Gene Eph (Fruit Fly)

Eph

Species: Fruit Fly
Alias: CG1511, RPTK Dek7, Dek7, Eph, Drosophila eph, SFO054, dek, Deph, DEK, Dek, eph, Ek7, CT3831
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 102C5--6,

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
Eph.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
Eph.AA Protein Various 1096 None Fasta, JSON

Protein domain

Protein domains of Eph.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd Eph.AA Ephrin_lbd 84-261 43 6.2e-105 327.25 Pfam 1-190 (190) Show / Hide 
Range on Protein: 84-261
Range on HMM: 1-190/190
Sequence Identity: 43% (84 aa)

QVVLLDTTREAT-LEWTRYPYGPQAQ----TPGWVEESFTDFVKGINWRSYVVC-DVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSC
.|||.||. . . |.|| |||. ...    .|.| | |..|  .|...| |.|| .|...|.||||....|.|. |.|.|.|..||.|||. |||.| .|
EVVLMDTKTATSDLGWTTYPYN-GRDDFWMEPQWEEVSGMD-ENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTC

KETFSLLFYEFDA---ATREPPPWQTDSYRLIARIAAGEGR-----FNQNSDVDINTEVKSI-AVNKKGVYFAFRDQGACISVLAVKVYYITC
||||.|..||.|.   |..|.|.|... |. | .||| | |     |.... . .||||.||  ..|.|.|.||.|||||.....|.|||..|
KETFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRW-MKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd Eph.AA EPH_lbd 84-261 40 1.1e-85 291.93 SMART 1-184 (184) Show / Hide 
Range on Protein: 84-261
Range on HMM: 1-184/184
Sequence Identity: 40% (77 aa)

QVVLLDT-TREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAY---HNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNAL-SCK
.|||.|| |... |.||.||.    ....| | | .|. . ...| |.||.|..   .| ||||.. .|.|..|.| |.|..||.|||. .||.|  |||
EVVLMDTKTETGELGWTTYPP----HGGTWEEVSGMDEHH-NPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCK

ETFSLLFYEFDAATR--EPPPWQTDSYRLIARIAAGEGRFNQN----SDVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITC
|||.| .||.|....  . |.|... |. | .||| |. ....    . ...|||| |.  ..|||.|.||.|||||.....|.|.| .|
ETFNLYYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRV-MKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 Eph.AA GCC2_GCC3 322-362 33 0.000261 16.98 Pfam 1-43 (49) Show / Hide 
Range on Protein: 322-362
Range on HMM: 1-43/49
Sequence Identity: 33% (15 aa)

GYEPNYTNKTCTECPLGTFKSPEVTK-CTPCPPNSNAS---KTGS
|.  |  ...|. || ||... |  . | ||||. . .   ..||
GTYYNKGQNPCEPCPRGTYQNEEGQDSCIPCPPG-K-TTTDYPGS
FN3 Eph.AA FN3 387-480 18 4e-11 44.19 SMART 1-69 (69) Show / Hide 
Range on Protein: 387-480
Range on HMM: 1-69/69
Sequence Identity: 18% (20 aa)

PAAPTN---LTLLFVDQT------SAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPV----TTYTVQIHA
| .|.|   |..  |. |      |. .||..|                  ||. .                       |.|.|.|     |.|.... |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------------------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRA

INS--VSHI
.|.  .   
VNGNDAGEG
FN3 Eph.AA FN3 531-613 18 7.5e-08 33.32 SMART 1-69 (69) Show / Hide 
Range on Protein: 531-613
Range on HMM: 1-69/69
Sequence Identity: 18% (18 aa)

LSTVFN---LRILAITNK------DADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLEN----TEYGFQVRCKTN--NGFG
 . . |   ||. ..|.        . |.|..|          .|..                    . . || ..    ||| |.||...   .| |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR-------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase Eph.AA Eph 741-999 73 2e-208 698.74 In-house 1-264 (264) Show / Hide 
Range on Protein: 741-999
Range on HMM: 1-264/264
Sequence Identity: 73% (195 aa)

ITIEAIIGGGEFGDVCRGRLKIP--PNFVQDID-VAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVND
|.||..||.||||.||.|||| |   . |. .| ||||||| |..||.|.|||.||||||||||||.|.|.||||.|.||||.||||||||||.||| .|
IKIEKVIGAGEFGEVCCGRLKLPSGKREVW-VDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHD

GKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENAS---DAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVV
|.|...||. ||||||||| ||||||||||||||||.|||..|.||..||||||..|. .   ..|||||||||.|||||||||.|||||||||||||.|
GQFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIV

LWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL
.||||||||||||..|||||||.||.|||||.||||||||.|||||||||.|.|||.|..|||.|
MWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase Eph.AA Pkinase_Tyr 741-999 43 2.5e-145 492.82 Pfam 1-270 (270) Show / Hide 
Range on Protein: 741-999
Range on HMM: 1-270/270
Sequence Identity: 43% (117 aa)

ITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKA--RCDFLTEASIMGQF-DHPNVIYLQGVVT-RSNP--VMIITEYMENGSLDTFLR
||.   .| |.||.|..|..|      ..|.||.|.||.|.....  | ||. ||.|| |. .|||.. | ||.| .. |  ..|..|||..|.|...||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VN---DGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDA-YTTRGGKIPVRWTAPEAIAFRKFTSASDVWS
 .   .... . .|. | . ||.||.||...|..||||||||.||. ....||.||||.| |.| .   ... |||.|..|.|||.|...|||..|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGVVLWEVMSYGERP-YWNWSNQDVIKSI-EKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL
.||..||...||| | |...||..|.. | |.|||.|.|..||. .|.||..||...  .||||. |.. |
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Eph.AA TyrKc 741-999 40 1.7e-136 460.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 741-999
Range on HMM: 1-280/280
Sequence Identity: 40% (117 aa)

ITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQF--DHPNVIYLQGVVTRS-------NPVMIITEYMENGSLDT
|| . ..| |.|| |..|..|        |.||.|.||...    | ||. ||.|| ..  .|||.. | ||.| .        |.||..|||..|.|. 
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENA------SDAYTTR---GGK--IPVRWTAPEAIAFR
.|| . .|... .|. .   ||.||.||...|..||||||||.||......||.||||||.|..       .| |...   |||  .|.||.|||.| ..
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

KFTSASDVWSYGVVLWEVMSYGERPYWN-----WSNQDVIKSIEKGYRLPAPMD--------CPEALYQLMLDCWQKQRTHRPTFASIVSTL
|||..|||||.||..||...||. ||..      |||.||. ...|||.| | .        ||...||.|..||. .   ||||. |.. .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Eph.AA TK 741-999 24 3.2e-124 418.59 In-house 1-486 (486) Show / Hide 
Range on Protein: 741-999
Range on HMM: 1-486/486
Sequence Identity: 24% (118 aa)

ITIEAIIGGGEFG---DVCRGRLKIP-PNFVQD-------------------IDVAIKTLKPGSSEKARC-------------DFLTEASIMGQFD----
||..  .| |.||   .|..|... . |.  ..                   ..||.|.||.|... ..              ||| ||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVIYLQGVVTRS------------NPVMIITEYMENGS----LDTFLRVNDGK--------------------------------------------
 |||.. | ||.|..             |.||..|||..|.    |...|| ...|                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FQTLQLIVMLRGIASGMSYLSDM------NYVHRDLAARNVLVNAQLI-----------CKIADFG---
                               . . ||. | . ||.||.||...      |.|||||||||.||. ...           |||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSREIENASDAYTTR------------------------GGKIPVRWTAPEAIA---------FRKFTSASDVWSYGVVLWEVMSYG-ERPYWNW
     |.|.|.. .| |...                        |||.|.||.|||...         ..|||..|||||.||..||...|| | .|...
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------QDVIKSIEKG--------------YRLPAPMDCP--------------EALYQLMLDCWQKQRTHRPTFASIVSTL
||         |.|.. ...|              .|.|.|..||              |..|.||..||...  .||||. ... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Eph.AA UTK 741-999 37 3.5e-116 392.27 In-house 1-296 (296) Show / Hide 
Range on Protein: 741-999
Range on HMM: 1-296/296
Sequence Identity: 37% (110 aa)

ITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSS-EKARC---DFLTEAS---IMGQFD-HPNVIYLQGVVTRSNPVMIITEYMENGSLDTF
. . . .| |.||.|...|.. ... ... |||.|....... .....   ||. ||    .|.||. ||||. |.||.|.. | ||.|||||||.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------VNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQ-------LICKIADFG---LSREIEN--------ASDAYTTRG-GK
||        ..  .   |.. | . ||.||.||. ...|||||||||.||...       ..|||||||   .||.. .         |. |. .. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPVRWTAPEAIAFR-KFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKG--YRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL
.|.||.||||.. . .||..|||||.|||.||....| .|| ..||..|......|  ||.|.| |||...|.||..||..    ||.|  .|...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Eph.AA Src 741-999 43 3.4e-111 375.72 In-house 1-255 (255) Show / Hide 
Range on Protein: 741-999
Range on HMM: 1-255/255
Sequence Identity: 43% (115 aa)

ITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLR-VNDGK
|. .  .| | ||.|  |       . . ..||.||||||.   .  .|| || || ...|.... |  |...  |. |.||||..||| ..|.   .|.
IKLCRKLGQGQFGEVWMGY------WNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGR

-FQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAY-TTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWE
  .  ||| |   .|.||.||. |||.|||||||||||. ...||.||||| | |..  | |    | |.|..||||||| ...||  |||||.|. |.|
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

VMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQ-LMLDCWQKQRTHRPTFASIVSTL
...||  ||  ..|..|.. .|.|||.| |. ||. ||. .|| ||.|.   ||||. . . |
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Eph.AA SFK-Src 741-1003 41 8.49999999999e-105 311.55 In-house 1-259 (259) Show / Hide 
Range on Protein: 741-1003
Range on HMM: 1-259/259
Sequence Identity: 41% (111 aa)

ITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKF
|  |   | | |||| .||        .  .||.||||||.       || || .| .  ||| | |  | |   |. |||| | .|||  .|.   |. 
IRLEKKLGSGQFGDVWKGR------WNNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRS

QTLQLIV-MLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTR-GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEV
 .... | |   .|.|| || . |.||||||||||||    .||..|||.|| ... .  || . | | |..||||||    .|   |||||.|. . |.
LRMPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEI

MSYGERPYWNWSNQDVIKSIEK--GYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLA
  ||  ||   .|. |.. ...  |||.|.|  ||...|..|.||||..   |||| |    ...  
VTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase Eph.AA Fer 741-1000 34 5.4e-95 321.9 In-house 1-283 (283) Show / Hide 
Range on Protein: 741-1000
Range on HMM: 1-283/283
Sequence Identity: 34% (98 aa)

ITIEAIIGGGEFGDVCRGR----LKIPPNFV-QDIDVAIKTLKPG-SSEKARCDFLTEASIMGQ-FDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFL
.|.. ..| | ||.|..||    .| . ..|  ...|. |..|   .... . .|. || || . .|||||. . || .   |.||. |.. .||||..|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RVNDGK-FQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNA-QLICK--IADFGLSREIENASDAYTTR--GGKIPVRWTAPEAIAFRKFTSASD
. |..|   . ..| |. ..|.|| ||  .| .|||.||||.|. . .. .|  |.|||.||. .    .|. .    |.|.||.|||.. .. .....|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSYGVVLWEVMSYGERPYWN----WSNQDV----IKSIEK-GYRLPAPMDCPEALYQLML-DCWQKQRTHRPTFASIVSTLD
|||.||..||... |. || .      .  |    .| |.| ||..| |  .|....|.|. .||||    |||...|. .| 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase Eph.AA TK-Unique 741-999 33 2.4e-94 319.75 In-house 1-294 (294) Show / Hide 
Range on Protein: 741-999
Range on HMM: 1-294/294
Sequence Identity: 33% (99 aa)

ITIEAIIGGGEFGDVCRGRLKIPP-NFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFD-HPNVIYLQGVVTRS-NPVMIITEYMENGSLDTFLRVND
.... .|| |.|| |.|| .. .. .. ... ||.|.|| ....  . ||| |...| . . |||.. . |. |.| .|.||| ||...|.|...|| . 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GK-------------------------FQTLQLIVMLRGIASGMSYLSD--MNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRG--GKIP
..                          .  .|.  . .||.||.||.   .. |||||.|||||..  ..|||.|||..|....   .| . .  |.||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIP

VRWTAPEAIA--FRKF-TSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDC-PEALYQLMLDCWQKQRTHRPTFASIVSTL
.|| |||..    . . |. |||||.||..||....|..|| . .. |... |..|||.| |  | ....|.||  |||. ...||.|..|.. |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase Eph.AA Frk 741-1003 44 1.8e-88 300.25 In-house 1-260 (260) Show / Hide 
Range on Protein: 741-1003
Range on HMM: 1-260/260
Sequence Identity: 44% (118 aa)

ITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLR-VNDG-
| .   .| | ||.|  |.      . . . ||.||||||. .    ||| || || .  || .| |  | |. .|..|||| |..||| ..|. .||  
IQLIRRLGSGQFGEVWEGL------WNNTTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKG

-KFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSR-EIENASDAYTTRGG-KIPVRWTAPEAIAFRKFTSASDVWSYGVVL
 . |  ||. |   .|.|| || ..||.|||||||||||. ..||||||||| |  . .  | | .| | ..|..||||||.   |||  |||||.|..|
RQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILL

WEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLA
 |.. ||  ||    |..|.. ...|||.| | .||. ||..||.||...  .||||  .   |..  
TEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase Eph.AA SrcB 741-1000 45 3.7e-88 298.33 In-house 1-251 (251) Show / Hide 
Range on Protein: 741-1000
Range on HMM: 1-251/251
Sequence Identity: 45% (120 aa)

ITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGS-SEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGK
. ..  .| | ||.|  |  .      ... ||.||.|.|. | .|   || || .| .  |  .. |  |||.  |. ||||||..|.|  ||. ..| 
LKLVKKLGAGQFGEVWMGYYN------NHMKVAVKTMKQGTMSPEA---FLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGS

FQTL-QLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTR-GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWE
 ..| .|| |   || || |.  |||.|||| | |.|| . |.|||||||| | ||  .. || | | | |..||||||| |  ||  |||||.|..| |
KLSLPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIE--DNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLME

VMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLD
.. ||  ||   .| .||...|.|||.| |  ||| ||..|  ||...   ||||  . | ||
IVTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase Eph.AA Ack 741-999 38 1.1e-86 292.41 In-house 1-266 (266) Show / Hide 
Range on Protein: 741-999
Range on HMM: 1-266/266
Sequence Identity: 38% (105 aa)

ITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPG--SSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPV-MIITEYMENGSLDTFLRVND
||    .| |.|| | ||  . | .  . | ||.| |...  .. ..  ||| |..|| . |||... | ||| .. |  | .||  . ||| . ||  .
ITLCEKLGDGCFGVVWRGEWTNPGG--KHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVV-LDQPMLMMVTELAPCGSLLDCLRK-H

GK--FQTLQLIVM-LRGIASGMSYLSDMNYVHRDLAARNVLVNAQ-LICKIADFGLSREIENASDAYTTRGGK---IPVRWTAPEAIAFRKFTSASDVWS
 .  | .. ..   .. ||.||.||   . .||||||||.|. ..    ||.||||.|    . | |.. . .   .|  | |||.. .|.|..|||||.
CRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWM

YGVVLWEVMSYGERPYWNWSNQDVIKSIE-KGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL
.|| |||. |||| |.   .  .... |. .| ||| | .|||..||.|. |||..   ||||..|.  |
FGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase Eph.AA S_TKc 741-997 23 1.1e-42 149.07 SMART 1-220 (231) Show / Hide 
Range on Protein: 741-997
Range on HMM: 1-220/231
Sequence Identity: 23% (61 aa)

ITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMEN--GSLDTFLRVNDG
 .|  .|| | || |...| |       .  |||| .|        .... | .|. . .|||.. | .|    . . ...||...  |.| .... . .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

K-----FQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTS-ASDVWSYG
.     |   .   ... |.... |. ... .||||   |.|..     ||.||||.|..         .       . ||| .   ...  ..|.|| |
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

VVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVS
..|.| .. |. |..    | ..| |            .. . ...  |.||  ..|||   .  
CILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase Eph.AA Pkinase 741-999 21 2.9e-42 150.51 Pfam 1-293 (293) Show / Hide 
Range on Protein: 741-999
Range on HMM: 1-293/293
Sequence Identity: 21% (66 aa)

ITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARC--DFL-TEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENG----SLDTFL
..|. .|| | || |.... |  .       ||.|..|  . ..  .  ... .|..||  ..|||.. | ....... . ...||.|.|    .| ...
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

R-VNDGKF--QTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLIC----KIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIA-FRKFTSA
.  ..|.|  .  ... ... |..|. |. .|. .||||   |.|.. .  .    ||.||||.. ..       . .     .. ||| |   .. ...
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVWSYGVVLWEVMSYGERPYWNW----SNQDVIKSIEKGYRLPAPMDCP-----------------------EALYQLMLDCWQKQRTHRPTFASIVST
.|.||.|..|.|... |. |...     .  | .. |..  . | . |.|                       |.. ... .|..|  . |||.. |.  
VDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
SAM_1 Eph.AA SAM_1 1029-1093 34 1.4e-22 82.91 Pfam 1-66 (66) Show / Hide 
Range on Protein: 1029-1093
Range on HMM: 1-66/66
Sequence Identity: 34% (23 aa)

GQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSD-MGITLVGHQKKILHQARQLD
... | . . |||.|.|..|..|| .|..|. ......|.. | . ||.||.||.|||..  ..| 
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
Sam7 Eph.AA sam7 1031-1093 30 1.6e-17 60.13 In-house 1-70 (70) Show / Hide 
Range on Protein: 1031-1093
Range on HMM: 1-70/70
Sequence Identity: 30% (21 aa)

NIFISTDLWLEHIKM---SRYCHHFKEANL----INAQQISRLTAQQLSDMGITLVGHQKKILHQARQLD
  | .   |||.|.|   ..|| .|....     .. ... ..| . | .||||..||.|||... .|. 
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM Eph.AA SAM 1028-1095 26 7.6e-16 59.89 SMART 1-67 (67) Show / Hide 
Range on Protein: 1028-1095
Range on HMM: 1-67/67
Sequence Identity: 26% (18 aa)

RGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQLDTI
   . . .   |||.|.|..|. .|.....  ........ . | .||||..||.||||.  ... . 
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
SAM_2 Eph.AA SAM_2 1039-1093 30 4.7e-15 54.5 Pfam 12-71 (71) Show / Hide 
Range on Protein: 1039-1093
Range on HMM: 12-71/71
Sequence Identity: 30% (18 aa)

WLEHIKM-SRYCHHFKEANLINAQQI-SRLTAQQL--S-DMGITLVGHQKKILHQARQLD
||..|.|  .|.  |...... ....  ..|...|    .||||.|||.|||.... .. 
WLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK