELYQRLQQF-----------GKFPLPVVSKIIRDVAQ---------------AIQYLHRKN-IFHRDLKAENILICKGKET
||  |.. ..||.| . .|.|.......           ..| .  ...|.. ..|               |..||| || |.|||.| ||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

KEHTDAHNSDDSISVHEHELVRMAHYTYKIADFGW--SVHHP----THGGRRRT--------------------------QCGTLDYLPPEVMLGQS---
                            ||.|||    .. .    || ....                           .|||. |..||.  |..   
---------------------------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDN

------YDKACDIWSLGALCYELICGTAPFYHDEIKITRQNIANVEYSFT------------------KDFSPASKDFIQR----MLIRSPEARIS-IED
      ||..||||||| . ||...|  ||         |.| . ...|                   |. |.  ||.|..    || . || ||. .|.
QQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQ

ILRHPFL
|| ||..
ILNHPWF
Kinase GL50803_5358.AA CAMKL 20-300 26 2e-66 210.93 In-house 1-297 (297) Show / Hide 
Range on Protein: 20-300
Range on HMM: 1-297/297
Sequence Identity: 26% (88 aa)

FEIGRFLGRGKYGLVYLARE-QSSKLVVALKVLYKSYIKS-------------ERVEGQVRRELDIHLNVR---HINIIRLYTWFQDETR------VFLV
..||. ||.| .| | ||.  .  .  || |.. |. |.              |...  .|||  |.  ..   | |||.||  .....       ..||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEVAPYGE--LYQRLQQF----GKFPLPVVSKIIRDVAQAIQYLHRKNIFHRDLKAENILIC-KGKETKEHTDAHNSDDSISVHEHELVRMAHYTYKIAD
.| .. ||  |......     |..| .   .. | .  |..|.|...| |||.|.||||.  .|..                           . ||.|
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---------------------------NIKIID

FGWSVHHPTH----GGRRRTQCGTLDYLPPEVMLG--QSYD-KACDIWSLGALCYELICGTAPFYHD--------EIKITRQNIANVEYSFTKDFSP-AS
|| | ..  .    |   .|.||.. | .||. .|  ..|| .. ||||.| . | ..||. ||  |         |   .  |    | ... ...   
FGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDC

KDFIQRMLIRSPEARISIEDILRHPFL
.|.|..|| . || |..|..|..||..
RDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase GL50803_5358.AA Ciliate-E2-Unclassified 20-300 24 1.4e-64 220.89 In-house 1-352 (352) Show / Hide 
Range on Protein: 20-300
Range on HMM: 1-352/352
Sequence Identity: 24% (91 aa)

FEIGRFLGRGKYGLVYLAREQSSKLV-------VALKVLYKSYIKSERVEGQVRRELDIH----------------LNVRHINIIRLYTWFQDETRVFLV
..|.. .|.| .| ||.... . |..       .. ..  |.. ...  . .   |. ..                ||  |..|.... .|||.  ...|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEVAPYGELYQRLQQFGK-----------------FPLPVVS-----KIIRDVAQAIQYLHRKN-IFHRDLKAENILICKGKETKEHTDAHNSDDSISVH
.| ...|.| | .....|                 |.   ..     .... . |...|||.|| | |||.| ||||. ....                 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-----------------

EHELVRMAHYTYKIADFGWSVHHPTHGGRRRTQ----------------CGTLDYL----PPEVMLGQSYD----KACDIWSLGALCYELICGTAPFYH-
         |  ||.||| | .  .  . . |.                |||. |.    .|||. || ||    ..||||||| ..||.. |. |||  
--------NYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDN

DEIK---------------ITRQNIANVEYSFTK--------DFSPASKDFIQ----RMLIRSPEARISIEDILRHPFL
....               . .||| . ...| |        . ||  ||||.    .||   |. ||..|.|| ||..
NCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_5358.AA CAMK-Unique 20-300 22 1.2e-59 195.44 In-house 1-363 (363) Show / Hide 
Range on Protein: 20-300
Range on HMM: 1-363/363
Sequence Identity: 22% (86 aa)

FEIGRFLGRGKYGLVYLAREQSSKLVVALKVLYKSYIKSERVEGQ-----------------VRRELDIHLNVRHINIIRLYTW----FQDET-------
 . .| .| | .|.|| .  .. .   | |.. | . ....   |                  .||..| . | | |||.|| |    |.|..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------RVFLVLEVAPYGELYQRLQQ--------------------FGKFPL--PVVSKIIRDVAQAIQYLHRKNIFHRDLKAENILICKG-KETKEH
        . ..|.| .. |.|.. .|.                     |.|      .. |.. ...|. |.| ..| |||||.|||..|.  |.    
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN--

