Gene GL50803_7579 (G.lamblia)

GL50803_7579

Species: G.lamblia
Alias: GL50803_7579, GK290
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_7579.AA Protein None 300 None Fasta, JSON
GL50803_7579.kin_dom Protein Kinase Domain None 282 None Fasta, JSON

Protein domain

Protein domains of GL50803_7579.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_7579.AA Pkinase 186-290 21 8e-17 60.56 Pfam 173-293 (293) Show / Hide 
Range on Protein: 186-290
Range on HMM: 173-293/293
Sequence Identity: 21% (28 aa)

GSKSYIAPEIHKQVMDCFASSKPVYPLLTPECDMWSLGALVYELCTGTPLIKQK----TKDYPAVLEAIQRPITLPKYG---------------------
|.  |.|||...            ..  .|..||||.| ..||...| |. ...    . |  .... | .|..   .                      
GTPWYMAPEVIR-----------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHN

--EELAHLVNSLLDPNPTRRPSASQVLALPLV
  ||. ......|...|..||.| |.|  | .
WSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_7579.AA AGC 186-290 19 1.4e-16 37.91 In-house 267-395 (395) Show / Hide 
Range on Protein: 186-290
Range on HMM: 267-395/395
Sequence Identity: 19% (28 aa)

G--SKSYIAPEIHKQVMDCFASSKPVYPLLTPECDMWS--LGALVYELCTGTPLIKQKT--------KDYPAVLEAIQ-------RPITLP---------
|  .  |.||||                  ...|| ||  ||.| ||. || |    ..        ..   . . |.        ....|         
GPCTPEYMAPEIL----------------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPE

--KYGEELAHLVNSLLDPNPTRRPS----------ASQVLALPLV
  .  .|. .|.. || ..|..|.           |... . |  
DRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
S_TKc GL50803_7579.AA S_TKc 9-290 16 3.2e-14 31.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-290
Range on HMM: 1-231/231
Sequence Identity: 16% (50 aa)

YTIQHTLADVPFGVLHRIRRNFDDKLFCARELEYADTCTSHHKLLKLDIDLLQKFKHNRIVRVLEVIHEEDAGVYYVIQEDATD--KYLLEMLQAARAGH
|.|  ..    ||. .. | . .....   ..          . ..  |..|.| .|  ||. ..|...   . .|.. | .      |.....  . . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

PP---AEEMIWGYIAQLAEVLSVMHNTSYQVDEEGSVPVVLVH-----GNLATDIVHTDPGDLHIIKLQTLGVGREVALGWNLVDTRGSKSYIAPEIHKQ
..    | ... |..|... |  .|.               .|      |.  |           ||.   |. |..          |.  |.|||.   
LRFPFPE-HARFYMYQICCALEYCHSHGI------------IHRDLKPENILLDE---------HIKICDFGLARQL------TTFCGTPWYMAPEVL--

VMDCFASSKPVYPLLTP-ECDMWSLGALVYELCTGTPLIKQKTKDYPAVLEAIQRPITLPKYGEELAHLVNSLLDPNPTRRPSASQVLA-------LPLV
               .. .||.||.| ..||...| |.      .. .... |          .|. .... .|. .|..||.| ..|.        | .
-------------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_7579.AA NEK8 258-290 45 1.8e-12 31.8 In-house 246-278 (278) Show / Hide 
Range on Protein: 258-290
Range on HMM: 246-278/278
Sequence Identity: 45% (15 aa)

KYGEELAHLVNSLLDPNPTRRPSASQVLALPLV
.|  |.  || ..|.  | .||||||..| ||.
HYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase GL50803_7579.AA Ciliate-E2 214-290 20 1.9e-12 39.04 In-house 274-365 (365) Show / Hide 
Range on Protein: 214-290
Range on HMM: 274-365/365
Sequence Identity: 20% (21 aa)

TPECDMWSLGALVYELCTGTPLIKQKTKDYPAVLEAIQR-PITLPKYG-------------------EELAHLVNS----LLDPNPTRRPS-ASQVLALP
. .||.|||| . ||...| |            .. |.  .| .|..                    .|  .| .     .|. .|  |.. ..|.|  |
DYKCDIWSLGVILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHP

LV
  
WF
Kinase GL50803_7579.AA RSKL 213-235 56 1.8e-10 19.95 In-house 355-377 (436) Show / Hide 
Range on Protein: 213-235
Range on HMM: 355-377/436
Sequence Identity: 56% (13 aa)

LTPECDMWSLGALVYELCTGTPL
||..|| ||.||. ||| .| .|
LTEACDWWSYGAVLYELLCGMSL
Kinase GL50803_7579.AA NEK 256-290 31 5.5e-10 31.76 In-house 249-286 (286) Show / Hide 
Range on Protein: 256-290
Range on HMM: 249-286/286
Sequence Identity: 31% (12 aa)

LP-K--YGEELAHLVNSLLDPNPTRRPSASQVLALPLV
.| .  | ..|  |....| ..|. |||..|.|..|..
IPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_7579.AA STE 217-290 22 1.4e-09 30.15 In-house 249-359 (359) Show / Hide 
Range on Protein: 217-290
Range on HMM: 249-359/359
Sequence Identity: 22% (25 aa)

CDMWSLGALVYELCTGTPLIKQKTKDYPAVLEAIQ---------------RPITLP--------------------KYGEELAHLVNSLLDPNPTRRPSA
||.|||| .. |..|| |     .  .   . ..                 | .||                    |. .|. . .|  |. .|  ||.|
CDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTA

SQVLA--LPLV
|| |    | .
SQLLKSEHPFI
Kinase GL50803_7579.AA Ciliate-E2-Unclassified 216-290 22 2.5e-09 28.53 In-house 250-352 (352) Show / Hide 
Range on Protein: 216-290
Range on HMM: 250-352/352
Sequence Identity: 22% (23 aa)

ECDMWSLGALVYELCTGTPLIKQKTKDYP--------------AVLEAI-QRPITLPKYGE---------ELAHLVN----SLLDPNPTRRPSASQVLAL
.||.|||| . ||...|..  ......                 ... | |..|  ||. .         | ....|    ..|. ||  |....|.|  
KCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNH

PLV
|. 
PWF
Kinase GL50803_7579.AA STE-Unique 218-290 28 4.2e-09 27.9 In-house 535-616 (616) Show / Hide 
Range on Protein: 218-290
Range on HMM: 535-616/616
Sequence Identity: 28% (23 aa)

DMWSLGALVYELCTGTPLIKQKTKD--YPAVLEAIQRPIT-------LPKYGEELAHLVNSLLDPNPTRRPSASQVLALPLV
|.||||... ..|.|.|.  | .    |.  .  |  .          ||.  |.. .  ..|..||. ||||.| |  .. 
DIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase GL50803_7579.AA CAMK 186-290 19 4.3e-09 24.7 In-house 281-425 (425) Show / Hide 
Range on Protein: 186-290
Range on HMM: 281-425/425
Sequence Identity: 19% (29 aa)

GSKSYIA-PEIHKQ----VMDCFASSKPVYPLLTPECDMWSLGALVYELCTGTPLIKQK-----------TKDYPAVLEAIQRPI-TLPKYG--------
|. .|.| ||. ..    .|   | .    |  .|.|||||.| . | . .|.|    .           .....  .| |..   . | .         
GTPEYMAAPEVLNGKGHCNMQN-A-TDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNY

-----------------EELAHLVNSLLDPNPTRRPSASQVLALPLV
                 .|  .|....| ..|..|....|.|. | .
GPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_7579.AA NEK1 257-290 41 9e-09 26.73 In-house 243-276 (276) Show / Hide 
Range on Protein: 257-290
Range on HMM: 243-276/276
Sequence Identity: 41% (14 aa)

PKYGEELAHLVNSLLDPNPTRRPSASQVLALPLV
| |..||  || ...  ||  |||. |.|  | .
PHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
TyrKc GL50803_7579.AA TyrKc 9-293 11 0.000507 -157.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-293
Range on HMM: 1-280/280
Sequence Identity: 11% (41 aa)

YTIQHTLADVPFGVLHRIRRNFDDKLFCA--RELEYADTCTSHHKLLKLDIDLLQKF--KHNRIVRVLEVIHEE-----DAGVYYVIQEDATDKYLLEML
 |  ..|    ||. .. . .    . .|     |.|      .. .   . .. |.  .|  ||| . |. ..      .. .... | .    |.. |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QAARAGHPPAEEMIWGYIAQLAEVLSVMHNTSYQVDEEGSVPVVLVHGNLATDIVHTDPGDLHIIKLQTLGVGREVALGWN-----------------LV
.. |                                                           .   . |     .| | .                 ||
RKHRPK---------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLV

DTRG------------SKSY----IAPEIHKQ----VMD-----------CFASSKPVYPLLTPECDMWSLGALVYELCT--GTPLIK---QKTKDYPAV
. ..             ...     . .  ..      .           |.      |   |.. | || | . .|..|  ..|      |  ..   |
GENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEV

LEAIQRPITLPKYGE-----------ELAHLVNSLLDPNPTRRPSASQVLALPLVQEM
.| ...   .|.  .           |.  .  .  . .|  ||. |..     ....
IEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase GL50803_7579.AA NEK1 218-231 71 0.00152 8.36 In-house 203-216 (276) Show / Hide 
Range on Protein: 218-231
Range on HMM: 203-216/276
Sequence Identity: 71% (10 aa)

DMWSLGALVYELCT
|.||||   |||||
DIWSLGCVLYELCT
Kinase GL50803_7579.AA NEK 95-129 25 0.007253 6.39 In-house 94-132 (286) Show / Hide 
Range on Protein: 95-129
Range on HMM: 94-132/286
Sequence Identity: 25% (10 aa)

LLEM---LQAAR-AGHPPAEEMIWGYIAQLAEVLSVMHN
| ..   ..  . .|..  ||.|| . .|..  |  ||.
LYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHD
Kinase GL50803_7579.AA NEK8 218-231 57 0.007357 3.86 In-house 204-217 (278) Show / Hide 
Range on Protein: 218-231
Range on HMM: 204-217/278
Sequence Identity: 57% (8 aa)

DMWSLGALVYELCT
|||.||   ||.|.
DMWALGCVLYEMCC
Kinase GL50803_7579.AA NEK 217-231 60 0.007737 6.29 In-house 205-219 (286) Show / Hide 
Range on Protein: 217-231
Range on HMM: 205-219/286
Sequence Identity: 60% (9 aa)

CDMWSLGALVYELCT
.|.|||| ..||.||
SDIWSLGCVLYEMCT