GL50803_8428

Species: G.lamblia
Alias: GK223, GL50803_8428
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_8428.AA Protein None 687 None Fasta, JSON
GL50803_8428.kin_dom Protein Kinase Domain None 250 None Fasta, JSON

Protein domain

Protein domains of GL50803_8428.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_8428.AA S_TKc 8-259 20 2.2e-15 48.74 SMART 1-231 (231) Show / Hide
Range on Protein: 8-259
Range on HMM: 1-231/231
Sequence Identity: 20% (54 aa)

YYDVSLLAEASFGYLYRVKKSGTEGFIALRVADMPEASPDDLVHLAEECRLYFQYQHHKIVQFNEPMIDWESGHIEVEMEYMPG--GTLEQYLVGNHG--
|  . .. . .||  |.... .|    |. . .          |.  | ..  . .|  ||.. . . |   .|. . |||..|  |.| .|.. . .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--SQIPEVDIWQILGDVTEGLAHLHSRINGRAPTAHCDLRPATILRKQNIFKLSFFSLSRFIMRRPNRKSLADARLYVAPETMRWQTSGPAADIWSLGLI
  ...|| ... ..  . ..|...||. .      |.|| |. ||  .   |.. | |.|..      ...   . |.||| .  . .....|.||.| |
LRFPFPE-HARFYMYQICCALEYCHSH-G----IIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCI

ILDLASTLTVRYGSAAHDLSSLSLSGYSETLTWLVHSCLLVDPTERITAAEIFA-------LLPT
.  ...  .  .    ..   . . | |. .  ..  || .||..|.|| |...           
LYEMLCGYPPFP----QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_8428.AA TKL 86-207 19 1.1e-13 45.61 In-house 117-284 (364) Show / Hide
Range on Protein: 86-207
Range on HMM: 117-284/364
Sequence Identity: 19% (35 aa)

MEYMPGGTLEQYLVGNHGSQIPEVDIWQILGDVTEGLAHLHSRIN--GRAP--TAHCDLRPATILRKQNI---------------FKLSFFSLSRFI---
|||.|||.|. ||            . ..  |.  |...|||..   .. .   .|.|| .. || ..|                 |.. | ||||.   
MEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQS

-----------------MRRPNRKSLADARLYVAPETMRWQ----------------TSGPAADIWSLGLIILDLAS
                 ..| .. .      . ||| .| |                .  ...|..| |...  ...
GNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT

Kinase GL50803_8428.AA Ciliate-E2-Unclassified 86-202 21 6.2e-08 23.62 In-house 100-260 (352) Show / Hide
Range on Protein: 86-202
Range on HMM: 100-260/352
Sequence Identity: 21% (36 aa)

MEYMPGGTLEQYLVGNHG---------------SQIPEVDIW-----QILGDVTEGLAHLHSR--INGRAPTAHCDLRPATILRKQN----IFKLSFFSL
|||..||.|.||.  ...                ...|  .      ...  . .|| .||.   |       | |. |  || ..|      |.. |..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNI------IHRDIKPENILFDNNGKNYYIKIIDFGI

SRF----------------IMRRPNRKSLADARLYV----APETMRWQTSG----PAADIWSLGLII
|..                | .. . .. .    |     ||| .. |  .     ..|||||| |.
SKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL

Kinase GL50803_8428.AA ASK 13-206 26 1e-07 21.51 In-house 1-191 (254) Show / Hide
Range on Protein: 13-206
Range on HMM: 1-191/254
Sequence Identity: 26% (52 aa)

LLAEASFGYLYRVKKSGTEGFIALRVADMPEASPDDLVHLAEECRLYFQYQHHKIVQFNEPMIDWESGHIEVEMEYMPGGTLEQYLVGNHGSQI-PEVDI
 |   ..|  |  .   |.  ||  . ..||    .   | ||  |. | .|. |||.     . | |.. . || .||| | . |    |     |  .
VLGKGTYGIVYAGRDMHTQVRIA--IKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGC--CSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTM

WQILGDVTEGLAHLHSRINGRAPTAHCDLRPATILRK--QNIFKLSFFSLSRFIMR-RPNRKSLADARLYVAPETMR--WQTSGPAADIWSLGLIILDLA
      . |||  || .        | |..   .|      . |.| |  .. . .  |  ..      |.||| .       |..|||||.|  ....|
NFYTKQILEGLKYLHENQ-----IVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMA





Kinase GL50803_8428.AA Pkinase 176-257 20 1.4e-07 27.9 Pfam 175-293 (293) Show / Hide
Range on Protein: 176-257
Range on HMM: 175-293/293
Sequence Identity: 20% (25 aa)

RLYVAPETMR-WQTSGPAADIWSLGLIILDLASTLTVRYGS----AAHDLSSLSLSGYS-------------------------------ETLTWLVHSC
. |.|||  |  |  ||..|.||.|.|.  ...  .  .|.      ||   .     .                               |..  .. .|
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LLVDPTERITAAEIFAL--L
| .||..|.||..|.    .
LCKDPKKRPTAEQILQHPWF

Kinase GL50803_8428.AA TKL-Unique 86-201 22 3.4e-07 21.63 In-house 79-217 (290) Show / Hide
Range on Protein: 86-201
Range on HMM: 79-217/290
Sequence Identity: 22% (32 aa)

MEYMPGGTLEQYLVG--------NHGSQIPEVDIWQILGDVTEGLAHLHSRINGRAPTAHCDLRPATILRKQN------IFKLSFFSLSRFIMRR---PN
|||.|||.|  .|          |  . ..   . ..  |.  |. .||...   .|..|.||..  .|  .|        |.. |.||.|  ..   .|
MEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE---PPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTN

R-------KSLADARLYVAPETMRW--QTSGPAADIWSLGLI
.        .  .  ...||| .|    .    .|..| | .
NEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIV

Kinase GL50803_8428.AA DRAK 86-201 29 5.2e-07 17.23 In-house 76-190 (259) Show / Hide
Range on Protein: 86-201
Range on HMM: 76-190/259
Sequence Identity: 29% (35 aa)

MEYMPGGTLEQYLVGNHGSQIPEVDIWQILGDVTEGLAHLHSRINGRAPTAHCDLRPATIL----RKQNIFKLSFFSLSRFIMRRPNRKSLADARLYVAP
.||  || . || | .    . | |. ... .. ||.  ||.|       .| ||.|  ||    .     |.  | .|| |    .   ..    ||||
LEYAAGGEIFQYCVADKEECFCEKDVQRCMRQILEGVHYLHQRN-----IVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAP

ETMRWQTSGPAADIWSLGLI
| . .     | |.|| | .
EILNYDPITMATDMWSIGVL

Kinase GL50803_8428.AA PEK 86-128 15 6.2e-07 19.37 In-house 362-446 (655) Show / Hide
Range on Protein: 86-128
Range on HMM: 362-446/655
Sequence Identity: 15% (13 aa)

MEYMPGGTLEQYLVGN------------------------------------------HGSQIPEVDIWQILGDVTEGLAHLHSR
||| ...||....  |                                            ...... .|.|. .. |||...||.
MEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQ

Kinase GL50803_8428.AA CAMK 86-199 16 6e-06 14.43 In-house 136-321 (425) Show / Hide
Range on Protein: 86-199
Range on HMM: 136-321/425
Sequence Identity: 16% (32 aa)

M---EYMPGG----TLEQYLVGNHG-------------SQIPEVDIWQILGDVTEGLAHLHS-RINGRAPTAHCDLRPATILRKQN--------------
|   ||..||     | .|.| . .               ..| .  ..   . ......||  |      .|.|| |  ||  .|              
MEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI------VHRDLKPENILLDDNNDDSDPVEHDEIFD

----IFKLSFFSLSRFIMR------------------------RPNRKSLADARLYVA-PETMRWQT--------------SGPAADIWSLG
      |.. | .......                         .  |       |.| ||  . ..               ||..|.||.|
WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCG

TyrKc GL50803_8428.AA TyrKc 8-257 16 1.2e-05 -131.19 SMART 1-280 (280) Show / Hide
Range on Protein: 8-257
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

YYDVSLLAEASFG--YLYRVKKSGTEGFIALRVA--DMPEASPDDLVHLAEECRLYFQY--QHHKIVQFNEPMID-----WESGHIEVEMEYMPGGTLEQ
      | |  ||  |. . |         . ||   . | .   .  . .| |.  ..  .|  ||..    ..      ... . . |||||.| | .
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLVGNHGSQIPEVDIWQILGDVTEGLAHLHSRINGRAPTAHCDLRPATI-----------LRKQNIFKLSFFSLSRFIMRR------PNRKSLA---DAR
||  ...  ..  |  ..  .. .| ..|||.                .           . .... | | | |||.|            .. .   ...
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK---------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

--L---YVAPETMRWQTSGPAADIWS----------------LG-----LIILDLASTLTVRYGSAAHDL----SSLSLSGYSETLTWLVHSCLLVDPTE
  |     |||...  .  .. |.||                 |     .   ..   .  .|     .     |.    . .. .  .  .|   || .
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPED

RITAAEIFALL
| | .||  ..
RPTFSEIHECF

Kinase GL50803_8428.AA WEE 106-128 56 1.3e-05 14.89 In-house 108-130 (297) Show / Hide
Range on Protein: 106-128
Range on HMM: 108-130/297
Sequence Identity: 56% (13 aa)

IPEVDIWQILGDVTEGLAHLHSR
.||  ||||| |. .||.|.||.
LPEWMIWQILVDICQGLHHIHSN

Kinase GL50803_8428.AA WEE 178-255 23 3.6e-05 13.39 In-house 199-293 (297) Show / Hide
Range on Protein: 178-255
Range on HMM: 199-293/297
Sequence Identity: 23% (22 aa)

YVAPETMR-WQTSGPA--ADIWSLGLIILDLASTLTV-RYGSAAHDLS---------SLS----LSGYSETLTWLVHSCLLVDPTERITAAEIFA
| |||.     . ...  ||| |||. |. ||. . . ..| . |...          .     . ..|. |. |. . .  ||. |.|......
YMAPEILQGYYHYTHLYKADIFSLGITIYELACNMDLPKNGDWWHQIRQGDLSFDKNQIPFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQ

Kinase GL50803_8428.AA NEK8 85-104 45 5.5e-05 10.04 In-house 78-97 (278) Show / Hide
Range on Protein: 85-104
Range on HMM: 78-97/278
Sequence Identity: 45% (9 aa)

EMEYMPGGTLEQYLVGNHGS
|||| .||||.|... . ..
EMEYADGGTLYQMIQHQQNK

Kinase GL50803_8428.AA Trbl 234-254 38 0.000159 9.86 In-house 231-251 (256) Show / Hide
Range on Protein: 234-254
Range on HMM: 231-251/256
Sequence Identity: 38% (8 aa)

WLVHSCLLVDPTERITAAEIF
.|. . | ..|.||.|| .|.
CLIRCLLRREPSERMTAQHIL

Kinase GL50803_8428.AA Trbl 177-201 51 0.000626 7.95 In-house 165-191 (256) Show / Hide
Range on Protein: 177-201
Range on HMM: 165-191/256
Sequence Identity: 51% (14 aa)

LYVAPETMRWQT--SGPAADIWSLGLI
.||.||    |   || |||.|||| .
AYVSPEILCTQGSYSGKAADMWSLGVM

Kinase GL50803_8428.AA Pkinase_Tyr 86-128 31 0.000863 13.46 Pfam 86-130 (270) Show / Hide
Range on Protein: 86-128
Range on HMM: 86-130/270
Sequence Identity: 31% (14 aa)

MEYMPGGTLEQYLVGN--HGSQIPEVDIWQILGDVTEGLAHLHSR
|||||.| |  ||  .   . ...  |. |.  .. .|...|.|.
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK

Kinase GL50803_8428.AA NEK8 226-257 41 0.000901 6.51 In-house 245-278 (278) Show / Hide
Range on Protein: 226-257
Range on HMM: 245-278/278
Sequence Identity: 41% (14 aa)

SGYSETLTWLVHSCLLVDPTERITAAEIFA--LL
..||  .  |||.|| .||  | .|..| |  |.
DHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC

Kinase GL50803_8428.AA CAMK 220-253 20 0.00258 5.74 In-house 371-419 (425) Show / Hide
Range on Protein: 220-253
Range on HMM: 371-419/425
Sequence Identity: 20% (10 aa)

LSSLS-------LSGYSET--------LTWLVHSCLLVDPTERITAAEI
.| .|        .. |.            |. ..| |||..|.|....
FSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQC

Pkinase GL50803_8428.AA Pkinase 8-128 20 0.038798 8.64 Pfam 1-127 (293) Show / Hide
Range on Protein: 8-128
Range on HMM: 1-127/293
Sequence Identity: 20% (27 aa)

YYDVSLLAEASFGYLYRVKKSGTEGFIALRVADMPEASPDDLVHLAE--ECRLYFQYQHHKIVQFNEPMIDWESGHIEVEMEYMPGG----TLEQYLVGN
|  .. . . |||  |. .. ||.   |. . . ...... .....   |...    .|  ||.. . . |  ..|| . |||..||     |  |. . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

HGSQI--PEVDIWQILGDVTEGLAHLHSR
 .  .  .| ..  ..  . .||...||.
RHGCFYFSEWECKFYMYQILRGLEYCHSM

Ank GL50803_8428.AA Ank 452-469 38 1.13483 6.68 Pfam 1-18 (33) Show / Hide
Range on Protein: 452-469
Range on HMM: 1-18/33
Sequence Identity: 38% (7 aa)

QEKTPLMWAAHMGATATV
   |||..|...| |  |
DGFTPLHLACRCGHTEVV

Ank GL50803_8428.AA Ank 481-503 47 3.9e-05 22.77 Pfam 1-23 (33) Show / Hide
Range on Protein: 481-503
Range on HMM: 1-23/33
Sequence Identity: 47% (11 aa)

LGDTALMFAASAGHLECVKLLLS
 |.|.|. |.. ||.|.||.||.
DGFTPLHLACRCGHTEVVKMLLQ

Ank GL50803_8428.AA Ank 520-546 37 0.003941 15.55 Pfam 1-26 (33) Show / Hide
Range on Protein: 520-546
Range on HMM: 1-26/33
Sequence Identity: 37% (10 aa)

SGWTALMKAAQNGHAVTTELLLLEAGA
 |.|.|. |...||.   ..||  .||
DGFTPLHLACRCGHTEVVKMLLQ-HGA

Ank GL50803_8428.AA Ank 550-580 38 3e-06 26.58 Pfam 1-31 (33) Show / Hide
Range on Protein: 550-580
Range on HMM: 1-31/33
Sequence Identity: 38% (12 aa)

DGMTALMLAAQANHYDSVRLLLEREACMQDQ
||.|.|.||.. .|.. |..||.. |.   |
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQ

Ank GL50803_8428.AA Ank 581-604 37 0.000123 20.98 Pfam 1-24 (33) Show / Hide
Range on Protein: 581-604
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

DGWTALMYAAREGSLASLRLLLER
||.|.|..|.| |..  ...||..
DGFTPLHLACRCGHTEVVKMLLQH

Ank GL50803_8428.AA Ank 612-632 38 0.127039 10.11 Pfam 1-21 (33) Show / Hide
Range on Protein: 612-632
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

NGQTALVAAIRAGQKECIQAL
.|.|.|  |.| |..|... |
DGFTPLHLACRCGHTEVVKML