Gene GL50803_8914 (G.lamblia)

GL50803_8914

Species: G.lamblia
Alias: GK179, GL50803_8914
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_8914.AA Protein None 597 None Fasta, JSON
GL50803_8914.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of GL50803_8914.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_8914.AA S_TKc 9-269 28 2.9e-76 260.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-231/231
Sequence Identity: 28% (80 aa)

YQELELLGTGNFGRVYKVVERKEGKKFACKEIFLPKLPEDLVDAQMREVALLKTIKHPNIVEVVDAFHEGDYLYILMPIYSH--GDLVAYRKKKT-----
|. |...| | ||.|||....| |...|.|.|          .  .||...||  .|||||   |.|.. |.||. |   ..  |||  | ||.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSEADVLVILIQVLQALAFLHGVREATSGIPSKIVHRDIKPANILMGEDDVVVLTDFGLSKIIDNMTDMQTVAGSVAYIAPEMHARSAYTE-AVDIWS
  ..| ..  .. |...||...|  .         |.|||.||.|||. |  .. ..||||....       |. |.  |.|||.     |.  ..|.||
FPFPE-HARFYMYQICCALEYCHSHG---------IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWS

LGVTIYELIANGKPLINSFFGSHILQEIQQWKRPLVIPNASQDLAKILNLMLTFSPENRPTALELLT-------MPAL
.|...||... |.|.       .. . ... .        |...  ... .|.. ||.|||| |.|.       .| .
CGCILYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase GL50803_8914.AA Pkinase 9-269 25 4.5e-70 243.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

YQELELLGTGNFGRVYKVVERKEGKKFACKEIFLPKLPEDLVDAQMR--EVALLKTIKHPNIVEVVDAFHEGDYLYILMPIYSHG----DLV----AYRK
|. .. .| |.||.||| .....||..|.|.| ...  ..   .  |  |....| ..|||||.  |.|...|..|. |.   .|    ||     . ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

KKTL--SEADVLVILIQVLQALAFLHGVREATSGIPSKIVHRDIKPANILMGEDDVV----VLTDFGLSKI--IDNMTDMQTVAGSVAYIAPEMHA-RSA
....  || ..  .. |.|..|...|           .|.|||.||.|||. .....     ..||||.|   . | . |.|..|.  |.||| .  .. 
HGCFYFSEWECKFYMYQILRGLEYCHSM---------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

YTEAVDIWSLGVTIYELIANGKPLINSFFGS---------HILQEIQQ--------WKRP-------------LVIPNASQDLAKILNLMLTFSPENRPT
|. .||.||.|...||..         | |.         .....| .        |...             .. .|.|... .... .|.. |. |||
YGPKVDMWSCGCILYEMLCGR----PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPT

ALELLTMPAL
| ..|  | .
AEQILQHPWF
Kinase GL50803_8914.AA AGC 9-269 20 2.2e-59 151.15 In-house 1-395 (395) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-395/395
Sequence Identity: 20% (83 aa)

YQELELLGTGNFGRVYKVVER------KEGKKFACKEIF----LPKLPEDLVDAQMRE------------VALLKTIK----------HPNIVE-VVDAF
.. | ..|.| ||.|| | ..        || .|.| .       .. .. |.  |.|               |....          ||.||     .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

HEGDY--LYILMPI---YSH------G-DLVAYR----KKKTLSEADVLVILIQ-------VLQALAFLHGVREATSGIPS-K-IVHRD-IKPANILMGE
.  |.  ||..|     |        | .|  .     |.....|  .  .. .       .. || .||          | . |.||| .|| |||. |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLH----------SHMGIIHRDYLKPENILLDE

DDVVVLTDFGLSKIID---------------------------------------------------NMTDMQTVAG--SVAYIAPEMHARSAYTEAVDI
|  . ||||||.|..                                                    ..   .|  |  .  |.|||.     |. |.|.
DGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDW

WS--LGVTIYELIANGKPLINSFFGS-------------HILQEIQ------QWKRPLVI---------PNASQDLAKILNLMLTFSPENRPT-------
||  ||. .||...   |    |.|               . | |.      .|| ..           .. |...  ... .|.  ||.|..       
WSFGLGCLMYEMLTGYPP----FYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFG

---ALELLTMPAL
   | |.   |  
DKGAEEIKNHPWF
Kinase GL50803_8914.AA Ciliate-E2 9-269 22 3.3e-56 191.42 In-house 1-365 (365) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-365/365
Sequence Identity: 22% (90 aa)

YQELELLGTGNFGRVYKVVERKEGKKFACK----------------------EIFLPKLPEDL--VDAQMREVA----------LLKTIKHPNIVEVVDA
|  ....|.|||| |||.  .|..|.|| |                      .|. ..  | .  .. .|||.           .|....||||.. ...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FH--EGDYLYILMPIYSHGDLVAYRKKK------------TLSEADVLVILIQVLQ---------------ALAFLHGVREATSGIPS-K-IVHRDIKPA
|     ...|. |  ...|||  | |..             ..|  .. |  |.||               || .||          | . |.|||||| 
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH----------SKNNIIHRDIKPE

NILMGEDDVVVLTDFGLSKIIDNMTDMQT--------------------------------VAGSVAYIAPEMHARSA---------YTEAVDIWSLGVT
|||.     . ..||||||..|.  ...|                                ..|.  | |||.. .           |....|||||||.
NILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVI

IYELIANGKPLINSFFGSHILQEIQQWKR-PLVIPNA-------------------SQDLAKILNL----MLTFSPENRPT-ALELLTMPAL
.||.. .  |             .|| |  .. .|..                   ||.   ...     ||   ||.|.| . ..|  | .
LYEMLFGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_8914.AA ULK 9-269 25 1.8e-52 180.63 In-house 1-324 (324) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-324/324
Sequence Identity: 25% (85 aa)

YQELELLGTGNFG-RVYKVV-ERKE--GKKFACKEIFLPKLPEDLVD--------AQMREVALLKTIK---HPN--IVEVVDAFHEG--DYLYILMPIYS
|.  . || | ||  |||   ....  ....||| | . |. ..  .         ...|. ..|..|   |||  ||.  | | .   ...|| |    
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

HGDLVAYRKKK----------TLSEADVLVILIQVLQALAFLHGVREATSGIPSKIVHRDIKPANILMGEDD------------VVVLTDFGLSKIIDN-
.|||  | ||.          .|||  .. ...| .... .||           .|.||||||.|||. ...            |. ..|||..|..|| 
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKH---------NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNN

-M--TDMQTVA------GSVAYIAPEMHA----RSAYTEA-VDIWSLGVTIYELIANGKPLINSFFGSHILQEIQQW------------KRPLVIP----
 |  ...||        |.  | ||.       .  |... .||||||. .||.. .  |  .. | . .|. ||.             ..|. .|    
NMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPK

--NASQDLAKILNLMLTFSPENRPTALELLTMPAL
  . |...  ..  ||.. .. | .  |.. .| .
DPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_8914.AA STE 9-269 23 2.1e-51 177.12 In-house 1-359 (359) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-359/359
Sequence Identity: 23% (89 aa)

YQELELLGTGNFGRVYKVVERK---------------EGKKFACKEIFLPKLP---------------EDLVDAQMREVALLKTIK--HPNIVEVVDAF-
.. .| .| |.|| ||| . .|                |. .| |.. | .                 .. ..  ..|. ..|  .  |||||.  ... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HEG------DYLYILMPIYSHGDLVAYRK-----KKTLS----------EADVLVILIQVLQA-LAFLHGVREATSGIPSKIVHRDIKPANILMGEDDVV
.||      |.|.| |   . | |    |     .|.|.          |  . .|. |.|.. |..||  .         |.||||||||||.     |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---------IIHRDIKPANILL-----V

VLTDFGLSKIIDN-MT----------------DMQTVAGSVAYIAPEMHAR------SAYTEAVDIWSLGVTIYELIANGKPLINSFFGSHILQEIQ---
 |.|||....... |.                  .|..|.  . |||.  .      . |.. .|||||| || |. |.|||    .     . .|.   
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM-ATGKPPWHDMHPMRAMFMIPFNY

--QW---------KRPLVIPN--------------------ASQDLAKILNLMLTFSPENRPTALELLT--MPAL
  |.         . |  .|.                     |...   .|. |.  |..|||| .||    | .
HMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_8914.AA CAMK 14-264 17 5.5e-51 162.13 In-house 1-420 (425) Show / Hide 
Range on Protein: 14-264
Range on HMM: 1-420/425
Sequence Identity: 17% (75 aa)

