Gene GK124 (G.lamblia)

GK124

Species: G.lamblia
Alias: GK124
External Links:
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GK124.AA Protein None 403 None Fasta, JSON
GK124.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of GK124.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase GK124.AA Pkinase 94-323 21 1e-29 106.12 Pfam 28-293 (293) Show / Hide 
Range on Protein: 94-323
Range on HMM: 28-293/293
Sequence Identity: 21% (58 aa)

ALKEILLDGLDKNSADAIRL--ELTALLDLSHPGVLRHHQVVEDEGLIYVVIDRHDKTLERLLTEH----KRRKTLI--PIAVILSVLRQVAAALAYLYG
|.|.| ... ...   . |.  |.  .. |.|| ..| . ..||.. ||.| . ....|. ..  .     .|.. .  .  .. ....|.. .|.|.. 
AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS

LSGIGTRGLVHRDLRPASILVSADGER---FIIADFGLCKDA-LWSGSTLMGIMA---YMAPEALL-HNEASPASDVWSLGVILYELTTLRKPDFLEG--
       | .|||| |. ||.. .|.    . |.||||.| . . ..| ....     ||||| .. ... .|..|.||.|.||||. . ..| | .   
M------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCW

----KVPAEVFVDGWRPDLSDVTDG----------------------FMQNVLERIFVLEPERRPTARELHET--L
       . .. ....|  .|                           .. ...... . |..||||... .   .
HDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GK124.AA TKL 150-323 18 2.8e-26 91.61 In-house 126-364 (364) Show / Hide 
Range on Protein: 150-323
Range on HMM: 126-364/364
Sequence Identity: 18% (47 aa)

LERLLTEHKRRKTLIPIAVILSVLRQVAAALAYLYGLS---GIGTRGLVHRDLRPASILVSADGE-------------RFIIADFGLCKDALWSGS----
|..|.           . ....  ...| ...||       .  .....|||| .. |||  ...             .  |.||||...  .||.    
LHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDT

---------------TLMGIM---AYMAPEALLHN----------------EASPASDVWSLGVILYELTTLRKPDF---LEGKVPA-------EVFVD-
               |.| .    ..||||.|  .                |.|...||.| |..|.|. | ..| .    .  ...       .. .| 
MTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDK

GWRPDLS------------DVTDGFMQNVLERIFVLEPERRPTARELHETL
| || .             . ..  | . ...    .|| ||.. |. ..|
GLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GK124.AA TK 104-323 13 2.6e-24 77.73 In-house 64-486 (486) Show / Hide 
Range on Protein: 104-323
Range on HMM: 64-486/486
Sequence Identity: 13% (59 aa)

DKNSADAIRL--------------ELTALLDLS-----HPGVLRHHQVVEDE------------GLIYVVIDRHDKT-----LERLLTEHKRRKTL----
| .|... ..              |. ..  ..     || ..| . |. ..            . ...|    ..      |   | .......     
DAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDC

--------------------------------------------------------------------IPIAVILSVLRQVAAALAYLYGL--SGIGTRG
                                                                    .. .  |   .|.|....||  .  ..|   .
PDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI--QN

LVHRDLRPASILVSADGER----------FIIADFG--------LCKDAL------------------------WSGSTLMGIMA-----YMAPEALLHN
.|||||    .||. .. .            |||||        |..|                          |.  ...   .     .||||.|...
FVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDR

E---------ASPASDVWSLGVILYELTTLRKPDFLEGKVP------------AEVFVDG---------------WRPDLSDVTD-------------GF
.          ...|||||.|| ..|. |. .  . .|                |  ..|                .|   . .|              .
VFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEE

MQNVLERIFVLEPERRPTARELHETL
.. .. . . ..||.||| ..||| |
YYDLMQQCWHYDPEDRPTFSQLHEQL
S_TKc GK124.AA S_TKc 82-325 24 1.2e-23 85.84 SMART 13-231 (231) Show / Hide 
Range on Protein: 82-325
Range on HMM: 13-231/231
Sequence Identity: 24% (64 aa)

GVVYSLKGYP---SLALKEILLDGLDKNSADAIRLELTALLDLSHPGVLRHHQVVEDEGLIYVVIDRHDK---TLERLLTEHKRRK--TLIPIAVILSVL
|.||  .        |.|.|          . || |.  |    || . . . | .| . .|.| .  |    .| ... ...|..    .|  .. ...
GKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYM

RQVAAALAYLYGLSGIGTRGLVHRDLRPASILVSADGERFIIADFGLCKDALWSGSTLMGIMAYMAPEALLHNEASP-ASDVWSLGVILYELTTLRKPDF
.|.. ||.|.  . ||     .|||| |. ||..    .  |.||||..      .|. |   ||||| |     .. ..|.||.|.||||. . ..| |
YQICCALEYCHSH-GI-----IHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPF

LEGKVPAEVFVDGWRPDLSDVTDGFMQNVLERIFVLEPERRPTARELHE-------TLAT
     ....|           .. . .  ...... .||.|||| |. .           
P---QMQMMFKKIG-------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GK124.AA TK-Unique 156-323 27 2.5e-18 59.88 In-house 120-294 (294) Show / Hide 
Range on Protein: 156-323
Range on HMM: 120-294/294
Sequence Identity: 27% (50 aa)

EHKRRKTLIPIAVILSVLRQVAAALAYLYG-LSGIGTRGLVHRDLRPASILVSADGERFIIADFGLCK----DALWSGSTL--MGIMAYMAPEALL--HN
..| |.. |     .. . |.| ...|| . . .|     |||||    .|.. |. .  |.|||. .    .   | ..   . . ..||||.|.  |.
PDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI-----VHRDLCARNVLLTEDK-VCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHG

EA-SPASDVWSLGVILYELTTLRKPDFLEG--KVPAEVFVDGWRPDLSDVT-DGFMQNVLERIFVLEPERRPTARELHETL
 . .. |||||.||...|. || .... .   | . | . || |... .      | |.... . .||| ||. |..   |
MYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase GK124.AA Ciliate-E2 114-270 21 2.6e-18 59.45 In-house 82-295 (365) Show / Hide 
Range on Protein: 114-270
Range on HMM: 82-295/365
Sequence Identity: 21% (49 aa)

ELTALLDLSHPGVLRHHQVVE--DEGLIYVVIDRHDK-TLERLLTEH-KRRKTLIP------IAVILSVLRQVAA---------------ALAYLYGLSG
|.  |  |.|| ... . . .  |.  || | .  .  .|. .. .. | |.  |.      .  |. . .|..                || ||     
EKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH----

IGTRG-LVHRDLRPASILVSADGERFIIADFGLCKDA--------------LWSGST---------------------LMGIMAYMAPEALL--------
   ..  .|||. |  ||.        |.||||.|..              ..                         . |   ||||| |         
--SKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQ

-HNEASPASDVWSLGVILYELTTLRKP
 ... . ..|.|||||||||. . . |
KQKGYDYKCDIWSLGVILYEMLFGKPP
Kinase GK124.AA ULK 149-270 21 3.8e-17 56.48 In-house 106-255 (329) Show / Hide 
Range on Protein: 149-270
Range on HMM: 106-255/329
Sequence Identity: 21% (34 aa)

TLERLLTEHKR------RKTLIPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPASILVSADGER-----------FIIADFGLCKDAL-W----
.|| .. ..|.      .|  ..   ......| .... .|.       .. .|||. |. ||.. . .            . |||||..|    .    
DLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELH------KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ

-SGSTLM------GIMAYMAPEALL----HNEASPA-SDVWSLGVILYELTTLRKP
    |        |   ||||. |     . . . . .|.||||.|.||. . . |
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPP
Kinase GK124.AA ULK 149-270 21 4.8e-17 57.06 In-house 103-251 (324) Show / Hide 
Range on Protein: 149-270
Range on HMM: 103-251/324
Sequence Identity: 21% (33 aa)

TLERLLTEHKR-----RKTLIPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPASILVSADGER-----------FIIADFGLCKDALW--SGST
.|| .. ..|.     .|  ..   ......| .... .|.       .. .|||. |. ||.. . .            . |||||..|         .
DLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELH------KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ

LM----------GIMAYMAPEALL----HNEASPA-SDVWSLGVILYELTTLRKP
..          |   ||||. |     . . . . .|.||||.|.||. . . |
MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYP
Kinase GK124.AA Ciliate-E2-Unclassified 193-264 30 9e-17 54.73 In-house 164-263 (352) Show / Hide 
Range on Protein: 193-264
Range on HMM: 164-263/352
Sequence Identity: 30% (30 aa)

GLVHRDLRPASILVSADGE--RFIIADFGLCKDALWS------------------GSTLMGIMAYM----APEALLHNEAS----PASDVWSLGVILYEL
. .|||. |  ||.. .|.  .  |.|||..|    .                   .| .|   ||    ||| |  .. .     ..|.|||||||||.
NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM
Kinase GK124.AA Fer 215-324 20 4.9e-15 47.75 In-house 155-283 (283) Show / Hide 
Range on Protein: 215-324
Range on HMM: 155-283/283
Sequence Identity: 20% (27 aa)

IADFGLCKD-ALWSGSTLMG-IM-----AYMAPEALLHNEASPASDVWSLGVILYELTTLRKPDFLE-------GKV----PAEVFVDGWRPDLSDVTDG
|.|||.... .    . .|. ..      ..|||..   . ||..|||| || ..|  |  . ....       . |     . . ..| .. . . .  
ISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPP

FMQNVLE-RIFVLEPERRPTARELHETLA
.. .... .... .|| |||. |....| 
EIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase GK124.AA RIPK 194-323 25 6.6e-15 47.2 In-house 130-290 (290) Show / Hide 
Range on Protein: 194-323
Range on HMM: 130-290/290
Sequence Identity: 25% (41 aa)

LVHRDLRPASILVSADGERFI-IADFGLCKDALWSGSTL----------------MGIMAYMAPEALLHNEASP------ASDVWSLGVILYELTTLRKP
. |||| |. |||  |..  . |||||| ..  || |.                  |  .||.||... ....|      ..|| | .....|. | ..|
IIHRDLKPENILV--DNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP

DFLE--GKVPAEVFVD-GWRPDLSDVTDGFMQ--------NVLERIFVLEPERRPTARELHETL
 ...       .. .. | ||.|..|.. . .        ....|    .|. ||. .|  |  
-YEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase GK124.AA UTK 94-266 22 1.7e-13 42.51 In-house 33-235 (296) Show / Hide 
Range on Protein: 94-266
Range on HMM: 33-235/296
Sequence Identity: 22% (47 aa)

ALKEILLDGLDKNSAD---AIRLELT---ALLDLS-HPGVLRHHQVVEDEGLIYVVIDRHDK--TLERLLTEHKR----RKTLIPIAVILSVLRQVAAAL
|.|.   .. .  . .    ...| .    .  .. || |||   |. .|. ...|. .. .   |  .|  |..    . ..      |.  ...|...
AVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVT-EYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGM

AYLYGLSGIGTRGLVHRDLRPASILVSADG------ERFIIADFG---LCKDAL------WSGSTLMGIMAY--------MAPEALLHN-EASPASDVWS
.||       ..|.|||||    .|| ...      . . |||||   .....        ......  ..         |||||| |.   . .|||||
QYLH------SCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWS

LGVILYELTT
.|| ..|. |
FGVVCWEIWT
TyrKc GK124.AA TyrKc 93-323 19 1.8e-13 -5.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 93-323
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

LALKEIL----------------------LDGLDKNSADAIRLELTALLDL--SHPGVLRHHQVVEDE-------GLIYVVID--RHDKTLERLLTEHKR
. |...|                       ..       ... |.  .  |  .|| ..| . |. ..       . ...|     |   ...|   ...
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

RKTLIPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPASILVSADGERFIIADFGLCKDALWS----------------GSTLMGIMAYMAPEAL
    .. .  ||   |.|.  .||         ...||||    .||.... .  |.||||..|                    |.  |     ||||..
----LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

LHNEASPASDVWSLGVILYELTTLRKPDFLEG----KVPAEVF---VDGWRPDLSDV--------TDGFMQNVLERIFVLEPERRPTARELHETL
 ... ...||||| || ..|. |. ..   .     . ..||.    .| |..  .             | .. ..    .|| ||| .|.|| .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GK124.AA Pkinase_Tyr 158-267 27 2.6e-10 35.57 Pfam 99-210 (270) Show / Hide 
Range on Protein: 158-267
Range on HMM: 99-210/270
Sequence Identity: 27% (33 aa)

KRR---KTLIPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPASILVSADGERFIIADFGLCKDA-------LWSGSTLMGIMAYMAPEALLHNE
...   |  ...  .|.  .|.|....||        ....||||.   .||. ..    |.||||..|          .|.. . |   ||||.. ...
RKHREDKQPLTMKDLLQMCWQIAKGMEYL------ESKNCIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYYYRKRGGGKLPI-KWMAPECINYGK

ASPASDVWSLGVILYELTTL
 . .||||| || ..|. |.
FTTKSDVWSFGVLMWEIFTY
Kinase GK124.AA Pkinase_Tyr 309-323 60 0.021521 8.73 Pfam 256-270 (270) Show / Hide 
Range on Protein: 309-323
Range on HMM: 256-270/270
Sequence Identity: 60% (9 aa)

EPERRPTARELHETL
.||.||| .|.|| |
DPEDRPTFSEIHEQL
Kinase GK124.AA UTK 309-323 26 0.028309 3.59 In-house 282-296 (296) Show / Hide 
Range on Protein: 309-323
Range on HMM: 282-296/296
Sequence Identity: 26% (4 aa)

EPERRPTARELHETL
.|..||....| ...
DPQERPDFEDLVQQM