Gene GK088b (G.lamblia)

GK088b

Species: G.lamblia
Alias: GK088b
External Links:
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL1

Sequence

Name Sequence Type Origin Length Description Download
GK088b.AA Protein None 309 None Fasta, JSON
GK088b.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of GK088b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase GK088b.AA Pkinase 10-267 23 3.8e-34 121.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-293/293
Sequence Identity: 23% (72 aa)

EDLGAELGSGAHGTVYGLKSAPDR---AVKEIPTDGLPPDAQASLEL--ELRTLPRLRHPNVVEYGRVVRHEGYIYVEMRRYAG-----SLDGAIRSLRR
  .|  .|||. |.||  .   ..   |||.|. ..  .. . .. .  |.. . ||.|||.|.. .... ...||. |    |     .|   |.  .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

RRQL--ALREMVVAVLRQVGAGLAYLHRPGKTDAAGAPLPALTHCDLRPANVLLDEAGAE---FAISDFGLCR---EGPGGLASMAV--PVYAAPEVLR-
.. .    .| .  ...|.  ||.|.|.               |.|| |.|.|.|. |     . |.||||..   . ... ..  .  | |.||||.| 
HGCFYFSEWE-CKFYMYQILRGLEYCHSM-----------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG

GGSHTPAADMWSLGMVAYELAAGGRPPFLSG-----RAPAEVYVAGWRPDLGAVGD-----------------------PVVRGVLAHLLVLEPERRLTA
|  ..|..||||.| . ||..  ||||| .      . . ....   .|.|    .                       .  . ..  .| . |..|.||
GQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

AALVEL--L
. ...   .
EQILQHPWF
S_TKc GK088b.AA S_TKc 10-267 24 3.6e-27 97.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

EDLGAELGSGAHGTVYGLKSAP---DRAVKEIPTDGLPPDAQASLELELRTLPRLRHPNVVEYGRVVRHEGYIYVEMRRYAG---SLDGAIRSLRR-RRQ
 ... ..|.|| |.||  .        |.|.|.          ... |.. | . .|||.| .  | .. ...|. |    |   .|   |.. .| ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

LALREMVVAVLRQVGAGLAYLHRPGKTDAAGAPLPALTHCDLRPANVLLDEAGAEFAISDFGLCREGPGGLASMAVPVYAAPEVLRGGSHTP-AADMWSL
  . |..  ...|.  .|.|.|. |             |.|| |.|.||||   .  |.||||.|.          | | |||||   .... ..|.||.
FPFPEHARFYMYQICCALEYCHSHG-----------IIHRDLKPENILLDE---HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GMVAYELAAGGRPPFLSGRAPAEVYVAGWRPDLGAVGDPVVRGVLAHLLVLEPERRLTAAALVE---------LL
| . ||... |.|||     .....            .| ..  . ..|. .||.|.||  . .          .
GCILYEMLC-GYPPFP---QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GK088b.AA TKL 114-267 18 2.4e-20 70.0 In-house 139-364 (364) Show / Hide 
Range on Protein: 114-267
Range on HMM: 139-364/364
Sequence Identity: 18% (43 aa)

RQVGAGLAYLHR--P--GKTDAAGAPLPALTHCDLRPANVLLDEAGAE-------------FAISDFGLCREGPGG---------------------LAS
...  |..|||   |  ..        |.. |.|| ..|.|.|| .                 |.||||.|.  .                        .
LDIARGMNYLHSMNPKWCT-------KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM

MAV--PVYAAPEVLRGG----------------SHTPAADMWSLGMVAYELAAGGRPPFLSGRAP------------AEVYVAGWRPDLG----------
. .  | . |||||||                 . ....|..| |.| .|.... | |.     .            . |.. | || .           
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMC

--AVGDPVVRGVLAHLLVLEPERRLTAAALVELL
     .| ..  . .    .|| |...  ... |
PCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GK088b.AA TK 10-267 14 1.5e-18 58.12 In-house 1-486 (486) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-486/486
Sequence Identity: 14% (71 aa)

EDLGAELGSGAHG---TVY-G---------------------------LKSAPDRAVKEIPTDGLPPDAQASL--------------ELELRTLPR---L
  || .||.|. |   .|| |                            .   . ||| .  .    ...  .              |.| . . .   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNVVEYGRVVRHEG--------------YIYVEMRRYA---GSLDGAIRSLRR---------------------------------------------
.|||.|    |. ...              .| .|.  .    |||.   |. |.                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------RRQLALREMVVAVLRQVGAGLAYLHRP---GKTDAAGAPLPALTHCDLRPANVLLDEAGA----------EF
                            ..|| .....    .|. .|..|||.    .         . . | ||   |.|..| .             
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL--MCWQIACGMEYLHSKNCEF--------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVC

AISDFGLCREGPGGLASMAVPV---------------------------------------YAAPEVLRGGS---------HTPAADMWSLGMVAYELAA
 |.||||.|.|  |. . ...                                        . |||.|...          .|.. |.||.| . .|.  
KIADFGLSRQGS-GVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT

GG-RPPF--LSG---------RAPAEVYVAG---------------WRPDLGAVGD-------------PVVRGVLAHLLVLEPERRLTAAALVELL
 |  |.   .|          .   |  ..|                .|      |             ...  ..     ..||.| | ..|.| |
YGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase GK088b.AA AGC 141-214 24 4.8e-18 41.81 In-house 177-304 (395) Show / Hide 
Range on Protein: 141-214
Range on HMM: 177-304/395
Sequence Identity: 24% (32 aa)

HCD-LRPANVLLDEAGAEFAISDFGLCREGPGG----------------------------------------------------LASMAV----PVYAA
| | | | |.||||      ..||||| ||...                                                    ...  .    | | |
HRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMA

PEVLRGGSHTPAADMWS--LGMVAYELAAGGRP
||.|    ...|.| ||  || . ||. .|  |
PEIL----YGKACDWWSFGLGCLMYEMLTGYPP
Kinase GK088b.AA Ciliate-E2-Unclassified 143-218 26 9.2e-14 44.13 In-house 169-272 (352) Show / Hide 
Range on Protein: 143-218
Range on HMM: 169-272/352
Sequence Identity: 26% (28 aa)

DLRPANVLLDEAGA--EFAISDFGLCR-------EGPGG------------LASMA-VPVYA----APEVLRGGSHT----PAADMWSLGMVAYELAAGG
|. | |.|.|. |   .  |.|||...       .  .             . ...  | |     |||||.|  .      ..|.||||...||.  | 
DIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY

RPPFLS
 .|| .
-YPFYD
Kinase GK088b.AA UTK 11-216 22 1.2e-13 43.03 In-house 2-241 (296) Show / Hide 
Range on Protein: 11-216
Range on HMM: 2-241/296
Sequence Identity: 22% (56 aa)

DLGAELGSGAHGTVYGLKSAP--------DRAVKEIPTDGLPPDAQA---SLELELR---TLPRLR-HPNVVE-YGRVVRHEGYIYVEMRRYA-GSLDGA
 ||..||.|| |.|.  .  .        |.|||.  ...  .....    . .| |    . ... ||||.  .| ... |. ... .. .. |.|.  
QLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSY

IRSLRRR---RQLALREM-VVAVLRQVGAGLAYLHRPGKTDAAGAPLPALTHCDLRPANVLLDEAG------AEFAISDFG---LCREGP---------G
 |. |.    ....|..   .   ... .|..|||. |           . |.||   |.|... .        ..|.|||   ..|. .         .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG-----------FVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWE

GLASMAVPVYA------APEVLRGG-SHTPAADMWSLGMVAYELAAGGRPPF
 . .|| .. .      |||.|  .  .| . |.||.| | .|. ..|| |.
SYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPY
Kinase GK088b.AA MSK 141-214 31 3e-13 41.14 In-house 124-209 (277) Show / Hide 
Range on Protein: 141-214
Range on HMM: 124-209/277
Sequence Identity: 31% (27 aa)

HCDLRPANVLLDEA--GAEFAISDFGLCREGPGGLASMAVP-----VYAAPEVLR----GGS-HTPAADMWSLGMVAYELAAGGRP
| || | |.|.|.   ...  ..|||. |. | . .  . .      |.|||.||    . . . .| |.|||| . |..  | .|
HRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVP
Kinase GK088b.AA RSK 143-214 32 3e-13 45.13 In-house 129-211 (278) Show / Hide 
Range on Protein: 143-214
Range on HMM: 129-211/278
Sequence Identity: 32% (27 aa)

DLRPANVLLDE--AGAEFAISDFGLCREGPGG-LASMAVPV----YAAPEVLR----GGSHTPAADMWSLGMVAYELAAGGRP
|| | |.|.|.    ..  ..|||.|....      .  ..    |.|||.|.    .| |. |.| |||| . ||. .| .|
DLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPP
Kinase GK088b.AA TyrKc 10-267 23 3.8e-13 -10.13 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

EDLGAELGSGAHGTVYG--LKSAPDRAVKEIPTDGLPPDAQASLELELRTLPRL--RHPNVVEYGRVVRHEG---------YIYVEMRRYAGSLDGAIRS
  || .||.|| |.||   .|   . ||| .  |      .. .  |.| . .|  .|||.|    |....|         .| .|   . |.|.  .|.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRK

LRRRRQLALREMVVAVLRQVGAGLAYLHRPGKTDAAGAPLPALTHCDLRPANVLLDEAGAEFAISDFGLCREGPGG----------LA-----SMA-VPV
 |..  | .... .    |. .| .|||.             . | ||   |.|..| .    ||||||.|..  .           .     . . .|.
HRPK--LCMKDL-LSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

-YAAPEVLRGGSHTPAADMWSLGMVAYELAAGGRPPF-------LSGRAPAEVYVAGWRPDLGAV--------GDPVVRGVLAHLLVLEPERRLTAAALV
   |||... |  |.. | || | . .|.   | .|        .| .   |   .| |..  .           . .  .       .|| | | ....
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

ELL
|..
ECF
Kinase GK088b.AA ULK 141-216 22 1e-12 40.79 In-house 153-257 (329) Show / Hide 
Range on Protein: 141-216
Range on HMM: 153-257/329
Sequence Identity: 22% (24 aa)

HCDLRPANVLLDEAGAE-----------FAISDFGLCRE-GPG----GLASMAV--------PVYAAPEVLR----GGSHTPA-ADMWSLGMVAYELAAG
|.|. |.|.|...  .            . |.|||...    .     ..  .|        | | ||..|     .  .. . .|.||||.. ||.  |
HRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG

GRPPF
  |..
KPPFY
Kinase GK088b.AA CAMK 141-211 22 1.8e-12 35.8 In-house 202-330 (425) Show / Hide 
Range on Protein: 141-211
Range on HMM: 202-330/425
Sequence Identity: 22% (29 aa)

HCDLRPANVLLDEAG----------------AEFAISDFGLCREGPGGL---------------------------ASMAVPVYAA-PEVLRGGS-----
|.|| | |.|||. .                .   |.|||. .. ..|                             .   | |.| ||||.| .     
HRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQ

---------HTPAADMWSLGMVAYELAAG
         ..|..||||.| . | .  |
NATDEEKPYYGPKCDMWSCGVILYIMLCG
Kinase GK088b.AA STE 143-211 25 5.6e-09 27.98 In-house 177-264 (359) Show / Hide 
Range on Protein: 143-211
Range on HMM: 177-264/359
Sequence Identity: 25% (24 aa)

DLRPANVLLDEAGAEFAISDFGLCREGPGGLA-------------------SMA-VPVYAAPEVLRG------GSHTPAADMWSLGMVAYELAAG
|. |||.||        ..|||.|      .|                   ...  | . ||||...      . ..  .|.|||| .. |.| |
DIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG
Kinase GK088b.AA CAMK 15-67 14 1.3e-07 19.84 In-house 1-101 (425) Show / Hide 
Range on Protein: 15-67
Range on HMM: 1-101/425
Sequence Identity: 14% (15 aa)

ELGSGAHGTVYGLKSAPDR---------------AVKEIPTDGLP--------------------------PDAQASLELELRTLPR-------LRHPNV
.||.|. |.|.  .   .                |.| |... |.                          |  ..... |.. . .       |.|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

V
.
I
Kinase GK088b.AA STE 10-69 12 1e-06 19.8 In-house 1-95 (359) Show / Hide 
Range on Protein: 10-69
Range on HMM: 1-95/359
Sequence Identity: 12% (12 aa)

EDLGAELGSGAHG-TVYGLKSAPD-----------------RAVKEIPTDGLPP---------------DAQASLELELRTLPRLR--HPNVVEY
 ..  ..|.|| | ......  ..                  |.|... .   .               . . ... |.... ...  |||.|.|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKY
Kinase GK088b.AA TKL 16-69 21 0.010053 5.65 In-house 1-90 (364) Show / Hide 
Range on Protein: 16-69
Range on HMM: 1-90/364
Sequence Identity: 21% (19 aa)

LGSGAHGTVYGLKSA-----------PDRAVKEIPTDGLPP----------------------DAQASLELELRTLPR---LRHPNVVEY
.|||. |.||  |              | ||| ....                          .|.   . | . .     |||||.| .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQF
Kinase GK088b.AA ULK 15-69 20 0.058597 2.73 In-house 6-83 (329) Show / Hide 
Range on Protein: 15-69
Range on HMM: 6-83/329
Sequence Identity: 20% (16 aa)

ELGSGAHGTVYGLK---S----APDRAVKEIPTDGLPPDAQA--------SLELELRTLPRLR--------HPNVVEY
.||.|. |.||  .   .    . . |.| |. . .  . .         .|. | ... .|         |||.|..
CLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKL