Gene btl (Fruit Fly)

btl

Species: Fruit Fly
Alias: DFGF-R1, DmHD-311, SFO187, btl, HD-311, BTL/FGFR2, Fgf-r, devenir, Fgf-r: Fibroblast-growth-factor-receptor, CT20816, Fibroblast-growth-factor-receptor, 0844/01, Tk2, Fibroblast-growth-factor-recepto, dtk2, FGFR, Dtk2, fgf-r, DFR2, FGFR1, l(3)00208, Dfr-2, dev, FGF receptor, Btl, CG6714, Fgf-r: Fibroblast-growth-factor-
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 70D2,

Classification

Group: TK
Family: FGFR

Sequence

Name Sequence Type Origin Length Description Download
btl.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON
btl.AA Protein Various 1052 None Fasta, JSON

Protein domain

Protein domains of btl.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG btl.AA IG 40-105 20 0.442915 0.34 SMART 1-58 (58) Show / Hide 
Range on Protein: 40-105
Range on HMM: 1-58/58
Sequence Identity: 20% (15 aa)

PRQRHLLSDMDITLQCVRPMAKWFYEDKFQLRATLLRLERAQSGNS---GNYGC--LDSQNRWY--NISLVVG
|.        ..||.||    .|.           |.. ..|  .|   |.| |    . . |   .. | | 
PP-VTVKEGETVTLTCVS-QIWWY-----------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
I-set btl.AA I-set 75-90 31 24.693702 0.25 Pfam 60-75 (92) Show / Hide 
Range on Protein: 75-90
Range on HMM: 60-75/92
Sequence Identity: 31% (5 aa)

LRLERAQSGNSGNYGC
|. ...|.. .| | |
LTISNVQPDDEGKYTC
IG btl.AA IG 149-233 22 1.9e-10 41.97 SMART 1-58 (58) Show / Hide 
Range on Protein: 149-233
Range on HMM: 1-58/58
Sequence Identity: 22% (20 aa)

PKTVQRTAGGLFQLNCSPMDPDAKGVNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDA---GSYHCELCVEQDCQRS-NPTQLEVI
|. |   .|.  .|.|          .|.|.                   ||. ..||||.   | | |.      .. | ..|.|.| 
PP-VTVKEGETVTLTC-VS-------QIWWY-------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 btl.AA IGc2 155-221 25 7e-05 21.65 SMART 1-56 (56) Show / Hide 
Range on Protein: 155-221
Range on HMM: 1-56/56
Sequence Identity: 25% (17 aa)

TAGGLFQLNCS-PMDPDAKGVNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCVEQD
  |. ..|.|    .||.   ||.|.. ....         ..|.||.   .|||.| |.|. . .  
HEGQSVTLTCPATGNPDP---NIHWYK-GQPLP--------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set btl.AA I-set 176-214 25 0.001541 14.52 Pfam 32-75 (92) Show / Hide 
Range on Protein: 176-214
Range on HMM: 32-75/92
Sequence Identity: 25% (11 aa)

ISWLHNDTQIL--GGRGRIKLKR---WSLTVGQLQPEDAGSYHC
.||.... ..   . | ... .     .||. . ||.|.|.| |
VSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTC
V-set btl.AA V-set 141-232 18 0.018485 10.31 Pfam 1-128 (128) Show / Hide 
Range on Protein: 141-232
Range on HMM: 1-128/128
Sequence Identity: 18% (24 aa)

SLKLLQPLPK----TVQRTAGGLFQLNCSPMDPD--AKGV-NISWLH-NDT------------QILGG----------RGRIK------LKRWSLTVGQL
.. . |  |.     |    |.   |.|...|.    ...  |.|    ..            .   .          .||.        ...|||  .|
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

QPEDAGSYHCELCVEQDCQRSNPTQLEV
||.| | |.|    .   .  . |.| |
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
IG btl.AA IG 247-347 15 8.7e-10 39.76 SMART 1-58 (58) Show / Hide 
Range on Protein: 247-347
Range on HMM: 1-58/58
Sequence Identity: 15% (16 aa)

PRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDG---GWYICIAENQVGRTVA--A
|. ..  .|..|...|  .       |.|.                                     |.. || .||    | | | |.   | . .   
PP-VTVKEGETVTLTC-VS------QIWWY-------------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQG

SYVDLY
 ..  .
TTLTVQ
IGc2 btl.AA IGc2 253-336 20 1e-06 29.55 SMART 1-56 (56) Show / Hide 
Range on Protein: 253-336
Range on HMM: 1-56/56
Sequence Identity: 20% (17 aa)

ALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVG
  |..|...|   . . .| |.|..      ..                          . |.. || .|| | | |.|.| .|
HEGQSVTLTCP-ATGNPDPNIHWYK---GQPLP------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set btl.AA I-set 314-336 43 4.177187 2.87 Pfam 60-82 (92) Show / Hide 
Range on Protein: 314-336
Range on HMM: 60-82/92
Sequence Identity: 43% (10 aa)

LRLGNVLMEDGGWYICIAENQVG
|.  ||  .| | | |.|.| .|
LTISNVQPDDEGKYTCVATNSFG
IGc2 btl.AA IGc2 407-469 38 3.8e-18 67.54 SMART 1-56 (56) Show / Hide 
Range on Protein: 407-469
Range on HMM: 1-56/56
Sequence Identity: 38% (25 aa)

LSGNTVNLACP--VYGKANITWTKDKKPLNRELGVYVQKNWTLRFVEATSEDSGLYNCKVCNAWG
..|..| | ||   .  .||.|.|  .||.        .||||.. ..| ||||.| |...|.||
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG btl.AA IG 401-480 18 5.9e-09 37.0 SMART 1-58 (58) Show / Hide 
Range on Protein: 401-480
Range on HMM: 1-58/58
Sequence Identity: 18% (16 aa)

KRLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELGVYVQKNWTLRFVEATSEDS---GLYNCKVCNAWGCIQF--DFSVQIN
 . .    | ||.| | |    .|.|.                   |.. ... |||   | | | .   .|...    . ... 
PP-VTVKEGETVTLTC-VS---QIWWY-------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set btl.AA I-set 394-479 24 4e-06 23.28 Pfam 1-92 (92) Show / Hide 
Range on Protein: 394-479
Range on HMM: 1-92/92
Sequence Identity: 24% (23 aa)

PVFRKELKRLQHSLSGNTVNLACPVYGK-A-NITWTKDKKPLN----RELGVYVQ-KNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQI
|.| . .|... .  | |... | | |.    ..|.|| .||.    |   .|..  . ||.. .....|.| | |.. |  |  . ......
PKFTQKPKDVEVQE-GETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
V-set btl.AA V-set 442-464 30 0.461768 5.49 Pfam 90-112 (128) Show / Hide 
Range on Protein: 442-464
Range on HMM: 90-112/128
Sequence Identity: 30% (7 aa)

QKNWTLRFVEATSEDSGLYNCKV
.....|.   ....||| | | |
KNDFSLTISNLQPSDSGTYYCAV
IG btl.AA IG 492-584 19 1.8e-14 55.28 SMART 1-58 (58) Show / Hide 
Range on Protein: 492-584
Range on HMM: 1-58/58
Sequence Identity: 19% (19 aa)

PQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQE---GWYTCLASSGLGRSNS--SVYLRVV
|. .|||. ......| |      ...|.                              ||. ||... .   | |.| |.   |   |  ...|.| 
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 btl.AA IGc2 498-573 21 2.9e-07 31.36 SMART 1-56 (56) Show / Hide 
Range on Protein: 498-573
Range on HMM: 1-56/56
Sequence Identity: 21% (16 aa)

KVNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLG
.  .|....| .  .  |...|..    . .|.                ..  ||..|||....| |||.|..  |
HEGQSVTLTCPATGNPDPNIHWYK----GQPLP----------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set btl.AA V-set 485-583 14 0.000357 16.22 Pfam 1-128 (128) Show / Hide 
Range on Protein: 485-583
Range on HMM: 1-128/128
Sequence Identity: 14% (18 aa)

SAPIIV-VPQ----NQTVKVNGSLVMKCTVYSDL----HP-TVSWKR-VVL-------------KNASLDGLKSVEIQNLNFT----VTNDSVVLTLRNV
. .. .  |       ||.. .|. ..|.. .|     |. ...| |   .             .... .. .. .  . ..|     ..... ||..|.
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TFDQEGWYTCLASSG-LGRSNSSVYLRV
. . .| |.| ....  .   ... |.|
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set btl.AA I-set 538-583 31 0.00109 15.03 Pfam 46-92 (92) Show / Hide 
Range on Protein: 538-583
Range on HMM: 46-92/92
Sequence Identity: 31% (15 aa)

QNLNFTVTN-DSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRV
.  ..| .. .   || .||. | || ||| |.  .| . ... | |
DRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
I-set btl.AA I-set 486-521 25 0.030721 10.11 Pfam 1-36 (92) Show / Hide 
Range on Protein: 486-521
Range on HMM: 1-36/92
Sequence Identity: 25% (9 aa)

APIIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSWKR
  .. .|....|..  ..  .|.|  |  |.|||..
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFK
Kinase btl.AA FGFR 712-996 64 3.6e-232 777.58 In-house 1-293 (293) Show / Hide 
Range on Protein: 712-996
Range on HMM: 1-293/293
Sequence Identity: 64% (188 aa)

LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNR
|.||..||||.||.|.||||.|...... .|..|||||.|..|||.|...||.|||.|||||||.|||||||||.|.|||.|||||..||||.|||...|
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PGAPQRRSDSDGYLDDKPLISTQH--------LGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRL
|.......||..|.|.||....|.        |..|.|...|.|.||||||||||.|||||||||||||.|.|||||.||||||||....||||.|||||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESF
||||||||.|....|..||||||||||||||||||.||||||.|.||||.||..|.|||||..||..||..|.|||||..|.||||..|||..
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase btl.AA Pkinase_Tyr 712-996 45 3.2e-149 506.02 Pfam 1-270 (270) Show / Hide 
Range on Protein: 712-996
Range on HMM: 1-270/270
Sequence Identity: 45% (133 aa)

LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTD--MASLVREMEVMKMIGKHINIINLLGCCS-QGGP--LWVIVEYAPHGNLKDF
...|  |||||||.|..... |   .|.  .. |||||.|| ... .  .... ||...|| .|.| ||..|.|.|. ||.|  .....||.|||.|.|.
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYY-RKNTNGRLPI
|...|                    . |.|  |.| ....|||.|||||.|..||||||||||.||... |.||.||||||||....|| || ..|.|||
LRKHR-------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPI

KWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQP-YPHILSAEELYSYL-ITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESF
||||||.....|. ..|||||.|||.|||.|||.|| || . | ||.| |.   |.||..| .|.  || .|.||||..   ||||.|..| .
KWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase btl.AA TyrKc 712-996 40 1.6e-148 500.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 712-996
Range on HMM: 1-280/280
Sequence Identity: 40% (128 aa)

LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIG-KHINIINLLGCCSQG-------GPLWVIVEYAPHGNL
..|| .|||||||.|. ...           . |||||.||..    .. . ||...|...| .| ||..|.|.|.|.       .||....||.|||.|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

KDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDT-------EYYR
||.|. .||                       |  |.| .|..|||.|||||.|..||||||||||.||......||.||||.||| |        .|||
KDYLRKHRPK----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYR

KNT--NGR--LPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHI----LSAEELYSYLITGQRMEKPAK--------CSLNIYVVMRQCWH
| .  .|.  |||.|||||.....|. ..|||||.||..|||.|||.|||| .    .|..|.. |. .| ||..|.         |.  .| .|.||||
KKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

FESCARPTFAELVESF
..   ||||.|..| |
EDPEDRPTFSEIHECF
Kinase btl.AA TK 712-996 26 4.5e-127 428.31 In-house 1-486 (486) Show / Hide 
Range on Protein: 712-996
Range on HMM: 1-486/486
Sequence Identity: 26% (128 aa)

LSLGSILGEGAFG---RVVMAEAEGLPR------------------SPQLAETIVAVKMVKEEHTDTDMA----------------SLVREMEVMKM-IG
. ||  ||||.||   .| ..|..|...                  ..  ..| |||||.||........                ....||..|.. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHINIINLLGCCSQG------------GPLWVIVEYAPHGN----LKDFLKQNRPGAPQRRSDSDG----------------------------------
.| ||..|.|.|.||            .|.....||.|||.    |.|.|...||.. .  . .|.                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------YLDDKPLISTQH---------LGEKELTKFAFQIARGMEYLASR------RCIHRDLAARNVLVSDGYV-----------MKIADFG---
           |. | |.....         |  ..|  ...|||.|||||.|.      ...||||||||.||....|            ||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARDIQDTEYYRKNT------------------------NGRLPIKWMAPESLQ---------EKKYDSQSDVWSYGVLLWEIMTYGDQPYPHIL
     |||||.. ..|.. .                        .|.|||.|||||.|.         ..|. ..|||||.|||.|||.|||..||.  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SA---------EELYSYLITG--------------QRMEKPAKCS--------------LNIYVVMRQCWHFESCARPTFAELVESF
|          .|.. || .|               ||..|. |.                .| .|.||||..   ||||..|.| .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase btl.AA TK-Unique 712-996 38 1.5e-106 360.3 In-house 1-294 (294) Show / Hide 
Range on Protein: 712-996
Range on HMM: 1-294/294
Sequence Identity: 38% (119 aa)

LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGG-PLWVIVEYAPHGNLKDFLKQN
| .|...|||||| |  .|..|..  .. . ..|||||.|...|||| . . .| ..|| .|.|.||...||||   . |   | ||.| ||| ..|...
LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

RPG--APQ------------RRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLAS--RRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEY
||.   .|            ...... ... | |..           ||.|||.|||||||  ....||||.|||||.....| ||.|||.|||..... 
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH-----------FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGV

YRKN-TNGRLPIKWMAPESLQ--EKKY-DSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKC-SLNIYVVMRQCWHFESCARPTF
| .. . ||.||.|||||||.  .. |  ..|||||.|||.|||.|.| .||| . ... .   .  | ||..|..| |  .| .|..||. |   ||.|
YSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSF

AELVESF
....  .
RQIKHRL
Kinase btl.AA UTK 712-996 33 6.5e-96 324.94 In-house 1-296 (296) Show / Hide 
Range on Protein: 712-996
Range on HMM: 1-296/296
Sequence Identity: 33% (104 aa)

LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMAS----LVREME---VMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLK
. ||  ||.|||| | .|...  . |..  | .||||  ........       . .|     .||.   | |...|.| |.|..|.....||.. |.| 
VQLGRQLGQGAFGEVHKARFT--QCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

DFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDG-------YVMKIADFG---LARDIQ----
..|  .|| .|               . . .| . .....| .|||||.||.|....||||||||.|| .        .| ||||||   ..|...    
SYLRRHRPTPP---------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHF

-----DTEYYRKNTNGRLPIKWMAPESLQEK-KYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITG--QRMEKPAKCSLNIYVVMRQCWHFE
     ...||... ..|.||.|||||.| .  .. ..|||||.||..|||.|.| .|||. .|....   .  |  .||..|. |....| .|..||| .
SNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPG-MSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYD

SCARPTFAELVESF
   ||.| .||. .
PQERPDFEDLVQQM
Kinase btl.AA Ret 712-998 41 2.7e-94 319.57 In-house 1-293 (293) Show / Hide 
Range on Protein: 712-998
Range on HMM: 1-293/293
Sequence Identity: 41% (124 aa)

LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEE-HTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGG--PLWVIVEYAPHGNLKDFLK
| |.  |||| ||.|| | |  .   |    | ||||| |..  .      |  |... | .  | ..| |.| |.| .  |. .||||.  | |  || 
LQLDDTLGEGHFGQVVKAQAFHIRGHPGY--TTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLR

QNRPGAP-------QRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNG
 .|  .|        | . . .. | |  |    .| |..  || || .|| ||..   .||||||||||| .| ..|| |||| ||.     | |   .
LSRKIGPYYEYSIGNRNCSIVDHPDGKDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKD

RLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDG
|.|.||||.|||    | ..|||||.|||.||| | |  ||| |  .| |.. | || ||. |  ||  .| .|||||  |   || |. .   |  
RIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGI-PPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase btl.AA InsR 712-1002 33 6.9e-92 308.93 In-house 1-278 (278) Show / Hide 
Range on Protein: 712-1002
Range on HMM: 1-278/278
Sequence Identity: 33% (99 aa)

LSLGSILGEGAFGRVVMAEAEGLPRSPQLAET--IVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQ
. |.  .|.|.|| |    |.|..  |  ...   .|.| |.|. ....      | .||| . .. ....||| ||.| |  |. |   .|.||..|  
IVLIRECGQGSFGMVYEGIAKGIV--PDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEF-NCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRS

NRPGAPQRRSDSDGYLDDKPLI-STQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWM
 || . .          . ...   .     ...  | .|. || |||..  .|||||.|| .|.. .  ||.|||..||| .. |||| . | ||. ||
RRPEEEF---------NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWM

APESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYL-ITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQ
||||| . .....|||||.||.|||. | | |||   || |.   |  . |  ...|  |.   . .|..||.. . .|||| ....    .|..
APESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPY-QGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIH----YLCD
Kinase btl.AA Trk 712-996 35 1.2e-84 286.82 In-house 1-275 (275) Show / Hide 
Range on Protein: 712-996
Range on HMM: 1-275/275
Sequence Identity: 35% (103 aa)

LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNR
. |   |||||||.|..|| . |.  |.   ..||||  |.      .    || |.. .  .| .|. . | |  . ||  . ||  || |. .|.|  
IVLKWELGEGAFGKVFLAECYNLC--PEQDKMMVAVKTLKDASE-NARKDFQREAELLTNL-QHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHG

PGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQD-TEYYRKNTNGRLPIKWMAP
|       | . |.. .| ..   |. ...   | ||| || |.||   .|||.|.|| || .. ..||.|||. ||. . |.|||    . ||| || |
P-------DAMCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPP

ESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQR-MEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESF
|| . .|.   |||||.|| .||..||| ||.   ||  |  ..   |.  .|.| .|  ..| .|. ||. |   | .  .. .  
ESIMYRKFTYESDVWSFGVVMWECFTYGKQPW-YQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase btl.AA Src 712-996 37 9.7e-84 284.37 In-house 1-255 (255) Show / Hide 
Range on Protein: 712-996
Range on HMM: 1-255/255
Sequence Identity: 37% (108 aa)

LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNR
. |   ||.| || | |.   |        .| ||||  |. .   . . . .| ..||   .| ....|.  |||. |   . ||  ||.| |.||.  
IKLCRKLGQGQFGEVWMGYWNG--------NTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK--

PGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQ-DTEYYRKNTNGRLPIKWMAP
                     ..||  ..|  .| |.|.||.|| |.. ||||||||||||... | |.||||||| |. | . |   .  ..||||.||
------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAP

ESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYV-VMRQCWHFESCARPTFAELVESF
| ... ..   |||||.|.||.||.|||  |||    .| |   .  | || .|..|  ..|  .|.|||| .   ||||. | . .
EAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQ-VERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase btl.AA VEGFR 831-996 51 2.1e-81 276.76 In-house 165-332 (332) Show / Hide 
Range on Protein: 831-996
Range on HMM: 165-332/332
Sequence Identity: 51% (87 aa)

ISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARD-IQDTEYYRKNTN-GRLPIKWMAPESLQEKKYDSQSDVWSYG
.. . |  ..|  ..||.|||||.|||| ||||||||||.|..  .| || ||||||. | .   | . .. ||||||||||||. .| | ..|||||||
MWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYG

VLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESF
|.|||| . |  ||| .   ||... |  | ||..|  |   || .| .||| |  .||.|.|||| .
VFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase btl.AA PDGFR 841-996 50 5.5e-74 236.82 In-house 203-358 (358) Show / Hide 
Range on Protein: 841-996
Range on HMM: 203-358/358
Sequence Identity: 50% (79 aa)

LTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQ
|  |..|.|.|||.|||  |.||||||||||.  | | || ||||||||     |    | |||.|||||||. .  |  ||||||||.||||| . |  
LLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLGGN

PYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESF
||| ..  .. |     | ||..|.  . .|| .|..|| |..  |||| .|..  
PYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase btl.AA Pkinase 712-996 22 2.9e-46 164.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 712-996
Range on HMM: 1-293/293
Sequence Identity: 22% (74 aa)

LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMA-SLVR--EMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHG----NLK
. .|...|.|.||.|  .   | ..       ||||| .| .|.. ..  ...|  | ..||.. .| ||. |....  .. .... ||...|     |.
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

DFLKQNRPGAPQRRSDSDGYLDDKPLISTQHL--GEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVS-DGYV---MKIADFGLARDIQDTEYYRKN
|...                       .   .   |.|. ... ||.||.||. |...|||||   |.|.. .|..    ||.|||||. .. .  .. .
DYIST---------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-M

TNGRLPIKWMAPESLQ-EKKYDSQSDVWSYGVLLWEIMTYGDQPYPHI-----LSAEELYSYLITGQRMEK-PAKCS-------------------LNIY
|     . .|||| ..  ..|.. .|.||.|..|.| .. |  |.|.      ..  ...     .. ..  | .||                    .  
TTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

VVMRQCWHFESCARPTFAELVES--F
 ... |...    |||.......  |
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase btl.AA S_TKc 712-1000 23 4.7e-44 153.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 712-1000
Range on HMM: 1-231/231
Sequence Identity: 23% (69 aa)

LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPH--GNLKDFLKQ
  .. ..|.||||.|  .   .          |||.|..|         .. ||....|.  .| ||..|....   . |... ||...  |.|.|..|.
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

NRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMA
.... ....                 . | .  ... ||....||. |.. |||||   |.|...  . ||.|||||| .         |       .||
RGRHGLRFP-----------------FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMA

PESLQEKKYDS-QSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESF-----DGIL
|| |   .|.   .|.|| |..|.| .. |  |.|     ....  .            |      .|.|....   |||  |. ..      .  .
PEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase btl.AA VEGFR 712-811 45 3.2e-36 126.65 In-house 1-101 (332) Show / Hide 
Range on Protein: 712-811
Range on HMM: 1-101/332
Sequence Identity: 45% (47 aa)

LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCS---QGGPLWVIVEYAPHGNLKDFLK
| ||  ||.|||| |. |.| |. ...    |.|||||.||  |    . |. |..... ||.| |  |.||||    |.||| ||||| ..||| ..|.
LKLGKMLGRGAFGQVHEASAFGIRKMETC--TTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLR

QNR
  |
TKR
Kinase btl.AA PDGFR 712-811 44 1.2e-28 88.76 In-house 1-98 (358) Show / Hide 
Range on Protein: 712-811
Range on HMM: 1-98/358
Sequence Identity: 44% (44 aa)

LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNR
|..| .|| ||||.|| | | || .|   |   ||||| |.    .    |  |  .|   |.| ||.|||| |  |||  .| ||   | | ..|...|
LQFGKTLGSGAFGKVVEATAYGLSKSQ--AVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR