Gene GL50803_87928 (G.lamblia)

GL50803_87928

Species: G.lamblia
Alias: GK204, GL50803_87928
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_87928.AA Protein None 465 None Fasta, JSON
GL50803_87928.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of GL50803_87928.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_87928.AA AGC 164-227 20 1.6e-14 32.5 In-house 180-296 (395) Show / Hide 
Range on Protein: 164-227
Range on HMM: 180-296/395
Sequence Identity: 20% (25 aa)

SLTPSNILFDSHGTVMLSDYGL-----------------------------------YYIRPLFGKKNR----------------------YPSFLAPEL
.| | |||.|..| ..|.| ||                                   . ..| . ..|.                       | ..||| 
YLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNK-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEI

QGPDAEYTEAVDVWC--LGCVLY
      |. |.| |.  |||..|
L-----YGKACDWWSFGLGCLMY
Kinase GL50803_87928.AA Ciliate-E2 165-284 15 7.3e-14 43.96 In-house 187-365 (365) Show / Hide 
Range on Protein: 165-284
Range on HMM: 187-365/365
Sequence Identity: 15% (30 aa)

LTPSNILFDSHGTVMLSDYGLYYIRPLFGKKNRY-----------------------------------PSFLAPELQGPDAE--------YTEAVDVWC
. |.||||     . ..| ||  .   . .....                                   | ..|||  .   .        |....|.|.
IKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS

LGCVLYSLCILQPPQFAPRELRRGVSIYSRSCPTDIR--------------------------LLLLK----CLSLNPANRPS-VLEIAMLPVV
||..|| ..  .||            .    |. |..                           |. |    .|  .| .|..   .|   |  
LGVILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_87928.AA TKL 160-278 18 2.6e-12 40.66 In-house 161-360 (364) Show / Hide 
Range on Protein: 160-278
Range on HMM: 161-360/364
Sequence Identity: 18% (37 aa)

LLHGSLTPSNILFDSHGT--------------VMLSDYGLYYIRPLFGKKNR-----------------------YPSFLAPEL-----QGPDA------
..|  |...||| |...|              . ..|.||       |..|.                        | ..|||.     . ...      
IIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEF

----EYTEAVDVWCLGCVLYSLCILQPPQFAPR-----------ELRRGVSIYS------------------RSCPTDIRLLLLKCLSLNPANRPSVLEI
    ||.|..||.  | ||. ..  ..| . .            |   .|.  .                   .||.... |. .| . .| .||| .||
CKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEI
S_TKc GL50803_87928.AA S_TKc 38-284 17 9.3e-11 -19.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 38-284
Range on HMM: 1-231/231
Sequence Identity: 17% (47 aa)

SAIIEF-------------NTRGLPDIVIKKYPVTGLRRFDAAGVHAILMRITKASGPNILEISSLQYYASHATYEITHPYCVG--GSLETLLYERRSST
  |..              ...      ||. .       . .     ...      |||  .    .   .  | ..  || |  |.| ... .|..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK---HHPNIVKLYDVFQD--DHLYMVM-EYCDGDLGDLFDYIKKRGRHG

TP--FSPLSIWKLFAQVVAGLLQLYGSTGASDDYGEMTYLLHGSLTPSNILFDSHGTVMLSDYGLYYIRPLFGKKNRY---PSFLAPELQGPDAEYTE-A
..  |..  ......|.. .|  .           ..   .|  | |.|||.|.  .....| ||  .       . .   | ..|||.      |.  .
LRFPFPE-HARFYMYQICCALEYCH----------SH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCK

VDVWCLGCVLYSLCILQPPQFAPRELRRGVSIYSRSCPTDIRLLLLKCLSLNPANRPSVLEIAM-------LPVV
.|.| .||.|| ..  .||     .. .   .     . . . .. |||  .|..||.. |.          | .
CDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_87928.AA MSK 162-229 33 4.8e-09 26.7 In-house 124-203 (277) Show / Hide 
Range on Protein: 162-229
Range on HMM: 124-203/277
Sequence Identity: 33% (27 aa)