TDAHNSDDSISVHEHELVRMAHYTYKIADFGWSVHHPTHGGRR--RTQCGTLDYLPP--------------EVMLGQSYDKAC----DIWSLGALCYELI
            |         .  |..||| ..|  .   .    | |||..|. |              ||  .| ||  |    ||||||.. |...
-----------HHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYML

CGTAPFYHDEIK--------ITRQNIANVEY-SFTK----D---FSPASKDFIQRMLIRSPEARISIEDILRHPFL
||  ||... ..         ....|   .| .| .    .    |.. |||... . . |  |.|.. .| |...
CGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase GL50803_5358.AA STE 20-300 18 1.1e-57 197.97 In-house 1-359 (359) Show / Hide 
Range on Protein: 20-300
Range on HMM: 1-359/359
Sequence Identity: 18% (74 aa)

FEIGRFLGRGKYGLVYLAREQ------SSKLV---------VALKVLYKSYIKS--------------ERVEGQVRRELDIHLNVR--HINIIRLYTWFQ
.|. ...|.| .| ||.|.        ... |         .| |.. ..  ..              .  . |. .|..|. . .  | ||.. |  . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE-------TRVFLVLEVAPYGELYQRLQ-----QF---------GKFPLPVVSKIIRDVAQA-IQYLHRKNIFHRDLKAENILICKGKETKEHTDAHNS
.|       . .....|  ..| | . ..     ..         ..|| .....|.|.. ..  .|||...| |||.|. |||.               
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------------

DDSISVHEHELVRMAHYTYKIADFGWSV----HHP------------THGGRRRTQCGTLDYLPPEVMLG------QSYDKACDIWSLGALCYELICGTA
                   |..||| .     ...            | ...| | .||  .  |||...      . ||  ||||||| .. |...|  
------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKP

PFYHDEIKITRQNIA----------------NVEYSFTK-------------------DFSPASKDFIQRMLIRSPEARISIEDILR--HPFL
|.          .|.                .   ..                      .||  ||||.. |.. |. | . .. |.  |||.
PWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_5358.AA AGC 186-300 22 6.8e-47 118.13 In-house 195-395 (395) Show / Hide 
Range on Protein: 186-300
Range on HMM: 195-395/395
Sequence Identity: 22% (47 aa)

KIADFGWSVHHPTHG------------------------------------------------GRRRTQ--CG--TLDYLPPEVMLGQSYDKACDIWS--
|..||| .   .. |                                                .| ||.  ||  | .|..||.     |.||||.||  
KLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFG

LGALCYELICGTAPFYHD-----------EIKITRQNI-------ANVEYSFT--------KDFSPASKDFIQRMLIRSPEARIS----------IEDIL
||.| ||...|  |||.|           . ..  . .        .|.. |         . |||  ||.|...| . || |.           .|.| 
LGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIK

RHPFL
.||. 
NHPWF
Kinase GL50803_5358.AA AGC 20-151 25 5.1e-43 107.88 In-house 1-188 (395) Show / Hide 
Range on Protein: 20-151
Range on HMM: 1-188/395
Sequence Identity: 25% (47 aa)

FEIGRFLGRGKYGLVYLAREQ------SSKLVVALKVLYKSY---IKSERVEGQVRRE------------LDIHLNVR----------HINIIR-LYTWF
||. . .|.| .| |||.|.       ... . |.||| |..   || .. . .. .|             .|  ...          | .|.. |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDETR--VFLVLEVAP----------YGELYQRLQ---QFGKFPLPVVSKIIRD-------VAQAIQYLHR-KNIFHRD-LKAENILI
||...  ...|.| .|           .||...||   . |.|. ...  ..         .. |..|||. ..| ||| || ||||.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILL
Kinase GL50803_5358.AA MARK 20-151 32 1.6e-33 107.08 In-house 1-137 (262) Show / Hide 
Range on Protein: 20-151
Range on HMM: 1-137/262
Sequence Identity: 32% (45 aa)

FEIGRFLGRGKYGLVYLAREQSSKLVVALKVLYKSYIKSERVEGQVRRELDIHLNVRHINIIRLYTWFQ--DETR-VFLVLEVAPYGELYQRLQQF--GK
..... .| | |. |.||. . ..  ||.|.. |  .        |.||..|.  . | |||.|.  ..  .|.. ..|..| |. ||||......  |.
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FPLPVVSKIIRDVAQAIQYLHRKNIFHRDLKAENILI
 . .   .| | .  |..|.|.||| |||.|.|||||
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILI
Kinase GL50803_5358.AA RSK 186-300 31 1.7e-32 114.26 In-house 147-278 (278) Show / Hide 
Range on Protein: 186-300
Range on HMM: 147-278/278
Sequence Identity: 31% (42 aa)

KIADFGWSVH-HPTHGGRRRTQCGTLDYLPPEVML---GQS-YDKACDIWSLGALCYELICGTAPFYH---DEIKITRQNIANVE--YSFT--KDFSPAS
|. ||| .   .. |...  | |.|..|..||.     .|. .|||||.||||.| ||.  |  ||..   .  | . ..| . .   ..   .  |.. 
KLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEA

KDFIQRMLIRSPEARIS-----IEDILRHPFL
||.|..|| | |. |..     .|.|..||..
KDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase GL50803_5358.AA MARK 186-300 38 4.3e-32 102.33 In-house 146-262 (262) Show / Hide 
Range on Protein: 186-300
Range on HMM: 146-262/262
Sequence Identity: 38% (46 aa)

KIADFGWSVHHPTHGGRRRTQCGTLDYLPPEVMLGQSYD-KACDIWSLGALCYELICGTAPFYHDE--IKITRQNIANVEYSFTKDFSPASKDFIQRMLI
||.|||.|.. |. | .  | |||. | .||..|.. || .. |||||| . | ..||. ||  |   .|  ...| . .|..    |.  ...|||.| 
KIIDFGFSICIPP-GQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLT

RSPEARISIEDILRHPFL
  || |..||.|..||..
VNPEERPTIEEIMKHPWM
Kinase GL50803_5358.AA RSK 23-150 31 1.7e-23 82.99 In-house 1-136 (278) Show / Hide 
Range on Protein: 23-150
Range on HMM: 1-136/278
Sequence Identity: 31% (43 aa)

GRFLGRGKYGLVYLAREQ---SSKLVVALKVLYKSYIKSERV-EGQVRRELDIHLNVR-HINIIRLYTWFQDETRVFLVLEVAPYGELYQRLQQFGK---
 . ||.| || |.| |.     .. . | ||| |. |.   .    ...| .| . .. | .|..|.  ||.|. ..|..|  . |||. .||. .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPLPVVSKIIRDVAQAIQYLHRKNIFHRDLKAENIL
|    .. ... .. |...|| . | ||||| ||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENIL
Kinase GL50803_5358.AA TyrKc 20-300 20 1.2e-15 30.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-300
Range on HMM: 1-280/280
Sequence Identity: 20% (66 aa)

FEIGRFLGRGKYGLVYLAREQSSKLVVALKVLYKSYIKSERVEGQVRRELDIHLNV--RHINIIRLYTWFQDE-------TRVFLVLEVAPYGELYQRLQ
 . |. ||.| .| ||...     . || |.| ..       .   .||. |  ..  .| ||.|||    ..         ...|.| .|.| | ..|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QFGK-FPLPVVSKIIRDVAQAIQYLHRKNIFHRDLKAENILICKGKETKEHTDAHNSDDSISVHEHELVRMAHYTYKIADFGWSVHHPTH--------GG
  .. ....   ..  ..|.  .|||.||. |||| | |.|. ...                            | ||.||| |  .  .          
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------------------------TVKISDFGLSRDIYDDDQQGESKDYY

RRRT--QC---GTLDYLPPEVMLGQSYDKACDIWSLGALCYELICGTAPFYHDEI---KITRQNIANVEYSFTKDFSPA---------SKDFIQRML---
| ..  ..     .  ..||..    .  . |.|| | ...|.    .. | ..|   .  .. |..|.  .  .  |          ...  | |.   
RKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCW

IRSPEARISIEDILRHPFL
 . || | . ..|  | ..
HEDPEDRPTFSEI--HECF
Kinase GL50803_5358.AA Pkinase_Tyr 20-191 24 1.5e-15 53.32 Pfam 1-156 (270) Show / Hide 
Range on Protein: 20-191
Range on HMM: 1-156/270
Sequence Identity: 24% (45 aa)

FEIGRFLGRGKYGLVYLAREQ----SSKLVVALKVLYKSYIKSERV--EGQVRRELDIHLNV-RHINIIRLYTWFQ-DETR--VFLVLEVAPYGELYQRL
 ..|. ||.| .| ||...      . |. || |.| |    ...        ||. |  .  .| ||.|||     ..    ...|.| .|.| |.  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QQ----FGKFPLPVVSKIIRDVAQAIQYLHRKNIFHRDLKAENILICKGKETKEHTDAHNSDDSISVHEHELVRMAHYTYKIADFG
..     ......   .. ...|.. .||..||. |||| | |.|. .                              . ||.|||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----------------------------NNVVKICDFG
Kinase GL50803_5358.AA Pkinase_Tyr 213-240 28 0.905367 3.23 Pfam 181-208 (270) Show / Hide 
Range on Protein: 213-240
Range on HMM: 181-208/270
Sequence Identity: 28% (8 aa)

LPPEVMLGQSYDKACDIWSLGALCYELI
..||..    .  . |.|| | |..|..
MAPECINYGKFTTKSDVWSFGVLMWEIF