GL50803_9658

Species: G.lamblia
Alias: GL50803_9658, GK172
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_9658.AA Protein None 303 None Fasta, JSON
GL50803_9658.kin_dom Protein Kinase Domain None 277 None Fasta, JSON

Protein domain

Protein domains of GL50803_9658.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_9658.AA Ciliate-E2-Unclassified 70-284 20 1.7e-26 88.9 In-house 76-352 (352) Show / Hide
Range on Protein: 70-284
Range on HMM: 76-352/352
Sequence Identity: 20% (59 aa)

LSHKNLVKYYDVYYNDTKNLGHFVMEYYERCCLMDVI------------LFYRMKERV-IPEETVW-----YILSHLAEALLYYHSPQKDNTDMGPLVHR
|.|.........|.  .|.   .|||| |   |.. |            || .||.|  ..|. .      ... .. ..| |.|. ..        .||
LNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN-------IIHR

NIKPSKVFLAADG---YCKLADSGTFRLLDNV----------------ILSSTIFGTLGFC----PPEVLKMERYT----EESDLWSLGALVYCVCALKP
.|||. ...  .|   |.|..| | .. ...                  ...|. ||...     .||||. . |     ...| |||| . |. .  ..
DIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY

PAYSANPEE----------------LLKKLQGFEVDVNELRE----REYSEELI----GTLQSMLNYDPKQRIDLSKLNAIPQI
| |. | |.                |... .  ......  .       |.| .      ||.||...|..||.....   | .
PFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

S_TKc GL50803_9658.AA S_TKc 9-284 22 1.8e-26 95.22 SMART 1-231 (231) Show / Hide
Range on Protein: 9-284
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

VSTGPVLAKTALGHVEVVRSLDPACNDGSQGQDYAVKVVNITSIPNRYRSVVRNDFIKLCSLSHKNLVKYYDVYYNDTKNLGHFVMEYYER--CCLMDVI
   . .. | | | |  .|  .        |. .|.|...           .|.    | .  |.|.||.|||...   .  ..|||| .     |.|.|
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYI

LFYRM--KERVIPEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAADGYCKLADSGTFRLLDNVILSSTIFGTLGFCPPEVLKMERYT
  ..   . ...|| ......  ...|| | || .         .|| .||. ..|      |..| |  |.|      .|. ||. ...||||    |.
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG--------IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYG

E-ESDLWSLGALVYCVCALKPPAYSANPEELLKKLQGFEVDVNELREREYSEELIGTLQSMLNYDPKQRIDLSKLNA-------IPQI
  ..| ||.| ..|  .. .|| .  ......||.               |.|..  .. .|..||..|.   .. .        | .
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_9658.AA Pkinase 69-284 20 2.2e-25 90.84 Pfam 56-293 (293) Show / Hide
Range on Protein: 69-284
Range on HMM: 56-293/293
Sequence Identity: 20% (52 aa)

SLSHKNLVKYYDVYYNDTKNLGHFVMEYYERC----CLMDVILFYRMKERVI--PEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAA
.|.|.| |..||.......    .|||| |       |.|.|    ......  .|...  ..  ....| | || .         .|| .||. ...  
RLNHPNIVRLYDWFEDKDHIY--MVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHS-M-------GIIHRDLKPENILIDN

DGYC----KLADSGTFRL--LDNVILSSTIFGTLGFCPPEVLK-MERYTEESDLWSLGALVYCVCALKPPAYSA------NPEELLKKLQGFEVDVNELR
.|..    |..| |  ..  . |    .|. ||.....|||..  . |. ..| ||.| ..|...  .|| ...      .. .....  | ... ..  
NGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPW

EREYS-----------------EELIGTLQSMLNYDPKQRIDLSKLNAIPQI
... |                 ||..  . ..|..|||.|.    .   | .
WCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase GL50803_9658.AA NEK6 67-275 31 1.7e-24 77.34 In-house 53-252 (252) Show / Hide
Range on Protein: 67-275
Range on HMM: 53-252/252
Sequence Identity: 31% (67 aa)