HGSLTPSNILFDSH---GTVMLSDYGLYYIRPLFGKKNRYP-----SFLAPELQG----PDAEYTEAVDVWCLGCVLYSL
|. | | |||||.    |.| |.| |.  ..| . ..  ..      . |||.      .| .| ||.|.| || .|| .
HRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTM
Kinase GL50803_87928.AA Ciliate-E2-Unclassified 161-284 18 6.2e-09 27.15 In-house 166-352 (352) Show / Hide 
Range on Protein: 161-284
Range on HMM: 166-352/352
Sequence Identity: 18% (34 aa)

LHGSLTPSNILFDSHG---TVMLSDYGLYY-------IRPLFG-------KKNRYPSFL----------APELQGPDAEYT---EAVDVWCLGCVLYSLC
.|  ..|.|||||. |    . ..|.|. .       ..  ..       |.... .|           |||. .    ..   ...|.|.||..|| ..
IHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEML

ILQPPQFAPR------------------ELRRGVS----------------IYSRSCPTDIRLLLLKCLSLNPANRPSVLEIAMLPVV
  ..| ...                   .|..                   . | ..   |. || |.|  || .|..  .|   |  
FGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_87928.AA STE 199-284 17 3e-07 21.79 In-house 227-359 (359) Show / Hide 
Range on Protein: 199-284
Range on HMM: 227-359/359
Sequence Identity: 17% (23 aa)

PSFLAPELQGP-----DAEYTEAVDVWCLGCVL-------YSLCILQPPQ----------------------FAPRELRRGVS------------IYSRS
| . |||   .     | .|.. .|.|.|||..       . .. ..|..                      . |  |   .|             |...
P-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHK

CPTDIRLLLLKCLSLNPANRPSVLEIAM--LPVV
.  . .  . |||  .| .||.. .      | .
WSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_87928.AA Pkinase 201-284 17 1e-06 24.33 Pfam 177-293 (293) Show / Hide 
Range on Protein: 201-284
Range on HMM: 177-293/293
Sequence Identity: 17% (21 aa)

FLAPELQGPDAEYTEAVDVWCLGCVLYSLCILQPPQFAP----RELRRGVSIYSRSC------------------------------PTDIRLLLLKCLS
..|||.   . .|. .||.| .||.|| ..  .||        . ..  . |. . .                              . . . .. .|| 
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

LNPANRPSVLEIAMLPVV
..|. ||.  .|   | .
KDPKKRPTAEQILQHPWF
Kinase GL50803_87928.AA NEK10 213-235 60 1e-06 17.92 In-house 197-219 (279) Show / Hide 
Range on Protein: 213-235
Range on HMM: 197-219/279
Sequence Identity: 60% (14 aa)

YTEAVDVWCLGCVLYSLCILQPP
| |  |||  ||.|| .| ||||
YGEKADVWAFGCCLYQMCTLQPP
Kinase GL50803_87928.AA TBCK 160-188 39 6e-06 17.28 In-house 101-133 (346) Show / Hide 
Range on Protein: 160-188
Range on HMM: 101-133/346
Sequence Identity: 39% (13 aa)

LLHGSLTPSNILFDSHG----TVMLSDYGLYYI
. |..| |.||. |. |     | |. ||||..
IVHRFLHPHNIYLDDNGNQKLHVKLANYGLYHM
Kinase GL50803_87928.AA RSK 165-185 41 1.6e-05 16.57 In-house 130-153 (278) Show / Hide 
Range on Protein: 165-185
Range on HMM: 130-153/278
Sequence Identity: 41% (10 aa)

LTPSNILFDS---HGTVMLSDYGL
| |.|||.|.   .|...|.| |.
LKPENILYDDESNEGHIKLTDFGF
Kinase GL50803_87928.AA NEK 255-284 30 6.6e-05 13.65 In-house 257-286 (286) Show / Hide 
Range on Protein: 255-284
Range on HMM: 257-286/286
Sequence Identity: 30% (9 aa)

