Gene Caki (Fruit Fly)

Caki

Species: Fruit Fly
Alias: CG13412, caki, cmg, calmodulin-dependent kinase, CamGUK, CMG/CASK, CAKI, Caki, Camguk, camguk, CG6703, SFO166
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 93F4--6,

Classification

Group: CAMK
Family: CASK

Sequence

Name Sequence Type Origin Length Description Download
Caki.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
Caki.AA Protein Various 897 None Fasta, JSON

Protein domain

Protein domains of Caki.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Caki.AA CASK 12-278 52 2.2e-202 663.07 In-house 1-330 (330) Show / Hide 
Range on Protein: 12-278
Range on HMM: 1-330/330
Sequence Identity: 52% (172 aa)

YELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPG-----LSTADLKREATICHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRR
|..|.|..||||..|||||||||||...||||||.|||..||     |.|.|.||||.|||.||||||.||..||.|..|.|||||||||.|.|||.|.|
YYMCQVMEKGPFCHVRRCIHRESNQHCVVKIVDVNKFTQHPGGFGIALPTEDIKREARICHCLKHPHICELCRTYNSDHMRYMVFEFMEGNDVCFEIVQR

----AVAGFVYSEAVACHYMRQILEALRYCHENEILHRDVRPACALLATVDN-------------------------------------SAPVKLGGFGS
    |.|||||||.|||||||||||||.|||.....||||||.|...|..||                                     ||||||.|||.
GLGPAKAGFVYSEYVACHYMRQILEALMYCHQWDHIHRDVRPHCRVMASKDNRQRITVEEALAHPWLRERDKFAPKVHLLETVEELKKFSAPVKLCGFGV

AIQLPGTRE-----------------TIETHGRVGCPHYMAPEVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFEAPEWKSIS
||||.....                 .....|||||||.||||||.|..||..||.||.||||..||||.|||.|...||......||.......|..||
AIQLSHKFTSFYSDPNTKHITDFADEDPMACGRVGCPHFMAPEVVRREPYGCPCDIWGCGVMLFILLSGCLPFFGTKDRLFEMIMKGRYDMDPRYWPHIS

ANAKDLVMKMLAANPHHRLSITEVLDHPWI
..|||||..||.|.||||.||.|.|.||||
ESAKDLVRRMLMADPHHRISIYEALNHPWI
Kinase Caki.AA CAMK 17-278 21 8.5e-98 315.72 In-house 1-425 (425) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-425/425
Sequence Identity: 21% (93 aa)

VIGKGPFSIVRRCIHRESN------------QQFAVKIVDVAKFTAS-----------------------PGLSTADLKREATICHM-------LKHPHI
..|.| |..|..|||....            |..|.||.|  | . .                        . . . ..||  |. .       |.||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VELLETYS------------SEGM--------LYMVF---EFMEGSDLCFEVVRRAVAG---------------FVYSEAVACHYMRQILEALRYCHENE
. |.|.|             .  .        .|||.   |...| .|....  . |.                . ..|. |..|.|||..|..|||.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDVRPACALLATVDNS--------------APVKLGGFGSAIQLPGTR---------------------ETIETHGRVGCPHYMA-PEVVTR-----
| |||  |   || . ...              ...|.  || |.....                       |.   . ..|.|.||| |||. .     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------RLYGKGCDVWGAGVMLHVLLSGRLPFLGSG--------------VRLQQSVARGRLSFEAPE------------WKSISAN--------AK
         . ||. ||.| .||.| ..|.|..|| |.                .| . . .|. .|. |.            |..|| .        .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLVMKMLAANPHHRLSITEVLDHPWI
||. |||  .| .|..|...|.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Caki.AA S_TKc 12-278 31 4.8e-83 283.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-278
Range on HMM: 1-231/231
Sequence Identity: 31% (89 aa)

YELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHMLKHPHIVELLETYSSEGMLYMVFEFMEG--SDLCFEVVRRAVA
||. ..|||| |. |..|.|.......|.||..             ...||  |... .||.|| |.... . . ||||.|...|   ||    ..|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G--FVYSEAVACHYMRQILEALRYCHENEILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYGK-GCDVWG
|  |...| .|..||.||..|| |||.. |.|||. |.  || .      .|.. ||.| ||         .  .| |.||||||.    |||  ||.| 
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWS

AGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANPHHRLSITEVLD-------HPWI
 |..|  .|.|. ||     .. . .               |  |||...|.|  .| .|... |.|        |||.
CGCILYEMLCGYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Caki.AA CAMK2 12-278 42 2.4e-74 251.83 In-house 1-259 (259) Show / Hide 
Range on Protein: 12-278
Range on HMM: 1-259/259
Sequence Identity: 42% (113 aa)

YELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGF
|.| | .||| ||.||||..  . | .| ||..  | .|        | ||| || .|||| || | .  . ||  |.||. . | .| || .   ||  
YQLFEELGKGAFSVVRRCVKKCTGQEYAAKIINTKKLSA---RDHQKLEREARICRKLKHPNIVRLHDSIQEEGFHYLVFDLVTGGEL-FEDI---VARE

VYSEAVACHYMRQILEALRYCHENEILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYGKGCDVWGAGVML
 |||| | | ..||||.. .||.|.| |||..|   |||     | |||  || || . | ..    .|  | | |..|||. .  |||  |.|  ||.|
YYSEADASHCIQQILESVNHCHQNGIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAW--FGFAGTPGYLSPEVLRKDPYGKPVDIWACGVIL

HVLLSGRLPFLGSGV-RLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANPHHRLSITEVLDHPWI
..|| |  ||      || | .  |   . .|||  .  .||.|. .||. ||. |.   | | ||||
YILLVGYPPFWDEDQHRLYQQIKAGAYDYPSPEWDTVTPEAKNLINQMLTINPKKRITADEALKHPWI
Kinase Caki.AA CAMK1 12-278 31 4.2e-71 205.93 In-house 1-276 (276) Show / Hide 
Range on Protein: 12-278
Range on HMM: 1-276/276
Sequence Identity: 31% (90 aa)

YELCEVIGKGPFSIVRRCIHRES---NQQFAVKIVD-VAKFTASPGLST---ADLKREATICH---MLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCF
||. ..||.| ||.|..|.|.|.   ..|.|.|. |     ..  . .    . |..|  | .    ..||.|. . | | |.  .|.| | . | .|  
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKK---KFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFD

EVVRRAVAGFVYSEAVACHYMRQILEALRYCHENEILHRDVRPACALLATVDNSAPVK--LGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTR---R
 .| .     .|.|  |.| |.|||.|. |.|.. | |||  |   |... |. ...|  .  || . .. .  .. .|  ..| | |.||||...    
RIVEKG----NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKT--ACGTPGYVAPEVLECKKDK

LYGKGCDVWGAGVMLHVLLSGRLPFLGSGVR--LQQSVARGRLSFEAPEWKSISAN-AKDLVMKMLAANPHHRLSITEVLDHPWI
 |.| ||.|..|| . .|| |  || .. |   | . . .. . |  |.| .||   |||.. .||  .|  |......|.||||
PYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase Caki.AA Pkinase 12-278 29 2.3e-68 238.26 Pfam 1-293 (293) Show / Hide 
Range on Protein: 12-278
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

YELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLK-REATICHMLKHPHIVELLETYSSEGMLYMVFEFMEGS----DLCFEVVRR
|.. ..||.| |. |..|.|. .....||||...   .....   .... .|. | ..|.||.||.|.... ... .|||.|..||     ||. .....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYIST

AVAGFVY--SEAVACHYMRQILEALRYCHENEILHRDVRPACALLA-TVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVT-RRLYGKGC
  .. ..  || ....||.|||..| |||.. |.|||. |.  |.  . ...|.||.. ||.| |.  .     .....| |.||||||.  .. ||. .
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWGAGVMLHVLLSGRLPFLGS----GVRLQQSVARGRLS----FEAPEWKSIS-----------------ANAKDLVMKMLAANPHHRLSITEVLDHPW
|.|..|..|. .|.||.|| |.    . . |. . . ...    |. |.| |||                  ..||.. ..|. .|. |......| |||
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

I
.
F
Kinase Caki.AA Ciliate-E2a 12-278 29 3.3e-63 184.91 In-house 1-275 (275) Show / Hide 
Range on Protein: 12-278
Range on HMM: 1-275/275
Sequence Identity: 29% (85 aa)

YELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLC--------FEV
|..  .|||| |  |.   |.. ..|||.|...  |.  . .   . ...|  |  .|.||.|  | |.| .|  .|.|.|. || .|         |  
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQ-KKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFE

VRRAVAGFVYSEAVACHYMRQIL-EALRYCHENEILHRDVRPACALLA-TVDNS---APVKLGGFGSAIQLPGTRETIE--THGRVGCPHYMA------P
           . ..|..|.|.| ..| |.| . |.||| .|   |.     ||   . .|.  || | . ..    ..   . ..| |.|.|      .
E----------IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD---EKKYMFQKCGTPGYVAPEVLNNK

EVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLG-SGVRLQQSVARGRLSFEAPE-WKSISANAKDLVMKMLAANPHHRLSITEVLDHPWI
|| ... |.. ||.| .||... ||.|..|| | .     |.. .  ..|. || |. .| ..|||. |||  .| .|..... |.||| 
EVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase Caki.AA RSK 14-278 30 3.7e-60 206.17 In-house 1-278 (278) Show / Hide 
Range on Protein: 14-278
Range on HMM: 1-278/278
Sequence Identity: 30% (85 aa)

LCEV--IGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHMLK-HPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAG
| .   .|.| ....|.|.|. ..|..|.|... ||. ..   .|.. ..| .|  . . || ||.| ...  || ||.. |...| .|     ..   |
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQ-KDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG

-FVYSEAVACHYMRQILEALRYCHENEILHRDVRPACALLATVDNS-APVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVT---RRL-YGKGCDV
 |  ||  || ||..|  |... |.  | |||  |   |..  . . . .||  || . |.   ...  |.  ..  .|||||...   ..  ..| ||.
CF--SEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQF-RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDW

WGAGVMLHVLLSGRLPFLG----SGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANPHHRLS-----ITEVLDHPWI
|  || .. .|.|..|| |    .   . . . .|..|.. |.|...|..||||. |||  .|| ||.     . |...|||.
WSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase Caki.AA Ciliate-E2 12-278 21 1.7e-58 199.38 In-house 1-365 (365) Show / Hide 
Range on Protein: 12-278
Range on HMM: 1-365/365
Sequence Identity: 21% (82 aa)

YELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAK-------------FTASPGLSTADLKREATICHMLK-------------------HPHIVELLE
|.. ..||.| |..|..| ... ..||| || |  |             . |   ..  ...    . |...                   ||.|... |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

TYS--SEGMLYMVFEFMEGSDLCFEVVRR---------AVAGFVYSEAVACHYMRQILE---------------ALRYCHENE-ILHRDVRPACALLATV
..   ..  .|.|.|. .| ||      .           .   ..|  ....|.|||.               ||.|.|..  |.|||  |   |.   
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

DNSAPVKLGGFGSAI----------------QLPGTRETIETHGR--------------VGCPHYMAPEVVTRRL---------YGKGCDVWGAGVMLHV
     .|.  || .                  ..  .  .... .              .| |.|||||.. .           |.. ||.| .||.|. 
-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

LLSGRLPFLGSGVRLQQSVARGRLSFEAPE--------------WKSISANAKDLVMK----MLAANPHHRLS-ITEVLDHPWI
.|.|..||       ||    . ..|  ||              ||..| ..|||  |    ||  .|  |.. . ..|.|||.
MLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Caki.AA MAPKAPK 16-278 30 1.9e-58 179.39 In-house 5-292 (292) Show / Hide 
Range on Protein: 16-278
Range on HMM: 5-292/292
Sequence Identity: 30% (91 aa)

EVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHMLK-HPHIVELLETYSS----EGMLYMVFEFMEGSDLCFEVVRRAVAG
||.| |    |..| |. ..| .||||..      .|| | .   ||  . .. . ||.||.... ..     .  .|.|.|.||| .|   . .|.   
EVLGEGIYGKVQTCVHKRTGQEYAVKILE-----DQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKH

FVYSEAVACHYMRQILEALRYCHENEILHRDVRPACALLATVDNSAPVKLGGFGSAIQ------LPGTRETIETHGRVGCPHYMAPEVVTRRL----YGK
|  .|  |   |..| .|....|.  | |||. |   |  . .  .||||. || | .      .. . .| |    .. | ||||||| .      | |
F--TEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFKEAHTYDK

GCDVWGAGVMLHVLLSGRLPFLGSGV------R-----------LQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANPHHRLSITEVLDHPWI
 || |  || . ..|.|  || ..                    . .. . |  .|  .||. ||. ||||. |.|  .|  ||.|..|..||||
SCDMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase Caki.AA RAD53 183-278 33 2e-39 114.77 In-house 188-305 (305) Show / Hide 
Range on Protein: 183-278
Range on HMM: 188-305/305
Sequence Identity: 33% (39 aa)

GCPHYMAPEVVTRR---------------LYGKGCDVWGAGVMLHVLLSGRLPFL-GSG-----VRLQQSVAR-GRLSFEAPEWKSISANAKDLVMKMLA
| | | ||||.|                  |.| .|.| .|. | ..|.|..||  ...     . | ... . |...|. |.|..|| .||||. .|| 
GTPQYVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLC

ANPHHRLSITEVLDHPWI
 .|..|..| |.| |||.
VDPEKRYTIDEALNHPWM
Kinase Caki.AA CAMK-Unique 179-278 27 2.9e-30 96.97 In-house 233-363 (363) Show / Hide 
Range on Protein: 179-278
Range on HMM: 233-363/363
Sequence Identity: 27% (36 aa)

HGRVGCPHYMAP--------------EVVTRRLYGKGC----DVWGAGVMLHVLLSGRLPFLGSGVR---------LQQSVARGRL-SFEAPEWKS---I
. ..| | ||||              ||. .. |.  |    | |  ||... .|.|..|| ...           . ..   |.. .|. . | .   |
QTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYI

SANAKDLVMKMLAANPHHRLSITEVLDHPWI
| .|||.| . .   | ||.|. | |.|.||
SQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase Caki.AA RAD53 12-141 27 1.4e-29 84.82 In-house 1-134 (305) Show / Hide 
Range on Protein: 12-141
Range on HMM: 1-134/305
Sequence Identity: 27% (37 aa)

YELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFT---ASPGLSTADLKREATICHMLKHPHIVELLETYSS-EGMLYMVFEFMEGSDLCFEVVRRA
| . ...|.| |..|.... ..  |..|.||.|  ||.    .   .. .. .|. |   |.|| |..... . . .  .||| |.|.| .|   .| . 
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

VAGFVYSEAVACHYMRQILEALRYCHENEILHRD
     ..|. .  | .|...|..| |.| | |||
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRD
Kinase Caki.AA CAMK-Unique 12-141 22 4e-28 89.77 In-house 1-182 (363) Show / Hide 
Range on Protein: 12-141
Range on HMM: 1-182/363
Sequence Identity: 22% (41 aa)

YELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLS---------------TADLKREATICHMLKHPHIVELLET----YSSEG-------
|.. ..||.| |..|..|. ||    .|.|.|  ..   . ..                   ||||. |  |..||.|..|...    .  .        
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------MLYMVFEFMEGSDLCFEVVRR-----------------AVAGFVYSE--AVACHYMRQILEALRYCHENEILHRD
         .|.| |. .| ||  .....                  . | ..||  . .| .|...|.|. | |.. | |||
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQG-HFSERCWDTCFIMQCLLSAVAYMHSQDIVHRD
Kinase Caki.AA TyrKc 12-284 18 3.7e-12 -26.13 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-284
Range on HMM: 1-280/280
Sequence Identity: 18% (59 aa)

YELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHML--KHPHIVELLETYSSE-------GMLYMVFEFMEGSDLCFE
 .| ...| | | .|.... .   .| ||| .   .         .|. ||| | ..|  .||.|| |.   ...       . |..|.|.|..   .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLK

VVRRAVAGFVYSEAVACHYMRQILEALRYCHENEILHRDVRPACALLAT----VDNSAPVKLGGFGSAIQLPGT------RETIETHGRVGCP-----HY
   |.  .   . .  .... || .  .| |.. . |||       ||.    |..   || . || .  .          ... . .. |.        
DYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRD-------LAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MAPEVVTRRLYGKGCDVWGAGVMLHVLLS-GRLPFLG------SGVRLQQSVARG-RLSFEAP-EWKSI-----SANAKDLVMKMLAANPHHRLSITEVL
||||.   . .    |||  ||..  ... |  |  |      |  .. . | .| |.   .  .   .     ..   ..  .  ...|. | . .|. 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-

DHPWIRDRDKL
       ....
-------HECF
Kinase Caki.AA CASK 279-312 51 1.8e-10 29.82 In-house 168-202 (330) Show / Hide 
Range on Protein: 279-312
Range on HMM: 168-202/330
Sequence Identity: 51% (18 aa)

RDRDKLQ-RTHLADTVEELKRYNARRKLKGAVQAI
|.|||   . || .||||||...|..||.|.. ||
RERDKFAPKVHLLETVEELKKFSAPVKLCGFGVAI
Kinase Caki.AA Pkinase_Tyr 12-99 25 9e-08 26.95 Pfam 1-94 (270) Show / Hide 
Range on Protein: 12-99
Range on HMM: 1-94/270
Sequence Identity: 25% (24 aa)

YELCEVIGKGPFSIVRRCIHR----ESNQQFAVKIVDVAKFTASPGLSTADLKREATICHML-KHPHIVELLETYS-SEGM--LYMVFEFMEGSDL
 .. ...|.| |  |.... .    . ... |||..     . .. .  .|. ||| | . | .||.|| |.   .  ..   .|.|.|.|.. ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
L27 Caki.AA L27 346-400 32 1.1e-16 64.74 Pfam 1-56 (56) Show / Hide 
Range on Protein: 346-400
Range on HMM: 1-56/56
Sequence Identity: 32% (18 aa)

AVQRILDCLDDIYSLQDAH-VDADVLRDMLRDNRLHQFLQLFDRIAATVVTSNGRA
||||.|..|....||...|  |.. |...|.....|..||..|..|..|.... ..
AVQRVLELLEQLQSLSEHHPEDLQELQQILQSPHMHSLLQVHDKVACKVYDPPSPE
L27 Caki.AA L27 346-400 25 1.8e-13 52.02 SMART 1-62 (62) Show / Hide 
Range on Protein: 346-400
Range on HMM: 1-62/62
Sequence Identity: 25% (16 aa)

AVQRILDCLDDIYSLQDAH----VDADVLRDMLRD---NRLHQFLQLFDRIAATVVTSNGRA
||||....|....|....|    .|.. ||..|..   . .|. |...|..|.|.  ..  .
AVQRVYEVLEELQSHLQHHEDMQEDLQELRQILQSMFMPHFHALLKIHDKVACTKYQPPPPP
L27 Caki.AA L27 405-464 38 1e-15 61.17 Pfam 1-56 (56) Show / Hide 
Range on Protein: 405-464
Range on HMM: 1-56/56
Sequence Identity: 38% (23 aa)

AVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEAAR
|| |....||||.|.|. .    ... .||...|  |||..||. ||.||..||.... .
AVQRVLELLEQLQSLSEHH----PEDLQELQQILQSPHMHSLLQVHDKVACKVYDPPSPE
L27 Caki.AA L27 405-464 33 8.7e-15 56.37 SMART 1-62 (62) Show / Hide 
Range on Protein: 405-464
Range on HMM: 1-62/62
Sequence Identity: 33% (21 aa)

AVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAA---PHMQALLHSHDVVARDVYGEEAAR
|| |...|||.|.|... .... .    ||...| .   ||..|||. ||.||  .| ..  .
AVQRVYEVLEELQSHLQHHEDM-QEDLQELRQILQSMFMPHFHALLKIHDKVACTKYQPPPPP
PDZ Caki.AA PDZ 494-572 23 8e-20 70.49 Pfam 1-86 (86) Show / Hide 
Range on Protein: 494-572
Range on HMM: 1-86/86
Sequence Identity: 23% (20 aa)

LVHFQKN-TDEPMGITLKMTEDG----RCIVARLMHG-GMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARG-SVTFKIV
.|...|. . ...|...|. .|.     ......|.| |...|.  .|.|| | .||||..   .. . . ......| .|. .| 
QVTLEKQDKRGGLGFSIKGGNDQRHDQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ
PDZ Caki.AA PDZ 503-575 22 1e-13 52.83 SMART 1-80 (80) Show / Hide 
Range on Protein: 503-575
Range on HMM: 1-80/80
Sequence Identity: 22% (19 aa)

EPMGITLKMTEDGRCIVARLMHGGMIHRQAT-----LHVGDEIREING-QPVQHQSVGQLQRMLREARG-----SVTFKIVPSY
...|....      ........||  ..  .     |..||.| |.|| |||.  .  | ..||....|     .||.....  
GGLGFSIVG----GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
SH3 Caki.AA SH3 584-649 31 3.3e-14 54.43 SMART 1-58 (58) Show / Hide 
Range on Protein: 584-649
Range on HMM: 1-58/58
Sequence Identity: 31% (21 aa)

IFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLGTVGGSAGLIPSPELQEWR
 .|||..||..       .    .||. |||.....||| .||..|...  |  |..||  ..| .
PYVRALYDYQA-------QNPDELSFKKGDIITVLEKDDDGWWKGRCNR-TGQEGWFPSNYVEEID
SH3_2 Caki.AA SH3_2 585-648 24 4.7e-14 52.1 Pfam 1-68 (68) Show / Hide 
Range on Protein: 585-648
Range on HMM: 1-68/68
Sequence Identity: 24% (18 aa)

FVRAQFDYNP-LDDELIPCAQAGISFQVGDILQII---SKDDHHWWQA-RL--GTVGGSA--GLIPSPELQEW
..|. .||.|  . . ..   ....|..||.. .|   .||...||.. .   |   | .  |..||  ..|.
YYRVHCDYVPATYCNENH--EPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWG---GRRMRGWFPSQWVEEC
SH3_1 Caki.AA SH3_1 607-642 40 6.7e-09 33.13 Pfam 14-49 (49) Show / Hide 
Range on Protein: 607-642
Range on HMM: 14-49/49
Sequence Identity: 40% (15 aa)

ISFQVGDILQIISKDDH-HWWQARLGTVGGSAGLIPS
.||. |||...|.|.|  .|| .|. .  |  |..||
LSFKKGDIIHVIEKSDDWDWWKGRCNNT-GQEGWFPS
Guanylate_kin Caki.AA Guanylate_kin 709-884 35 2.6e-77 266.01 Pfam 1-198 (198) Show / Hide 
Range on Protein: 709-884
Range on HMM: 1-198/198
Sequence Identity: 35% (70 aa)

QRKTLVLLGAHGVG---RRHIKNTLISKYPDKY-V-YPIPHTTRPAKPEEENGRSYYFV-SHDEMMADIGANEYLEYGT-HEDAMYGTKLDTIRRIHTEG
|....||.|..|||   ..|||..|....|.|  . |..||||||  | |..|. |.|| |..||...| ..|..|... ... ||||.. |||.||  |
QMRPIVLSGPSGVGYEVKSHIKKALWDEHPHKFDGRYCVPHTTRPPRPGEVDGKHYHFVSSREEMWNMIQNHEFIEWAQVFNGNMYGTSKETIRQIHEQG

KM---AILDVE-PQALKILRTA-EFTPYVVFIAAPSLQNIADY-----DGSLERLAKESEMLRQLYGHF-----FDLTIVNNDISETIATLETAIDRV
|    .|||.. .|..|.||.. |. |..|||..||.|.  .      ....| ..|..| ..|...|      ||. |||.|. .... |.....  
KIMQLCILDIDTWQGVKQLRKTYELHPIMVFIKPPSMQELQRRLRCRNTEQEEKINKRMEAAEQEMQHYDEPGMFDYIIVNDDFDKAYWHLKEILEAE
GuKc Caki.AA GuKc 709-885 33 1.7e-70 241.39 SMART 1-203 (203) Show / Hide 
Range on Protein: 709-885
Range on HMM: 1-203/203
Sequence Identity: 33% (68 aa)

QRKTLVLLGAHGVGRRHIKNTLISKYPD--KYVYPIPHTTRPAKPEEENG--RSYYFVS-HDEMMADIGANEYLEYGTHEDA-MYGTKLDTIRRIHTEGK
.|...||.|..|||....|..|...|||  |. ...|||||| .| |.||  . |.||| ..||. .|..|..||.|..... .|||...|.| .|  ||
HRRPIVLSGPSGVGKSTLKHMLMQEYPDYPKFEFSVPHTTRPPRPGEVNGCVVDYHFVSLKEEMEQMIKHNKFLEWGEYHGNLYYGTSKETVRQVHEQGK

MAILDVEPQALKILRTA----EFTPYVVFIAAPSLQNIADYDGS--------LERLAKESEM-LRQLYGHF------FDLTIVNNDISETI-ATLETAID
..|||..||... ||.|    .| |.|.||..||.. . . . .        .||..|...   .....|       ||..|||.|.....   | ....
HCILDIDPQGVRQLRYARRYSYFYPIVIFIKPPSMEELEERLRQPCQRGTETEERIQKRLAHQAQKEMQHYPKCHHEFDYVIVNDDLEDACYKELKEIME

RVH
  .
QEQ