LLGTGNFGRVYKVVERKEG------------KKFACKEIFLPKLPED------------------------LVDAQ--MREVALLKT-------IKHPNI
 ||.|.|| |....... .            .|.|.| |   ||...                         .| .  .||....|.       ..||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VEVVDAFHEGDY-------------------LYILM---PIYSHG----DLVAYRKKK----------------TLSEADVLVILIQVLQALAFLHGVRE
.   ...  ..|                   .|. |      | |    ||  | ...                 ..|...  .  |...|....|    
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH--

ATSGIPSKIVHRDIKPANILMGEDD-----------------VVVLTDFGLSKIIDN------------------------MTDMQTVAGSVAYIA-PEM
       .|||||.|| |||. ...                  . ..|||.....|                            |.|. |. .|.| ||.
-------NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV

HAR--------------SAYTEAVDIWSLGVTIYELIANGKPLINSFFGSH----------------ILQEIQQWKRPLVIPN-----------------
  .                |....|.||.||  | .     |    | |..                ... |.. |     |                  
LNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPP----FYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDIS

------ASQDLAKILNLMLTFSPENRPTALELL
       ||.    .. ||.  ||.|.|. . |
DEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCL
Kinase GL50803_8914.AA ULK 9-269 25 3.4e-50 173.09 In-house 1-329 (329) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-329/329
Sequence Identity: 25% (87 aa)

YQELELLGTGNFGRVYKVV-ERKE---GKKFACKEIFLPKLPEDLVD--------AQMREVALLKTIK--------HPNIVEVVDAFHEG--DYLYILMP
|.  . || | ||.|||   ....   ..|.||| | . |. ... .          ..|. ..|..|        |||||.  | | .   ...|| | 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

IYSHGDLVAYRKKK-----------TLSEADVLVILIQVLQALAFLHGVREATSGIPSKIVHRDIKPANILMGEDD------------VVVLTDFGLSKI
   .|||  | ||.           .|||  .. ...| |... .||           .|.||||||.|||. ...            |. ..|||..| 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH---------NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH

IDNMT----DMQTVA------GSVAYIAPEMHA----RSAYTEA-VDIWSLGVTIYELIANGKPLINSFFGSHI---LQEIQQW---------KRPLVIP
.|| .    .|.|        |.  | ||.       .  |... .||||||. .||.. .  |  .. | . .   .|.  ..         |.|| .|
VDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFP

------NASQDLAKILNLMLTFSPENRPTALELLTMPAL
      . |...  ..  ||.. .. | .  ||. .| .
KDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_8914.AA CAMK-Unique 9-207 24 1.1e-47 155.38 In-house 1-287 (363) Show / Hide 
Range on Protein: 9-207
Range on HMM: 1-287/363
Sequence Identity: 24% (73 aa)

YQELELLGTGNFGRVYKVVERKEGKKFACKEIFLPKLPEDLVDAQ------------------MREVALLKTIKHPNIVEVVDA----FHEGD-------
|  ....|.|||| ||..  |..|||.||| . . .  ..  ..|                  .||....|. .||||....|     |.  .       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------YLYILMPIYSHGDLVAYRKK---------------------KTLSE--ADVLVILIQVLQALAFLHGVREATSGIPSKIVHRDIKPANILMG
        |.||.| .   ||| ..  |                       .||  .|.. |  ..|.|.|..|           .|||||.|. ||.  
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQ---------DIVHRDLKLENIMVC

ED--D--------------VVVLTDFGLSKIID-NMTD--MQTVAGSVAYIAP--------------EMHARSAYTEAV----DIWSLGVTIYELI
.   |               ..|.||||.. .. |  .  |||. |.  |.||              |. ... | . .    |||||||. |...
YSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYML
Kinase GL50803_8914.AA Ciliate-E2-Unclassified 9-269 23 1.3e-45 156.23 In-house 1-352 (352) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-352/352
Sequence Identity: 23% (84 aa)

YQELELLGTGNFGRVYKVVERKEGKKFACKEIF-------LPKLPED---LVDAQMREVA-------------LLKTIKHPNIVEVVDAFHEGDYLYILM
|  .. .|.|.|| |||....|.....| |..        . .. .|   .   .| .               .|. ..||.||  ...|   ...|| |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

