Gene Egfr (Fruit Fly)

Egfr

Species: Fruit Fly
Alias: dEGFR, torpedo/Egfr, Ellipse torpedo, l(2)57Ea, top: torpedo, EGFr, DER, Elp-B1RB1, egfr, DER orpedo, flb: faint little ball, Egf-r, top/flb, CG10079, El: Ellipse, Drosophila epidermal growth factor receptor homologue, Torpedo, epidermal growth factor, Torpedo/DER, Degfr, D-Egf, Elp-B1, Der: Drosophila epidermal growth, top, Torpedo/Egfr, DER/top, EGF, EGF receptor, DER-Ellipse, torpedo, SFO062, epidermal growth factor receptor, l(2)05351, DER/EGFR, EGFR, Drosophila epidermal growth fact, DmHD-33, Elp-1, EgfR, Der, faint little ball, EGF Receptor, l(2)57EFa, C-erb, Egf, DER flb, Elp, flb, l(2)57DEFa, DER/faint little ball, Egfr, top/DER, l(2)09261, c-erbB, EGF-R, EK2-6, Der: Drosophila epidermal growth factor receptor homologue, torpedo/DER, EGF-receptor, Ellipse, HD-33
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 57F5--8,

Classification

Group: TK
Family: EGFR

Sequence

Name Sequence Type Origin Length Description Download
Egfr.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
Egfr.AA Protein Various 1426 None Fasta, JSON

Protein domain

Protein domains of Egfr.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain Egfr.AA Recep_L_domain 128-239 39 7.5e-39 132.35 Pfam 1-121 (121) Show / Hide 
Range on Protein: 128-239
Range on HMM: 1-121/121
Sequence Identity: 39% (49 aa)

NCTYVDGNLELTWLPNEN---LDLSFLDNIREVTGYILISHV--DVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSK---MYTLEIPDLRDVLN--G
||| ..||||.||  . |    ||||. ||||.|||.|| ..   ..  .||.|.|||||.||      ..|||.. . .   .. |  . |.....  |
NCTVIYGNLEITWRDEHNELEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHD----DNYALYIYDNPNMGLQELWMWNLKNITRKNG

QVGFHNNY--NLCHMRT-IQWSEIV
.| .|||   .||...| |.|..|.
GVYIHNNPHPKLCYTHTEIMWWMIY
Furin-like Egfr.AA Furin-like 255-404 42 5.1e-79 259.71 Pfam 1-182 (182) Show / Hide 
Range on Protein: 255-404
Range on HMM: 1-182/182
Sequence Identity: 42% (78 aa)

ERECP--------KCHESC------THG--CWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPT-QKDCIACKNFFDEGVCKEECPP
.||||        .||..|      ..|  |||..|..||...|  | .|| ..||.||||.||||  |.||||||. ..||.||..|...|.|...|||
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPP

MRKYNPTTYVLETNPEGKYAY-GATCV--KECP--------GHLLRDNGACVRSCPQDKM----DKGGECVPCNGPCPKTCP
|  |||||. .|.||.|.| . |..||  ||||         ... .||.|.| ||....    .. ..|.||.|||||.| 
MMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKLSHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU Egfr.AA FU 299-343 34 2.9e-10 41.35 SMART 1-48 (48) Show / Hide 
Range on Protein: 299-343
Range on HMM: 1-48/48
Sequence Identity: 34% (17 aa)

PREC--CHLFCAGGCTGPTQKDCIACKNFFDE---GVCKEECPPMRKYNP
 ..|  ||  ||.||.||.. .|..|.....    |.| ..||   .|.|
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCP--PGYYP
FU Egfr.AA FU 255-295 35 6e-06 26.91 SMART 1-48 (48) Show / Hide 
Range on Protein: 255-295
Range on HMM: 1-48/48
Sequence Identity: 35% (17 aa)

ERECPKCHESCTHGCWGEGPKNCQK---FSKL----TCSPQCAGGRCY
...|..||..| .|||| || .|..   .  |    || .||  |  .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain Egfr.AA Recep_L_domain 419-548 36 8.6e-44 148.95 Pfam 1-121 (121) Show / Hide 
Range on Protein: 419-548
Range on HMM: 1-121/121
Sequence Identity: 36% (50 aa)

NCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSS---LYSL
|||||.||..|. ......                ..| |..|....||||||.| .| ... ||| |.||..|.||||......||.|.. .   |..|
NCTVIYGNLEITWRDEHNE----------------LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQEL

EMRNLKQISS--GSVVIQHNR--DLCYVSN-IRWPAIQ
 |.||| |..  |.|.|..|   .|||.   |.|. | 
WMWNLKNITRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
FU Egfr.AA FU 563-612 30 1.4e-09 39.1 SMART 1-48 (48) Show / Hide 
Range on Protein: 563-612
Range on HMM: 1-48/48
Sequence Identity: 30% (16 aa)

ADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFN---GTCIADCGYISNA
.. |      |...| . ||||.| |||..|.....    |||...|   ...
DGVC----KPCHPECAT-GCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Furin-like Egfr.AA Furin-like 581-606 40 0.000726 13.29 Pfam 72-98 (182) Show / Hide 
Range on Protein: 581-606
Range on HMM: 72-98/182
Sequence Identity: 40% (11 aa)

GCWGAG-TDQCLTCKNFNFNGTCIADC
|| | . .  |. |..|..|||| . |
GCTGPNNDTDCVACRHFYHNGTCVDQC
FU Egfr.AA FU 617-660 45 1.1e-14 55.98 SMART 1-48 (48) Show / Hide 
Range on Protein: 617-660
Range on HMM: 1-48/48
Sequence Identity: 45% (22 aa)

NRTCKICHPECRT-CNGAGADHCQECVHVRDGQH---CVSECPKNKYN
...|| ||||| | |.|.|.|.|..| | ....|   |||.|| . | 
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
FU Egfr.AA FU 662-717 29 6.2e-11 43.57 SMART 1-48 (48) Show / Hide 
Range on Protein: 662-717
Range on HMM: 1-48/48
Sequence Identity: 29% (17 aa)

RGVCRECHATCDG-CTGPKDTIGIGACTTC-NLAIINNDATVKRCLLKDDKCPDGYFW
.|||..||..|.. |.||.     ..||.| .   ....    .|.    .||.||..
DGVCKPCHPECATGCWGPG----PDQCTSCPHGYYLHHN---GTCVS---QCPPGYYP
Furin-like Egfr.AA Furin-like 643-676 25 6.68885 0.29 Pfam 144-182 (182) Show / Hide 
Range on Protein: 643-676
Range on HMM: 144-182/182
Sequence Identity: 25% (10 aa)

HVRDGQHCVSECPKNKY----NDRGVCRECHATCD-GCT
.| ..  |. |||....    |... |  |  .|.  |.
YVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
Furin-like Egfr.AA Furin-like 617-639 32 7.9163 0.05 Pfam 1-40 (182) Show / Hide 
Range on Protein: 617-639
Range on HMM: 1-40/182
Sequence Identity: 32% (13 aa)

NRTCK--------ICHPECRT---------CNGAGADHCQ
||.|          ||| |.|         | |....|||
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQ
FU Egfr.AA FU 734-779 30 4.6e-08 34.02 SMART 1-48 (48) Show / Hide 
Range on Protein: 734-779
Range on HMM: 1-48/48
Sequence Identity: 30% (15 aa)

RAVCRKCHPLCEL-CTNYGYHEQVCSKCTHYKRR---EQCETECPADHYT
. ||..||| |.  |.  |  .  |..| |..      .| ..||. .|.
DGVCKPCHPECATGCWGPG--PDQCTSCPHGYYLHHNGTCVSQCPPGYYP
FU Egfr.AA FU 783-839 32 2.5e-13 51.54 SMART 1-48 (48) Show / Hide 
Range on Protein: 783-839
Range on HMM: 1-48/48
Sequence Identity: 32% (19 aa)

QRECFQCHPECNG-CTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRH
...|  ||||| . |.|||.|.|.||....... |            | |.||    .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN----------GTCVSQCPPGYYP
Furin-like Egfr.AA Furin-like 789-810 54 0.526583 3.91 Pfam 65-88 (182) Show / Hide 
Range on Protein: 789-810
Range on HMM: 65-88/182
Sequence Identity: 54% (13 aa)

CHPEC-NGCTGPG-ADDCKSCRNF
||..|  |||||. . || .||.|
CHEQCLGGCTGPNNDTDCVACRHF
Kinase Egfr.AA EGFR 938-1195 65 2.6e-189 633.94 In-house 1-258 (258) Show / Hide 
Range on Protein: 938-1195
Range on HMM: 1-258/258
Sequence Identity: 65% (168 aa)

LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGS
|.|..|||.||||.||||.|.|||||||||||||.| ..||....||.|.|||.||||.|..|..||.|||.|||.|.||.||.||||||||...|.|||
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIGS

KALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFG
..||||..||||||.||||.|.||||||||||||..|. ||||||||||||..|..||.|.||||||||.|||||..|..|..||||..|||.|||.|||
QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFG

QRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFA
|.|...|||..||||.|.| .|.||.||..|.|.....||..|..||||||.|...| 
QKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase Egfr.AA TyrKc 938-1194 37 2e-127 430.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 938-1194
Range on HMM: 1-280/280
Sequence Identity: 37% (109 aa)

LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASV--EHVNLLKLLAVCMS--------SQMMLITQLMPLGCLLDY
...| .|| ||||.||||.|        |.||.| | ...     |.|.||| || ..  .| |...|..||..         ..|... .||.|.|.||
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

VRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSD------SNEYKAA---GGK--MPIKWLALECIRNRV
 |..|.|.  | ||....|||.||.||..|...||||||||.||  .  |||.||||.. . .|      .  |...   |||  .||.|.|.|||. ..
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FTSKSDVWAFGVTIWELLTFGQRPHEN-----IPAKDIPDLIEVGLKLEQPEI--------CSLDIYCTLLSCWHLDAAMRPTFKQLTTVF
||.|||||.|||..||..|.|| |...     ......  ... |  ..||.         |. ..|   ..||| |...||||...   |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Egfr.AA Pkinase_Tyr 938-1194 42 3.3e-127 431.43 Pfam 1-270 (270) Show / Hide 
Range on Protein: 938-1194
Range on HMM: 1-270/270
Sequence Identity: 42% (116 aa)

LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAES--SEEFLREAYIMASV-EHVNLLKLLAVCM--SSQ--MMLITQLMPLGCLLDYVRN
...| .|| ||||.||||.| ....| |||||.| |  ..  |   .|.|.||| || .   | |...|..||.  . .  ..... .||.|.|||| |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---RDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNE-YKAAGGKMPIKWLALECIRNRVFTSKSDVWAF
.   ....  | ||....||||||.|||.|...||||||||.||  .  |||.|||||... .|..  .|. |||.||||.|.|||....||.|||||.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVTIWELLTFGQRP-HENIPAKDIPDLI-EVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVF
||..||..|.|. |  ....  .. ..| | |  ...|| |. .||  ...||| |...||||...   .
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Egfr.AA TK 938-1194 22 7e-107 359.45 In-house 1-486 (486) Show / Hide 
Range on Protein: 938-1194
Range on HMM: 1-486/486
Sequence Identity: 22% (110 aa)

LRKGGVLGMGAFG---RVYKGVWVPE---------------------GENVKIPVAIKELLKSTGAESSE-------------EFLREAYIMASVE----
.. | .|| |.||   .|||| | ..                     .|..|.|||.| | . ..... |             .||.|| .|.       
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HVNLLKLLAVCMSSQ-------------MMLITQLMPLGC----LLDYVRNNRDK--------------------------------------------
 | |...|..||. ..             .|... .||.|.    |.|| |..|.|                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IGSKALLNWSTQIAKGMSYLEEK------RLVHRDLAARNVLVQTPSL-----------VKITDFG---
                               .  . || .. |||.||.||..|      ..|||||||||.||                .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLLSSDSNEYKAA------------------------GGKMPIKWLALECIRNRV---------FTSKSDVWAFGVTIWELLTFG-QRPHENI
     ||. . ||.. |..                         |||.||.|.| ||.. ||         ||.|||||.|||..||..|.| . .....
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PA---------KDIPDLIEVG--------------LKLEQPEICSL-------------DIYCT-LLSCWHLDAAMRPTFKQLTTVF
.          ... .... |              . ..||. |.              ..|   ...|||.|.. ||||.||   .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Egfr.AA TK-Unique 938-1194 33 4.2e-88 299.02 In-house 1-294 (294) Show / Hide 
Range on Protein: 938-1194
Range on HMM: 1-294/294
Sequence Identity: 33% (98 aa)

LRKGGVLGMGAFGRVYKGVWVP--EGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVE-HVNLLKLLAVCM-SS-QMMLITQLMPLGCLLDYVRNNR
|. | |.|.|||| |..|  ..  .... .. ||.| | ..   ..  .||.|. .| ..  | |....| .|. |. ..|.|   .| |.|..| |..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

DK-------------------------IGSKALLNWSTQIAKGMSYLEE--KRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAG--GKMP
..                         | .| |...  |||.||.||..  |. |||||.|||||..    .||.|||.|. ..   ..|   .  |..|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIP

IKWLALECIR--NRVF-TSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEIC-SLDIYCTLLSCWHLDAAMRPTFKQLTTVF
|.|.|.| ..   ... |.|||||.|||..||..|.|..|  ..|.||| ..|. |  ..||| | | ..|  . |||.... .||.| |.. ..
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase Egfr.AA UTK 938-1194 30 8.1e-87 294.74 In-house 1-296 (296) Show / Hide 
Range on Protein: 938-1194
Range on HMM: 1-296/296
Sequence Identity: 30% (90 aa)

LRKGGVLGMGAFGRVYKGVWVPEGENVKI-PVAIKELL-KSTGAESSE---EFLREAY---IMASVE-HVNLLKLLAVCMSSQ-MMLITQLMPLGCLLDY
.. |  || |||| |.|. .... | ..   ||.|..  ....  ..|   .|..||    .|. .. |.|.|.|..||.... .|..| .|. | |..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

VRNNRDKIG-------SKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTP-------SLVKITDFG---LAKLLSS--------DSNEYKAAG-GK
.|..|.. .       .  .| .. .|| ||.||.....|||||||||.||          ...|| |||   .......        .|..|.|.. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

MPIKWLALECIRNR-VFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVG--LKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVF
.||.| | |.. ..  ||.|||||.|||. ||..|.|..| ... . ..   .. |  . ...|. |....|  ...||| | ..||.|..|. ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Egfr.AA Src 938-1194 38 2.7e-84 286.27 In-house 1-255 (255) Show / Hide 
Range on Protein: 938-1194
Range on HMM: 1-255/255
Sequence Identity: 38% (101 aa)

LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSS-QMMLITQLMPLGCLLDYVR--NNRDK
..    || | || |..|.|     | ...||.| | . |   | | ||.|| || .. | .|..|.|||        .| .|  |.|||| .      .
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

IGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEY-KAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWEL
.  . |.  ..|.|.||.|||.....||||||||||| . ...|. |||||.|.  | .||    | |.|||| | |.|. ..|| ||||| ||. ..|.
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

LTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYC-TLLSCWHLDAAMRPTFKQLTTVF
 |.|. | .    ..  . .| | .. .|. |   .|   .| ||| |.  ||||. |  ..
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Egfr.AA Ack 938-1194 37 2.4e-83 281.01 In-house 1-266 (266) Show / Hide 
Range on Protein: 938-1194
Range on HMM: 1-266/266
Sequence Identity: 37% (99 aa)

LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAES--SEEFLREAYIMASVEHVNLLKLLAVCMSSQM-MLITQLMPLGCLLDYVRNNRD-
.. .  || | || | .|.|     .  |.||.| |    .     ...||||. || | .| .|..|  |  .. | |..| | |.| |||  |     
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRT

-KIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTP-SLVKITDFGLAKLLSSDSNEYKAAGGK---MPIKWLALECIRNRVFTSKSDVWAFGV
 .     |.... |||.||.||| ||..||||||||.|. ..  .||| ||||   |    . |. .. .    |. | | ||.| | |...||||.|||
AFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGV

TIWELLTFGQRPHENIPAKDIPDLIE-VGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVF
|.||  ..|. |    .. .|  .|.  |  |..|. |. |||  .. ||  ..| |||| ..   .
TLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase Egfr.AA Syk 938-1188 39 8.3e-81 274.77 In-house 1-257 (257) Show / Hide 
Range on Protein: 938-1188
Range on HMM: 1-257/257
Sequence Identity: 39% (102 aa)

LRKGGVLGMGAFGRVYKGVWVPE---GENVKIPVAIKELLKSTGAE--SSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNR
| ..  .| | || | ||.       || . |.||||  ||  . .  . .||.||| .|.  .|    ... .|   .||..  . .|| ...|  ..|
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIK-MLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHR

DKIGSKALLN-WSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKA-AGGKMPIKWLALECIRNRVFTSKSDVWAFGVTI
. |  .. |  | ||.| || |||||  |||||||||||  .    || |||. | |  ||..|.|  .|| |.|| | |||  . | .||||| ||||.
HEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTM

WELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFK
|| .  ||.|   .   .. ..|| |  ...|. |  ..|    .||  ..  |||| 
WEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase Egfr.AA Met 939-1188 32 1.1e-72 237.57 In-house 1-271 (271) Show / Hide 
Range on Protein: 939-1188
Range on HMM: 1-271/271
Sequence Identity: 32% (89 aa)

RKGGVLGMGAFGRVYKGVWVP-EGENVKIPVAIKELL--KSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQM---MLITQLMPLGCLLDYVRNNR
 .. |.| | || ||.|   .  |.  ....|.| |     |  .  ..||||. .|   .| | |.|. .|...     . ..  |  | |. ..||  
HFDDVIGQGHFGCVYHGMYHDNDGN--EHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQ

DKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLL----SSDSNEYKAAGGKMPIKWLALECIR---------NRVFTS
  .  . |.    |.||||.|. ... ||||||.|| .      ||. ||||.  .    .. | . . .  . |.||.|.|| .         .|.||.
NNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTT

KSDVWAFGVTIWELLTFGQRPHENIPA-KDIPDLIEVG--LKLEQPEICSLDIY-CTLLSCWHLDAAMRPTFK
||||| ||| .|||.| |  |  ..    ||    . |    | ||| |   .|    |.||| ....||.| 
KSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase Egfr.AA Abl 938-1194 41 5e-72 239.46 In-house 1-252 (252) Show / Hide 
Range on Protein: 938-1194
Range on HMM: 1-252/252
Sequence Identity: 41% (109 aa)

LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVC-MSSQMMLITQLMPLGCLLDYVR-NNRDKI
.     || | .| ||.|||       .  ||.| |   | .   .|||.|| ||  ..| || .|| ||   .   .||  |. | ||||.| ..|...
IMMKHKLGGGQYGEVYEGVW----KRHDCTVAVKTLKEDTME--VHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREEL

GSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKA-AGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELL
 . .||   |||| ||||||..  .|||||||| ||    .||. |||||...  |   | | || | |||| | | .    | |||||||||| .||. 
PAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDT--YTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIA

TFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVF
|.|  |   |  ... ...| | ..|.|| |  ..|  .. ||. ... ||.||..   .
TYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase Egfr.AA Csk 938-1194 39 7.6e-71 240.96 In-house 1-251 (251) Show / Hide 
Range on Protein: 938-1194
Range on HMM: 1-251/251
Sequence Identity: 39% (103 aa)

LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQ--MMLITQLMPLGCLLDYVRN-NRDK
|  |   | | || |  | .     | |  ||.|  .|  | .  . || || .|   .| || .|. | . ..  . ...  |  | |.||.|   |  
LHLGECIGHGEFGDVMQGEY----QNRK--VAVK-CIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHV

IGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELL
|. . ||  .  ...|| |||.| .|||||||||.||      |. ||||||  .| . .  ...||.|||| | |  |.  |..||||| ||. .||. 
ITRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDD--STSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIY

TFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVF
 ||  |   || ||.   .|.| . | || |   .|    .||||..|.||||.|.    
SFGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase Egfr.AA S_TKc 938-1195 21 1.7e-41 145.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 938-1195
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPL--GCLLDYVRNNRDK-
 ... ..| ||||.|||....      .  ||||..         | ..||  |. .  | |. ||. |. .. . ... ...   | |.|| .... . 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

----IGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTS-KSDVWAFGVT
    .       .  ||.... |. ... .||||   |.|. .   .||.|||||..|                 ..| | .    ..  |.|.|..|..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTT--------VFA
..|.|. |. | .     ..  .... .        | .    .  |.. | . |||  .. .         . 
LYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Egfr.AA Pkinase 938-1194 22 3.8e-36 128.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 938-1194
Range on HMM: 1-293/293
Sequence Identity: 22% (69 aa)

LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEE--FLR--EAYIMASVEHVNLLKLLAVCM-SSQMMLITQLMPLG----CLLDYV
...|...| |.||.|||.... .|.     ||.|.. |. ...|...   .|  |..||... | | ..|. ... .. . ... ... |     | ||.
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

R-NNRDKI--GSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQ-TPSL---VKITDFGLAKLLSSDSNEYKAAGGKMPIK----WLALECIR-NRV
.  .. ..    . . .. .||..|. |. ... .||||   |.|.  .. .   |||.||||||...     |   .  . .     ..| | || .. 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQY

FTSKSDVWAFGVTIWELLTFGQRPHENI----PAKDIPDLIEVGLK----LEQPEICS-------------------LDIYCTLLSCWHLDAAMRPTFKQ
 ..|.|.|..|....|.|. |. |  .     .  |   .|.  ..     . |. ||                    .    . .|...| . |||..|
YGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LTTV--F
.     |
ILQHPWF