TDIRLLLLKCLSLNPANRPSVLEIAMLPVV
.| . |. ..|  .| .|||. .|  .| .
QDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_87928.AA NEK 213-235 52 0.000102 12.99 In-house 201-225 (286) Show / Hide 
Range on Protein: 213-235
Range on HMM: 201-225/286
Sequence Identity: 52% (13 aa)

YTEAVDVWCLGCVLYSLCILQP--P
|.. .|.| |||||| .| |.|  |
YNNKSDIWSLGCVLYEMCTLKPKHP
TyrKc GL50803_87928.AA TyrKc 25-288 17 0.000189 -150.68 SMART 14-280 (280) Show / Hide 
Range on Protein: 25-288
Range on HMM: 14-280/280
Sequence Identity: 17% (54 aa)

EVYKESPATLDAGSAIIEFNTRGLPDIVIKKYPVTGLRRFDAAGVHAILMR----ITKA--SGPNILEISSLQYYAS------HATYEITHPYCVGGSLE
||||   .|..              .  .|.              .. .||     .|   . |||. .       .      .  . ..  |. .|.| 
EVYK---GTWK-------------IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVM-EYMPHGDLK

TLLYERRSSTTPFSPLSIWKLFAQVVAGLLQLYGSTGASDDYGEMTYLLHGSLTPSNILFDSHGTVMLSDYGL------Y--------YIRPLFGKKNR-
  | ..|     ...    .   |. .|   |               . |  |   |.| .. .||  || ||      .        |.|.  .|  . 
DYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-YPSF-LAPELQGPDAEYTEAVDVWCLGCVLY---SLCILQPPQ-----FAPRELRRGVSIY-----SRS--------CPTDIRLLLLKCLSLNPANRPS
  |   .|||    . ..|.. |||  | ...   ...   .|        ..|... |          .        ||...  . ..|   .|..||.
MLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

VLEIAMLPVVREAY
  ||      .|  
FSEI------HECF
Kinase GL50803_87928.AA RSK 201-227 30 0.000244 12.19 In-house 174-203 (278) Show / Hide 
Range on Protein: 201-227
Range on HMM: 174-203/278
Sequence Identity: 30% (9 aa)

FLAPELQG---PDAEYTEAVDVWCLGCVLY
..|||.     ..  ...|.|.| ||...|
YMAPEMLKRANQQGGHDKACDWWSLGVLMY
Kinase GL50803_87928.AA TBCK 254-284 29 0.005824 6.31 In-house 316-346 (346) Show / Hide 
Range on Protein: 254-284
Range on HMM: 316-346/346
Sequence Identity: 29% (9 aa)

PTDIRLLLLKCLSLNPANRPSVLEIAMLPVV
.   . .. |||. .|  |||  | .  |. 
CEWLIQIIRKCLQMCPMKRPSPTELMEHPMF
Kinase GL50803_87928.AA TBCK 198-230 28 0.051739 2.86 In-house 146-198 (346) Show / Hide 
Range on Protein: 198-230
Range on HMM: 146-198/346
Sequence Identity: 28% (15 aa)

YPSFLAPE--LQGPDAE------------------YTEAVDVWCLGCVLYSLC
||...|||  |||..                     .   ||| |||..  .|
YPRYMAPERILQGEMKTTDHMPPTNPLPPKTTNLSSNPKSDVWSLGCIMLEIC
Kinase GL50803_87928.AA Pkinase 167-185 39 0.205506 6.08 Pfam 136-158 (293) Show / Hide 
Range on Protein: 167-185
Range on HMM: 136-158/293
Sequence Identity: 39% (9 aa)

PSNILFDSHGTV----MLSDYGL
|.|||.|..|..     ..| ||
PENILIDNNGHIDACVKICDFGL