PIYSHGDLVAYRKK------------------KTLSEADVL-----VILIQVLQALAFLHGVREATSGIPSK--IVHRDIKPANILMGEDD---VVVLTD
    .|||  | ||                  | ..|  ..      .. |.||.| .||          .|  |.|||||| |||. ..     . ..|
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH----------HKNNIIHRDIKPENILFDNNGKNYYIKIID

FGLSKIIDNMTD----------------MQTVAGSVAYI----APEMHARSAYT----EAVDIWSLGVTIYELIANGKPLI-NS----------------
||.|| .... .                |.|..|.  |.    |||.  .  |     ...||||||| .||.. .  |   |.                
FGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAY

---FFGSHILQEIQQWKRPL-----VIPNASQDLAK-ILNLMLTFSPENRPTALELLTMPAL
   ..   . ..||. | |       ...  .|. . .|  ||   |..|.|. ..|  | .
RKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_8914.AA NEK 9-208 32 2.8e-44 153.45 In-house 1-219 (286) Show / Hide 
Range on Protein: 9-208
Range on HMM: 1-219/286
Sequence Identity: 32% (74 aa)

YQELELLGTGNFGRVYKVVERKEGKK-----FACKEIFLPKLPEDLVDAQM-REVALLKTIKHPNIVEVVDAFHEGD--YLYILMPIYS-HGDLVAY---
|.... .| |.||.||||  .. ||.     .. |.| . .. |   .. .  || .|| .||||||.  |.| | .  .|.| |      |||      
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

RKKK-----TLSEADVLVILIQVLQALAFLH----GVREATSGIPSKIVHRDIKPANILMGEDDV----VVLTDFGLSKIIDNMTDMQ-T-VAGSVAYIA
 ||.      ..|  .. ..|| . || ..|    .          ||.||||||.|| .  ..     | . |||.||. .. |||. | . |   |..
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGP--------QRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMS

PEMHARSAYTEAVDIWSLGVTIYELIA
||.     |.. .||||||. .||. .
PEVCQNKPYNNKSDIWSLGCVLYEMCT
Kinase GL50803_8914.AA STE20 9-212 30 9.2e-39 135.1 In-house 1-225 (288) Show / Hide 
Range on Protein: 9-212
Range on HMM: 1-225/288
Sequence Identity: 30% (72 aa)

YQELELLGTGNFGRVYKVVERKEGKK----FACKEIFLPKLPE--DLVDAQMREVALLKTIKHPNIVEVVDAFHEG----DYLYILMPIYSHG---DLVA
|. || .| |..| |||. ... |..     | | . | |  .  | ..  . |.  .|  ||||||.  ...  .    | |.|.|.  . |   |.. 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

--YRKKK-----TLSEADVLVILIQVLQALAFLHGVREATSGIPSKIVHRDIKPANILMGEDDVVVLTDFGLSKIIDN-----MT-DMQTVAGSVAYIAP
  ....|     ...|. . .|. .|||.|..||           .|.||||| .|||..||  | |.|||..  ...     |    .|. |.  . ||
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHS---------NHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAP

EMHAR-----SAYTEAVDIWSLGVTIYELIANGKP
|. ..     . |.. .|||||| |. |. |.|.|
EVIQCMEGPDKGYDYKCDIWSLGITAIEM-AEGEP
Kinase GL50803_8914.AA TyrKc 9-269 23 2.5e-26 94.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

YQELELLGTGNFGRVYKVVERKEGKKFACKEIFLPKLPEDLVDAQMREVALLKTI--KHPNIVEVVDAFHEG-------DYLYILMPIYSHGDLVAYRKK
 . .. || |.||.||| . .    . | | .   .     . . |||  ... .  .|||||  . .  ..       . |.|.|   .||||  | .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KT--LSEADVLVILIQVLQALAFLHGVREATSGIPSKIVHRDIKPANILMGEDDVVVLTDFGLSKIIDNM------TDMQTV----AGS----VAYIAPE
.   |. .| | . .|. .  ..||           ...|||.   |.| ||. .|  .|||||. |..       .|. ..     |     .   |||
HRPKLCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

