Gene Abl (Fruit Fly)

Abl

Species: Fruit Fly
Alias: DROTKABL3, Abl, CG4032, abelson, Dsrc7, cAbl, DAbl, 4674, abl, l(3)73Ba, D-abl, c-abl, Dabl, l(3)04674, Am ABL, ABL, l(3)c-abl, SFO191, Ddash/abl, Abl1, D-abelson, C-abl, Dash, D-ash, Abelson, Abl oncogene, abl1
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 73B1--4,

Classification

Group: TK
Family: Abl

Sequence

Name Sequence Type Origin Length Description Download
Abl.AA Protein Various 1504 None Fasta, JSON
Abl.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Abl.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 Abl.AA SH3 190-247 35 1.3e-20 75.74 SMART 1-58 (58) Show / Hide 
Range on Protein: 190-247
Range on HMM: 1-58/58
Sequence Identity: 35% (21 aa)

QLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSD-SGNVGWVPSNYVTPLN
. ..||||.|| ... ||.|||. ...|. . ...|...  . .|..||.|||||....
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 Abl.AA SH3_1 193-240 34 2.2e-18 64.91 Pfam 1-49 (49) Show / Hide 
Range on Protein: 193-240
Range on HMM: 1-49/49
Sequence Identity: 34% (17 aa)

VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGN-VGWVPS
|||||.|| ... ||.|||... ... .....|... ..... .||.||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 Abl.AA SH3_2 191-246 19 1.2e-10 40.2 Pfam 1-68 (68) Show / Hide 
Range on Protein: 191-246
Range on HMM: 1-68/68
Sequence Identity: 19% (13 aa)

LFVALYDFQA-GGENQ-----LSLKKGEQVRIL--SYNKSGEWCEAHSD--SGNV--GWVPSNYVTPL
..... |...  ..|      |..|||......  .  ....|....     | .  ||.||..| ..
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH3_3 Abl.AA SH3_3 207-244 28 0.000532 15.13 Pfam 18-55 (55) Show / Hide 
Range on Protein: 207-244
Range on HMM: 18-55/55
Sequence Identity: 28% (11 aa)

SLKKGEQVRILSYNKSGEWCEAHSDSGNVGWV-PSNYVT
.|..|..| ...    . |..    .|  |||  |.||.
QLPNGTKVNVIGCQNGYGWYKINY-NGKTGWVLSSDYVS
SH2 Abl.AA SH2 254-329 49 3.5e-43 128.59 Pfam 1-81 (81) Show / Hide 
Range on Protein: 254-329
Range on HMM: 1-81/81
Sequence Identity: 49% (40 aa)

WYHGPISRNAAEYLLSS--GINGSFLVRESESSPGQRSISLRYEG---RVYHYRISEDPDGKVFVTQEAKFNTLAELVHHH
||||.|||. || || .  . .|.||||||||.||. ..|.|..|   ||.|||| ....|....| . ||..|.|||.|.
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 Abl.AA SH2 252-335 45 1.6e-34 121.94 SMART 1-87 (87) Show / Hide 
Range on Protein: 252-335
Range on HMM: 1-87/87
Sequence Identity: 45% (40 aa)

HSWYHGPISRNAAEYLLSS--GINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQ--EAKFNTLAELVHHHSVPHEG
. ||||.|||  || || .  . .|.||||.|||.||. ..|.|..|.|.|||| ...|||.....  . ||..| |||.|.. .  |
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase Abl.AA Abl 371-622 83 4.7e-200 670.9 In-house 1-252 (252) Show / Hide 
Range on Protein: 371-622
Range on HMM: 1-252/252
Sequence Identity: 83% (210 aa)

IMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALL
|||||||||||||||||.||||...||||||||||||....||.||||||||||||||||.||||||||||||||||..|||||.||...||.|.||.||
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

YMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYP
||||||||||||||.|..|||||||||||||....||||||||||.|.||||||||||||||||||||.|||||||.|||||||||||||||||||||||
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

AIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHAL
.|||..|||||.||||||||.||||.||.||||||||..||||.||.||||.
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase Abl.AA Pkinase_Tyr 371-622 52 4.5e-156 529.2 Pfam 1-270 (270) Show / Hide 
Range on Protein: 371-622
Range on HMM: 1-270/270
Sequence Identity: 52% (142 aa)

IMMKHKLGGGQYGEVYEAVWK----RYGNTVAVKTLKEDTMAL----KDFLEEAAIMKEM-KHPNLVQLIGVCT-REPP--FYIITEFMSHGNLLDFLRS
| . .||| |..||||...||      . .||||.|||..|      .||..||.|||.. .|||.|.|.|||| .. |   ||..|.| ||.|||.||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

A--GRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLM-RDDTY-TAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAF
   ... |.   || |..|||.||.||||.|.||||||||||||..|. ||..||||||..  ||.| ... |.|.||||.||| ..|.||.||||||.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVLLWEIATYGMSP-YPAIDLTDVYHKL-DKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHAL
|||.||| |||..| || .. ..||... ..||||..|..||.|.||||.|||..|. |||||. ||. |
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Abl.AA SFK-Src 371-626 53 2.4e-151 452.17 In-house 1-259 (259) Show / Hide 
Range on Protein: 371-626
Range on HMM: 1-259/259
Sequence Identity: 53% (139 aa)

IMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRS-AGRETLDAVAL
| .. ||| ||.|.|.  .|    . |||||||  .|  . ||.||..|| ..||||.||  |||   | ||||| |  | |||.|.. .||  |    |
IRLEKKLGSGQFGDVWKGRWNNTTE-VAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGR-SLRMPQL

LYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLAR-LMRDDT-YTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMS
  || |.|.|| |||  |..|||||||| |||||  .||.|||..| |  ||  |||| ||||||||||||   .|.||.|||||.||.|. || |||  
VDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRI

PYPAIDLTDVYHKLDK--GYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMF
|||      |  ..|.  ||||. ||.||.| | .|..|||  . ||||| |    .|  |
PYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase Abl.AA TyrKc 371-622 46 3e-148 499.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 371-622
Range on HMM: 1-280/280
Sequence Identity: 46% (132 aa)

IMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEM--KHPNLVQLIGVCTRE-------PPFYIITEFMSHGNLLDFLRSAGR
| ...||| |..||||...||    .||||.||||.  ..||..|| ||..   .|||.|.|.|||| .       .| .|..|.|.||.|.|.||. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

ETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDD--------TYTAHA--GAK--FPIKWTAPEGLAYNKFSTKS
. |    ||....|||.||.||.|.|.|||||||||||||.|. ||..||||.|   ||        .|..    |.|  .||.|.||| . |.||.|||
K-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWAFGVLLWEIATYGMSPYPA-----IDLTDVYHKLDKGYRMERPPG--------CPPEVYDLMRQCWQWDATDRPTFKSIHHAL
|||.|||..||| |||..|||      .. ..|......||||..||         ||.|.|..|.|||. |. |||||. ||. .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Abl.AA Src 371-622 55 1.7e-146 492.95 In-house 1-255 (255) Show / Hide 
Range on Protein: 371-622
Range on HMM: 1-255/255
Sequence Identity: 55% (142 aa)

IMMKHKLGGGQYGEVYEAVWKRYGNT-VAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLR-SAGRETLDAVA
| .. ||| ||.|||....|.  ||| |||||||..||. ..||.|| |||...|..||||  ||..| |.||.||.||||.|||.|. .    .|    
IKLCRKLGQGQFGEVWMGYWN--GNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQ

LLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMR--DDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGM
|..||.|.|.||.||||.||||||||||| |||.| ..||||||||||.   || |.|. |||||||||||| . |..|..||||| ||.||.|| ||| 
LIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGR

SPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYD-LMRQCWQWDATDRPTFKSIHHAL
 |||  .  .|  ....|||| .|..||.|.|. .|.|||. |. .||||. ... |
VPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Abl.AA SFK-Abl 371-622 57 5.8e-146 479.54 In-house 1-251 (251) Show / Hide 
Range on Protein: 371-622
Range on HMM: 1-251/251
Sequence Identity: 57% (145 aa)

IMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSA-GRETLDAVAL
| . | ||.|||||||  .|     .||.|| |.. |  |||. || ||| |.|||||.|||||||| | ||..|||  |||||.|.|  .|  .| | .
IILGHRLGEGQYGEVYKGIWNN--HRVAIKTIKDESMETKDFMKEAHIMKRMQHPNLVRLIGVCTREGPMYIVQEFMNYGNLLDYLQSPQSRIQIDHVSM

LYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPY
.. | ||| ||| || ...|||||||||||||||  .||||||.||.   | |.|  | |.|||||||| |.|  |. |||||.||. ||||||||  ||
MHCAQQIADGMSFLEEQHFIHRDLAARNCLVGDNLQIKVADFGMARFVDSDFYEARIGTKMPIKWTAPESLCYDIFTIKSDVWSFGITLWEIATYGDVPY

PAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHAL
| |.  ||  .|  |||| || .|| |.|. | |||  .   || |    | |
PGIHHRDVINQLMMGYRMQRPQDCPMEIYNIMTQCWDVNPDERPSFHDLQHQL
Kinase Abl.AA TK 371-622 28 1.5e-130 440.0 In-house 1-486 (486) Show / Hide 
Range on Protein: 371-622
Range on HMM: 1-486/486
Sequence Identity: 28% (137 aa)

IMMKHKLGGGQYG---EVYEAVWKRYG-------------------------NTVAVKTLKED-TMALKD--------------FLEEAAIMKEMK----
| . .||| ||.|   |||.. |.. .                          .||||.|||. .|. ..              |||||..|| |.    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVQLIGVCTRE------------PPFYIITEFMSHGN----LLDFLRSAG----------------------------------------------
 |||.|.|.||||..            .|..|..|.|.||.    |.|.||.                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------RETLDAVALLYMATQIASGMSYLESR------NYIHRDLAARNCLVGDNKL-----------VKVADFGLAR
                            ...|.   || |. |||.||.||.|.      |..||||||||||||.|.            .|.|||||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LMRDD----TYTAHA------------------------GAKFPIKWTAPEGLA---------YNKFSTKSDVWAFGVLLWEIATYG-MSPYPAI
     | ||.     |...                         |.|.||.|.||| |.         |.||.||||||.||||.||| ||| . .|. .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DL---------TDVYHKLDKG--------------YRMERPPGCP--------------PEVYDLMRQCWQWDATDRPTFKSIHHAL
.          ..|. .| .|              .||..||.||              .|.||||.|||..|. |||||. .|..|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Abl.AA Src-Unclassified 371-622 44 6.9e-130 437.8 In-house 1-284 (284) Show / Hide 
Range on Protein: 371-622
Range on HMM: 1-284/284
Sequence Identity: 44% (127 aa)

IMMKHKLGGGQYGEVYEAVWKRYG-NTVAVKTLKED---TMALKDFL--------EEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRS
.  . ||| || |||. . |.  |   |||||....   ||.   ||        .||.|||...|.|||.| .||..| |.|||||.|. | ||..|| 
VHLLRKLGRGQFGEVWYGKWR--GKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLRE

AGRETLDAVAL------------LYMATQIASGMSYLESRNYIHRDLAARNCLVGDNK-----LVKVADFGLA--RLMRDDTYTAHAGAKFPIKWTAPEG
 |  .|   ..             ..|.|.|||| ||||. |.|||||||| |.|.|      .|||.|||||  .|| || | .  ||.||.||.||| 
GGGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPEC

LAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERP--PGCPPEVYD-LMRQCWQWDATDRPTFKSIHHAL
  | .||.||||| .|.|||||.|.|  |||  .   |   .  |||| .|   .||  .|. .| .||  |   ||||    | .
FIYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase Abl.AA Tec 371-624 43 5.1e-120 405.03 In-house 1-254 (254) Show / Hide 
Range on Protein: 371-624
Range on HMM: 1-254/254
Sequence Identity: 43% (112 aa)

IMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAV-AL
...   || ||.| |  . |.     ||.|..|| .|   ||.||| .|..  ||.|||| |||. . | ||.||.|.|| ||..||. . .   ..  |
LTFMKELGSGQFGVVHLGKWRH-QYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAIL

LYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPY
|.|  ..  || |||. ..||||||||||||||.. |||.|||..|   || ||   |.|||.|| .|| . |...| |||||||||| ||. . |  ||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEH
.. . ..|  .  .|.|..||  |. ..|. | .||.  . .||||.    ... 
ENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase Abl.AA Frk 371-626 52 2.6e-118 399.34 In-house 1-260 (260) Show / Hide 
Range on Protein: 371-626
Range on HMM: 1-260/260
Sequence Identity: 52% (138 aa)

IMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLR--SAGRETLDAVA
| . ..|| ||.|||.|  |      |||||||  ||  .||| || |||...|| |.||  |||.| | ||||| | || |...|.  .   . .    
IQLIRRLGSGQFGEVWEGLWNNT-TPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQ

LLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLAR-LMRDDT--YTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYG
|. || |.|.|| ||||.||||||||||| |||... .|.||||||| ||.|.   | .. ||.|||||||||   ||||..|||||.||.|| || |||
LVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYG

MSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMF
  ||| .   .| . .|.|||| .||.||...|..| .||. |.  ||||  ..  ||. |
RMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase Abl.AA Csk 371-622 47 4.2e-113 382.04 In-house 1-251 (251) Show / Hide 
Range on Protein: 371-622
Range on HMM: 1-251/251
Sequence Identity: 47% (121 aa)

IMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKED-TMALKDFLEEAAIMKEMKHPNLVQLIGVCTREP-PFYIITEFMSHGNLLDFLRSAGRETLDAVA
. .  . | | .| |    ..  .. |||| .|.|   ..  || ||..| ...||||||||||   ..   ||..|.|| |||.|.||| ||. .    
LHLGECIGHGEFGDVMQGEYQ--NRKVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQ

LLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAH--AGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGM
||  |  ...|| |||... .|||||||| || .    || |||||   ...... .  .. |||||||||| |   ||||||||| ||.|||||  .| 
LLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLA---KEECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGR

SPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHAL
 ||| | | || ..  |||||| | ||||.|| .|.|||. .. .||||. .   |
VPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase Abl.AA SrcB 371-623 49 2.4e-109 369.55 In-house 1-251 (251) Show / Hide 
Range on Protein: 371-623
Range on HMM: 1-251/251
Sequence Identity: 49% (125 aa)

IMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALL
. . .||| ||.|||. . ...    |||||.|. ||. . ||.|| .||...|  ||.|  | |.| | |||||.| .| |||||..     |    |.
LKLVKKLGAGQFGEVWMGYYNNH-MKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLI

YMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYP
 |. ||| || |.| .||||||| | | || .  . |.|||||||.. |. |||. |||||||||||| . .  |  |||||.||.|| || |||  |||
DMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYP

AIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALE
     .| . |..|||| ||  ||.|.|..|..||.  . .||||  ..  |.
GMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase Abl.AA S_TKc 371-626 26 3.1e-65 223.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 371-626
Range on HMM: 1-231/231
Sequence Identity: 26% (71 aa)

IMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSH--GNLLDFLRSAGRET----L
  .  |.| | .|.|| ...|. |  ||.| .|      .... | .|.|. .|||.|.|..|.     .|...|....  |.|.|.... ||.     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

DAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFST-KSDVWAFGVLLWEIAT
.     ... ||.... |. |.. |||||   | |. .   .|..||||||..                . ||| |   .... |.|.|..|..|.| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

YGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHH-----ALEHMF
 |  |.|  ..  ...|.            .||. |..|.|.|.| ..|||   . .     ..   |
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Abl.AA Pkinase 371-625 23 5.1e-50 177.3 Pfam 1-293 (293) Show / Hide 
Range on Protein: 371-625
Range on HMM: 1-293/293
Sequence Identity: 23% (71 aa)

IMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLE-----EAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHG----NLLDFLR--SA
.  . |.| | .|.||....| .| .||||..| ..   .   .     |..|||...||| |.|........  |...|.. .|     | |...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLV----KVADFGLARLMRDDTYTAHAGAKFP---IKWTAPEGLA-YNKFSTKSDV
|. ...   .  ...||..|. |. |.. |||||   |.|. .|  .    |..|||||....   |     .. .   . . ||| .  ... ..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WAFGVLLWEIATYGMSPYPAI----DLTDVYHKLDKGYRMERPPGCP-----------------------PEVYDLMRQCWQWDATDRPTFKSIHHALEH
|..|..|.| .. |  |.|      .  | ......  . . .  .|                       .|  |... |...| ..|||   ....|.|
WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQH

--M
  .
PWF
FABD Abl.AA FABD 1363-1504 43 1.3e-83 284.99 SMART 1-153 (153) Show / Hide 
Range on Protein: 1363-1504
Range on HMM: 1-153/153
Sequence Identity: 43% (66 aa)

PQIQQKPAVPHKPTKLTIYATPIAKLTEPASSASSTQISRESILELVGLLEGSLK-------HPVNAIAGSQWLQLSDKLNILHNSCVIFAENGAMPPHS
|||..|.|.....|.||||||||||||.||....|..||...|||....|.....       |........||||.|||...|||.|...|..|.|..|.
PQIMHKVALRKTRTQLTIYATPIAKLTQPAERIPSDKISKDMILECTECLCSAFHNLFNLATHSEQMVSHQQWLQMSDKGHQLHNYCMGYADCGIMQMHN

KFQFRELVTRVEAQSQHLR----SAGSKNVQDNERLVAEVGQSLRQISNALNR
||||||||||.|.|...||    ||||.|...|.............||....|
KFQFRELVTRLENQNRQLRFCSTSAGSRNSPNNNQDFMNLHSCVKEISDVVQR