LCSLSHKNLVKYYDVYYNDTKNLGHFVMEYYERCCLMDVILFYRMKERVIPEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAADGYC
| .| |.|..|||. . ..  |    |.|  .   .  .| ... ..|.||| |.|     |. ||   ||          ..|| |||  ||. |.|  
LKQLNHPNVIKYYASFIEN--NELNIVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMHSKR--------VMHRDIKPANVFITANGIV

KLADSGTFRLL-DNVILSSTIFGTLGFCPPEVLKMERYTEESDLWSLGALVYCVCALKPPAYS--ANPEELLKKLQGFEVDVNELREREYSEELIGTLQS
|| | |  |    .      . ||  .  || .. . |   ||.|||| |.| . ||. | |    |   | ||..  . |   |    |||.|   .  
KLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIE--QCDYPPLPADHYSEQLRQLVCM

MLNYDPKQRIDL
... ||..| |.
CIHPDPEWRPDI

Kinase GL50803_9658.AA Ciliate-E2 67-278 20 2.2e-24 80.62 In-house 86-359 (365) Show / Hide
Range on Protein: 67-278
Range on HMM: 86-359/365
Sequence Identity: 20% (59 aa)

LCSLSHKNLVKYYDVYYNDTKNLGHFVMEYYERCCLMDVILFYRMKERVIPE-------ETVWYILSHLAE---------------ALLYYHSPQKDNTD
| .|.|.|..|.|..... ..|   .||||..   |.| |   . |.  ..|       . . ||  ....               || | ||       
LEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS-------

MGPLVHRNIKPSKVFLAADGYCKLADSGTFRLLDNV--------------------------------ILSSTIFGTLGFCPPEVLKMER---------Y
 .. .||.|||. ...     .|..| |. . .|.                                  .  || ||.|. .||.|...          |
KNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGY

TEESDLWSLGALVYCVCALKPPAYSANPEELLKKLQGFEVDVNELR--------------EREYSEELIGTLQS----MLNYDPKQRID-LSKL
....|.|||| . |. .  |||         ... .  ..| ..                  . |.| .  ..     ||..||..||.  ...
DYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI

Kinase GL50803_9658.AA NEK 69-284 29 9.1e-22 73.72 In-house 60-286 (286) Show / Hide
Range on Protein: 69-284
Range on HMM: 60-286/286
Sequence Identity: 29% (68 aa)

SLSHKNLVKYYDVYYNDTKNLGHFVMEYYE-RCCLMDV---ILFYRMKERVIPEETVWYILSHLAEALLYYHSP--QKDNTDMGPLVHRNIKPSKVFLAA
.| | | ||||| .. . .|  . |||| |    |..    |  .. |   ..||..| .. ... || | |.          .  .|| |||. .|| .
QLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGP-----QRKILHRDIKPQNIFLTK

DGY----CKLADSGTFRLLD-NVILSST-IFGTLGFCPPEVLKMERYTEESDLWSLGALVYCVCAL--KPPAYSA--NPEELL-KKLQGFEVDVNELRER
..      |. | |  ..|. .. . .|   ||  .  |||.. . |.. || |||| ..|  |.|  |.| ..   | ..|  |  .|   . . . ..
NNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG--PQYPPIPSH

E-YSEELIGTLQSMLNYDPKQRIDLSKLNAIPQI
  ||..|   ...||. ||.|| . ... . |.|
RMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase GL50803_9658.AA CAMK 39-276 16 1.1e-21 66.02 In-house 31-417 (425) Show / Hide
Range on Protein: 39-276
Range on HMM: 31-417/425
Sequence Identity: 16% (64 aa)

GQDYAVKVVNITSIPNRY----------------------RSVVRN------DFIKLCS-----LSHKNLVKYYDVYYNDT-----------------KN
|| .|.|... . ...                        | . |       .  |...     |.|.|..| |.|| ...                 ..
GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDK

LGHFVM---EYYERCCL----MDVILFYRMKE-----------RVIPEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAADG------
  ..||   || .  .|     | |   . .            . ..|. . ..   ...|. | ||       ..  ||| .||  . |  ..      
HMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS-------HN-IVHRDLKPENILLDDNNDDSDPV

----------Y-CKLADSGTFRLLDN------------------------VILSSTIFGTLGFCP-PEVLKM--------------ERYTEESDLWSLGA
          .  |..| |  . .|                           . .| .||..... ||||.               . |....| ||.| 
EHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGV

LVYCVCALKPPAYSA-------------NPEELLKKLQGFEVDVNELR------------EREYSEE--------LIGTLQSMLNYDPKQRIDLS
. |     .|| |.              |..||..| .  . |  .                . |.|         .  ...||..||..|. ..
ILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIE

Kinase GL50803_9658.AA STE 34-278 19 4e-21 71.42 In-house 34-351 (359) Show / Hide
Range on Protein: 34-278
Range on HMM: 34-351/359
Sequence Identity: 19% (66 aa)

NDGSQGQDYAVKVVNITSIPN---------------RYRSVVRNDFIKLCSLS--HKNLVKYYDVYYND---TKN--LGHFVMEYYERCCLMDVIL-FYR
|.|..|. .|.|..|. .  |                 .  . ..   .  ..  |.| ||||. |...   .||    . .||| .  .| |.|   | 
NNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYG

MKE---------RVIPEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAADGYCKLADSGTFRLLDN-----------------VILSS
...          ..||. . ||.  . ..||||.  ..        .|| |||. ..|     .||.| |.   |..                 .  . 
CGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-------IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRN

TIFGTLGFCPPEVLKMER------YTEESDLWSLGALVYCVCALKPPAYS-ANPEELLKKLQGF------------EVDVNELRE---------------
|. ||  .  |||.. ..      |.. .| |||| ..   .  |||     ... .. .....            . .   | .               
TFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGT

---REYSEELIGTLQSMLNYDPKQRIDLSKL
   ...|.|..  ..  |..||..| . |.|
TYPHKWSPEFKDFINKCLQKDPNKRPTASQL

Kinase GL50803_9658.AA NEK10 70-286 26 9.2e-16 48.21 In-house 70-279 (279) Show / Hide
Range on Protein: 70-286
Range on HMM: 70-279/279
Sequence Identity: 26% (58 aa)

LSHKNLVKYYDVYYNDTKNLGHFVMEYYERCCLMDVILFYRMKERVIPEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAADGYCKLA
. | | | || ..     .    |||  | | | . .   . |.    || .| ..  .  || | |   .        |||  .|  . .  .      
MRHPNIVRYYRTFVEPQNHRMYIVMELIEGCPLYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLHKEKQ-------IVHRDLTPNNIMMGDKDRVTIT

DSGTFRLLD--NVILSSTIFGTLGFCPPEVLKMERYTEESDLWSLGALVYCVCALKPPAYSANPEELLKKLQGFEVDVNELREREYSEELIGTLQSMLNY
| |  .     .  . | . ||  .  ||... | | |  | |. |  .|  | |.|| ||.|   |  |    |   . . |  .|...  |... |  
DFGLAKQKQPDPSKMTSVV-GTILYSCPEIVQSEPYGEKADVWAFGCCLYQMCTLQPPFYSTNMLTLAMKIV--EHFYDPVNEGMWSDDVRFTITRCLTP

DPKQRIDLSKLNA-IPQIVD
||. | |. |  . . .| |
DPEARPDIVKVSSVLRMIQD

Kinase GL50803_9658.AA TKL 39-272 13 2e-15 52.04 In-house 26-354 (364) Show / Hide
Range on Protein: 39-272
Range on HMM: 26-354/364
Sequence Identity: 13% (48 aa)

GQDYAVKVVNITS-------------------------IPNRYRSVVRNDFIKLCSLSHKNLVKYYD---------VYYN--DTKNLGHFVMEYYERCCL
|.| |||. ....                          . ..|   ..    . .|.| |.|...          | ..  ....  ..||||... .|
GKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSL

MDVILFYRMKERVIPEETVWYILSHLAEALLYYHS--P---QKDNTDMGP--LVHRNIKPSKVFLAADGY--------------CKLADSGTFRLLDNVI
 ....           .    .    | .. | ||  |   .       .  ..||..|.. ...  ..               ||..| |. | ...  
LHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-------KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSG

--------------------LSSTIFGTLGFCPPEVLKME----------------RYTEESDLWSLGALVYCVCALKPPAYSANPEELLKK---LQGFE
                     ..|. ||.....||||...                 |.| .| .| | . . ... ..| |  .... .      . |.
NMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFM

VDVNELRE----------------REYSEELIGTLQSMLNYDPKQR
..... .                     ....  .|   ..||..|
MVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR

Kinase GL50803_9658.AA Ciliate-E2b 149-217 30 8.3e-14 38.5 In-house 124-201 (272) Show / Hide
Range on Protein: 149-217
Range on HMM: 124-201/272
Sequence Identity: 30% (24 aa)

VHRNIKPSKVFLAADGYCKLADSGTFRLLDNVIL----SSTIFGTLGFCPPEVLK-----MERYTEESDLWSLGALVY
..| |||. . .  .||.||.| ||  ...          || ||. .  ||...        || ..|.||.|   |
IYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLY

Kinase GL50803_9658.AA NEK2 195-284 32 6.1e-11 32.96 In-house 233-319 (319) Show / Hide
Range on Protein: 195-284
Range on HMM: 233-319/319
Sequence Identity: 32% (29 aa)

PEVLKMERYTEESDLWSLGALVYCVCALKPPAYSANPEELLKKLQGFEVDVNELREREYSEELIGTLQSMLNYDPKQRIDLSKLNAIPQI
||...   | | || ||.| |.|  |||.||    |  .|  | .. . .   . .. ||..|     .|.| |...|     . . |||
PEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFR--RIPYQ-YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI

TyrKc GL50803_9658.AA TyrKc 9-284 16 3.1e-09 -73.35 SMART 1-280 (280) Show / Hide
Range on Protein: 9-284
Range on HMM: 1-280/280
Sequence Identity: 16% (51 aa)

VSTGPVLAKTALGHVEVVRSLDPACNDGSQGQDYAVKVVNITSIPNRYRSVVRNDFIK----LCSL--SHKNLVKYYDVYYNDTK-----NLGHFVMEYY
.. | .|   | | |   .            .. |||...  .         | ||..    .|.|  .|.|.|. | |   .            |||| 
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM

ERCCLMDVILFYRMKERVIPEETVWYILSHLAEALLYYHSPQKDNTDMGPLVHRNIKPSKVFLAADGYCKLADSGTFRLLDNV--------ILS-----S
.  .| | .  .| |   .. ..  ..    |.   | ||         ...|| .    . ..... .| .| |  | ...           .     .
PHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

TIF-GTLGFCPPEVLKMERYTEESDLWSLGALVYCVCAL-KPPAYS-----ANPEELLKKLQGFEVDVNELREREY---------SEELIGTLQSMLNYD
. .   .  ..||...  ..|..|| || | . . .. . ..| .       ...|......  .     ..  ..         ..|.    ..  ..|
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR----MPQPPNDYPMSFVCCPDEMYQIMKQCWHED

PKQRIDLSKLNAIPQI
|..|   | .  . ..
PEDRPTFSEI--HECF

Kinase GL50803_9658.AA NEK2 70-164 30 4.2e-08 23.24 In-house 55-162 (319) Show / Hide
Range on Protein: 70-164
Range on HMM: 55-162/319
Sequence Identity: 30% (33 aa)

LSHKNLVKYYDVYYNDTKNLGHFVMEYYERCCLMDVILFYRMKERVIPEETVWYILSHLAEALLYYHS---------------PQKDNTDMGPLVHRNIK
| | | |.|||   . ..     |||| |.  |  .|  .|   . ..|| .| |.  |  ||   |                | .|.       || ||
LKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHT--ILHRDIK

PSKVFLAADG
|  .|| .|.
PANIFLDYDH