MHARSAYTEAVDIWSLGVTIYELIANGKPLINS-----FFGSHILQEIQQWKRPLVIPN--------ASQDLAKILNLMLTFSPENRPTALELLTMPAL
    . .|.. |.|| ||...|.  .|..            ..... ..| .|.   ||        ..... .|      . ||.|||  |.     .
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase GL50803_8914.AA Pkinase_Tyr 9-211 26 2.8e-19 65.94 Pfam 1-212 (270) Show / Hide 
Range on Protein: 9-211
Range on HMM: 1-212/270
Sequence Identity: 26% (60 aa)

YQELELLGTGNFGRVYKVVER----KEGKKFACKEIFLPKLPEDL--VDAQMREVALLKTI-KHPNIVEVVDAFH-EGDY--LYILMPIYSHGDLVAYRK
 . .. || |.||.||| . .    ... . | | .  ..  ..    .. |||....|.. .|||||  . .   .|.   .|| |.   ||||  | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KK-----TLSEADVLVILIQVLQALAFLHGVREATSGIPSKIVHRDIKPANILMGEDDVVVLTDFGLSKIIDNMTDMQ-TVAG----SVAYIAPEMHARS
|.      |.  | | . .|. .....|.  .         ..|||.   |.| .|. ||  .||||.. |   .|   ...|     .   |||  . .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---------CIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYG

AYTEAVDIWSLGVTIYELIANGK
 .|.. |.|| ||...|..  |.
KFTTKSDVWSFGVLMWEIFTYGE
Kinase GL50803_8914.AA NEK 239-269 41 9.7e-08 23.75 In-house 256-286 (286) Show / Hide 
Range on Protein: 239-269
Range on HMM: 256-286/286
Sequence Identity: 41% (13 aa)

SQDLAKILNLMLTFSPENRPTALELLTMPAL
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SQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_8914.AA STE20 239-269 35 0.0013 9.42 In-house 258-288 (288) Show / Hide 
Range on Protein: 239-269
Range on HMM: 258-288/288
Sequence Identity: 35% (11 aa)

SQDLAKILNLMLTFSPENRPTALELLTMPAL
|...   ....|.  ||.|||| .||. | .
SPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Ank GL50803_8914.AA Ank 339-372 20 0.003941 15.55 Pfam 1-33 (33) Show / Hide 
Range on Protein: 339-372
Range on HMM: 1-33/33
Sequence Identity: 20% (7 aa)

AGKTALMIAAELNATDVIAQLIRPQKGHIDERRM
 | |.|..|.. . |.|.  |.  .   .. .  
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank GL50803_8914.AA Ank 308-338 25 64.394813 0.35 Pfam 1-30 (33) Show / Hide 
Range on Protein: 308-338
Range on HMM: 1-30/33
Sequence Identity: 25% (8 aa)

DGNNIVMRCILHGAFHLVSDILKCFRGEVNA
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DGFTPLHLACRCGHTEVVKMLLQ-HGADVNA
Ank GL50803_8914.AA Ank 376-398 34 0.524148 7.89 Pfam 1-21 (33) Show / Hide 
Range on Protein: 376-398
Range on HMM: 1-21/33
Sequence Identity: 34% (8 aa)

RGKTALMHAAEKGDVCEASVKLL
 | |.|. |...|  ..  ||.|
DGFTPLHLACRCG--HTEVVKML
Ank GL50803_8914.AA Ank 409-429 28 0.025101 12.65 Pfam 1-21 (33) Show / Hide 
Range on Protein: 409-429
Range on HMM: 1-21/33
Sequence Identity: 28% (6 aa)

EQWTALMMAAANGSMLIVRQL
. .|.|..|. .|.. .|. |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_8914.AA Ank 440-461 40 0.000562 18.6 Pfam 1-22 (33) Show / Hide 
Range on Protein: 440-461
Range on HMM: 1-22/33
Sequence Identity: 40% (9 aa)

TGQTALMIAAAANRVEVVRQLL
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DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_8914.AA Ank 471-503 27 0.017004 13.26 Pfam 1-33 (33) Show / Hide 
Range on Protein: 471-503
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

ARRTALMYAAMNGHEECVGILRRYEAKMRDKEK
  .|.|..|...||.|.|  |  . |    . .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD