Gene GL50803_94927 (G.lamblia)
GL50803_94927
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_94927.AA | Protein | None | 1065 | None | Fasta, JSON |
| GL50803_94927.kin_dom | Protein Kinase Domain | None | 241 | None | Fasta, JSON |
Protein domains of GL50803_94927.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | GL50803_94927.AA | S_TKc | 10-250 | 19 | 1.9e-14 | 35.12 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-250 Range on HMM: 1-231/231 Sequence Identity: 19% (52 aa) YRDAVFVDRGSAGALFRAVRVQDGVVVAVRALDPERIGVARCEELAREHTAAAALPHPRLLACGPAVSEPDAVLLETEWCPD--GSLAGLLRRQRRAGP- |. . .|. | .... . .| .||. .. | . || || . . . . | . . .| |. |.| ......| |. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --FSEDRIWELAAQLAEALAFLHSPLKARGVLAHGRVSPSAVLLAGPRAKLGD-----CLRAPSPPG--PYAAPEVARGGPPTP-AADVWALGCVLVELC |.| ... ...|...||...|| . | . |. .|| . |..| | . | | |||| . .. ..|.|..||.| |.. FPFPE-HARFYMYQICCALEYCHSH-G----IIHRDLKPENILLDE-HIKICDFGLARQL--TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML TLRAPCWDPAALAADPVPALERCPDTLRAAAAACLCVDPARRISAATFVT-------FPPA . . | . .. . . .. .. ||..||..|..| . | CGYPPFP-QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_94927.AA | Pkinase | 167-242 | 20 | 8.4e-09 | 32.2 | Pfam | 176-285 (293) | Show / Hide |
Range on Protein: 167-242 Range on HMM: 176-285/293 Sequence Identity: 20% (23 aa) PYAAPEVAR-GGPPTPAADVWALGCVLVELCTLRAPCWDP----AALAADPVPALERC------------------------------PDTLRAAAAACL .|.|||| | | . .|..|.|..||.| |... | |... . . . .. .. ..... || WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL CVDPARRISAA |.||..|..|. CKDPKKRPTAE |
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| Pkinase | GL50803_94927.AA | Pkinase | 10-128 | 21 | 2.9e-08 | 30.32 | Pfam | 1-126 (293) | Show / Hide |
Range on Protein: 10-128 Range on HMM: 1-126/293 Sequence Identity: 21% (27 aa) YRDAVFVDRGSAGALFRAVRVQDGVVVAVRALDPERIGVARCEELAR--EHTAAAALPHPRLLACGPAVSEPDAVLLETEWCPDG----SLAGLLRRQRR |. . .|| | ...... .| .||| .. ... .....| | . | || . . .. ..| . . .|.|. | .|. .... .| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR AGPF--SEDRIWELAAQLAEALAFLHS |.| ||. . . |....|...|| HGCFYFSEWECKFYMYQILRGLEYCHS |
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| Kinase | GL50803_94927.AA | STE | 163-241 | 17 | 2.9e-08 | 25.41 | In-house | 226-348 (359) | Show / Hide |
Range on Protein: 163-241 Range on HMM: 226-348/359 Sequence Identity: 17% (22 aa) SPPGPYAAPEVARG------GPPTPAADVWALGCVLVELCTLRAPC---WDP--AALAA----------------DPVPALE------------------ .| . |||| .. .. . .|.| |||...|..| . |. .. ... .| | |. TP---WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTY --RCPDTLRAAAAACLCVDPARRISA .. . .. . || || | .| PHKWSPEFKDFINKCLQKDPNKRPTA |
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| Kinase | GL50803_94927.AA | NEK8 | 184-199 | 68 | 4.7e-08 | 18.95 | In-house | 204-219 (278) | Show / Hide |
Range on Protein: 184-199 Range on HMM: 204-219/278 Sequence Identity: 68% (11 aa) DVWALGCVLVELCTLR |.||||||| |.|.|. DMWALGCVLYEMCCLK |
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| TyrKc | GL50803_94927.AA | TyrKc | 10-248 | 17 | 1.9e-07 | -102.3 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 10-248 Range on HMM: 1-280/280 Sequence Identity: 17% (51 aa) YRDAVFVDRGSAGALFRAVRVQDGVVVAVRALDPERIGVARCEELAREHTAAAAL--PHPRLLACGPAVSEP-------DAVLLETEWCPDGSLAGLLRR . .| | .... . ||| | .. |.. || | || .... ..... . ... .| .| |.| ||. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK QRRAGPFSEDRIWELAAQLAEALAFLHSP------LKARGVLAHGRVSPSAVLLAGPRAKLGD------------------CLRA----PSP-PGPYA-- |. .. . . . | |. ..||| | || .| . . ..| .| |. . . |. HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM APEVARGGPPTPAADVWALGCVLVELCTLRAPCWDP-------------AALAADPVPALER--------CPDTLRAAAAACLCVDPARRISAATFVTFP |||. . | |.. |||. | .. |..|. .. . . . | . ||| . | ||. | . .. . . APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | GL50803_94927.AA | TK-Unique | 170-198 | 37 | 1.9e-07 | 21.87 | In-house | 204-235 (294) | Show / Hide |
Range on Protein: 170-198 Range on HMM: 204-235/294 Sequence Identity: 37% (12 aa) APEVAR--GGPP-TPAADVWALGCVLVELCTL |||. . .|. |. |||..|... |..|| APESLKCYHGMYHTTKSDVWSFGVLMWEIFTL |
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| Kinase | GL50803_94927.AA | AGC | 168-197 | 37 | 2.1e-07 | 13.66 | In-house | 273-300 (395) | Show / Hide |
Range on Protein: 168-197 Range on HMM: 273-300/395 Sequence Identity: 37% (12 aa) YAAPEVARGGPPTPAADVWA--LGCVLVELCT | |||. ..|.| |. |||.. |. | YMAPEIL----YGKACDWWSFGLGCLMYEMLT |
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| Kinase | GL50803_94927.AA | NEK-Unclassified | 168-197 | 43 | 8.8e-07 | 18.16 | In-house | 163-192 (258) | Show / Hide |
Range on Protein: 168-197 Range on HMM: 163-192/258 Sequence Identity: 43% (13 aa) YAAPEVARGGPPTPAADVWALGCVLVELCT . .||| | |||.|||.. |.|| WMSPEVCQDQPYNNRSDVWSLGCIIYEMCT |
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| Kinase | GL50803_94927.AA | NEK10 | 168-201 | 47 | 9.3e-07 | 18.06 | In-house | 186-219 (279) | Show / Hide |
Range on Protein: 168-201 Range on HMM: 186-219/279 Sequence Identity: 47% (16 aa) YAAPEVARGGPPTPAADVWALGCVLVELCTLRAP | ||. . | ||||| ||.| ..|||. | YSCPEIVQSEPYGEKADVWAFGCCLYQMCTLQPP |
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| Kinase | GL50803_94927.AA | UTK | 25-128 | 21 | 1e-06 | 18.91 | In-house | 16-136 (296) | Show / Hide |
Range on Protein: 25-128 Range on HMM: 16-136/296 Sequence Identity: 21% (26 aa) FRAVRVQDG-----VVVAVRALDPERIGVARCE---ELAREHT---AAAALP-HPRLLA-CGPAVSEPDAVLLETEWCPDGSLAGLLRRQRRAGP----- ..| ..|. ..||| ..... . | .. .| . ... || .| |. ..| .. || ...|.|. .|||.|.. | HKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSYLRRHRPTPPACPHW FSEDRIWELAAQLAEALAFLHS ..... . |.. |.....||| LTLHQRLCMAWDIARGMQYLHS |
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| Kinase | GL50803_94927.AA | NEK | 85-128 | 26 | 1e-06 | 19.83 | In-house | 84-132 (286) | Show / Hide |
Range on Protein: 85-128 Range on HMM: 84-132/286 Sequence Identity: 26% (13 aa) ETEWCP-DGSLAGL---LRRQR-RAGPFSEDRIWELAAQLAEALAFLHS . |.| | |. . . .|. . .|.|. ||. .|.. || ..|. VMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHD |
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| Kinase | GL50803_94927.AA | NEK | 183-199 | 57 | 1e-05 | 16.58 | In-house | 205-223 (286) | Show / Hide |
Range on Protein: 183-199 Range on HMM: 205-223/286 Sequence Identity: 57% (11 aa) ADVWALGCVLVELCTL--R .|.|.||||| |.||| . SDIWSLGCVLYEMCTLKPK |
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| Kinase | GL50803_94927.AA | TK | 170-248 | 14 | 3.3e-05 | 12.59 | In-house | 353-486 (486) | Show / Hide |
Range on Protein: 170-248
Range on HMM: 353-486/486
Sequence Identity: 14% (19 aa)
APEVARGGP---------PTPAADVWALGCVLVELCTLR-APCWD-------------PAALAADPV------------------PALERCPD-------
|||. ... |.. |||..|... |..|. .| . |. . |||
APECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMH
------TLRAA-AAACLCVDPARRISAATFVTFP
.. . | ||..| . .. . .
PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | GL50803_94927.AA | TK | 62-128 | 8 | 3.4e-05 | 12.52 | In-house | 98-252 (486) | Show / Hide |
Range on Protein: 62-128
Range on HMM: 98-252/486
Sequence Identity: 8% (14 aa)
AALPHPRLLACGPAVSEPDA------------VLLETEWCPDGS----LAGLLRRQRRAGP---------------------------------------
... || .. . ...... ... .|..| |. | ||. |. .
SLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEE
----------------------------------FSEDRIWELAAQLAEALAFLHS
.. . ..|.|.....|||
QDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHS
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| Kinase | GL50803_94927.AA | STE11 | 170-201 | 37 | 3.6e-05 | 14.98 | In-house | 203-237 (303) | Show / Hide |
Range on Protein: 170-201 Range on HMM: 203-237/303 Sequence Identity: 37% (13 aa) APEVARGGP---PTPAADVWALGCVLVELCTLRAP |||| .... . .||.|.|||. .| .| . | APEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPP |
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| Kinase | GL50803_94927.AA | NEK-Unclassified | 87-128 | 27 | 0.001289 | 7.5 | In-house | 73-115 (258) | Show / Hide |
Range on Protein: 87-128 Range on HMM: 73-115/258 Sequence Identity: 27% (12 aa) EWCPDGSLAGLLRRQRRA-GPFSEDRIWELAAQLAEALAFLHS ..| | | .....| || | || |. .|... |. DYCDGGNLDRRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQ |
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| Kinase | GL50803_94927.AA | STE11 | 87-128 | 42 | 0.001522 | 9.02 | In-house | 93-134 (303) | Show / Hide |
Range on Protein: 87-128 Range on HMM: 93-134/303 Sequence Identity: 42% (19 aa) EWCPDGSLAGLLR-RQRRAGP--FSEDRIWELAAQLAEALAFLHS |.|| |||. .|| .. || |.| | |. |.|..||| EYCPGGSLSSMLRHKW---GPMKFDEMVIRKYTKQILEGLQYLHS |
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| Kinase | GL50803_94927.AA | AGC | 97-128 | 34 | 0.001524 | 3.44 | In-house | 131-171 (395) | Show / Hide |
Range on Protein: 97-128 Range on HMM: 131-171/395 Sequence Identity: 34% (14 aa) LLRRQ-R-RAGPFSEDRIWELAAQ-------LAEALAFLHS .|. | | . | |.|.|. ||. .. || .||| FLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHS |
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| Kinase | GL50803_94927.AA | TK-Unique | 34-128 | 20 | 0.003184 | 7.11 | In-house | 31-149 (294) | Show / Hide |
Range on Protein: 34-128 Range on HMM: 31-149/294 Sequence Identity: 20% (24 aa) VVVAVRALDPERIGVARCEELAREHTAAAALPHPRLLACGPAVSEPD-AVLLETEWCPDGSLAGLLRRQRRA--GP---------------------FSE ..||| .| . .. . . | . . .|| .. | . ..| ... |.|| |.| ..||. |.| .. |. KCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISP DRIWELAAQLAEALAFLHS . | |.| ....|.| KDLYHFAWQIACGMEYLAS |
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| Kinase | GL50803_94927.AA | UTK | 170-197 | 37 | 0.003502 | 6.74 | In-house | 207-235 (296) | Show / Hide |
Range on Protein: 170-197 Range on HMM: 207-235/296 Sequence Identity: 37% (11 aa) APEVARGG-PPTPAADVWALGCVLVELCT |||. . .| . |||..| |. |..| APEALTHHTRFTTKSDVWSFGVVCWEIWT |
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| Kinase | GL50803_94927.AA | NEK10 | 107-127 | 47 | 0.004359 | 5.76 | In-house | 116-136 (279) | Show / Hide |
Range on Protein: 107-127 Range on HMM: 116-136/279 Sequence Identity: 47% (10 aa) FSEDRIWELAAQLAEALAFLH |.|.|||.. |. || .|| FEEERIWHMFIQMCLALRYLH |
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| Kinase | GL50803_94927.AA | STE | 87-128 | 22 | 0.053724 | 2.99 | In-house | 117-170 (359) | Show / Hide |
Range on Protein: 87-128 Range on HMM: 117-170/359 Sequence Identity: 22% (12 aa) EWCPDGSLAGLLRRQRRA-----------GPFSEDRIWELAAQLAEA-LAFLHS |... ||| .... ..|.|. | . |. .. |..||| EYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS |
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| Ank | GL50803_94927.AA | Ank | 360-378 | 26 | 57.787925 | 0.52 | Pfam | 1-19 (33) | Show / Hide |
Range on Protein: 360-378 Range on HMM: 1-19/33 Sequence Identity: 26% (5 aa) TRKTLLMLAVETQAIEMIE | |.||.. .|... DGFTPLHLACRCGHTEVVK |
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| Ank | GL50803_94927.AA | Ank | 389-410 | 27 | 0.383352 | 8.38 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 389-410 Range on HMM: 1-22/33 Sequence Identity: 27% (6 aa) EDCTALMIAAKEGKYRCLMHLL . .|.|..|.. | .... || DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_94927.AA | Ank | 419-440 | 31 | 0.003674 | 15.66 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 419-440 Range on HMM: 1-22/33 Sequence Identity: 31% (7 aa) TGKSALMYAAEYGFSDCVSLLL | ..|..|...| ..|..|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_94927.AA | Ank | 750-771 | 36 | 0.006568 | 14.75 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 750-771 Range on HMM: 1-22/33 Sequence Identity: 36% (8 aa) SNCTALMIAAARGDAECTKHLL .|.|..|. .|..|. | || DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_94927.AA | Ank | 780-801 | 40 | 0.256403 | 9.01 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 780-801 Range on HMM: 1-22/33 Sequence Identity: 40% (9 aa) SKCTSLTYAILGGHHECVRLLL .| | .|.. ||.|.|..|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_94927.AA | Ank | 837-860 | 33 | 0.002636 | 16.18 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 837-860 Range on HMM: 1-24/33 Sequence Identity: 33% (8 aa) PGRTALMIAAQLGNKESVEALVDY |.|.|..|.. |..| |. |... DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_94927.AA | Ank | 868-891 | 37 | 2.8e-05 | 23.28 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 868-891 Range on HMM: 1-24/33 Sequence Identity: 37% (9 aa) DGITALYLASSNNQLDCIKLLLEK || |.| ||.........|.||.. DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_94927.AA | Ank | 899-922 | 37 | 0.000331 | 19.43 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 899-922 Range on HMM: 1-24/33 Sequence Identity: 37% (9 aa) VGWTALMAAAQKGHADSVQLLLEA |.|.|. |...||.. |..||.. DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_94927.AA | Ank | 930-950 | 42 | 1.5e-05 | 24.25 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 930-950 Range on HMM: 1-21/33 Sequence Identity: 42% (9 aa) DGWTALMLAAQAGHADCASLL ||.|.|.||.. ||......| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_94927.AA | Ank | 961-983 | 47 | 9e-06 | 25.12 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 961-983 Range on HMM: 1-23/33 Sequence Identity: 47% (11 aa) DGWTALMIAAQEGHHRVVKVLMK ||.|.|..|.. ||..||| |.. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_94927.AA | Ank | 992-1012 | 38 | 0.031587 | 12.29 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 992-1012 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) TGISALMLAAQSGHDRCVLLL | ..|.||...|| ..| .| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_94927.AA | Ank | 1023-1054 | 21 | 3.580635 | 4.88 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 1023-1054 Range on HMM: 1-21/33 Sequence Identity: 21% (7 aa) RGLTALDYASQLKEDNIDREQQEKHALCVSYL | |.| .|.. |. .|..| DGFTPLHLACRCG-----------HTEVVKML |
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