Gene GK145 (G.lamblia)
GK145
Species: G.lamblia
Alias: GK145
External Links:
Annotation:
Sequence
Protein domains of GK145.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Pkinase | GK145.AA | Pkinase | 123-323 | 17 | 1.1e-17 | 63.67 | Pfam | 59-293 (293) | Show / Hide |
Range on Protein: 123-323
Range on HMM: 59-293/293
Sequence Identity: 17% (44 aa)
HPDVLKYHQVLTDGNTILVVTDRC-CG----DLRQFIT--DYKDIHEPIPSELMLSLLGQLAGALAHLHGLSRGAHNGLPSSVV---LEPDNVMFAGDGR
|| ..... . .|.. | .|.. | .| || .|. ... . . . . . |.. .|...| ... | |.|... .|
HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY--FSEWECKFYMYQILRGLEYCHSM----------GIIHRDLKPENILIDNNGH
R---VVLADFGFCE---GISSGAAK--AGDPAYMAPETLL-SGDTTAASDVWSLGAVAYELATLRKPDFLGG------REPEDVFVDGWRSDLSGVA---
| ..|||... ... .. .| | ||||| .. . . . ..|.||.| . ||... ..| | | .. . .. .... .
IDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWC
-------------------DDLARNVLERMLVLDPAERPTARGLVRL--L
.. .. .....| .||..||||. .. .
SISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | GK145.AA | AGC | 202-266 | 20 | 1.4e-15 | 35.31 | In-house | 183-300 (395) | Show / Hide |
Range on Protein: 202-266 Range on HMM: 183-300/395 Sequence Identity: 20% (25 aa) PDNVMFAGDGRRVVLADFGFCEGISSGA----------------------------------------------------AK--AG--DPAYMAPETLLS |.|... | . |.|||.| . .. .. | | ||||| | PENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-- GDTTAASDVWS--LGAVAYELAT . | | || ||.. ||. | --YGKACDWWSFGLGCLMYEMLT |
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| S_TKc | GK145.AA | S_TKc | 70-328 | 22 | 4.1e-15 | 44.76 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 70-328 Range on HMM: 1-231/231 Sequence Identity: 22% (61 aa) RRLGNMLSKDAHGAVYSLRGCP---YLAVREIRLDGLDQHSVDAIRRRLTALLGTLHPDVLKYHQVLTDGNTILVVTDRCCG---DLRQFITDYKD--IH .... . | | | || | . |. .|. . ||| . | || . |.. | | . . .|.. | | ||...| ... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR EPIPSELMLSLLGQLAGALAHLHGLSRGAHNGLPSSVV---LEPDNVMFAGDGRRVVLADFGFCEGISSGAAKAGDPAYMAPETLLSGDTTAASDVWSLG |.| ... |.. ||...| . .. | |.|... .. ..|||.. . | | ||||| | | .....|.||.| FPFPE-HARFYMYQICCALEYCHSHG----------IIHRDLKPENILLDE---HIKICDFGLARQL---TTFCGTPWYMAPEVL--GYGKCKCDWWSCG AVAYELATLRKPDFLGGREPEDVFVDGWRSDLSGVADDLARNVLERMLVLDPAERPTARGLVR----LLRRPGI . ||... ..| | ... . . .. |.. ....|. ||..|||| . . | . CILYEMLC-GYPPFP----QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GK145.AA | STE | 202-268 | 25 | 4.2e-13 | 42.71 | In-house | 180-265 (359) | Show / Hide |
Range on Protein: 202-268 Range on HMM: 180-265/359 Sequence Identity: 25% (24 aa) PDNVMFAGDGRRVVLADFGFCEGISSGAA----------------K----AGDPAYMAPETLLS------GDTTAASDVWSLGAVAYELATLR |.|... | |.|||.| ... | | .| | .|||| .. .. .. .|.|||| .. |.|| . PANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK |
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| Kinase | GK145.AA | Ciliate-E2 | 202-270 | 20 | 3.3e-12 | 38.2 | In-house | 189-295 (365) | Show / Hide |
Range on Protein: 202-270 Range on HMM: 189-295/365 Sequence Identity: 20% (23 aa) PDNVMFAGDGRRVVLADFGFCEGISS--------GAAK---------------------------AGDPAYMAPETLLSGD---------TTAASDVWSL |.|..| . ..|||.. .. .| .| | ||||| | ... . ..|.||| PENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL GAVAYELATLRKP | . ||. . . | GVILYEMLFGKPP |
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| Kinase | GK145.AA | NEK6 | 123-270 | 32 | 3.8e-12 | 36.03 | In-house | 58-202 (252) | Show / Hide |
Range on Protein: 123-270
Range on HMM: 58-202/252
Sequence Identity: 32% (49 aa)
HPDVLKYHQVLTDGNTILVVTDRC-CGDLRQFITDYKDIHEPIPSELMLSLLGQLAGALAHLHGLSRGAHNGLPSSVVLEPDNVMFAGDGRRVVLADFGF
||.|.|| . . | . .| . ||. . | .| || . ||. ||.|.| | | . | || ..| | | | |
HPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMH-SKRVMHRD------IKPANVFITANG-IVKLGDLGL
CEGISSGAAKA----GDPAYMAPETLLSGDTTAASDVWSLGAVAYELATLRKP
|| | | | ||.|| . ||.|||| . ||.| | |
GRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSP
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| Kinase | GK145.AA | Ciliate-E2-Unclassified | 200-270 | 23 | 1.2e-11 | 36.7 | In-house | 170-269 (352) | Show / Hide |
Range on Protein: 200-270 Range on HMM: 170-269/352 Sequence Identity: 23% (23 aa) LEPDNVMFAGDGR--RVVLADFGFCEGISS-------------------GAAKAGDPAYM----APETLLSGDTT----AASDVWSLGAVAYELATLRKP . |.|..| .|. .. ..|||.. . . ..| | || ||| | . ..|.|||| ..||. . . | IKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP |
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| Kinase | GK145.AA | TK | 207-323 | 19 | 1.3e-11 | 34.37 | In-house | 283-486 (486) | Show / Hide |
Range on Protein: 207-323 Range on HMM: 283-486/486 Sequence Identity: 19% (39 aa) FAGDGRRVVLADFGFC---------------EGISSGAAKAGDPA-----------------------YMAPETLL---------SGDTTAASDVWSLGA | |.|. . .|||| . . ... ..|.|. .||||.|. | | .|||||.| FDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV VAYELATLRKPDFLGGREPEDVFVD------------------------GWRSDLS---GVAD-------------DLARNVLERMLVLDPAERPTARGL . .|. |. . . || .|| .| | | . . | .. .. . .||..||| . | LMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQL VRLL .. | HEQL |
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| Kinase | GK145.AA | CAMK | 202-316 | 14 | 1.6e-11 | 32.65 | In-house | 207-416 (425) | Show / Hide |
Range on Protein: 202-316
Range on HMM: 207-416/425
Sequence Identity: 14% (31 aa)
PDNVMFAGDG----------------RRVVLADFGFCEGISSGA---------------------------AKAGDPAYMA-PETLLS------------
|.|... .. . ..|||| . .| | |.||| || |..
PENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDE
--GDTTAASDVWSLGAVAYELATLRKPDFLGGREPEDVF---------------VDGWRSDLSGVAD-D-----------------------------LA
. ..|.||.| . | . | |. | . . .. ..| | . .
EKPYYGPKCDMWSCGVILYIM--------LCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC
RNVLERMLVLDPAERPTA
.. . .||. || .|.|.
KDLIRKMLQVDPEKRMTI
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| Kinase | GK145.AA | Fer | 237-324 | 20 | 2.5e-11 | 34.93 | In-house | 184-283 (283) | Show / Hide |
Range on Protein: 237-324 Range on HMM: 184-283/283 Sequence Identity: 20% (20 aa) YMAPETLLSGDTTAASDVWSLGAVAYELATLRKPDFLG-----------GREPEDVFVDGWRSDLS-GVADDLARNVLERMLVLDPAERPTARGLVRLLR ..||||. .| .. ..|||| | ...| | . ...| .. . . ..| . . ........ .... . || .|||. ... |. WLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| Kinase | GK145.AA | TKL | 202-323 | 14 | 3.6e-11 | 36.47 | In-house | 168-364 (364) | Show / Hide |
Range on Protein: 202-323 Range on HMM: 168-364/364 Sequence Identity: 14% (28 aa) PDNVMFAGDGR-------------RVVLADFGFCEGISSGAA-----------------------KAGDPAYMAPETLL----------------SGDTT ..|.. ... .. ..|||.. .| . | |..|||| | ... . SKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS AASDVWSLGAVAYELATLRKPDF-LGGREPE---------DVFVD-GWRSDLS------------GVADDLARNVLERMLVLDPAERPTARGLVRLL ..||.| | | .|..| ..| . .. .... . .| | | . ... .. ... || .||.. .. | EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| TyrKc | GK145.AA | TyrKc | 70-323 | 17 | 1.2e-09 | -66.89 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 70-323
Range on HMM: 1-280/280
Sequence Identity: 17% (55 aa)
RRLGNMLSKDAHGAVY-----------SLRGCPYLAVREIRLDGLDQHSVDAIRRRLTALLGT--LHPDVLKYHQVLTDG-------NTILVVTDRCC-G
.|| .| | | || .|. . . ...| . . || ... . | |.. ...|. .. |
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG
DLRQFITDYKDIHEPIPSELMLSLLGQLAGALAHLHGLSRGAHNGLPSSVV---LEPDNVMFAGDGRRVVLADFGFCEGISSG--------AAKA----G
||.... .... .. . .|| | | ..|| .. | |.. . .. .| .||| . | .. .. |
DLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG
DP-----AYMAPETLLSGDTTAASDVWSLGAVAYELATLRKPDFLGG----REPEDVF---VDGWRSDLSGV--------ADDLARNVLERMLVLDPAER
||||.. | | .||||| | . .|. |. .. | ....|. .| | . . | .. .. ||..|
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR
PTARGLVRLL
|| . .....
PTFSEIHECF
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| Kinase | GK145.AA | STE11 | 202-266 | 24 | 2.2e-09 | 30.41 | In-house | 144-233 (303) | Show / Hide |
Range on Protein: 202-266 Range on HMM: 144-233/303 Sequence Identity: 24% (22 aa) PDNVMFAGDGRRVVLADFGFCEGISSGAAK--------------AGDPA--------YMAPETLLSGD---TTAASDVWSLGAVAYELAT ..|.. || .. ||||| . ... . . | | .||||.. . ....|.||||.. .| || GANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMAT |
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| Kinase | GK145.AA | Pkinase_Tyr | 238-267 | 46 | 0.001751 | 12.42 | Pfam | 181-210 (270) | Show / Hide |
Range on Protein: 238-267 Range on HMM: 181-210/270 Sequence Identity: 46% (14 aa) MAPETLLSGDTTAASDVWSLGAVAYELATL |||| . | | .||||| | . .|. |. MAPECINYGKFTTKSDVWSFGVLMWEIFTY |
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| Kinase | GK145.AA | TK | 123-184 | 9 | 0.004535 | 5.28 | In-house | 102-251 (486) | Show / Hide |
Range on Protein: 123-184
Range on HMM: 102-251/486
Sequence Identity: 9% (15 aa)
HPDVLKYHQVLTDGNT------------ILVVTDRCC-GD----LRQFITDYKDIHEP------------------------------------------
|| ... . | |.| . ...|. .. || ||.. . .. .
HPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYD
------------------------------IPSELMLSLLGQLAGALAHLH
.. . .| |.| ....||
DDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH
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| Kinase | GK145.AA | STE11 | 298-319 | 40 | 0.069104 | 2.96 | In-house | 276-297 (303) | Show / Hide |
Range on Protein: 298-319 Range on HMM: 276-297/303 Sequence Identity: 40% (9 aa) ARNVLERMLVLDPAERPTARGL .|. | . .. || .||||. | CRDFLRHCFEHDPKKRPTANQL |
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| Kinase | GK145.AA | Ciliate-E2-Unclassified | 289-316 | 32 | 0.0982 | 1.82 | In-house | 316-343 (352) | Show / Hide |
Range on Protein: 289-316 Range on HMM: 316-343/352 Sequence Identity: 32% (9 aa) DLSGVADDLARNVLERMLVLDPAERPTA ..| | |. .. | .||. .| .|.|. HWSPEAKDFINDLLQKMLKKNPNKRITF |
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| Kinase | GK145.AA | Pkinase_Tyr | 309-323 | 40 | 0.290897 | 4.9 | Pfam | 256-270 (270) | Show / Hide |
Range on Protein: 309-323 Range on HMM: 256-270/270 Sequence Identity: 40% (6 aa) DPAERPTARGLVRLL ||..||| . ... | DPEDRPTFSEIHEQL |
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| Ank | GK145.AA | Ank | 421-437 | 35 | 22.641373 | 1.99 | Pfam | 6-22 (33) | Show / Hide |
Range on Protein: 421-437 Range on HMM: 6-22/33 Sequence Identity: 35% (6 aa) LMRAVDRNDVEAVKALI |. |. ....| || |. LHLACRCGHTEVVKMLL |
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| Ank | GK145.AA | Ank | 457-477 | 33 | 0.116177 | 10.25 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 457-477 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) YEGTALMRAAVYGHAGIVELL . |.|. |. .||. .|..| DGFTPLHLACRCGHTEVVKML |
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| Ank | GK145.AA | Ank | 488-509 | 36 | 1.4e-05 | 24.41 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 488-509 Range on HMM: 1-22/33 Sequence Identity: 36% (8 aa) NGWTALMWAVKNDHTDCVRLLM .|.|.|..|....||..|..|. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GK145.AA | Ank | 518-538 | 33 | 9.878559 | 3.29 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 518-538 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) NGGTALDMAKLWRRHEIVALL .| |.| .| .. ..|.| .| DGFTPLHLACRCGHTEVVKML |
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